I-TASSER results

I-TASSER results for job id Rv3903c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (846 residues)
MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAGDDPAGAVFGRSYDGSA
AALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAPPPSGCVGVGAPPS
AVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRSAGTQFALTEIQSTAGPMGVI
RAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDAYAARIDAVHAAVLDLLARICDP
LTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMAD
HAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAFGMAKDSWDLGPLRASIDPFGWYRSWE
EMLTGMAPLAGLGGENAPGVVESWKQFGKSLIHWDEWTTNPNEALGKTVFDAATLALPGG
PLSKLGSKGRDILAGVRGLKERLEPTTPHLEPPATPPRPGPQPPRIEPPESGHPAPAPAA
KPAPVPANGPLPHSPTESKPPPVDRPAEPVAPSSASAGQPRVSAATTPGTHVPHGLPQPG
EHVPAQAPPATTLLGGPPVESAPATAHQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRS
LSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQ
YGEPLSRHWDFTDNPADRSRINPVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPW
GQQYSNFPPNNGAVPGTRIAYTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQR
ALHVTSLRDPYHAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIR
RGVLRQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAGDDPAGAVFGRSYDGSAAALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAPPPSGCVGVGAPPSAVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRSAGTQFALTEIQSTAGPMGVIRAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDAYAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMADHAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAFGMAKDSWDLGPLRASIDPFGWYRSWEEMLTGMAPLAGLGGENAPGVVESWKQFGKSLIHWDEWTTNPNEALGKTVFDAATLALPGGPLSKLGSKGRDILAGVRGLKERLEPTTPHLEPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESKPPPVDRPAEPVAPSSASAGQPRVSAATTPGTHVPHGLPQPGEHVPAQAPPATTLLGGPPVESAPATAHQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQYGEPLSRHWDFTDNPADRSRINPVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPWGQQYSNFPPNNGAVPGTRIAYTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQRALHVTSLRDPYHAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIRRGVLRQ
Prediction	CCCEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCHHHHHHHCCCCC
Conf.Score	985675779999999999999999999999999988765778898878999999999999999999999999999999999987666665445578889988889999988766788888889998888865788888776689999999999999999999999876556666545545666776799999999999888999999999999999999999999999999999999876665666666555765899999999999999999999999988877888888887765666555554457888877665688877777777777777777777888766789888888887777888887778889988888887667778888888888988888888889888888999999999999999988889999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999988999999999999999899999999999999999999999988889999988888888888889999988888999999998888899888889988888888998887667777888889988757999768997677999999855669
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAGDDPAGAVFGRSYDGSAAALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAPPPSGCVGVGAPPSAVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRSAGTQFALTEIQSTAGPMGVIRAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDAYAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMADHAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAFGMAKDSWDLGPLRASIDPFGWYRSWEEMLTGMAPLAGLGGENAPGVVESWKQFGKSLIHWDEWTTNPNEALGKTVFDAATLALPGGPLSKLGSKGRDILAGVRGLKERLEPTTPHLEPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESKPPPVDRPAEPVAPSSASAGQPRVSAATTPGTHVPHGLPQPGEHVPAQAPPATTLLGGPPVESAPATAHQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQYGEPLSRHWDFTDNPADRSRINPVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPWGQQYSNFPPNNGAVPGTRIAYTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQRALHVTSLRDPYHAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIRRGVLRQ
Prediction	744030314101300320230043014003301430431110003140044004401510340040002002001100200100010102023225264454423243454414132111220434421410210041042301411341045014203400430242144222303210432412103402520440353044004204400410440252045025303400540142042132022003344353044005303400530241044124304411420441143035114440441135411120132124203211330111032113222120012142223214311431232122214324412421441133002134144334432244314112221343224442444442343244244435245344423444443424244342253444323344414334454242441444512445424534424524455244443442454424442435525354444544345432452424424425333424424423444144442345414424262524415444434213534125424442332433422434414454244233424514423245434444531354443634346325535434434152443444424431442444232344215642225242342551442245223414311256131021144142441552212152244201313044104404144142221111000000000014643311032004221157
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCHHHHHHHCCCCC
MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAGDDPAGAVFGRSYDGSAAALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAAPLPAPPPSGCVGVGAPPSAVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRSAGTQFALTEIQSTAGPMGVIRAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDAYAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGEVDALAAEITAVVSHAEAVITAMADHAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAFGMAKDSWDLGPLRASIDPFGWYRSWEEMLTGMAPLAGLGGENAPGVVESWKQFGKSLIHWDEWTTNPNEALGKTVFDAATLALPGGPLSKLGSKGRDILAGVRGLKERLEPTTPHLEPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESKPPPVDRPAEPVAPSSASAGQPRVSAATTPGTHVPHGLPQPGEHVPAQAPPATTLLGGPPVESAPATAHQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSEPPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQYGEPLSRHWDFTDNPADRSRINPVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPWGQQYSNFPPNNGAVPGTRIAYTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQRALHVTSLRDPYHAYTIDWLPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIRRGVLRQ

