I-TASSER results

I-TASSER results for job id Rv3921c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (366 residues)
MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSVMFLVFTLRALLYKPFV
RQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHGFNPILGCLPMLAQIPVFL
GLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVGHFLDANLFGAPIGAYMTQRS
GLDAFVDFSRPALIAVGVPVMILAGIATYFNSRASIARQSAEAAANPQTAMMNKLALYVF
PLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGMIEKEEEAKKQEAVRRRAANAPAPG
AKPKRSPKTAPATNAAAPTEAGDTDDGAESDASTERPADTSNPARRNSGPSARTPRPGVR
PKKRKR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSVMFLVFTLRALLYKPFVRQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHGFNPILGCLPMLAQIPVFLGLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVGHFLDANLFGAPIGAYMTQRSGLDAFVDFSRPALIAVGVPVMILAGIATYFNSRASIARQSAEAAANPQTAMMNKLALYVFPLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGMIEKEEEAKKQEAVRRRAANAPAPGAKPKRSPKTAPATNAAAPTEAGDTDDGAESDASTERPADTSNPARRNSGPSARTPRPGVRPKKRKR
Prediction	CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	986433345899999999999999999998757788755799999999999999998679999999999999999999999985799999999999999999997555899999999999999999987665556666655554456666666665665554444554688545545666666667777754677888999999999999999985557889999986899999999999999999999989999999999999999999999974776578888998988776568887766466788888887777766665555444555544454556666677766667777666654579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSVMFLVFTLRALLYKPFVRQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHGFNPILGCLPMLAQIPVFLGLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVGHFLDANLFGAPIGAYMTQRSGLDAFVDFSRPALIAVGVPVMILAGIATYFNSRASIARQSAEAAANPQTAMMNKLALYVFPLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGMIEKEEEAKKQEAVRRRAANAPAPGAKPKRSPKTAPATNAAAPTEAGDTDDGAESDASTERPADTSNPARRNSGPSARTPRPGVRPKKRKR
Prediction	642131132333212220121213130013013333220000000100121222121012301312420450343155037415733541152025005626121100132332231131000100231243343333333322433333322132332332230300002011102213331112211000000000000000001111111122344455445444233012313333133233333332200021022103211201100222155654544455355545645555455554554455555555554565565555655555556555645565545554455654566668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSVMFLVFTLRALLYKPFVRQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHGFNPILGCLPMLAQIPVFLGLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVGHFLDANLFGAPIGAYMTQRSGLDAFVDFSRPALIAVGVPVMILAGIATYFNSRASIARQSAEAAANPQTAMMNKLALYVFPLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGMIEKEEEAKKQEAVRRRAANAPAPGAKPKRSPKTAPATNAAAPTEAGDTDDGAESDASTERPADTSNPARRNSGPSARTPRPGVRPKKRKR

3wo6A

0.28

0.16

0.55

1.74

MUSTER

ITSESEGIWNHFFVYPMSWLITTVANLLN--------GSYGLSIIIVTILIRLALLPLTLKQQKSMRAMQVIRPEMEAIQKKYKEKQQEMQKELLGLYQKHGVNPMAGCLPLFIQLPILMAFYFAIMRTEEIRYHTFLWFDLGQPD---------------------------------------------------YILPFVAGITTYFQFKMTM-----------SHQMQMKVMLYVMPVMIIIAGLSLPSALSLYWVIGNIFMIIQTY-----------------------------------------------------------------------------------------------

3wo6A

0.28

0.16

0.55

1.63

dPPAS

ITSESEGIWNHFFVYPMSWLITTVANLLN--------GSYGLSIIIVTILIRLALLPLTLKQQKSMRAMQVIRPEMEAIQKKYKEKQQEMQKELLGLYQKHGVNPMAGCLPLFIQLPILMAFYFAIMRTEEIRYHTFLWFDLGQPD---------------------------------------------------YILPFVAGITTYFQFKMTM-----------SHQMQMKVMLYVMPVMIIIAGLSLPSALSLYWVIGNIFMIIQTY-----------------------------------------------------------------------------------------------

