I-TASSER results

I-TASSER results for job id Rv3912

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (254 residues)
MSAADKDPDKHSADADPPLTVELLADLQAGLLDDATAARIRSRVRSDPQAQQILRALNRV
RRDVAAMGADPAWGPAARPAVVDSISAALRSARPNSSPGAAHAARPHVHPVRMIAGAAGL
CAVATAIGVGAVVDAPPPAPSAPTTAQHITVSKPAPVIPLSRPQVLDLLHHTPDYGPPGG
PLGDPSRRTSCLSGLGYPASTPVLGAQPIDIDARPAVLLVIPADTPDKLAVFAVAPHCSA
ADTGLLASTVVPRA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSAADKDPDKHSADADPPLTVELLADLQAGLLDDATAARIRSRVRSDPQAQQILRALNRVRRDVAAMGADPAWGPAARPAVVDSISAALRSARPNSSPGAAHAARPHVHPVRMIAGAAGLCAVATAIGVGAVVDAPPPAPSAPTTAQHITVSKPAPVIPLSRPQVLDLLHHTPDYGPPGGPLGDPSRRTSCLSGLGYPASTPVLGAQPIDIDARPAVLLVIPADTPDKLAVFAVAPHCSAADTGLLASTVVPRA
Prediction	CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEHCCCCEEEEEEHCCCCCEEEEEEHCCCCCCCCCCEEEEEEHCCC
Conf.Score	99888888888888899999999999875899999999999999859899999999999999999858899999999989999999989876778887655566777666545665555455666676666556899999998887777778888888888656677776566778888888999999999998799989876777889988877599999589988699999869999999865666655689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSAADKDPDKHSADADPPLTVELLADLQAGLLDDATAARIRSRVRSDPQAQQILRALNRVRRDVAAMGADPAWGPAARPAVVDSISAALRSARPNSSPGAAHAARPHVHPVRMIAGAAGLCAVATAIGVGAVVDAPPPAPSAPTTAQHITVSKPAPVIPLSRPQVLDLLHHTPDYGPPGGPLGDPSRRTSCLSGLGYPASTPVLGAQPIDIDARPAVLLVIPADTPDKLAVFAVAPHCSAADTGLLASTVVPRA
Prediction	64575555575744361312340000022431467305402520562450352051044025304714566443563245215434431454556454444444434434341101001000000001111233456344544444563544544444526454025204434534553121535620430144241457333112230415443000000114424301000002504463223004541568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEHCCCCEEEEEEHCCCCCEEEEEEHCCCCCCCCCCEEEEEEHCCC
MSAADKDPDKHSADADPPLTVELLADLQAGLLDDATAARIRSRVRSDPQAQQILRALNRVRRDVAAMGADPAWGPAARPAVVDSISAALRSARPNSSPGAAHAARPHVHPVRMIAGAAGLCAVATAIGVGAVVDAPPPAPSAPTTAQHITVSKPAPVIPLSRPQVLDLLHHTPDYGPPGGPLGDPSRRTSCLSGLGYPASTPVLGAQPIDIDARPAVLLVIPADTPDKLAVFAVAPHCSAADTGLLASTVVPRA

5frfA

0.12

0.05

0.40

1.20

wdPPAS

MSAGEPHETD----------LDHLYEFLDKEMPDSDAVKFEHHFEESSPCLEKYGLEQAVKKLVKRAAGQDDVPGDLRAKVMGRLDLIRSGQSVPEHDVAAAPSSSAPQES-----------------------------------------------------------------------------------------------------------------------------------------------

5frfA

0.18

0.07

0.39

1.27

wPPAS

MSAGEPHETD----------SEILDHLYEKEMPDSDAVKFEHHFEESSPCLEKYGLEQAVKKLVKR----AAGQDDVPGDLRAKVMGRLDLIRGQSVPEHDVAAAPSSSAPQES--------------------------------------------------------------------------------------------------------------------------------------------