2pffB

0.12

0.11

0.99

1.41

MUSTER

TRPLTLSPTASFFIASQLQAADDEPTTPAELVGKFLGYVSSLVEPSQFDQVLNLCLTEFENCYIHALAAKLLQLVKTKELIKNYITARIMAKRPFDKKSNSALFRA-VGEGNAQLVAIFGGQGNTDDYHVLVGDLIKFSALEWPDKDVIQLAHYVVTAKLLGFTPGELRSYLKGATAVAIAETDSWE--SFFVSVRKAITVLFFIGVRCYEAYPPPSILEDSLEN-QEQVQDYVNKTNSHLPAGKQVEISLVNGAPQSLYGLNLTLRPASDLINKDLVKNGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----GGGGGGGGGGGGGGGGGGGG

3hr2A

0.10

0.08

0.80

1.39

dPPAS

-------------------------------------------------------------------------------------------QMSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGQGFQGPGE------GEGGSGPMG----------------------PPGPGPGKNGDDGEAGKP----------------------------------------------------GRGERGPGPQGARGLGTAGLGMGHRGFSGLDGAKGDTGPAGPKGEGSGENGTGQMGPRGLGERGRGPGTAGARGNDGAVGAAGPGPTGPTGPGFGAAGAKGEAGPQGARGSEGPQGVRGEGPGPAGAAGPAGNGADGQGAKGANGAGIAGAGFGARGPSGPQGPSGAGPKGTSGEGAGNKGDTGAKGEGPAGVQGPGPAGEEGKRGARGEGPSGLGPGERGGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGPDGKTGPGPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERG-VGPGAVGPAGKDGEAGAQGAGPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGGERGAAGLGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPGPAGAGDKGEAGPSGPAGPTGARGAGDRGEAGPGPAGFAGPGADGQGAKGEGDTGVKGDAGPGPAGPAGPGPIGNVGAGPGSRGAAGPGATGFGAAGRVGPGPSGNAGPGPGPVGKEGGKGPRGETGPAGRGEV

3hr2A

0.12

0.09

0.73

0.88

wdPPAS

-------------------------------------------------------------------------------------------QMSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGQGFQGPGE--------GGSGPMGPP-------------GPGPGKNGDDGEAGKPGRGERGPGPQGAR------------------------------------------------------------LGTAG----------------------------------------------MGHRGFSGLDGAKGDTGPAGPKGEGSGENGTGQMGPRGLGERGRGPGTAGARGNDVGAAGPGPTGPTGPGFGAAGAKGEAGPQGARGSEGPQGVRGEGPGPAGAAGPAGNGADGQGAKGANGAGIAGAGFGARGPSGPQGPSGAGPKGTSGEGAGNKGDTGAKGEGAGVQGPGPAGEEGKRGARGEGPSGLGPGERGGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGPDGKTGPGPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPAGKDGEAGAQGPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGMGERGAAGLGPKGDRGDAGPKGADGSPGDGVRGLTGPIGPGPAGAGDKGEAGPSGPAGPTGARGAGDRGEAGPGPAGFAGPG--ADGQGAKGEGDTGVKGDAGPGPGPAGPG------PIGNVGAG------PGSRGA

