I-TASSER results

I-TASSER results for job id Rv3916c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (244 residues)
MSARITALRLEAFEQLPKHARRCVFWEVDPAILGKDDHLADPEFEKEAWLSMVMLEWGSC
GQVATAVPDERSHAEPPCLGYVLYAPPSAVPRAQRFPTAPVSADAVLLTSMGIERGQADD
DLPHSLIARVIEELVRRGVRALEAFGRTPAATDLQNPGAVTPDVRPVLEALGDCCVEHCI
IDANFLMDVGFVVVAPHPYFPRLRLELDKGLGWKAEVEAALERLLENARLQEPIAAGSTA
GNTS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSARITALRLEAFEQLPKHARRCVFWEVDPAILGKDDHLADPEFEKEAWLSMVMLEWGSCGQVATAVPDERSHAEPPCLGYVLYAPPSAVPRAQRFPTAPVSADAVLLTSMGIERGQADDDLPHSLIARVIEELVRRGVRALEAFGRTPAATDLQNPGAVTPDVRPVLEALGDCCVEHCIIDANFLMDVGFVVVAPHPYFPRLRLELDKGLGWKAEVEAALERLLENARLQEPIAAGSTAGNTS
Prediction	CCEEEEHCCHHHHHHCCHHHHHEEEEEHCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCEEEEEHCCHHHCCCCCCCCCCCCCCHHHEEEEEEHCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCCCHHCHHHHCCCCCCCCCCCCCHHHHHHHCCEEEHCCCCCCCEEHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
Conf.Score	9879998585567875666643566775756655666567658899999999998758886788757887777788866999986876698755688999986565566556676565688789999999999999898567775478887767788777754444555445577788865599999889889867888875555476677758999999999998676777778888888789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSARITALRLEAFEQLPKHARRCVFWEVDPAILGKDDHLADPEFEKEAWLSMVMLEWGSCGQVATAVPDERSHAEPPCLGYVLYAPPSAVPRAQRFPTAPVSADAVLLTSMGIERGQADDDLPHSLIARVIEELVRRGVRALEAFGRTPAATDLQNPGAVTPDVRPVLEALGDCCVEHCIIDANFLMDVGFVVVAPHPYFPRLRLELDKGLGWKAEVEAALERLLENARLQEPIAAGSTAGNTS
Prediction	7734043033721650353013000010215336546544434231210023013332200200133544444353200000000124202303413423122000000001024624564123200320032026340400000023454552644542446334325444633462000204103614041035234211010104752513430340045116515264424544446648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEHCCHHHHHHCCHHHHHEEEEEHCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCEEEEEHCCHHHCCCCCCCCCCCCCCHHHEEEEEEHCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCCCHHCHHHHCCCCCCCCCCCCCHHHHHHHCCEEEHCCCCCCCEEHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MSARITALRLEAFEQLPKHARRCVFWEVDPAILGKDDHLADPEFEKEAWLSMVMLEWGSCGQVATAVPDERSHAEPPCLGYVLYAPPSAVPRAQRFPTAPVSADAVLLTSMGIERGQADDDLPHSLIARVIEELVRRGVRALEAFGRTPAATDLQNPGAVTPDVRPVLEALGDCCVEHCIIDANFLMDVGFVVVAPHPYFPRLRLELDKGLGWKAEVEAALERLLENARLQEPIAAGSTAGNTS

2wpxA

0.12

0.11

0.88

0.84

MUSTER

GELEFVPLAANDDETV-GQWLDL----MALAAETGPRAAPPC----NVDMVGSLRFAPPATALDD----WVVRSGGRVVGALRLAL-------------PDGAPTARVDQLLVHPGRRRRGIGRALWAHARELARKHDRTTLTATVVES----LPSGPAQDPGPAAFAAAMGAHRSDIPAGTHQWLVPAGYSLVTWGTITPVSELELRAAQEVRTSYARQFETMRVGRGRRAYHTGAVHDATGA

