I-TASSER results

I-TASSER results for job id Rv3899c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (410 residues)
MVTGQPAAAGAHSLSEGAMTAMQSGSVPPPQATPPITTPPVVSAPTMAAGIEATHGPVDT
PANTSGAPPASTGTTGPVAPTVVTAGPVAAPAAPVVGGSAVPAGPLPAYGSDLRPPVVAA
PAVPSVPTAPVSGAPVAPSASSAPSAGGALVSPVERAASKAVAGQAGASSSTMAGASALS
ATAGATAGAVSARAAEQQRLQRIVDAVARQEPRISWAAGLRDDGTTTLLVTDLAGGWIPP
HVRLPANVTLLEPTARRRDADVIDLLGAVVAVAAHESNTYVAEPGPDAPALTGDRSARSA
IPKVDEFGPTLVEAVRRRDSLPRIAQAIALPAVRKTGVLENEAELLHGCITAVKESVLKA
YPSHELTAVGDWMLLAAIEALIDEQDYLANYHLAWYAVTTRRGGSRGFAA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVTGQPAAAGAHSLSEGAMTAMQSGSVPPPQATPPITTPPVVSAPTMAAGIEATHGPVDTPANTSGAPPASTGTTGPVAPTVVTAGPVAAPAAPVVGGSAVPAGPLPAYGSDLRPPVVAAPAVPSVPTAPVSGAPVAPSASSAPSAGGALVSPVERAASKAVAGQAGASSSTMAGASALSATAGATAGAVSARAAEQQRLQRIVDAVARQEPRISWAAGLRDDGTTTLLVTDLAGGWIPPHVRLPANVTLLEPTARRRDADVIDLLGAVVAVAAHESNTYVAEPGPDAPALTGDRSARSAIPKVDEFGPTLVEAVRRRDSLPRIAQAIALPAVRKTGVLENEAELLHGCITAVKESVLKAYPSHELTAVGDWMLLAAIEALIDEQDYLANYHLAWYAVTTRRGGSRGFAA
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
Conf.Score	99999999998889999988889999999999999999999999999999888899999999999999999999999999999999999999999999999999999999999999999999999998999999999999999999999988888999999988899999999888888888899999989999988888777788888999888888999999888888889999999988899888778998888888877788887667788999888899999999999988888899887777654445677778876888887655678777765778899999999999999778888889998899999998865875434677899999987888877789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVTGQPAAAGAHSLSEGAMTAMQSGSVPPPQATPPITTPPVVSAPTMAAGIEATHGPVDTPANTSGAPPASTGTTGPVAPTVVTAGPVAAPAAPVVGGSAVPAGPLPAYGSDLRPPVVAAPAVPSVPTAPVSGAPVAPSASSAPSAGGALVSPVERAASKAVAGQAGASSSTMAGASALSATAGATAGAVSARAAEQQRLQRIVDAVARQEPRISWAAGLRDDGTTTLLVTDLAGGWIPPHVRLPANVTLLEPTARRRDADVIDLLGAVVAVAAHESNTYVAEPGPDAPALTGDRSARSAIPKVDEFGPTLVEAVRRRDSLPRIAQAIALPAVRKTGVLENEAELLHGCITAVKESVLKAYPSHELTAVGDWMLLAAIEALIDEQDYLANYHLAWYAVTTRRGGSRGFAA
Prediction	66445364243443446434437454344565534464454443343446453463445544544434444445444443543554344444434446443466534364454634444446345444434544434346454244554434334444453444464454343454443544444454434444265541422152035455624234443464444332442442311112422531432424533443413512332242242334341453444333345654445432404410220040034433014003200421235211144314103210430243004402514141002000000020114435200200000020014443443147
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
MVTGQPAAAGAHSLSEGAMTAMQSGSVPPPQATPPITTPPVVSAPTMAAGIEATHGPVDTPANTSGAPPASTGTTGPVAPTVVTAGPVAAPAAPVVGGSAVPAGPLPAYGSDLRPPVVAAPAVPSVPTAPVSGAPVAPSASSAPSAGGALVSPVERAASKAVAGQAGASSSTMAGASALSATAGATAGAVSARAAEQQRLQRIVDAVARQEPRISWAAGLRDDGTTTLLVTDLAGGWIPPHVRLPANVTLLEPTARRRDADVIDLLGAVVAVAAHESNTYVAEPGPDAPALTGDRSARSAIPKVDEFGPTLVEAVRRRDSLPRIAQAIALPAVRKTGVLENEAELLHGCITAVKESVLKAYPSHELTAVGDWMLLAAIEALIDEQDYLANYHLAWYAVTTRRGGSRGFAA