2pffB

0.11

0.98

1.32

wMUSTER

TRPLTLSPTASFFIASQLQEAADDEPTTPAELVGKFLGYVSSLVEGQFDQVLNLCLTEFENCYLEGIHALAAKLLQTLVKTKELIKNYITARIMAK-----RPFDKKSNSALFRAVGEGNAQGQGNTD-DYFEELRDLY-QTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGILEWLNPSNTPQLAHYVVTAKLLG-SQGLVTAVAIAETDSWESFFVSVRKAITVLFFIGVRCYEPPSILEDSLENISNLTQEQVQDYVNKTNSHLPAGKQPPQSLYGLNLTLRKALVPASDLINKDLVKNNVSFNAKDPVYDTFDGTQFKATHILDFGPGGASGLGVLTHNKDGTGVRVIVAGTLDINPDDDYGFKQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG------GGGGGGGGGGGGGGGGGGGG

3hr2A

0.14

0.10

0.73

1.47

wPPAS

TGP----------AGPK----GE-------------GSGENGTGQM--GPR-GLG----------------------ER-----------GPGTAGARGNDGAVGAAGPGPTGPTGPGFGAAGKGEAGPQG--------GSEGPQGVR-----------------GPGPAGAAGPAGNGADGQGAK--------------------------------------------------------------------------------------------------------------------GANGAGIAGAGF-----GARGPSPQGPGAGPKGTSGEGAGNKGDTGAKGEGPAGVQGPGPAGEEGKRGARGEGPSGLGPERGGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGPDGKTGPGPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPAGKDGEAQGAGPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDAKGDTGAGAGSQGAGLQGMGERGAAGLGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPGPAGADKGEAGPSGPAGPTGARGAGDRGEAGPGPAGFAGPGADGQGAKGEGDTGVKGDAGPGPAGPAGPGPIGNVGAGPGSRGAAGPGATGFGAAGRVGPGPSGNAGPGPGPVGKEGGKPRGETGPAGEVGPGPGPAGEKGSGADGPAGSGTPGPQGIAGQRGVVGLGQRGKRGFGGPSGGKQGG--------ASGER---------G--PG

3hr2B

0.12

0.07

0.62

1.99

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKGVSAGPGPMGLMGPPGAVGAGPQGFQGPAGEGEGQTGPAGSRGPAGPG-KAGEDGHGKPGRGERGVVGPQGARGFGTGLGFGIRGHNGLDGLKGQG-AQGVGEGAGENGTGQAGARGLGERGRVGAGPAGARGSDGSVGPVGPAGPIGSAGPGFGAGPGELGPVGNGPAGPAGPRGEAGLGLSGPVGPGNPGANGLTGAGATGLGVAGAGLGPRGIGPVGAAGATGPRGLVGEGPAGSGETGNKGEGSA-GAQGPGPSGEEGKRGSPGEPGSAGPAGPGLRGSGSRGLGADGRAGVMGPPGNRGSTGPAGVRGPNGDAGRGEGLMGPRGLGSGNVGPAGKEGPVGLGIDGRGPIGPAGPRGEAGNIGFGPKGPSGDGKGEKGHPGLAGARGAGPDGNNGAQGPGPQGVQGGKGEQGPAGPGFQGLGPSGTAGEVGKGERGLPGEFGLGPAGPRGERGPGESGAAGPSGPIGIRGPSGAGPDGNKGEAGAVGAPGSAGASGPGGLGERGAAGI------GGKGEK---------GETGL