2a4nA

0.10

0.07

0.71

1.27

dPPAS

--MIISEFDRNNPVLKDQLSDL--------LRLTWPEEYGDSSAEEVEEMM-------NPERIAV-----AAVDQDELVGFIGAIPQY-------------GITGWELHPLVVESSRRKNQIGTRLVNYLEKEVASRGGITIYLGTDDLDHGTTLSQTDLYEHTFDKVASIQNLREH----PYEFYEKLGYKIVGVLPNANGMAKTIIPRPD--------------------------------

2a4nA

0.10

0.07

0.68

1.46

wdPPAS

M--IISEFDRNNPVLKDQLSDL--------LRLTWPEEYGDSSAEEVEEM---------------NPERIAAVDQDELVGFIGAIP---------------GITGWELHPLVVESSRRKNQIGTRLVNYLEKEVASRGGITIYLGTDDLDHGTTLSQTDLYEHTFDKVASIQNLREH----PYEFYEKLGYKIVGVLPNA--MAKTIIPRPD--------------------------------

2cy2A

0.16

0.11

0.65

1.05

wMUSTER

--VRIRRAGLEDLPGVARVLVDT--WRVPEAFLEGLS-----YEGQAERWAQRLKTPTWPGRLFV-----AESESGEVVGFAAFGP----DRASGFPGYTA-----ELWAIYVLPTWQRKGLGRALFHEGARLLQAEGYGLVWVL---------------------------KENPKG----RGFYEHLGGVLLGERAKLWAYGFDLG-GHKW-------------------------------

2cy2A

0.15

0.09

0.64

1.43

wPPAS

V--RIRRAGLEDLPGVARVLVDT--WRVPEAFLEGLS-----YEGQAERWAQRLKTPTWPGRLFV-----AESESGEVVGFAAFGP---------DRASGFPGYTAELWAIYVLPTWQRKGLGRALFHEGARLLQAEGYRLVWVL---------------------------KENPKG----RGFYEHLGGVLLGEREIE-AYGFDL-GGHKW-------------------------------

3fynA

0.12

0.07

0.56

2.40

dPPAS2

LSPQVRTAHIGDVPVLVRLSEF--------YQEAGFALP---HDAAIRAFKALLGK-PDLGRIWL------IAEGTESVGYIVLTLGFSEYGGLR----------GFVDDFFVRPNARGKGLGAAALQTVKQGCCDLGVRALLVAGFEESGRLLGQALAPPIHE--------------------------------------------------------------------------------

2cy2A

0.14

0.09

0.64

1.14

PPAS

V--RIRRAGLEDLPGV-VDTWRATYRGVVPEAFLEGLS----YEGQAERWAQRLKTPTWPGRLFV-----AESESGEVVGFAAFGP---------DRASGFPGYTAELWAIYVLPTWQRKGLGRALFHEGARLLQAEGYRLVWVLKEN----------------------------------RGFYEHLGGVLLGEREIE-AYGFDL-GGHKW-------------------------------

2cy2A

0.14

0.09

0.66

1.45

Env-PPAS

V--RIRRAGLEDLPGVLVDTWRATYRGVVPEAFLEGLS----YEGQAERWAQRLKTPTWPGRLFV-----AESESGEVVGFAAFGP---------DRASGFPGYTAELWAIYVLPTWQRKGLGRALFHEGARLLQAEGYRLVWVLKEN-------------------PKG------------RGFYEHLGGVLLGEREKLWEVAYGFDGGHKW-------------------------------

4zm6A2

0.12

0.10

0.86

0.76

MUSTER

ATFIVDDYRND--DDLDHVTAM---WD---DIFGKDWPLR------KDKINLGLQRAKLKHKVARDS-------QGKIVGFVATQIVVV------------NKKHGQLMLLMVSPSYQGKGVGTLLHDAALEHFREQGADCIKLGSTYPFFPGVPDDDAQSRKAQAFFSKKGWRMDDNLVHIQARMLKEKIWFGRIKPSETWELYAFQQR--NFPHWLSTYQHHVELGDYQDLIVARQDDENGR