5gaoE

0.21

0.17

0.82

1.50

MUSTER

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------------------------------------------------

5fmwA

0.09

0.08

0.97

1.31

MUSTER

IEVFGQFNGKRCTDAVGDRRQCVPTEPCECGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVMRNRDVVLTTTPTTYEKGEYFAFLETSSSGSLGGLYELIYVLKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKL---SPIYN--------LVP--VKMKNAHLKKQNLERAIEDYINEFSVRKGTVI

5gaoE

0.20

0.17

0.82

1.82

dPPAS

-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-----------------------------------------------------------------------

5c2vC

0.10

0.07

0.72

1.32

wMUSTER

-----------------------------------------------------------------------QPRVISTIQTGATWEPLGREEPLTVPEVHFRVKHSPFKSELVRAAWSLQGSYSASCHYERGQTTGLIWDLGDEGWGSWKNTKYIRGGRYLPPFRHEGFTGHPDEIVGATSSLDRVCGRDPGFVFRSENFSPMRLEALICYIRALEFTGSPFRNADGSLTEAQKRGQK-----EDPKVGCLE-PGDPMDPRALFSDAQTHDVGTGRVGVNGFRSTPGKVFNISALEAGEDPYGVESNTPIIGLDLVKEFDTPTL-------DIYASGFHDGGARTLMDTIN--------NTVNDKDMHGRTSHL--------KQQELQD---VEYLKAL-----------

5gaoE

0.21

0.16

0.75

1.56

wdPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------------------------------------------------------------------------------

5fmwA

0.08

0.96

1.69

PPAS

IEVFGQFNGKRCTDAVGDRRQCVPTEPCECGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVMRNRDVVLTTTPTTYEKGEYFASSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFE--LKEKLLRGTVIDVTDFVNWASSINDAPVLISQKL---SPIYN--------LVP--VKMKNAHLKKQNLERAIEDYINEFSVRKGTVI

5gaoE

0.22

0.18

0.80

1.80

wMUSTER

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYK------KLSQKFHGTKSNKK--------------------------------------------------------------------------

5fmwA

0.10

0.09

0.95

1.26

wdPPAS

IEVFGQFNGKRCTDAVGDRRQCVPTEPCECGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVMRNRDVVLTTALPTTYEKGTHYSSSGSLGGLYELIYVLDKASMK---RKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKY---AFELKEKLLRGTVIDVTDFV-----------SSINDAPSQKLSPIYN--LVPV--KMKNAHLKKQNLERAIEDYINEFSVRKGTVI

5gaoE

0.22

0.18

0.80

2.36

wPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEA-------KKLSQKFHGTKSNKK--------------------------------------------------------------------------

2atyA

0.09

0.08

0.87

1.28

wMUSTER

-------------ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLEGSIEGRGGSELADPEVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQLYTIPPPKEQMAKDKVS-ITDFFPEDITVEWQWNGQPA------ENYKNTQPIMNTN----------------ESY-NVQKS---NWE---------AGNTFTCSLH----EGLHNHHTEKSLSH

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.65

Estimated TM-score = 0.51±0.15

Estimated RMSD = 10.7±4.6Å

Download Model 2

C-score=-3.64

Download Model 3

C-score=-4.33

Download Model 4

C-score=-3.73

Download Model 5

C-score=-4.13

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5fmwA	0.811	3.29	0.079	0.915
2	3ojyB	0.514	4.40	0.063	0.641
3	3t5oA	0.512	4.55	0.058	0.651
4	3ojyA	0.462	5.07	0.056	0.612
5	3nsjA1	0.379	4.42	0.070	0.471
6	2bk1A	0.376	5.96	0.076	0.544
7	2qqhA	0.353	4.24	0.056	0.432
8	2qp2A	0.347	5.63	0.050	0.485
9	3qmzA	0.340	6.07	0.040	0.512
10	2cseW	0.338	7.06	0.027	0.563

