I-TASSER results

I-TASSER results for job id Rv3873

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (368 residues)
MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGG
SDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLT
ATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQ
STTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTG
GGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLI
EKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDED
DWDEEDDW

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW
Prediction	CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98666885676766556999589999999999999999999999999999986667779999999999999999999999999999999999999999998699878999999999999998657775899999999999999999999999899999998866789999877888876554454445566776545556677788776555566776554556778877655566666555666665555455566655667666666665665544566777766777777766666677877777877778888777877888788888888888888888888888888888888876666789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW
Prediction	54010100020001020111000021002002300430230031023001201431111001001200330131012003304420320310010222022111323303111310020111001000000002123403430231002002001311211333442431342243544433433234223433343222213313322331132233223223222312332333233323333333322221111222333212222222111121223322222132333322222233332222223223222222122111112112313311233102323222346346546563566665
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW

2g38B

0.27

0.12

0.47

1.45

MUSTER

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.18

0.16

0.90

1.67

PPAS

---------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK---------

2g38B

0.27

0.12

0.47

1.68

dPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.26

0.12

0.47

2.70

wdPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQ-FTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.26

0.12

0.46

1.88

wMUSTER

--FEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQ-FTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.26

0.12

0.46

4.08

wPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQ-FTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.12

0.47

3.61

dPPAS2

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.12

0.47

3.24

PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.27

0.12

0.47

3.71

Env-PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4wgvA

0.12

0.11

0.94

0.72

MUSTER

--------------VYMDPGITSMQGGAQTLLFVILISSLAAMLLQSMTVRLGIATGKDLAQMTRHFLKPVAIIFWIIAELAIIATDIAEVIGSAIALDLIFGIPLIVGALITFDVFLLLFIMRFGF-----RKIEAIVGTLIFTVLAIFVFEVFISSQLTDILNGFVPHKEIVTNQGILYIALGIIGATIMPHNLYLHSSIVKAQAIKYATIDSNLQLSIAFVVNCLLLTLGAALFFGTKTNDLGGFYDLYHALKTEPVLGATLGGVMSTLFAVALLASGQNSTITGTLAGQIVMEGFLRLSIPNLITRSLAVIPVIICLIIFKGNSEKIEQLLVFSQVFLSIALPFSLIPLQLATSNKKL---GPF

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.09

Estimated TM-score = 0.47±0.15

Estimated RMSD = 11.6±4.5Å

Download Model 2

C-score=-4.09

Download Model 3

C-score=-4.01

Download Model 4

C-score=-4.09

Download Model 5

C-score=-2.55

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4wgvA	0.904	1.98	0.093	0.959
2	3hfxA	0.750	4.04	0.093	0.943
3	4djiA	0.749	3.99	0.048	0.938
4	4us3A	0.732	4.46	0.070	0.948
5	3gi9C	0.727	3.91	0.071	0.902
6	2q6hA	0.725	4.21	0.077	0.927
7	2witA	0.721	4.17	0.072	0.918
8	5i6xA	0.712	4.50	0.065	0.940
9	3dh4A	0.701	4.66	0.089	0.924
10	4m48A	0.693	4.74	0.059	0.940

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	4	4d1aA	NA	Rep, Mult	12,13,15,16,280,281,283,284
2	0.12	4	4xpbA	CLR	Rep, Mult	43,220,368
3	0.06	2	3l1lA	ARG	Rep, Mult	18,82,83,86,87,90,189,190,191,288,342
4	0.03	1	3gjcA	NA	Rep, Mult	49,50,51,52,53
5	0.03	1	2g38B	MN	Rep, Mult	148,151,152
6	0.03	1	2witC	BET	Rep, Mult	17,18,38,39
7	0.03	1	3ob6A	ARG	Rep, Mult	89,93,97,281,335
8	0.03	1	3gjdA	BOG	Rep, Mult	91,107,108,110,113
9	0.03	1	4wgwA	MN	Rep, Mult	15,18,189,192

