I-TASSER results

I-TASSER results for job id Rv3900c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (311 residues)
MVAADLPPGRWSAVLVGPWWPAPSAALRAAAQHWATWAMQKQELARNLISQHDLLLRNQG
RTAEDLIGRYLRGAKSEVTKAEKYEIKKGAFNTAADAIDYLRSRLTGIAGEGNKEIDDVL
ASKKPLPEQLAEIQAIQTRCNADAANASRDAVDKVMTAMQEILEAEDIGDDPRTWARANG
FNVDDAPPPRLIRENDLAALTGPGARGGSFGSVEGAGDLASPQSVGAGGFSGSGVQAACS
QPAPRAIGASSRHASAGPVPPAPVVTTPAAATPPVIATGPRWRCPAGRCRRRPSDRAYRL
RRLGNRLRPGW

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVAADLPPGRWSAVLVGPWWPAPSAALRAAAQHWATWAMQKQELARNLISQHDLLLRNQGRTAEDLIGRYLRGAKSEVTKAEKYEIKKGAFNTAADAIDYLRSRLTGIAGEGNKEIDDVLASKKPLPEQLAEIQAIQTRCNADAANASRDAVDKVMTAMQEILEAEDIGDDPRTWARANGFNVDDAPPPRLIRENDLAALTGPGARGGSFGSVEGAGDLASPQSVGAGGFSGSGVQAACSQPAPRAIGASSRHASAGPVPPAPVVTTPAAATPPVIATGPRWRCPAGRCRRRPSDRAYRLRRLGNRLRPGW
Prediction	CCCCCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCC
Conf.Score	98778999875567874789998578999999999999999999999999999875665577999999999989999999999988888888999999999999999999889999999997588688999999999986554678999999999999999986456788864555664888899999998988888888899998899998889999999999999999998888999999999999998899999999999899999999998889998888888888898888645666556677899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVAADLPPGRWSAVLVGPWWPAPSAALRAAAQHWATWAMQKQELARNLISQHDLLLRNQGRTAEDLIGRYLRGAKSEVTKAEKYEIKKGAFNTAADAIDYLRSRLTGIAGEGNKEIDDVLASKKPLPEQLAEIQAIQTRCNADAANASRDAVDKVMTAMQEILEAEDIGDDPRTWARANGFNVDDAPPPRLIRENDLAALTGPGARGGSFGSVEGAGDLASPQSVGAGGFSGSGVQAACSQPAPRAIGASSRHASAGPVPPAPVVTTPAAATPPVIATGPRWRCPAGRCRRRPSDRAYRLRRLGNRLRPGW
Prediction	74245134340001000011244452242014204411523452254145335324344042023005403520430352154153425314300400430353045126423530450166544255315403421330233233113401432141034214345224434231454516376343444354741546544444436444443264444354445444444444443443343524454354463433434344434333333255445353444515443462313045315414668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCC
MVAADLPPGRWSAVLVGPWWPAPSAALRAAAQHWATWAMQKQELARNLISQHDLLLRNQGRTAEDLIGRYLRGAKSEVTKAEKYEIKKGAFNTAADAIDYLRSRLTGIAGEGNKEIDDVLASKKPLPEQLAEIQAIQTRCNADAANASRDAVDKVMTAMQEILEAEDIGDDPRTWARANGFNVDDAPPPRLIRENDLAALTGPGARGGSFGSVEGAGDLASPQSVGAGGFSGSGVQAACSQPAPRAIGASSRHASAGPVPPAPVVTTPAAATPPVIATGPRWRCPAGRCRRRPSDRAYRLRRLGNRLRPGW

4uicA

0.11

0.98

0.86

MUSTER

TETGQFPDIK-----VYAAYNKAKQAYANAVAVVNKAGAKKDAYLADLQAIYETYVFKAATKLDKMRQELKAAVDALKKAEELYHKISYELKTRTVILDRVQSTRELLRSTFKADAQALRDRLITVAMKAREAQDAVKAGNLDKAKAALDQVNQYVSKVTDAFKAELQKAAQDAKAAYEAALTPKVESVSAIDSTSFKTFTKPVDKATAIPKNFSITLKGTETKLYPKSVEVSESGLTATVTLYDTLVDGKTYTVVTSGLKDTAGKEFETSTNEFTYNKPVPASITFNFNKLPEDSAVDLTKYGNVIKSGF

4ke2A

0.14

0.09

0.63

0.68

dPPAS

------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------------------------

2g38B

0.18

0.09

0.51

0.62

wdPPAS

--A--YPP---SANI-GP-----PDSMLAAARAWRSLDVEMTAVQRSFNRTLLLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMPLAQIYNNRAERQILID-GQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKL-------------------TPWKAPPPIA------------------------------------------------------------------------------------------------------------------------