5frfA

0.14

0.06

0.40

1.14

dPPAS2

MSAGEPHETD---------CSEILDHLYEKEMPDSDAVKFEHHFEESSPCLEKYGLEQAVKKLVKRAAGQDDVPGDLRAKVMGRLDLIRSGQSVPEHDVAAAPSSSAPQES-----------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.20

1.00

1.10

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

2q1zB

0.13

0.09

0.68

1.17

wdPPAS

IR---------------HVSDALLTAYAAGTLSEAFSLVVATHLSLCDECRARAGALDAVGGSLME----ETAPVALSEGSLASVMAQLDRQIADPRAPAPLADYVGRRLEDV-------RTLGGGVRQAILPTGGEAIAR------WIPGGQAVPDHGHRGLELTLVLQGA-DETDRFGA--------------GADQELE---HTPVAERGLDCICLAATD-------------------------------

2q1zB

0.15

0.10

0.64

1.16

wPPAS

IR--------------V--SDALLTAYAAGTLSEAFSLVVATHLSLCDECRARAGALDAVGGSLME----ETAPVALSEGSLASVMAQLDRQIADPRAPAPLADYVGRRL-------------------------------EDVRWRTLGGGVRQAILPTGGEAIARLL----------PG--------------GVPDHG---GLELTLV-GGAGDIEIADQELEHTPVA---GLDC------CLAATD----

4ke2A

0.12

0.09

0.74

1.11

dPPAS2

------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATIKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-----------------------------------------------------

5gaoE

0.22

0.14

0.66

1.02

dPPAS2

AAAAAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-----------------------------------------------------------------------------

4fmyA

0.10

0.07

0.68

1.02

dPPAS2

--VKNDEQDVELAD----------HDARIAANTKAINILEVRLTTAEGKIVVLRSDVDYLLDEVIDIQAHLVTVDQRLDGVESDVSDIKSDYVSKTVTESQSLASPLDVKT---------SYSVDGIQVVGARQTGWTAATGTPLLGSFNANQSYTVGTTYTQSEVAALATGLEQARQR-----ILALETALRLHGLID-------------------------------------------------------

1e3aB

0.12

0.11

0.93

0.74

MUSTER

PQKDYPASDLFAFLWGGADRVTEIDRLLEPRLTADQAWDVIRQTSRDLNLRLFLPTLQAATS---GLTQSD---------PRRQLVETLTRWDGINLLNDDGKT---WQQPGSAILNVWLTSMLKRTVVAAVPMPFDKWYSASGYETTQDGPTGSLNISVGAKILYEAVQGSPIPQAVDLFAGKEDTWETLSKRYGTPAMALTFRANNVPQAAAEETRHQAEYQRGTENDMIVFSP--TTSDRPVLAWDVVAPG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.02

Estimated TM-score = 0.28±0.09

Estimated RMSD = 15.7±3.3Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-4.78

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1ocrN	0.387	5.61	0.043	0.610
2	2o78A	0.378	5.51	0.049	0.614
3	1j36A	0.377	5.43	0.030	0.591
4	1gntA	0.377	6.65	0.049	0.693
5	2vpwA	0.373	6.31	0.055	0.673
6	1tg7A	0.371	6.61	0.041	0.681
7	1oa0A	0.371	6.23	0.038	0.657
8	3a23A	0.371	5.42	0.038	0.591
9	1v7vA	0.366	5.63	0.067	0.595
10	1kqgA	0.365	6.08	0.029	0.622