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1mhlC	0.361	6.27	0.083	0.568	1.11.1.7	106,333
2	0.060	3en1A	0.329	5.49	0.035	0.473	1.14.12.11	NA
3	0.060	1obbA	0.336	6.79	0.061	0.554	3.2.1.20	NA
4	0.060	1iduA	0.334	7.16	0.045	0.579	1.11.1.10	NA
5	0.060	1qmgA	0.365	6.44	0.046	0.573	1.1.1.86	353
6	0.060	3fr8B	0.362	6.39	0.038	0.571	1.1.1.86	353
7	0.060	1wgzA	0.346	6.47	0.046	0.562	3.4.24.66	NA
8	0.060	1q16A	0.326	7.45	0.051	0.595	1.7.99.4	NA
9	0.060	2vn0A	0.333	6.35	0.035	0.524	1.14.14.1	NA
10	0.060	1y791	0.387	6.43	0.042	0.620	3.4.15.5	NA
11	0.060	1hbmA	0.337	6.64	0.037	0.549	2.8.4.1	NA
12	0.060	3e6iA	0.336	6.44	0.036	0.535	1.14.13.-	33,35
13	0.060	1uliC	0.333	5.80	0.042	0.492	1.14.12.18	NA
14	0.060	1llwA	0.359	6.31	0.053	0.557	1.4.7.1	NA
15	0.060	1cvuA	0.364	5.45	0.040	0.535	1.14.99.1	91
16	0.060	1xmeA	0.363	5.76	0.062	0.522	1.9.3.1	NA
17	0.060	5coxA	0.364	5.51	0.053	0.533	1.14.99.1	149,274
18	0.060	1prhA	0.359	5.80	0.056	0.538	1.14.99.1	NA
19	0.060	1i1iP	0.384	6.56	0.041	0.617	3.4.24.16	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.26	0.904	1.98	0.09	0.96	4wgvA	GO:0005215 GO:0005886 GO:0006810 GO:0006811 GO:0015293 GO:0016020 GO:0016021 GO:0030001 GO:0046872 GO:0055085
1	0.15	0.749	3.99	0.05	0.94	4djiA	GO:0003333 GO:0005886 GO:0005887 GO:0006810 GO:0006865 GO:0015171 GO:0015179 GO:0015297 GO:0015807 GO:0016020 GO:0016021 GO:0051454 GO:1902475
2	0.14	0.746	4.21	0.09	0.95	2wsxA	GO:0005215 GO:0005886 GO:0006810 GO:0009437 GO:0015226 GO:0015297 GO:0015879 GO:0016020 GO:0016021 GO:0044667 GO:0055085 GO:1900749 GO:1900751 GO:1902270 GO:1902603
3	0.14	0.732	4.46	0.07	0.95	4us3A	GO:0005328 GO:0006810 GO:0006836 GO:0015293 GO:0016020 GO:0016021 GO:0055085
4	0.14	0.750	4.07	0.09	0.95	2wswA	GO:0005215 GO:0005886 GO:0006810 GO:0009437 GO:0015297 GO:0016020 GO:0016021 GO:0044667 GO:0055085 GO:1900749 GO:1900751 GO:1902270
5	0.13	0.745	4.17	0.08	0.94	4c7rA	GO:0005215 GO:0005886 GO:0006810 GO:0016020 GO:0016021 GO:0042802
6	0.13	0.725	4.21	0.08	0.93	2q6hA	GO:0005215 GO:0005328 GO:0005887 GO:0006810 GO:0006836 GO:0015293 GO:0016020 GO:0016021 GO:0055085
7	0.12	0.727	3.91	0.07	0.90	3gi9C	GO:0003333 GO:0005886 GO:0005887 GO:0015171 GO:0015179 GO:0015297 GO:0015807 GO:0016020 GO:0016021 GO:1902475
8	0.11	0.712	4.50	0.07	0.94	5i6xA	GO:0001666 GO:0005328 GO:0005335 GO:0005768 GO:0005829 GO:0005886 GO:0005887 GO:0006810 GO:0006836 GO:0006837 GO:0007268 GO:0007420 GO:0007584 GO:0007613 GO:0007623 GO:0008504 GO:0009636 GO:0010008 GO:0010033 GO:0010628 GO:0012505 GO:0015222 GO:0015293 GO:0015844 GO:0016020 GO:0016021 GO:0017022 GO:0017075 GO:0017137 GO:0019811 GO:0021794 GO:0021941 GO:0032227 GO:0032355 GO:0035176 GO:0042310 GO:0042493 GO:0042713 GO:0042803 GO:0043005 GO:0045121 GO:0045665 GO:0045787 GO:0046621 GO:0046872 GO:0048854 GO:0050998 GO:0051015 GO:0051259 GO:0051260 GO:0051610 GO:0055085 GO:0071300 GO:0071310 GO:0071321 GO:0098793
9	0.11	0.697	4.56	0.06	0.92	4xp9C	GO:0005328 GO:0005329 GO:0005330 GO:0005886 GO:0005887 GO:0006810 GO:0006836 GO:0015293 GO:0015872 GO:0016020 GO:0016021 GO:0019811 GO:0030431 GO:0042745 GO:0043005 GO:0046872 GO:0051583 GO:0055085 GO:0072488 GO:0098793 GO:0099509 GO:1990834
10	0.11	0.696	4.52	0.07	0.91	3ob6B	GO:0003333 GO:0005886 GO:0005887 GO:0006810 GO:0006865 GO:0015171 GO:0015179 GO:0015181 GO:0015297 GO:0015807 GO:0016020 GO:0016021 GO:0051454 GO:1902475 GO:1903826
11	0.10	0.690	4.33	0.08	0.89	3p03A	GO:0005215 GO:0005886 GO:0006810 GO:0016020 GO:0016021 GO:0042802
12	0.09	0.663	4.40	0.06	0.86	3lrbA	GO:0003333 GO:0005886 GO:0006810 GO:0006865 GO:0015171 GO:0015297 GO:0016020 GO:0016021
13	0.06	0.337	6.61	0.04	0.54	4q65A	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006857 GO:0015031 GO:0015197 GO:0015333 GO:0015833 GO:0015992 GO:0016020 GO:0016021 GO:0042936 GO:0042938
14	0.06	0.275	6.80	0.04	0.46	3jysA	GO:0046872
15	0.06	0.243	6.43	0.02	0.39	4gieA	GO:0000166 GO:0001516 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0006693 GO:0016491 GO:0036131 GO:0047017 GO:0055114
16	0.06	0.231	5.84	0.04	0.35	4naxA	GO:0016740
17	0.06	0.227	7.58	0.06	0.41	3r05A	GO:0005886 GO:0007155 GO:0016020 GO:0016021 GO:0030054 GO:0042734 GO:0045202 GO:0046872 GO:0097109
18	0.06	0.232	6.62	0.04	0.38	1t8tB	GO:0000139 GO:0005794 GO:0006024 GO:0008146 GO:0008467 GO:0016020 GO:0016021 GO:0016740 GO:0033872

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:1901236	GO:1901235	GO:0015297	GO:0015293	GO:0046943
GO-Score	0.52	0.51	0.51	0.37	0.36	0.31
Biological Processes	GO:0006812	GO:1902603	GO:0006577	GO:0045852	GO:0003333	GO:0006865	GO:0051453
GO-Score	0.52	0.51	0.51	0.31	0.31	0.31	0.31
Cellular Component	GO:0016021	GO:0031226
GO-Score	0.60	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
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