4uicA

0.12

0.11

0.97

0.90

wMUSTER

TETGQFPD--YAA------YNKAKQAYANAVAVVNKAGAKKDAYLADLQAIYETYVFKAATKLDKMRQELKAAVDALKKAEELYHKISYELKTRTVILDRVQSTRELLRSTFKADAQALRDRLITVAMKAREAQDAVKAGNLDKAKAALDQVNQYVSKVTDAFKAELQKAAQDAKAAYEAALTPKVESVSAIDSTSFKTFTKPVDKATAIPKNFSITLKGTETKLYPKSVEVSESGLTATVTLYDTLVDGKTYTVVTSGLKDTAGKEFETSTNEFTYNKPVPASITFNFNKLPEDSAVDLTKYGNVIKSGF

2g38B

0.17

0.09

0.51

0.77

wPPAS

EA---YPP---SANI-GP-----PDSMLAAARAWRSLDVEMTAVQRSFNRTLLLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMPLAQIYNNRAERQILID-GQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKL---------TP-----------KAPPPIA------------------------------------------------------------------------------------------------------------------------

4ke2A

0.14

0.09

0.63

0.93

dPPAS2

------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------------------------

5gaoE

0.17

0.16

0.95

1.11

PPAS

----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGT

2vsgA1

0.12

0.10

0.83

0.84

Env-PPAS

---------THFGVK---------------YELWQPECELTAELRKTAGVAKMKV--NSDLNSFKTLELTKMKLLTFAAKFPESKEALTLRALEAALNTDLRALRDNIANGIDRAVRATAYA-SEAAGALFSGIQTLHDATDGTTY---------------CLSASGQGSNGNAAMASQGCKPLALPELLTEDSYNTDVISDKPKISPLTNAQGQGKSGECGLFQAASGAQATNTGVQFSGGSRINLGLGAIVASAAQQPTRPDLSDFSGTARNQADTLYGKAHAS----------ITELLQLAQGPKP--

4cgkA

0.15

0.14

0.88

0.79

MUSTER

---SNL---------------AQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQ-AESKKLEGEITELSKNIVSRNQSLEKQARSAGAVTSYINTIVNRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTV--IANQQKLADDAQALTTKQAELKA------AELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAPWAGDY----------WGNGAQWATSAAAAGSTPQVGA

5cwqA

0.10

0.07

0.75

0.66

dPPAS

----------------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH--------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.76

Estimated TM-score = 0.50±0.15

Estimated RMSD = 10.3±4.6Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-4.51

Download Model 5

C-score=-4.83

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4uicA	0.876	2.66	0.097	0.994
2	2ra1A	0.583	4.71	0.085	0.801
3	3k1dA	0.445	6.13	0.092	0.727
4	3p8cA	0.433	6.34	0.044	0.717
5	4w8jA	0.430	5.69	0.063	0.646
6	4lmhA	0.422	6.09	0.039	0.695
7	2q3zA	0.421	5.56	0.050	0.630
8	4c90A	0.418	6.05	0.030	0.675
9	3p8cB	0.415	6.10	0.037	0.675
10	4i43B	0.413	6.47	0.042	0.704

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	3	3k71G	CA	Rep, Mult	190,191,192,193,196,199
2	0.05	3	3erzD	HG	Rep, Mult	36,41,45
3	0.03	2	5ioaB	ZN	Rep, Mult	85,88
4	0.03	2	3cvsA	NUC	Rep, Mult	79,81
5	0.02	1	2vn4A	MAN	Rep, Mult	267,268
6	0.02	1	3jz0A	APC	Rep, Mult	139,144
7	0.02	1	4dfdA	MG	Rep, Mult	5,9,171
8	0.02	1	4o6nB	MPG	Rep, Mult	86,93
9	0.02	1	3r4iB	CA	Rep, Mult	43,65
10	0.02	1	4tt0B	IOD	Rep, Mult	176,177,180
11	0.02	1	3sl9A	IMD	Rep, Mult	62,103
12	0.02	1	2hcjB	GDP	Rep, Mult	141,142,143,144,145,146
13	0.02	1	2q8hA	TF4	Rep, Mult	55,70,108,149,152
14	0.02	1	5ioeB	ZN	Rep, Mult	149,153
15	0.02	1	3pp5A	CA	Rep, Mult	82,85
16	0.02	1	1ncg0	III	Rep, Mult	198,199,200,201,202,259,260,268,269,271
17	0.02	1	4eyaB	NUC	Rep, Mult	92,96
18	0.02	1	2qviA	CA	Rep, Mult	131,156,167,170
19	0.02	1	3bpxA	SAL	Rep, Mult	145,149
20	0.02	1	3rj1H	SE	Rep, Mult	115,120

