I-TASSER results

I-TASSER results for job id Rv3896c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (302 residues)
MSTWHRIGTEGEPLTDPLTTQAIAALSRGHGLFAGGVSGADIDAPQIQQYANAISWVANA
VPTAAAYRWRGAARALRRLANTDEALAQIMAAAQIDHAHARTATRALLEAAKTDAMALTD
TPLGRREAMARMAARLRAQHRHIARCRSRARLLGLRLRRLRYLRTAAARRPQVTTPGGRA
QVLAAIQKALDIQGVHDPAARARWTRGMDLVARRESNYNANAINHWDSNAARGTPSRGVW
QFIAPTFAAYHEPGTSTNIHDLVAQACAFINYARGHYGVAADASNLADLIQQADPRRSPR
GY

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTWHRIGTEGEPLTDPLTTQAIAALSRGHGLFAGGVSGADIDAPQIQQYANAISWVANAVPTAAAYRWRGAARALRRLANTDEALAQIMAAAQIDHAHARTATRALLEAAKTDAMALTDTPLGRREAMARMAARLRAQHRHIARCRSRARLLGLRLRRLRYLRTAAARRPQVTTPGGRAQVLAAIQKALDIQGVHDPAARARWTRGMDLVARRESNYNANAINHWDSNAARGTPSRGVWQFIAPTFAAYHEPGTSTNIHDLVAQACAFINYARGHYGVAADASNLADLIQQADPRRSPRGY
Prediction	CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCC
Conf.Score	98765556678766666545778877654444446888777777655455556665445566544444445666667765777645555555544555544456788887766556677776566788888876655554444444566655454455566666655457877778875679999999999989998887678999999999998689998656787778899887544564657789876899899999979999999999999869877777766666546889999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTWHRIGTEGEPLTDPLTTQAIAALSRGHGLFAGGVSGADIDAPQIQQYANAISWVANAVPTAAAYRWRGAARALRRLANTDEALAQIMAAAQIDHAHARTATRALLEAAKTDAMALTDTPLGRREAMARMAARLRAQHRHIARCRSRARLLGLRLRRLRYLRTAAARRPQVTTPGGRAQVLAAIQKALDIQGVHDPAARARWTRGMDLVARRESNYNANAINHWDSNAARGTPSRGVWQFIAPTFAAYHEPGTSTNIHDLVAQACAFINYARGHYGVAADASNLADLIQQADPRRSPRGY
Prediction	64203310442413242134311310130241244334455153443442442343344424322333343224203433445432331243233331323412331043235444544544334344134324434434443443443343342434425434534454444444444740340033016216344442444115102400440243334121322332543410200111035015322243254322100100100021025312224303313332442445443513
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCC
MSTWHRIGTEGEPLTDPLTTQAIAALSRGHGLFAGGVSGADIDAPQIQQYANAISWVANAVPTAAAYRWRGAARALRRLANTDEALAQIMAAAQIDHAHARTATRALLEAAKTDAMALTDTPLGRREAMARMAARLRAQHRHIARCRSRARLLGLRLRRLRYLRTAAARRPQVTTPGGRAQVLAAIQKALDIQGVHDPAARARWTRGMDLVARRESNYNANAINHWDSNAARGTPSRGVWQFIAPTFAAYHEPGTSTNIHDLVAQACAFINYARGHYGVAADASNLADLIQQADPRRSPRGY

1slyA

0.13

0.94

0.98

wMUSTER

QELRDIVAWMGNDVTDEQAKWRDDAIMRSQSTLIERRVRMALGTGDRRGLNTWLARLPMEAKEKDEWRYWQADLLLERGR--EAEAKEILHQLMQQRGFYPMVAAQRIKAPQNVDSALTQGPMARVRELMYWDNTARSEWANLVKSKSKTEQAQLARYAFNNWDLSVQATIAGKLWDHLEERNDLFKRYTSGKEIP--------QSYAMAIARQESAWNPKVK--------SPVGASGLMQIMPGTATHTVIPGYSSQLLDPETNINIGTSYLQYVYQQFGNNRIFSSAAYNAGLGRAGRGY