3hr2A

0.10

0.08

0.78

2.27

PPAS

-------------------------------------------------------------------------------------------QMSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGPGFQGPGE------GEGGSGPMGPP-------------GPGPGKNGDDGEAGKPGRGERGPGPQGAR------------------------------------------------------------LGTAGLGM------------------LDGAKGDTGPAGPKGEGSGENGTGQMGPRGLGERGRGPGTAGARGNDGAVGAAGPGPTGPTGPGFGAAGAKGEAGPQGAREGPQGVRGEGPGPAGAAGPAGNGADGQGAKGANGAGIAGAGFGARGPSNKGDTGAKGEGPAGVQGPGPAGEEGKRGARGEGPSGLGPGERGGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGPDGKTGPGPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPADGEAGAQGAGPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGMGERGAAGLGPPIGPGPAGAGDKGEAGPSGPAGPTGARGAGDRGEAGPGPAGFAGPGADGQGAKGEGDTGVKGDAGPGPAGPAGPGPIGNVGAGPGSRGAAGPGATGFGAAGRVGPGPSGNAGPGPGPVGKEGGKGPRGETGPAGRGEVGPGPGP-AGEKGSGADGPAGSGTPGPQGIAGQRGVVGLGQ

4uicA

0.09

0.07

0.84

1.55

Env-PPAS

----------ATDVATVVSQAKAQMKEAYYTYSHTVTET----GQFPDIKDVYAAYNKAKQAYANAVAVVNKAGGAKKDAYLADLQAIYETYVFKA------------------------------NPKSGEARVATYI-------DAYNYATKLDKMRQELKAAVDAKD-----------------LKKAEELYHKISYELKTRTVILDRVQSTRELLRSTFKADAQALRDRLIYDITVAMKAREAQDAVKAGNLDKAKAALDQVNQYVSKV---TDAFKAELQKAAQDAKAAYEAALTPKVESVSAIDSTSFKVTFTKPVDKATAIPKNFSITLKGTETKLYPKSVEVSESGLTATVTLYDTLVDGKTYTVVTSGLKDTAGKEFETSTNEFTYNKPVPASITFNFNKLPEDSAVDLTKYVTVKDAAGNVIKSGFELEFTSSEKLTQGKFINTTGKKSVIVNATVKGTN-------VTTGNVILAVEDEKAAEVSELKLTKDNKEVVTLYANGNAFDKDGNQISSGTLTLTAKFKDQYGNELTGKVAGTDYTFESLNPEVLVVAPDGSVTPIVPGTAL------------------------------------------------VKVKYGEVTKTIPVTVKANPVLETIAVDSTGVSVAKGQKATFKVTLKDQYGNKFTGNVNVTSDKTETATVSVSNSGIGQSEYTVTVNGVAEGSTTITIKSGTKEVKVPVNVVAGGPVANYQIKVLVQLKVYAVDANGNIVGDITNDVTITSGVIVNASKSTANGDTVYVITDNETLTVKLGTVTLGTVD-VEVLKATVVTKKADLIEL-----------

5a1uE

0.08

0.07

0.94

1.38

MUSTER

----HLEKSAVLQEARVFNETPINPRKCAHILTKIL--YLINQGEH-----LGTT------EATEAFFAMTKLFQSNDPTLRRMC--YLTIKEMSCIAEDVIIVTSSTGKEDNYRGPAVRALCQITD-STMLQAVERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIM------------------------VQYHALGLLYHVRKNDRLAVSKMISKFTRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFDFIESCLRNKHE----MVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKTNNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDNEVRDRATFYLNVLEQKQKALNAGYILNGLTVSIPGLEKALQQYTLEPSQPEKVAATRQEIFQEQLAAVPEFQGLGPLFKSSPEPVALTESETEYVIRCTSDHLVFQFDCTNTLNDQTLENVTVQMEPTEAYEVLSYVPARSLPYNQPGALPTEDPTAVACTFSCVMKFTVKDCDPNTGEIDEEGYEDEYVLEDLEVTVADHIQKVMKVNFEAAWDEVGDEFEKEETFTLSTIKTLEEAVGNIVKFLGMHPCERSDKVPENKNTHTLLLAGVFRGGVRSRLLLLDTVTMQVTARSSEELPVD

3chnS

0.06

0.04

0.64

1.29

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGSSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEER