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1hn0A	0.349	6.11	0.038	0.559	4.2.2.20	NA
2	0.060	2x0sA	0.346	6.62	0.025	0.611	2.7.9.1	NA
3	0.060	2gv9B	0.382	6.79	0.038	0.678	2.7.7.7	176
4	0.060	1g8mA	0.361	6.87	0.054	0.656	3.5.4.10,2.1.2.3	NA
5	0.060	2uv8G	0.341	7.33	0.043	0.653	2.3.1.86	NA
6	0.060	2zxqA	0.336	7.16	0.039	0.614	3.2.1.97	NA
7	0.060	2hg4C	0.341	7.16	0.047	0.643	2.3.1.94	198,272
8	0.060	1z0hB	0.290	5.84	0.032	0.453	3.4.24.69	132
9	0.060	1kv3A	0.277	6.91	0.023	0.498	2.3.2.13	NA
10	0.060	2pmzQ	0.345	6.77	0.031	0.605	2.7.7.6	112
11	0.060	1dceA	0.383	5.57	0.050	0.572	2.5.1.60	76
12	0.060	3dsxA	0.274	6.16	0.038	0.441	2.5.1.60	75
13	0.060	3h0gA	0.367	6.53	0.050	0.614	2.7.7.6	102,105,107
14	0.060	2epoB	0.305	5.59	0.075	0.473	3.2.1.52	184
15	0.060	2vz8B	0.337	6.99	0.036	0.614	2.3.1.85	NA
16	0.060	2vz9B	0.337	6.98	0.029	0.614	2.3.1.85	NA
17	0.060	1etuA	0.162	4.84	0.028	0.225	3.6.5.3	NA
18	0.060	2q3zA	0.421	5.56	0.050	0.630	2.3.2.13	NA
19	0.060	1js4A	0.358	6.44	0.024	0.592	3.2.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.308	6.72	0.04	0.55	2vr5A	GO:0003824 GO:0004133 GO:0004177 GO:0004553 GO:0005975 GO:0005980 GO:0006508
1	0.06	0.298	6.89	0.05	0.53	5e70C	GO:0003824 GO:0003844 GO:0004553 GO:0005975 GO:0005977 GO:0005978 GO:0016740 GO:0016757 GO:0043169
2	0.06	0.287	6.06	0.06	0.47	5e70B	GO:0003824 GO:0003844 GO:0004553 GO:0005975 GO:0005977 GO:0005978 GO:0016740 GO:0016757 GO:0043169
3	0.06	0.342	5.84	0.07	0.53	2ya1A	GO:0003824 GO:0004553 GO:0005576 GO:0005618 GO:0005975 GO:0016020 GO:0016021 GO:0030246
4	0.06	0.316	6.35	0.03	0.54	3amlA	GO:0003824 GO:0003844 GO:0004553 GO:0005975 GO:0005978 GO:0005982 GO:0009501 GO:0009507 GO:0009536 GO:0016740 GO:0016757 GO:0019252 GO:0043169
5	0.06	0.275	6.64	0.02	0.48	3uwxA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
6	0.06	0.445	6.13	0.09	0.73	3k1dA	GO:0003824 GO:0003844 GO:0004553 GO:0005886 GO:0005975 GO:0005977 GO:0005978 GO:0009250 GO:0016740 GO:0016757 GO:0040007 GO:0043169 GO:0045227
7	0.06	0.330	6.01	0.04	0.53	4okdA	GO:0003824 GO:0004553 GO:0005975
8	0.06	0.280	6.90	0.04	0.50	1eh9A	GO:0003824 GO:0004553 GO:0005737 GO:0005975 GO:0005992 GO:0008152 GO:0016787 GO:0016798 GO:0033942
9	0.06	0.323	6.22	0.06	0.54	3fawA	GO:0003824 GO:0004553 GO:0005576 GO:0005618 GO:0005975 GO:0016020 GO:0016021 GO:0030246
10	0.06	0.298	6.22	0.02	0.49	2wskA	GO:0003824 GO:0004133 GO:0004135 GO:0004553 GO:0005975 GO:0005977 GO:0005980 GO:0006974 GO:0008152 GO:0016787 GO:0016798
11	0.06	0.269	6.26	0.01	0.44	3wdhA	GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046872 GO:0051060
12	0.06	0.329	6.00	0.03	0.53	1bf2A	GO:0003824 GO:0004553 GO:0005576 GO:0005975 GO:0005977 GO:0008152 GO:0016787 GO:0016798 GO:0019156 GO:0046872
13	0.06	0.319	6.43	0.06	0.55	4aq1A	GO:0046872
14	0.06	0.291	5.27	0.03	0.42	1cdgA	GO:0003824 GO:0005576 GO:0005975 GO:0016740 GO:0016757 GO:0030246 GO:0043169 GO:0043895 GO:0046872 GO:2001070
15	0.06	0.217	7.01	0.04	0.40	3ucqA	GO:0003824 GO:0005975
16	0.06	0.274	6.94	0.06	0.49	3ttoA	GO:0005975 GO:0009250 GO:0016740 GO:0016757 GO:0046527 GO:0046872 GO:0047849
17	0.06	0.308	6.60	0.04	0.53	4aygA	GO:0005975 GO:0009250 GO:0016740 GO:0016757 GO:0046527 GO:0046872 GO:0047849
18	0.06	0.325	6.21	0.07	0.52	5cltA	GO:0003824 GO:0003844 GO:0004553 GO:0005829 GO:0005975 GO:0005977 GO:0005978 GO:0006091 GO:0016740 GO:0016757 GO:0043169 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0016798	GO:0016758	GO:0043167
GO-Score	0.56	0.36	0.36
Biological Processes	GO:0009250	GO:0005977
GO-Score	0.36	0.36
Cellular Component	GO:0009507	GO:0005576	GO:0016021	GO:0009501	GO:0005618
GO-Score	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.