3w6bA

0.11

0.05

0.41

1.21

wdPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------PPTNPPTTVTKPAEVPSRIWTYVMNADNAYG-----KGGDFALLLSAVIKKESYFGDGL-------SGSPSAGDGLMQVEPNTRNAYLSQGHAYNHSSEQDQVYMGSLILNEKIVRFGS---IYSGLLHYNGGYWYPGA

5gaoE

0.20

0.17

0.85

1.21

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAATTKEAYKKLSQKFHGTKSNKK---------------------

1slyA4

0.16

0.05

0.29

1.99

wPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAYNDLFKRYTSGKEIP--------QSYAMAIARQESAWNPKVK--------SPVGASGLMQIMPGTATHTVIPGYSSQLLDPETNINIGTSYLQYVYQQFGN--------------------

4owdA

0.11

0.10

0.88

1.20

PPAS

ADNLDDLSREGGPAGLTPGREDDASVRYSHTYLDVTNGQQRPTRLKGSSHAEQLAELKKQYPELKYSDAVEVVDLLRMVDVGDI---SNELAMNQVYFPNVRVAFDFGEARGLAWALPGGDDDSLMNEVNAFLDQAKKEGLLQRLKDRYYGHVDVLGYVGAYTFAQHLQ-------QRLPRYESHFKQSGKQLDTD--------WRLLAAIGYQESLWQPGAT--------SKTGVRGLMMLTNRTAQAMGV----SNRLDPKQSIQGGSKYFVQIRSELPESIKEPDRSWFA-------AY

1slyA4

0.16

0.05

0.29

1.23

PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAYNDLFKRYTSGKEIP--------QSYAMAIARQESAWNPKVK--------SPVGASGLMQIMPGTATHTVIPGYSSQLLDPETNINIGTSYLQYVYQQFGN--------------------

4c5fA

0.12

0.11

0.88

1.61

Env-PPAS

---WVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKT----LLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLKSRSNGLRIIYSVTINMVPNHLDKRA------------HKYLGMVRQASRKYGVD--------ESLILAIMQTESSFNPYAV--------SRSDALGLMQVVQHTAGKDVKSGTPSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYVFSNDKIQAA

4c5fA2

0.16

0.05

0.28

2.14

Env-PPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLGMVRQASRKYGVD--------ESLILAIMQTESSFNPYAV--------SRSDALGLMQVVQHTAGKDVFTPSRSFLFDPASNIDTGTAYLAMLNNVYLG--------------------

1slyA

0.13

0.96

0.98

MUSTER

QELRDIVAWRGNDVTDEQAKWRDDAIMRSQSTLIERRVRMALGTGDRRGLNTWLARLPMEAKEKDEWRYWQADLLLER---REAEAKEILHQLMQQRGFYPMVAAQRIELKIDKAPQNVDSALTQGPEMARVRELMYWNLDNTARSEWANLVKSKSKTEQAQLARYAFNNQWWIAGKLWDHLEERFPLAYNDLFKRYTSGKEIPQSYAMAIARQESAWNPKVK--------SPVGASGLMQIMPGTATHTVIPGYSSQLLDPETNINIGTSYLQYVYQQFGNNRIFSSAAYNAGLGRNSAGR

4ke2A

0.15

0.10

0.65

dPPAS

---------------MNIDPAARAAAAAA------ASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.40

Estimated TM-score = 0.34±0.11

Estimated RMSD = 14.5±3.7Å

Download Model 2

C-score=-3.89

Download Model 3

C-score=-3.90

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1slyA	0.825	2.77	0.094	0.950
2	4yibA	0.750	3.61	0.103	0.930
3	3nowA	0.496	5.46	0.060	0.758
4	5fvmA	0.491	5.77	0.038	0.765
5	2ww2A	0.483	6.05	0.061	0.785
6	4i2wA	0.472	5.89	0.045	0.762
7	2vdcA	0.461	6.38	0.068	0.781
8	4jspB	0.451	6.00	0.054	0.732
9	3feyA1	0.451	5.31	0.036	0.682
10	4fyeA	0.450	5.76	0.051	0.709