3wo6A

0.29

0.16

0.55

3.33

wdPPAS

ITSESEGIWNHFFVYPMSWLITTVANLLN--------GSYGLSIIIVTILIRLALLPLTLKQQKSMRAMQVIRPEMEAIQKKYKEKQQEMQKELLGLYQKHGVNPMAGCLPLFIQLPILMAFYFAIMRTEEIRYHTFLWF-------------------------------------DLGQPD--------------YILPFVAGITTYFQFKMTM-----------SHQMQMKVMLYVMPVMIIIAGLSLPSALSLYWVIGNIFMIIQTY-----------------------------------------------------------------------------------------------

3wo6A

0.29

0.16

0.55

2.32

wMUSTER

ITSESEGIWNHFFVYPMSWLITTVANLLN--------GSYGLSIIIVTILIRLALLPLTLKQQKSMRAMQVIRPEMEAIQKKYKEKQQEMQKELLGLYQKHGVNPMAGCLPLFIQLPILMAFYFAIMRTEEIRYHTFLW-------------------------------------FDLGQPD--------------YILPFVAGITTYFQFKMTM-----------SHQMQMKVMLYVMPVMIIIAGLSLPSALSLYWVIGNIFMIIQTY-----------------------------------------------------------------------------------------------

3wo6A

0.29

0.16

0.55

5.04

wPPAS

ITSESEGIWNHFFVYPMSWLITTVANLLN--------GSYGLSIIIVTILIRLALLPLTLKQQKSMRAMQVIRPEMEAIQKKYKEKQQEMQKELLGLYQKHGVNPMAGCLPLFIQLPILMAFYFAIMRT-----------------------------------EEIRYHTF-LWF-DLGQPD--------------YILPFVAGITTYFQFKMTM-----------SHQMQMKVMLYVMPVMIIIAGLSLPSALSLYWVIGNIFMIIQTY-----------------------------------------------------------------------------------------------

3wo6A

0.28

0.16

0.55

4.38

dPPAS2

ITSESEGIWNHFFVYPMSWLITTVANLLN--------GSYGLSIIIVTILIRLALLPLTLKQQKSMRAMQVIRPEMEAIQKKYKEKQQEMQKELLGLYQKHGVNPMAGCLPLFIQLPILMAFYFAIMRTEEIRYHTFLWFDLGQPD---------------------------------------------------YILPFVAGITTYFQFKMTM-----------SHQMQMKVMLYVMPVMIIIAGLSLPSALSLYWVIGNIFMIIQTY-----------------------------------------------------------------------------------------------

3wo6A

0.28

0.16

0.55

3.26

PPAS

ITSESEGIWNHFFVYPMSWLITTVANLLN--------GSYGLSIIIVTILIRLALLPLTLKQQKSMRAMQVIRPEMEAIQKKYKEKQQEMQKELLGLYQKHGVNPMAGCLPLFIQLPILMAFYFAIMRTEEIRYHTFLWFDLGQPD---------------------------------------------------YILPFVAGITTYFQFKMTM-----------SHQMQMKVMLYVMPVMIIIAGLSLPSALSLYWVIGNIFMIIQTY-----------------------------------------------------------------------------------------------

3wo6A

0.29

0.16

0.55

4.70

Env-PPAS

ITSESEGIWNHFFVYPMSWLITTVANLLN--------GSYGLSIIIVTILIRLALLPLTLKQQKSMRAMQVIRPEMEAIQKKYKEKQQEMQKELLGLYQKHGVNPMAGCLPLFIQLPILMAFYFAIMRT-----------------------------------EEIRYHTF------LWFDLGQPD----------YILPFVAGITTYFQFKMTM-----------SHQMQMKVMLYVMPVMIIIAGLSLPSALSLYWVIGNIFMIIQTY-----------------------------------------------------------------------------------------------

3wvfA2

0.29

0.15

0.51

1.57

MUSTER

-----DYGWLWFISQPLFKLLKWIHSFVG---------NWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRISQEMMALYKAEKVNPLGGCFPLLIQMPIFLALYYMLMGS-----------------------------------VELRQAPFALWIHDLSAQDPYY------------ILPILMGVTMFFIQK----------------------IMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQ------------------------------------------------------------------------------------------------

3wvfA2

0.28

0.14

0.51

1.34

dPPAS

-----DYGWLWFISQPLFKLLKWIHSFVG---------NWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRISQEMMALYKAEKVNPLGGCFPLLIQMPIFLALYYMLMGSVELRQAPFAL-----------------------------------WIHDLSAQDPYY------------ILPILMGVTMFFIQK----------------------IMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQ------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.26