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3de8B	CA	Rep, Mult	383,385,386
2	0.04	2	4z90A	4LE	Rep, Mult	393,397
3	0.04	2	1mcxA	CA	Rep, Mult	337,338,340
4	0.04	2	2xoeA	ZN	Rep, Mult	340,344
5	0.04	2	2zh0L	HIS	Rep, Mult	391,392
6	0.02	1	3ax0A	CU	Rep, Mult	229,241
7	0.02	1	3pmvA	557	Rep, Mult	78,112,113,114,121,122
8	0.02	1	2o01G	CLA	Rep, Mult	362,363
9	0.02	1	1m34A	SF4	Rep, Mult	381,382
10	0.02	1	1rmgA	MAN	Rep, Mult	171,172
11	0.02	1	3tdjA	3TJ	Rep, Mult	112,113,114,115,116
12	0.02	1	3lsfE	PZI	Rep, Mult	228,395,399,400,403
13	0.02	1	3lxvN	CO3	Rep, Mult	402,404
14	0.02	1	1vcrA	CLA	Rep, Mult	342,406
15	0.02	1	3gj7A	MG	Rep, Mult	6,7
16	0.02	1	3rgnA	C8E	Rep, Mult	154,251,252,254,255,300
17	0.02	1	3ijxD	HCZ	Rep, Mult	180,267,268,269
18	0.02	1	5a8wC	COM	Rep, Mult	150,199
19	0.02	1	3il1H	B5D	Rep, Mult	93,94,232,233,234