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	7	4hjzA	NAG	Rep, Mult	215,240,241,243,291,292
2	0.06	3	1slyA	BLG	Rep, Mult	215,224,225,234,241,243,246,272,291,292,294,295
3	0.06	3	2vdcA	F3S	Rep, Mult	179,182,183,209,210,216
4	0.06	3	4dd2A	GOL	Rep, Mult	215,216,217,219,222,224
5	0.04	2	4a25A	MN	Rep, Mult	258,261
6	0.04	2	1c10A	XE	Rep, Mult	190,239,240,262,265,266
7	0.02	1	3l7gB	MN	Rep, Mult	214,215
8	0.02	1	2q8zA	NUP	Rep, Mult	227,243,246
9	0.02	1	4e9cA	PG0	Rep, Mult	261,265
10	0.02	1	4owaA	IOD	Rep, Mult	189,261,262
11	0.02	1	2c6pA	UUU	Rep, Mult	208,211,212,215,241

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2rd0A	0.365	6.34	0.061	0.626	2.7.1.153	212,214,259,261
2	0.060	1cb8A	0.404	6.08	0.062	0.649	4.2.2.5	NA
3	0.060	1ea0A	0.376	6.42	0.063	0.646	1.4.1.13	NA
4	0.060	1js4A	0.410	5.87	0.040	0.639	3.2.1.4	NA
5	0.060	1bglA	0.359	6.67	0.043	0.632	3.2.1.23	NA
6	0.060	1hcuB	0.405	5.92	0.059	0.646	3.2.1.113	NA
7	0.060	1gaiA	0.429	5.97	0.074	0.679	3.2.1.3	NA
8	0.060	3ihyC	0.405	6.04	0.028	0.656	2.7.1.137	186,188
9	0.060	1fo2A	0.403	6.20	0.046	0.669	3.2.1.113	163
10	0.060	1slyA	0.825	2.77	0.094	0.950	4.2.2.-	288
11	0.060	1ksdA	0.406	5.43	0.048	0.609	3.2.1.4	237
12	0.060	2a4zA	0.399	5.96	0.050	0.642	2.7.1.153	NA
13	0.060	2x6fA	0.410	6.33	0.057	0.702	2.7.1.137,2.7.1.153,2.7.1.154	194,197
14	0.060	2vdcF	0.397	6.84	0.056	0.709	1.4.1.13	NA
15	0.060	1h12A	0.404	5.43	0.066	0.606	3.2.1.8	NA
16	0.060	2q1fA	0.401	5.89	0.055	0.639	4.2.2.21	NA
17	0.060	2qnoA	0.403	5.57	0.040	0.616	3.2.1.4	191,286
18	0.060	1a17A	0.286	3.47	0.063	0.358	3.1.3.16	214
19	0.060	1l2aE	0.407	5.59	0.058	0.623	3.2.1.4	194,272