Estimated TM-score = 0.35±0.12

Estimated RMSD = 14.6±3.7Å

Download Model 2

C-score=-3.23

Download Model 3

C-score=-3.66

Download Model 4

C-score=-3.64

Download Model 5

C-score=-3.90

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3g61A	0.396	5.96	0.057	0.612
2	2f3oA	0.395	6.91	0.059	0.675
3	1xdpA	0.393	6.52	0.054	0.639
4	1h19A	0.385	6.17	0.044	0.601
5	3ehnA	0.379	6.35	0.034	0.598
6	2iwhB	0.377	7.04	0.069	0.653
7	3pflA	0.377	6.78	0.056	0.642
8	1c96A	0.376	7.27	0.056	0.678
9	1l1lA	0.375	6.67	0.038	0.612
10	3clwA	0.374	6.33	0.076	0.598

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	4	3fu3A	IMD	Rep, Mult	204,207,208,211,256,259,260,263
2	0.04	2	3a0bF	MGE	Rep, Mult	55,69,70
3	0.04	2	4kt0B	CLA	Rep, Mult	125,129
4	0.04	2	2xsjC	UUU	Rep, Mult	108,109
5	0.04	2	2hitH	PEV	Rep, Mult	259,269
6	0.04	2	1ocoO	HEA	Rep, Mult	69,107,109
7	0.04	2	3fuhA	5H1	Rep, Mult	200,203,246,249,253,258
8	0.02	1	3l22A	ZN	Rep, Mult	86,93
9	0.02	1	5a43B	DMU	Rep, Mult	20,28
10	0.02	1	2r9rB	PGW	Rep, Mult	48,63
11	0.02	1	3dtuB	DMU	Rep, Mult	74,82
12	0.02	1	4hw3F	19G	Rep, Mult	13,47,51,54,55,111,114,115,118,262
13	0.02	1	1s5lk	CLA	Rep, Mult	111,118
14	0.02	1	3prqX	CLA	Rep, Mult	113,120
15	0.02	1	3arch	CLA	Rep, Mult	118,121,122
16	0.02	1	3br0A	IMD	Rep, Mult	80,83
17	0.02	1	1ugiE	IMD	Rep, Mult	102,104
18	0.02	1	3fu5A	IMD	Rep, Mult	48,51,261,262,265