1z4eA

0.11

0.07

0.61

1.25

dPPAS

-HVTIREATEGDLEQMVHMLADD-----VLGRKRERYEKPLPVSYVRAFKEIKKDK----NNELI-----VACNGEEIVGMLQVTFTPYLTYQGSW--------RATIEGVRTHSAARGQGIGSQLVCWAIERAKERGCHLIQL-----------TTDKQRPDALRFYEQLGFKASHEGLKMHF------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.73

Estimated TM-score = 0.51±0.15

Estimated RMSD = 9.6±4.6Å

Download Model 2

C-score=-2.55

Download Model 3

C-score=-2.54

Download Model 4

C-score=-3.16

Download Model 5

C-score=-4.98

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2a4nA	0.606	2.65	0.093	0.701
2	4ksfA	0.583	4.31	0.103	0.795
3	2ygwA	0.578	4.36	0.104	0.795
4	4ksaA	0.568	4.63	0.148	0.799
5	1yleA	0.564	4.21	0.060	0.779
6	4ks9A	0.561	4.56	0.141	0.779
7	4fd7A	0.556	3.12	0.109	0.676
8	2cy2A	0.555	3.24	0.122	0.672
9	4fd5A	0.551	3.41	0.102	0.684
10	2refA	0.550	3.83	0.084	0.713

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.33	36	1gheA	ACO	Rep, Mult	23,108,109,110,111,112,113,118,119,121,122,123,124,144,145,146,182,184,185,186,188
2	0.03	3	3p2hA	NOO	Rep, Mult	35,108,109,110,111,112,142,143,144,145,146,147,182,203
3	0.02	2	2j8mB	AZI	Rep, Mult	190,192,204,205,206
4	0.01	1	2j8rA	AZI	Rep, Mult	81,110,112
5	0.01	1	3j0oK	NUC	Rep, Mult	202,204,205
6	0.01	1	2j8rA	AZI	Rep, Mult	46,49,81,110,112
7	0.01	1	2b0qA	MG	Rep, Mult	173,188
8	0.01	1	1vs0A	MG	Rep, Mult	27,29
9	0.01	1	1yklG	DHB	Rep, Mult	80,86
10	0.01	1	2pdoB	ZN	Rep, Mult	11,14,15
11	0.01	1	1icuD	NIO	Rep, Mult	44,143
12	0.01	1	3t1gA	ZN	Rep, Mult	41,45
13	0.01	1	2j8mB	AZI	Rep, Mult	16,20,53,81
14	0.01	1	2cjaB	MG	Rep, Mult	204,206