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.833	2.67	0.10	0.95	1qsaA	GO:0000270 GO:0004553 GO:0008933 GO:0009253 GO:0016020 GO:0016829 GO:0016837 GO:0030288 GO:0042597 GO:0071555
1	0.07	0.496	5.46	0.06	0.76	3nowA	GO:0007525 GO:0031034 GO:0034605 GO:0045824 GO:0050829 GO:0061077
2	0.06	0.379	6.41	0.04	0.64	3zw3A	GO:0000166 GO:0001525 GO:0001816 GO:0001932 GO:0002250 GO:0002376 GO:0002407 GO:0002675 GO:0002679 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0005829 GO:0005886 GO:0005942 GO:0005944 GO:0006468 GO:0006661 GO:0006897 GO:0006935 GO:0006954 GO:0007186 GO:0007204 GO:0010818 GO:0010897 GO:0014065 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030168 GO:0030593 GO:0032252 GO:0033628 GO:0035004 GO:0035005 GO:0035747 GO:0036092 GO:0042098 GO:0042110 GO:0042629 GO:0043085 GO:0043303 GO:0043406 GO:0045087 GO:0046854 GO:0046875 GO:0046934 GO:0048015 GO:0051897 GO:0055118 GO:0070527 GO:0071320 GO:0072672 GO:0097284 GO:1903169 GO:2000270
3	0.06	0.417	6.51	0.05	0.72	2x6kA	GO:0000166 GO:0000421 GO:0005524 GO:0005769 GO:0006897 GO:0006914 GO:0009267 GO:0010506 GO:0016301 GO:0016303 GO:0016310 GO:0016322 GO:0016740 GO:0033227 GO:0034271 GO:0035004 GO:0035005 GO:0035032 GO:0035096 GO:0036092 GO:0045850 GO:0046854 GO:0046934 GO:0048015
4	0.06	0.405	6.04	0.03	0.66	3ihyC	GO:0000045 GO:0000166 GO:0000910 GO:0004672 GO:0005524 GO:0005768 GO:0005770 GO:0005776 GO:0005829 GO:0005930 GO:0005942 GO:0006468 GO:0006661 GO:0006914 GO:0007032 GO:0007049 GO:0016020 GO:0016236 GO:0016301 GO:0016303 GO:0016310 GO:0016485 GO:0016740 GO:0030496 GO:0030670 GO:0031410 GO:0032465 GO:0034162 GO:0035004 GO:0035032 GO:0036092 GO:0042149 GO:0043201 GO:0045022 GO:0045335 GO:0046854 GO:0048015 GO:0050708 GO:0051301
5	0.06	0.367	6.78	0.07	0.66	5ab0C	GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005783 GO:0005788 GO:0005789 GO:0005886 GO:0006508 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0046872 GO:0070006
6	0.06	0.407	6.39	0.06	0.69	4uwhA	GO:0000045 GO:0000166 GO:0000910 GO:0004672 GO:0005524 GO:0005768 GO:0005770 GO:0005776 GO:0005829 GO:0005930 GO:0005942 GO:0006468 GO:0006661 GO:0006914 GO:0007032 GO:0007049 GO:0016020 GO:0016236 GO:0016301 GO:0016303 GO:0016310 GO:0016485 GO:0016740 GO:0030496 GO:0030670 GO:0031410 GO:0032465 GO:0034162 GO:0035004 GO:0035032 GO:0036092 GO:0042149 GO:0043201 GO:0045022 GO:0045335 GO:0046854 GO:0048015 GO:0050708 GO:0051301
7	0.06	0.500	5.84	0.06	0.80	4i2wA	GO:0005886 GO:0005938 GO:0009792 GO:0018991 GO:0031625 GO:0032154 GO:0040011 GO:0042802 GO:0045214
8	0.06	0.371	5.76	0.04	0.58	3qjzA	GO:0000166 GO:0001525 GO:0001816 GO:0001932 GO:0002250 GO:0002376 GO:0002407 GO:0002675 GO:0002679 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0005829 GO:0005886 GO:0005942 GO:0005944 GO:0006468 GO:0006661 GO:0006897 GO:0006935 GO:0006954 GO:0007186 GO:0007204 GO:0010818 GO:0010897 GO:0014065 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030168 GO:0030593 GO:0032252 GO:0033628 GO:0035004 GO:0035005 GO:0035747 GO:0036092 GO:0042098 GO:0042110 GO:0042629 GO:0043085 GO:0043303 GO:0043406 GO:0045087 GO:0046854 GO:0046875 GO:0046934 GO:0048015 GO:0051897 GO:0055118 GO:0070527 GO:0071320 GO:0072672 GO:0097284 GO:1903169 GO:2000270
9	0.06	0.396	6.37	0.04	0.67	4d0lE	GO:0000139 GO:0000166 GO:0004430 GO:0005524 GO:0005737 GO:0005739 GO:0005741 GO:0005768 GO:0005783 GO:0005794 GO:0005829 GO:0006661 GO:0006898 GO:0007165 GO:0012505 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0030867 GO:0046854 GO:0048015 GO:0048471 GO:0071889