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1aorB	0.353	6.89	0.055	0.593	1.2.7.5	199
2	0.060	1n1hA	0.364	6.70	0.052	0.609	2.7.7.48	211,212
3	0.060	2pflA	0.379	6.72	0.061	0.642	2.3.1.54	251
4	0.060	5acnA	0.302	7.39	0.037	0.541	4.2.1.3	NA
5	0.060	2jg0A	0.360	6.85	0.052	0.609	3.2.1.28	NA
6	0.060	1ayxA	0.367	6.25	0.029	0.577	3.2.1.3	222
7	0.060	1a0dA	0.359	6.21	0.076	0.574	5.3.1.5	NA
8	0.060	1ut9A	0.364	6.24	0.039	0.571	3.2.1.4	NA
9	0.060	2f6dA	0.368	6.16	0.026	0.574	3.2.1.3	NA
10	0.060	3ebgA	0.368	6.31	0.052	0.585	3.4.11.-	NA
11	0.060	2vn4A	0.368	6.45	0.048	0.587	3.2.1.3	NA
12	0.060	1ygeA	0.355	6.70	0.040	0.596	1.13.11.12	NA
13	0.060	1dgjA	0.365	6.74	0.032	0.596	1.2.-.-	NA
14	0.060	2qnoA	0.385	6.33	0.043	0.615	3.2.1.4	43
15	0.060	2ow6A	0.363	6.78	0.072	0.607	3.2.1.114	NA
16	0.060	1h19A	0.385	6.17	0.044	0.601	3.3.2.6	105
17	0.060	2vn7A	0.367	6.41	0.055	0.585	3.2.1.3	NA
18	0.060	2iukA	0.360	6.45	0.064	0.582	1.13.11.12	NA
19	0.060	1l1lA	0.375	6.67	0.038	0.612	1.17.4.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.364	6.83	0.04	0.61	4m1mA	GO:0000086 GO:0000166 GO:0002481 GO:0002485 GO:0002489 GO:0002591 GO:0005524 GO:0005886 GO:0006810 GO:0006855 GO:0008559 GO:0009986 GO:0015893 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0042623 GO:0042626 GO:0042908 GO:0046581 GO:0055085 GO:0070062 GO:0072089
1	0.06	0.377	6.96	0.07	0.65	2iw3B	GO:0000166 GO:0001933 GO:0003723 GO:0003746 GO:0005524 GO:0005737 GO:0005840 GO:0006412 GO:0006414 GO:0006415 GO:0006469 GO:0010494 GO:0016887 GO:0019843 GO:0022626 GO:0042788
2	0.06	0.331	7.29	0.06	0.58	2vf8B	GO:0000166 GO:0003677 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009380 GO:0009381 GO:0016887 GO:0046872 GO:0090305
3	0.06	0.304	7.04	0.03	0.52	2r6fB	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
4	0.06	0.326	7.19	0.04	0.58	3zqjF	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0060543 GO:0090305
5	0.06	0.288	7.54	0.07	0.53	3fxgA	GO:0003824 GO:0008152 GO:0046872
6	0.06	0.313	6.71	0.08	0.52	2vf7B	GO:0000166 GO:0003677 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009380 GO:0009381 GO:0016887 GO:0046872 GO:0090305
7	0.06	0.279	7.45	0.03	0.51	4crmP	GO:0000054 GO:0000166 GO:0003743 GO:0005506 GO:0005524 GO:0005634 GO:0005737 GO:0005852 GO:0006364 GO:0006412 GO:0006413 GO:0006415 GO:0006810 GO:0016887 GO:0022626 GO:0032790 GO:0042254 GO:0042273 GO:0043024 GO:0045727
8	0.06	0.302	5.38	0.03	0.42	4ry2A	GO:0005524 GO:0006508 GO:0006810 GO:0008233 GO:0008234 GO:0016020 GO:0016021 GO:0016887 GO:0022885 GO:0042626 GO:0043213 GO:0055085
9	0.06	0.337	6.87	0.02	0.56	4f4cA	GO:0000166 GO:0005524 GO:0006810 GO:0006855 GO:0008559 GO:0010038 GO:0015562 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0016887 GO:0042626 GO:0042908 GO:0045087 GO:0050829 GO:0055085 GO:0093002
10	0.06	0.316	7.15	0.07	0.55	2r6fA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
11	0.06	0.370	6.85	0.05	0.62	3zqjA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0060543 GO:0090305
12	0.06	0.294	7.10	0.04	0.51	3j5sD	GO:0000049 GO:0000166 GO:0003723 GO:0005524 GO:0005737 GO:0006412 GO:0006417 GO:0016887 GO:0019843 GO:0043022 GO:0045900
13	0.06	0.307	7.04	0.05	0.54	3ozxB	GO:0000054 GO:0000166 GO:0005506 GO:0005524 GO:0005623 GO:0005852 GO:0006413 GO:0006415 GO:0016887 GO:0043024
14	0.06	0.291	5.51	0.02	0.42	4pl0B	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0015031 GO:0016020 GO:0016021 GO:0016887 GO:0030153 GO:0042626 GO:0043213 GO:0055085
15	0.06	0.289	5.87	0.03	0.43	4ayxA	GO:0000166 GO:0005215 GO:0005524 GO:0005739 GO:0005743 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0032592 GO:0042626 GO:0042803 GO:0055085
16	0.06	0.292	6.87	0.05	0.49	5da9A	GO:0000723 GO:0005089 GO:0005524 GO:0005634 GO:0006281 GO:0016887 GO:0030870 GO:0035023 GO:0043547
17	0.06	0.295	5.11	0.03	0.41	3wmgA	GO:0000166 GO:0005524 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0055085
18	0.06	0.276	7.02	0.05	0.47	4yerA	GO:0000166 GO:0005524 GO:0016887 GO:0043215 GO:1900753

Consensus prediction of GO terms

Molecular Function	GO:0032550	GO:0017111	GO:0035639	GO:0032559	GO:0004520	GO:0003676	GO:0043169
GO-Score	0.56	0.56	0.56	0.56	0.36	0.36	0.36
Biological Processes	GO:0033554	GO:0006259
GO-Score	0.36	0.36
Cellular Component	GO:0044424	GO:1990391	GO:1902494
GO-Score	0.46	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.