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.16

Estimated TM-score = 0.69±0.12

Estimated RMSD = 8.9±4.6Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2pffB	0.920	3.07	0.104	0.989
2	3hmjG	0.907	3.24	0.080	0.986
3	2uvcG	0.893	3.57	0.079	0.985
4	4z9rA	0.384	3.85	0.063	0.429
5	4z38A	0.380	3.83	0.080	0.424
6	3cmuA	0.373	8.67	0.057	0.588
7	4cw5A	0.367	3.95	0.073	0.414
8	3k1qA	0.344	8.48	0.043	0.538
9	1ej6A	0.343	8.44	0.041	0.535
10	4bedA	0.342	8.72	0.024	0.547

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.18	11	2uv8G	FMN	Rep, Mult	394,395,396,397,398,447,449,478,502,528,531,532,560,561,590,591,594,811,816
2	0.03	2	3mflB	DHY	Rep, Mult	790,791
3	0.03	2	2uvcI	NAP	Rep, Mult	419,422,449,454,533,534,535,636,719,768,770,771,788,789,791,811
4	0.03	2	3cmvC	ANP	Rep, Mult	451,453,454,455,456,457,458
5	0.03	2	1llwA	F3S	Rep, Mult	513,514,515,516,517,518,523,552
6	0.02	1	2wsc2	CLA	Rep, Mult	25,82
7	0.02	1	3m4bA	ZN	Rep, Mult	196,239
8	0.02	1	3cmvE	ANP	Rep, Mult	427,429,430,431,432,467
9	0.02	1	2a01B	AC9	Rep, Mult	171,174
10	0.02	1	3cmvB	ANP	Rep, Mult	422,423,426,427,428,429
11	0.02	1	1xrmA	III	Rep, Mult	74,77
12	0.02	1	1ft6A	SO3	Rep, Mult	133,179
13	0.02	1	2wse4	CLA	Rep, Mult	82,108
14	0.02	1	3egmA	FE	Rep, Mult	86,90
15	0.02	1	1lm1A	F3S	Rep, Mult	402,403,404,408,409,410,415,444
16	0.02	1	1cxpA	UUU	Rep, Mult	798,799