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2x38A	0.291	7.03	0.048	0.480	2.7.1.153	NA
2	0.060	2z8yP	0.274	7.43	0.057	0.473	2.3.1.169	NA
3	0.060	1bxrA	0.281	7.57	0.038	0.505	6.3.5.5	NA
4	0.060	1f13A	0.295	7.06	0.045	0.493	2.3.2.13	NA
5	0.060	1qbaA	0.289	7.12	0.038	0.485	3.2.1.52	NA
6	0.060	1cf9A	0.310	6.58	0.064	0.493	1.11.1.6	NA
7	0.060	2ow6A	0.272	7.71	0.032	0.488	3.2.1.114	59
8	0.060	1dmtA	0.284	7.21	0.034	0.476	3.4.24.11	NA
9	0.060	1c7sA	0.281	7.35	0.052	0.485	3.2.1.52	185
10	0.060	2vumA	0.250	7.60	0.025	0.442	2.7.7.6	NA
11	0.060	2iukB	0.293	7.33	0.040	0.493	1.13.11.12	85
12	0.060	2cseW	0.338	7.06	0.027	0.563	3.6.4.13	NA
13	0.060	1iphA	0.281	7.08	0.029	0.466	1.11.1.6	127
14	0.060	1o0sA	0.284	6.91	0.052	0.461	1.1.1.38	NA
15	0.060	1n63B	0.297	7.68	0.067	0.534	1.2.99.2	NA
16	0.060	1t3qB	0.288	7.42	0.071	0.510	1.3.99.17	NA
17	0.060	1dgjA	0.294	7.16	0.054	0.502	1.2.-.-	365
18	0.060	1eulA	0.251	7.04	0.039	0.407	3.6.3.8	NA
19	0.060	1hdhA	0.283	6.86	0.054	0.466	3.1.6.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.16	0.811	3.29	0.08	0.91	5fmwA	GO:0002376 GO:0005576 GO:0005579 GO:0005737 GO:0005886 GO:0005887 GO:0006955 GO:0006957 GO:0006958 GO:0016020 GO:0016021 GO:0019835 GO:0019836 GO:0030449 GO:0045087 GO:0070062 GO:0072562
1	0.10	0.514	4.40	0.06	0.64	3ojyB	GO:0002376 GO:0005576 GO:0005579 GO:0005615 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0016020 GO:0019835 GO:0030449 GO:0032403 GO:0045087 GO:0070062 GO:1903561
2	0.07	0.462	5.07	0.06	0.61	3ojyA	GO:0001848 GO:0002376 GO:0005576 GO:0005579 GO:0005615 GO:0005886 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0016020 GO:0016021 GO:0019835 GO:0030449 GO:0032403 GO:0045087 GO:0070062 GO:0072562
3	0.07	0.529	4.12	0.06	0.64	4e0sB	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
4	0.07	0.512	4.55	0.06	0.65	3t5oA	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
5	0.07	0.489	4.19	0.06	0.60	4a5wB	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
6	0.06	0.379	4.42	0.07	0.47	3nsjA	GO:0001771 GO:0002357 GO:0002418 GO:0005509 GO:0005576 GO:0005768 GO:0005886 GO:0016020 GO:0016021 GO:0016023 GO:0019835 GO:0022829 GO:0031904 GO:0044194 GO:0046872 GO:0051260 GO:0051607 GO:0055085
7	0.06	0.347	5.63	0.05	0.49	2qp2A	GO:0046872
8	0.06	0.352	4.97	0.07	0.45	2rd7A	GO:0001848 GO:0002376 GO:0005576 GO:0005579 GO:0005615 GO:0005886 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0016020 GO:0016021 GO:0019835 GO:0030449 GO:0032403 GO:0045087 GO:0070062 GO:0072562
9	0.06	0.353	4.24	0.06	0.43	2qqhA	GO:0001848 GO:0002376 GO:0005576 GO:0005579 GO:0005615 GO:0005886 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0016020 GO:0016021 GO:0019835 GO:0030449 GO:0032403 GO:0045087 GO:0070062 GO:0072562
10	0.06	0.232	7.84	0.04	0.42	3ki9A	GO:0006508 GO:0008152 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0016805 GO:0046872
11	0.06	0.302	5.52	0.04	0.42	5j67C	GO:0005509 GO:0005768 GO:0016020 GO:0016021 GO:0043533 GO:0060187 GO:2000009
12	0.06	0.231	7.35	0.06	0.40	2xrcB	GO:0002376 GO:0004252 GO:0005044 GO:0005576 GO:0005615 GO:0006508 GO:0006898 GO:0006958 GO:0008233 GO:0008236 GO:0016020 GO:0016787 GO:0030449 GO:0045087 GO:0046872 GO:0070062
13	0.06	0.228	6.65	0.05	0.37	2xrcC	GO:0002376 GO:0004252 GO:0005044 GO:0005576 GO:0005615 GO:0006508 GO:0006898 GO:0006958 GO:0008233 GO:0008236 GO:0016020 GO:0016787 GO:0030449 GO:0045087 GO:0046872 GO:0070062
14	0.06	0.251	6.41	0.06	0.39	1n7dA	GO:0001618 GO:0001948 GO:0002020 GO:0004872 GO:0005041 GO:0005509 GO:0005764 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005886 GO:0005887 GO:0005905 GO:0006629 GO:0006810 GO:0006869 GO:0006897 GO:0006898 GO:0008202 GO:0008203 GO:0009897 GO:0009986 GO:0010008 GO:0010867 GO:0010899 GO:0012505 GO:0015914 GO:0016020 GO:0016021 GO:0016032 GO:0016323 GO:0030169 GO:0030229 GO:0030299 GO:0030301 GO:0030669 GO:0032050 GO:0034362 GO:0034383 GO:0042157 GO:0042159 GO:0042632 GO:0042802 GO:0043235 GO:0045177 GO:0046718 GO:0070508 GO:1990666 GO:2000188
15	0.06	0.228	7.20	0.04	0.39	4o6fA	GO:0000122 GO:0000993 GO:0002039 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006351 GO:0006355 GO:0007507 GO:0008168 GO:0008285 GO:0010452 GO:0016278 GO:0016279 GO:0016568 GO:0016571 GO:0016740 GO:0018024 GO:0018026 GO:0018027 GO:0032259 GO:0043516 GO:0046872 GO:0046975 GO:1901796
16	0.06	0.212	7.03	0.05	0.35	1w0rA	GO:0002376 GO:0005576 GO:0005615 GO:0005788 GO:0006955 GO:0006956 GO:0006957 GO:0030449 GO:0031012 GO:0036066 GO:0042742 GO:0045087
17	0.06	0.183	6.38	0.06	0.28	4v2aA	GO:0005886 GO:0006915 GO:0007165 GO:0007275 GO:0007411 GO:0016020 GO:0016021 GO:0031175 GO:0031226 GO:0032589 GO:0032809 GO:0033564 GO:0038007 GO:0042995 GO:0045121
18	0.06	0.205	6.14	0.02	0.31	3vywD	GO:0016645 GO:0046872 GO:0051536 GO:0051539 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0044877	GO:0005515
GO-Score	0.33	0.33
Biological Processes	GO:0030449	GO:0006958	GO:0001897	GO:0052331	GO:0006957
GO-Score	0.39	0.39	0.33	0.33	0.30
Cellular Component	GO:0005615	GO:0070062	GO:0005579	GO:0044424
GO-Score	0.45	0.39	0.39	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.