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	2zxwN	CDL	Rep, Mult	53,57,77,81,84,85,88
2	0.04	2	1gkfB	EDO	Rep, Mult	13,14,157,163
3	0.04	2	3g6wA	GTP	Rep, Mult	55,59,62
4	0.04	2	3n87J	N87	Rep, Mult	26,29
5	0.04	2	3favC	ZN	Rep, Mult	22,26
6	0.02	1	3ag4N	CDL	Rep, Mult	45,46,85,89,92
7	0.02	1	5c65A	37X	Rep, Mult	53,85
8	0.02	1	1gm7B	EDO	Rep, Mult	45,46,96,108,156
9	0.02	1	1lnyA	MG	Rep, Mult	184,205
10	0.02	1	3mdoA	CA	Rep, Mult	34,67
11	0.02	1	1um0A	FMN	Rep, Mult	204,205
12	0.02	1	1t5bB	FMN	Rep, Mult	32,41
13	0.02	1	3e3gB	SO4	Rep, Mult	59,78
14	0.02	1	3wmm7	CRT	Rep, Mult	54,64
15	0.02	1	1gk9B	EDO	Rep, Mult	47,48,49,144,145,157
16	0.02	1	1fipA	III	Rep, Mult	18,19
17	0.02	1	3ablA	CDL	Rep, Mult	186,190,193,197
18	0.02	1	4qjsW	MG	Rep, Mult	122,184
19	0.02	1	3bwxA	CA	Rep, Mult	98,101