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2uv8G	0.911	3.17	0.082	0.986	2.3.1.86	NA
2	0.060	2vz8B	0.336	7.43	0.046	0.469	2.3.1.85	NA
3	0.060	1xc6A	0.279	7.13	0.036	0.389	3.2.1.23	402,406
4	0.060	3ecqB	0.296	8.62	0.030	0.467	3.2.1.97	NA
5	0.060	2jfdA	0.242	4.69	0.038	0.282	2.3.1.85	405,597
6	0.060	1i8qA	0.286	8.19	0.030	0.440	4.2.2.1	471
7	0.060	1ug9A	0.276	8.80	0.079	0.448	3.2.1.70	NA
8	0.060	2vz9B	0.335	7.33	0.041	0.466	2.3.1.85	NA
9	0.060	2vkzG	0.907	3.24	0.080	0.986	2.3.1.38,3.1.2.14	419,479,591,634
10	0.060	2vdcA	0.306	8.19	0.036	0.461	1.4.1.13	NA
11	0.060	1f1sA	0.287	8.27	0.030	0.442	4.2.2.1	NA
12	0.060	3btaA	0.333	8.48	0.027	0.522	3.4.24.69	NA
13	0.060	2z6iB	0.322	2.72	0.076	0.344	1.3.1.9	479,811
14	0.060	2vuaA	0.169	7.11	0.032	0.240	3.4.24.69	424,430
15	0.060	2vdcF	0.312	8.44	0.046	0.485	1.4.1.13	396,456
16	0.060	3bicA	0.286	7.30	0.059	0.405	5.4.99.2	NA
17	0.060	3bw4A	0.312	3.45	0.072	0.344	1.7.3.1	568,815
18	0.060	3bicB	0.288	6.86	0.043	0.390	5.4.99.2	397,472
19	0.060	1e1cA	0.294	7.28	0.054	0.417	5.4.99.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.369	3.75	0.06	0.41	2pffB	GO:0003824 GO:0004312 GO:0004313 GO:0004314 GO:0004318 GO:0004319 GO:0004320 GO:0004321 GO:0005811 GO:0005829 GO:0005835 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016295 GO:0016296 GO:0016297 GO:0016409 GO:0016491 GO:0016740 GO:0016787 GO:0016829 GO:0019171 GO:0042759 GO:0047451 GO:0055114
1	0.06	0.330	2.77	0.07	0.35	2z6iB	GO:0000166 GO:0003824 GO:0004318 GO:0016491 GO:0018580 GO:0051213 GO:0055114
2	0.06	0.272	8.89	0.04	0.44	5flmA	GO:0001047 GO:0001055 GO:0003677 GO:0003899 GO:0005665 GO:0005719 GO:0006351 GO:0006366 GO:0016740 GO:0016779
3	0.06	0.253	5.15	0.06	0.30	3tzwA	GO:0003824 GO:0005618 GO:0005829 GO:0005886 GO:0008152 GO:0009058 GO:0016740 GO:0016747 GO:0016788 GO:0019367 GO:0031177 GO:0034081 GO:0040007 GO:0051260 GO:0071768 GO:0071769
4	0.06	0.272	8.54	0.03	0.43	5iy6A	GO:0000398 GO:0000974 GO:0001055 GO:0001172 GO:0003677 GO:0003899 GO:0003968 GO:0005634 GO:0005654 GO:0005665 GO:0005730 GO:0006283 GO:0006351 GO:0006353 GO:0006355 GO:0006366 GO:0006367 GO:0006368 GO:0006370 GO:0008543 GO:0010467 GO:0016740 GO:0016779 GO:0031047 GO:0031625 GO:0033120 GO:0035019 GO:0042795 GO:0044822 GO:0046872 GO:0050434
5	0.06	0.231	8.92	0.02	0.38	4mz0A	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
6	0.06	0.232	8.19	0.03	0.35	4hnxA	GO:0004596 GO:0005737 GO:0006474 GO:0017196 GO:0022626 GO:0031415 GO:0031416
7	0.06	0.239	4.87	0.07	0.28	4qbuA	GO:0003824 GO:0008152 GO:0016740 GO:0031177
8	0.06	0.221	4.02	0.09	0.25	2cuyA	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
9	0.06	0.229	4.10	0.06	0.26	3tqeA	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
10	0.06	0.228	3.71	0.07	0.26	3qatA	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
11	0.06	0.225	3.61	0.06	0.25	2c2nA	GO:0003824 GO:0004314 GO:0005739 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0044822
12	0.06	0.229	3.74	0.08	0.26	3k89A	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
13	0.06	0.216	8.86	0.04	0.35	4mz0B	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
14	0.06	0.223	3.73	0.11	0.25	3ezoA	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
15	0.06	0.221	3.88	0.11	0.25	3im8A	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
16	0.06	0.230	4.03	0.10	0.26	2h1yB	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
17	0.06	0.225	3.62	0.06	0.25	3h0pB	GO:0003824 GO:0004314 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746
18	0.06	0.226	8.72	0.05	0.36	1ng9A	GO:0000018 GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0005829 GO:0006281 GO:0006298 GO:0006974 GO:0008301 GO:0016887 GO:0030983 GO:0032136 GO:0032300 GO:0042802 GO:0043531

Consensus prediction of GO terms

Molecular Function	GO:0003824
GO-Score	0.32
Biological Processes	GO:0055114	GO:0042759	GO:0040007	GO:0006367	GO:0000398	GO:0006283	GO:0033120	GO:0019367	GO:0042795	GO:0051260	GO:0006355	GO:0006370	GO:0071768	GO:0071769	GO:0050434	GO:0006368	GO:0006353	GO:0031047	GO:0035019	GO:0001172	GO:0008543
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0005665	GO:0005811	GO:0005835	GO:0005618	GO:0005719	GO:0000974	GO:0034081	GO:0005886	GO:0005730
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.