10	0.06	0.435	6.31	0.07	0.72	5dfzC	GO:0000166 GO:0000329 GO:0000407 GO:0004672 GO:0005524 GO:0005643 GO:0005768 GO:0005777 GO:0005794 GO:0006468 GO:0006810 GO:0006914 GO:0010008 GO:0015031 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030242 GO:0032968 GO:0034271 GO:0034272 GO:0036092 GO:0046854 GO:0048015 GO:0071561
11	0.06	0.369	6.11	0.05	0.60	4bfrA	GO:0000166 GO:0001935 GO:0001952 GO:0005524 GO:0005634 GO:0005730 GO:0005737 GO:0005886 GO:0005942 GO:0006874 GO:0006897 GO:0006914 GO:0007155 GO:0007156 GO:0009611 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030168 GO:0031526 GO:0035005 GO:0036092 GO:0040016 GO:0043560 GO:0045171 GO:0046854 GO:0046934 GO:0048015 GO:0060055
12	0.06	0.381	5.23	0.10	0.55	4p0gA	GO:0000270 GO:0008933 GO:0009279 GO:0016020 GO:0016829 GO:0016837 GO:0016998 GO:0071555
13	0.06	0.406	6.23	0.05	0.66	1e8wA	GO:0000166 GO:0001525 GO:0002376 GO:0004674 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006468 GO:0006897 GO:0006935 GO:0006954 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0035005 GO:0036092 GO:0046854 GO:0046934 GO:0048015
14	0.06	0.388	6.05	0.05	0.64	1e7uA	GO:0000166 GO:0001525 GO:0002376 GO:0004674 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006468 GO:0006897 GO:0006935 GO:0006954 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0035005 GO:0036092 GO:0046854 GO:0046934 GO:0048015
15	0.06	0.359	5.77	0.04	0.56	1he8A	GO:0000166 GO:0001525 GO:0001816 GO:0001932 GO:0002250 GO:0002376 GO:0002407 GO:0002675 GO:0002679 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0005829 GO:0005886 GO:0005942 GO:0005944 GO:0006468 GO:0006661 GO:0006897 GO:0006935 GO:0006954 GO:0007186 GO:0007204 GO:0010818 GO:0010897 GO:0014065 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030168 GO:0030593 GO:0032252 GO:0033628 GO:0035004 GO:0035005 GO:0035747 GO:0036092 GO:0042098 GO:0042110 GO:0042629 GO:0043085 GO:0043303 GO:0043406 GO:0045087 GO:0046854 GO:0046875 GO:0046934 GO:0048015 GO:0051897 GO:0055118 GO:0070527 GO:0071320 GO:0072672 GO:0097284 GO:1903169 GO:2000270
16	0.06	0.371	6.34	0.06	0.63	4lqlA	GO:0005737 GO:0005975 GO:0005996 GO:0008152 GO:0008733 GO:0016853 GO:0016861 GO:0019568 GO:0019569 GO:0046872
17	0.06	0.432	5.95	0.05	0.69	5dxhA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
18	0.06	0.363	6.19	0.04	0.59	5dxuA	GO:0000166 GO:0001779 GO:0001816 GO:0002250 GO:0002376 GO:0002551 GO:0002679 GO:0005524 GO:0005737 GO:0005829 GO:0005886 GO:0005942 GO:0006468 GO:0006661 GO:0006935 GO:0006954 GO:0007165 GO:0010628 GO:0010818 GO:0014065 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030101 GO:0030154 GO:0030217 GO:0030335 GO:0030593 GO:0035004 GO:0035005 GO:0035747 GO:0035754 GO:0036092 GO:0042110 GO:0042113 GO:0042629 GO:0043303 GO:0045087 GO:0046854 GO:0046934 GO:0048015 GO:0050852 GO:0050853 GO:0060374 GO:0072672

Consensus prediction of GO terms

Molecular Function	GO:0035004	GO:0032550	GO:0052742	GO:0035639	GO:0032559	GO:0004553	GO:0016837	GO:0008933
GO-Score	0.36	0.36	0.36	0.36	0.36	0.31	0.31	0.31
Biological Processes	GO:0046834	GO:0006661	GO:0048017	GO:0009253	GO:0071555
GO-Score	0.36	0.36	0.36	0.31	0.31
Cellular Component	GO:0016020	GO:0030288
GO-Score	0.39	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.