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2pdaA	0.355	6.38	0.043	0.642	1.2.7.1	NA
2	0.060	1xc6A	0.370	6.24	0.046	0.642	3.2.1.23	NA
3	0.060	1mswD	0.333	5.79	0.040	0.555	2.7.7.6	NA
4	0.060	2qtlA	0.343	6.01	0.054	0.579	1.16.1.8	NA
5	0.060	2hs4A	0.344	5.68	0.020	0.563	6.3.5.3	NA
6	0.060	1b0pA	0.359	6.51	0.056	0.653	1.2.7.1	NA
7	0.060	1qlaD	0.344	6.85	0.030	0.661	1.3.99.1	80,88,122
8	0.060	1kqfA	0.366	6.23	0.032	0.646	1.2.1.2	NA
9	0.060	1c4aA	0.306	5.96	0.030	0.516	1.12.7.2	NA
10	0.060	2cqsA	0.319	6.44	0.051	0.587	2.4.1.20	NA
11	0.060	1b8fA	0.301	5.95	0.064	0.504	4.3.1.3	NA
12	0.060	2pmgB	0.337	6.33	0.058	0.595	5.4.2.2	34
13	0.060	2qubA	0.346	5.98	0.034	0.598	3.1.1.3	NA
14	0.060	1aroP	0.323	5.23	0.053	0.504	2.7.7.6	NA
15	0.060	2o6yA	0.384	5.62	0.087	0.626	4.3.1.-	NA
16	0.060	3c8yA	0.337	6.20	0.054	0.598	1.12.7.2	NA
17	0.060	1occA	0.382	5.45	0.054	0.602	1.9.3.1	NA
18	0.060	1h2rL	0.365	6.09	0.047	0.630	1.12.2.1	NA
19	0.060	1h2aL	0.362	6.18	0.043	0.634	1.12.2.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.432	5.81	0.04	0.70	1m56A	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
1	0.06	0.390	5.56	0.03	0.61	1qleA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
2	0.06	0.376	6.70	0.05	0.70	1e1dA	GO:0003824 GO:0005737 GO:0016491 GO:0016661 GO:0046872 GO:0050418 GO:0051536 GO:0051539 GO:0055114
3	0.06	0.426	5.51	0.06	0.67	3eh3A	GO:0004129 GO:0005506 GO:0005886 GO:0006119 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
4	0.06	0.415	5.60	0.08	0.66	2yevA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015002 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0046872 GO:0055114 GO:0070469 GO:1902600
5	0.06	0.382	5.45	0.05	0.60	1occA	GO:0004129 GO:0005506 GO:0005739 GO:0005743 GO:0006119 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0045277 GO:0046872 GO:0055114 GO:0070469 GO:1902600
6	0.06	0.386	5.46	0.05	0.63	1w27A	GO:0003824 GO:0005737 GO:0006559 GO:0009698 GO:0009800 GO:0016829 GO:0016841 GO:0045548
7	0.06	0.390	5.57	0.03	0.62	1fftA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006811 GO:0009055 GO:0009060 GO:0009319 GO:0009486 GO:0015078 GO:0015453 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016682 GO:0019646 GO:0020037 GO:0046872 GO:0048039 GO:0055114 GO:0070469
8	0.06	0.338	6.20	0.05	0.61	1h6dA	GO:0006061 GO:0008152 GO:0016491 GO:0042597 GO:0047061 GO:0055114
9	0.06	0.335	6.25	0.04	0.59	3czoB	GO:0003824 GO:0004397 GO:0005737 GO:0009072 GO:0009698 GO:0009699 GO:0009800 GO:0016829 GO:0016841 GO:0045548 GO:0051289
10	0.06	0.340	5.78	0.09	0.56	3nz4B	GO:0003824 GO:0005737 GO:0006558 GO:0006559 GO:0009698 GO:0009800 GO:0009820 GO:0009821 GO:0016829 GO:0016841 GO:0016853 GO:0016869 GO:0042617 GO:0045548 GO:0051289
11	0.06	0.323	6.78	0.04	0.61	3kdyA	GO:0003824 GO:0009403 GO:0016829 GO:0016841 GO:0016853 GO:0017000 GO:0050368 GO:0052883
12	0.06	0.383	5.57	0.04	0.62	2nyfA	GO:0003824 GO:0005737 GO:0009072 GO:0009698 GO:0009699 GO:0009800 GO:0016829 GO:0016841 GO:0045548 GO:0051289
13	0.06	0.381	5.57	0.04	0.62	4v2rB	GO:0003824 GO:0005737 GO:0006558 GO:0006559 GO:0009698 GO:0009800 GO:0009820 GO:0009821 GO:0016829 GO:0016841 GO:0016853 GO:0016869 GO:0042617 GO:0045548 GO:0051289
14	0.06	0.387	5.35	0.04	0.60	4c6gB	GO:0003824 GO:0005737 GO:0006558 GO:0006559 GO:0009698 GO:0009800 GO:0009820 GO:0009821 GO:0016829 GO:0016841 GO:0016853 GO:0016869 GO:0042617 GO:0045548 GO:0051289
15	0.06	0.297	6.37	0.04	0.53	3bkkA	GO:0001822 GO:0001974 GO:0002003 GO:0002005 GO:0002019 GO:0002446 GO:0002474 GO:0003081 GO:0003779 GO:0004175 GO:0004180 GO:0005576 GO:0005615 GO:0005737 GO:0005764 GO:0005768 GO:0005886 GO:0006508 GO:0007283 GO:0008144 GO:0008217 GO:0008233 GO:0008237 GO:0008238 GO:0008240 GO:0008241 GO:0008270 GO:0009897 GO:0014910 GO:0016020 GO:0016021 GO:0016787 GO:0019229 GO:0031404 GO:0031434 GO:0031711 GO:0032943 GO:0042312 GO:0042447 GO:0043171 GO:0046872 GO:0050435 GO:0050482 GO:0051019 GO:0060047 GO:0060177 GO:0060218 GO:0061098 GO:0070062 GO:0070573 GO:0071838 GO:1900086 GO:1902033 GO:1903597 GO:2000170
16	0.06	0.303	5.73	0.03	0.49	2rjqA	GO:0004222 GO:0005178 GO:0005576 GO:0005578 GO:0005615 GO:0005788 GO:0006508 GO:0008201 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0022617 GO:0031012 GO:0036066 GO:0042742 GO:0046872 GO:0050840
17	0.06	0.373	5.35	0.08	0.59	1gk2A	GO:0003824 GO:0004397 GO:0005737 GO:0006547 GO:0006548 GO:0016829 GO:0016841 GO:0019556 GO:0019557
18	0.06	0.387	6.33	0.07	0.69	1gnlA	GO:0003824 GO:0005737 GO:0016491 GO:0016661 GO:0046872 GO:0050418 GO:0051536 GO:0051539 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0015002	GO:0046914	GO:0015078	GO:0016676	GO:0046906
GO-Score	0.47	0.47	0.47	0.47	0.47
Biological Processes	GO:0015672	GO:0045333	GO:0098662	GO:0006818	GO:0046034	GO:0016310
GO-Score	0.47	0.47	0.47	0.47	0.47	0.47
Cellular Component	GO:0071944	GO:0031224
GO-Score	0.47	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.