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.188	2cntD	0.493	2.68	0.136	0.574	2.3.1.128	108,147,183,191
2	0.141	1qsmD	0.507	2.96	0.100	0.598	2.3.1.48	189
3	0.067	1q2yA	0.464	2.64	0.098	0.537	2.3.1.-	NA
4	0.066	2jevB	0.490	3.29	0.074	0.607	2.3.1.57	108,185
5	0.066	1yghA	0.474	3.51	0.068	0.590	2.3.1.48	108
6	0.066	1cm0A	0.469	3.05	0.057	0.570	2.3.1.48	108
7	0.066	1i1dD	0.462	3.56	0.076	0.582	2.3.1.4	NA
8	0.060	2z11A	0.494	3.74	0.056	0.639	2.3.1.128	NA
9	0.060	1k4jA	0.469	3.75	0.064	0.611	2.3.1.184	NA
10	0.060	1yleA	0.564	4.21	0.060	0.779	2.3.1.109	28,109
11	0.060	3d2pB	0.457	3.22	0.126	0.553	2.3.1.1	NA
12	0.060	2vqyA	0.535	3.82	0.100	0.693	2.3.1.82	122
13	0.060	2p0wA	0.453	3.98	0.086	0.594	2.3.1.48	NA
14	0.060	3igrA	0.516	3.66	0.101	0.652	2.3.1.128	117,144,191
15	0.060	2beiB	0.479	3.03	0.123	0.574	2.3.1.57	84,127,144
16	0.060	1z4rA	0.468	3.13	0.057	0.566	2.3.1.48	108
17	0.060	1nmtA	0.478	3.75	0.086	0.619	2.3.1.97	113,127,146
18	0.060	2o28A	0.452	3.67	0.061	0.582	2.3.1.4	185
19	0.060	3d3sA	0.477	3.00	0.114	0.574	2.3.1.178	NA
20	0.060	2nsmA	0.433	5.48	0.053	0.697	3.4.17.3	NA
21	0.060	2boaA	0.423	5.38	0.047	0.647	3.4.17.-	NA
22	0.060	2vezA	0.459	3.51	0.090	0.574	2.3.1.4	185
23	0.060	1ro5A	0.523	3.70	0.095	0.664	2.3.1.184	206
24	0.060	2r8vA	0.464	3.13	0.131	0.561	2.3.1.1	NA
25	0.060	2c1cA	0.424	5.32	0.060	0.647	3.4.17.2	NA
26	0.060	1iykA	0.477	3.73	0.086	0.615	2.3.1.97	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.515	3.09	0.12	0.62	4mbuA	GO:0008080 GO:0016740
1	0.18	0.524	3.00	0.13	0.62	2ge3A	GO:0008080 GO:0016740
2	0.17	0.479	3.37	0.06	0.59	4yfjB	GO:0008080 GO:0016740
3	0.17	0.533	3.38	0.12	0.65	2qecA	GO:0008080 GO:0016740
4	0.16	0.480	3.33	0.10	0.59	2euiA	GO:0004596 GO:0006474 GO:0008080 GO:0016740 GO:0031248
5	0.15	0.486	3.28	0.09	0.59	5f47B	GO:0008080
6	0.15	0.602	2.92	0.10	0.71	1b87A	GO:0008080
7	0.12	0.550	3.83	0.08	0.71	2refA	GO:0003824 GO:0008080 GO:0008152 GO:0016740 GO:0031177
8	0.12	0.485	3.04	0.12	0.58	2beiB	GO:0004145 GO:0005737 GO:0008080 GO:0009447 GO:0016740 GO:0016746 GO:0032918 GO:0032919 GO:0032920 GO:0046204 GO:0070062
9	0.12	0.483	3.37	0.11	0.60	2q0yA	GO:0008080 GO:0016740 GO:0046872
10	0.12	0.494	3.90	0.09	0.65	1u6mA	GO:0008080 GO:0016740
11	0.11	0.510	3.20	0.08	0.62	1wwzA	GO:0008080
12	0.11	0.487	3.47	0.08	0.61	4e0aA	GO:0008080
13	0.10	0.480	3.15	0.09	0.58	1z4eA	GO:0008080
14	0.10	0.496	2.97	0.09	0.59	2ob0C	GO:0004596 GO:0005737 GO:0006474 GO:0008080 GO:0010485 GO:0016740 GO:0016746 GO:0031415 GO:0043967 GO:0052858 GO:0070062 GO:0071962
15	0.10	0.362	5.32	0.07	0.58	3o4sA	GO:0004721 GO:0004725 GO:0005737 GO:0005829 GO:0005856 GO:0006470 GO:0009898 GO:0016311 GO:0016787 GO:0016791 GO:0035335
16	0.09	0.484	2.82	0.10	0.57	3pp9A	GO:0008080 GO:0016740 GO:0046677
17	0.07	0.494	2.32	0.10	0.56	3blnA	GO:0008080
18	0.07	0.515	3.32	0.10	0.64	4e2aB	GO:0008080 GO:0016740
19	0.07	0.507	2.96	0.10	0.60	1qsmD	GO:0004402 GO:0008080 GO:0016568 GO:0016573 GO:0016740 GO:0016746 GO:0042802 GO:0042803 GO:0051289
20	0.07	0.502	3.20	0.11	0.62	1vhsA	GO:0004596 GO:0006474 GO:0008080 GO:0009635 GO:0016740 GO:0016746 GO:0031248 GO:0046677
21	0.07	0.489	3.31	0.11	0.61	3d8pB	GO:0008080
22	0.07	0.570	4.51	0.13	0.80	4ksaA	GO:0006633 GO:0016829 GO:0050080
23	0.07	0.578	4.36	0.10	0.80	2ygwA	GO:0002931 GO:0005102 GO:0005737 GO:0005739 GO:0005759 GO:0005777 GO:0005782 GO:0006085 GO:0006629 GO:0006631 GO:0006633 GO:0006637 GO:0010906 GO:0016829 GO:0016831 GO:0046321 GO:0050080 GO:2001294
24	0.07	0.460	2.67	0.15	0.54	1yvkA	GO:0004596 GO:0006474 GO:0008080 GO:0016740 GO:0016746 GO:0031248
25	0.07	0.584	4.29	0.10	0.80	4ksfA	GO:0006633 GO:0050080
26	0.07	0.572	4.53	0.14	0.80	4ks9B	GO:0006633 GO:0016829 GO:0050080
27	0.07	0.564	4.49	0.11	0.80	4f0xA	GO:0002931 GO:0005102 GO:0005737 GO:0005739 GO:0005759 GO:0005777 GO:0005782 GO:0006085 GO:0006629 GO:0006631 GO:0006633 GO:0006637 GO:0010906 GO:0016829 GO:0016831 GO:0046321 GO:0050080 GO:2001294
28	0.07	0.475	3.42	0.11	0.59	2fe7B	GO:0008080 GO:0016740
29	0.07	0.450	3.40	0.08	0.55	1bo4A	GO:0008080 GO:0016740
30	0.06	0.350	5.75	0.03	0.58	3jcrB	GO:0000166 GO:0000398 GO:0003924 GO:0005525 GO:0005634 GO:0005654 GO:0005681 GO:0005737 GO:0006397 GO:0006412 GO:0008380 GO:0015030 GO:0016020 GO:0016607 GO:0031012 GO:0035690 GO:0042220 GO:0044822 GO:0071013
31	0.06	0.304	5.76	0.03	0.52	3v3kA	GO:0004197 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0006508 GO:0006915 GO:0006919 GO:0006974 GO:0007568 GO:0008047 GO:0008233 GO:0008234 GO:0008630 GO:0008635 GO:0009411 GO:0014070 GO:0016787 GO:0017124 GO:0019901 GO:0030220 GO:0032025 GO:0032355 GO:0032496 GO:0034349 GO:0034644 GO:0042770 GO:0042981 GO:0043065 GO:0043293 GO:0043525 GO:0046677 GO:0071407 GO:0071549 GO:0097153 GO:0097192 GO:2001020
32	0.06	0.375	5.93	0.04	0.64	4xpqA	GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246
33	0.06	0.317	5.31	0.05	0.49	2a3kA	GO:0004721 GO:0004725 GO:0005737 GO:0005829 GO:0005856 GO:0006470 GO:0009898 GO:0016311 GO:0016787 GO:0016791 GO:0035335
34	0.06	0.279	6.43	0.04	0.51	4p0gA	GO:0000270 GO:0008933 GO:0009279 GO:0016020 GO:0016829 GO:0016837 GO:0016998 GO:0071555
35	0.06	0.316	6.03	0.04	0.54	4qyzI	GO:0003723 GO:0043234 GO:0051607 GO:0071667
36	0.06	0.303	5.17	0.04	0.47	2btpA	GO:0005737 GO:0005739 GO:0005829 GO:0005925 GO:0006605 GO:0007264 GO:0008022 GO:0016020 GO:0019904 GO:0021762 GO:0030659 GO:0034766 GO:0043234 GO:0044325 GO:0045892 GO:0047485 GO:0061024 GO:0070062 GO:0071889 GO:1900740
37	0.06	0.274	5.80	0.07	0.46	1vqtA	GO:0003824 GO:0004590 GO:0005829 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205

Consensus prediction of GO terms

Molecular Function	GO:0034212
GO-Score	0.33
Biological Processes	GO:0031365	GO:0006473
GO-Score	0.33	0.33
Cellular Component	GO:1902493	GO:0044424
GO-Score	0.33	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.