I-TASSER results

I-TASSER results for job id Rv3856c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (335 residues)
MDPVTALRQIAYYKDRNRHDPRRVMAYRNAADIIEGLDDAARQRHGQANSWQSLAGIGPK
TAKVIAQAWSGREPDLLAELRADAEDLGGGAIRAALRGDLHLHSNWSDGSAPIEEMMATA
AALGHQYCALTDHSPRLTIANGLSPDRLRKQLDVIDELREKFAPLRILTGIEVDILEDGS
LDQEPEMLDRLDIVVASVHSKLSMDSAAMTRRMVRAVANGHTDVLGHCTGRLIAGNRGIR
PESKFDAEAVFTACREHGTAVEINSRPERRDPPTRLLHLARDIGCVFSIDTDAHAPGQLD
FLGYGAQRALDAEVPADRIVNTWPADTLLAWTGSH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDPVTALRQIAYYKDRNRHDPRRVMAYRNAADIIEGLDDAARQRHGQANSWQSLAGIGPKTAKVIAQAWSGREPDLLAELRADAEDLGGGAIRAALRGDLHLHSNWSDGSAPIEEMMATAAALGHQYCALTDHSPRLTIANGLSPDRLRKQLDVIDELREKFAPLRILTGIEVDILEDGSLDQEPEMLDRLDIVVASVHSKLSMDSAAMTRRMVRAVANGHTDVLGHCTGRLIAGNRGIRPESKFDAEAVFTACREHGTAVEINSRPERRDPPTRLLHLARDIGCVFSIDTDAHAPGQLDFLGYGAQRALDAEVPADRIVNTWPADTLLAWTGSH
Prediction	CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCHHHHCCHHHHHCCCCCEEHCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHCCCCCCCCCHHHHHHCCEEEEEHCCCCCCCHHHHHHHHHHHHHCCCCEEHCCCCCEEHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHCCCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCHHHCHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHC
Conf.Score	98999999999998767887789999999999998678568888876566544577776579999999867998754666556545545456777565545546666889999999999999899799996689988888888989999999999999998589779886765556898777688898778989998757888999999999999999599758856786566478888998778999999999999998998599888898699999999989969995889995776449999999999899887744678899999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDPVTALRQIAYYKDRNRHDPRRVMAYRNAADIIEGLDDAARQRHGQANSWQSLAGIGPKTAKVIAQAWSGREPDLLAELRADAEDLGGGAIRAALRGDLHLHSNWSDGSAPIEEMMATAAALGHQYCALTDHSPRLTIANGLSPDRLRKQLDVIDELREKFAPLRILTGIEVDILEDGSLDQEPEMLDRLDIVVASVHSKLSMDSAAMTRRMVRAVANGHTDVLGHCTGRLIAGNRGIRPESKFDAEAVFTACREHGTAVEINSRPERRDPPTRLLHLARDIGCVFSIDTDAHAPGQLDFLGYGAQRALDAEVPADRIVNTWPADTLLAWTGSH
Prediction	65034002100200225603421230043004104313473245325555255045124502400330273611410442354355244332353020010100210015220430042026240500000000221424412223314401510440375056030000000002342214115400330100000001335342420040012004233021000002010222243245132003200310253400110023222341033003103726020000040220410320430041057170556200103316302500677
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCHHHHCCHHHHHCCCCCEEHCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHCCCCCCCCCHHHHHHCCEEEEEHCCCCCCCHHHHHHHHHHHHHCCCCEEHCCCCCEEHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHCCCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCHHHCHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHC
MDPVTALRQIAYYKDRNRHDPRRVMAYRNAADIIEGLDDAARQRHGQANSWQSLAGIGPKTAKVIAQAWSGREPDLLAELRADAEDLGGGAIRAALRGDLHLHSNWSDGSAPIEEMMATAAALGHQYCALTDHSPRLTIANGLSPDRLRKQLDVIDELREKFAPLRILTGIEVDILEDGSLDQEPEMLDRLDIVVASVHSKLSMDSAAMTRRMVRAVANGHTDVLGHCTGRLIAGNRGIRPESKFDAEAVFTACREHGTAVEINSRPERRDPPTRLLHLARDIGCVFSIDTDAHAPGQLDFLGYGAQRALDAEVPADRIVNTWPADTLLAWTGSH

2w9mB2

0.42

0.31

0.73

1.86

MUSTER

------------------------------------------------------------------------------------PDPAELVTVGDLRGMIHTHSTWSDGGASIREMAEATLTLGHEFLGTADHSRAAYYANGLTIERLREQLKEIRELQRA--GLPIVAGSEVDILDDGSLDFPDDVLGELDYVVVSVHSNFTLDAARQTERLIRAVSHPLVTVLGHATGRLL----LRRPGYALDLDAVLGACEANGTVVEINANAARLDLDWREALRWRE-RLKFAINTDAHVPGGLRDARYGVMQARKAGLTPAHVVNSLGRAEFLDFVARQ

3au2A

0.32

0.31

0.95

2.72

wMUSTER

VPPESYGAGLQYLTGSKAHSRLRALAQEKGLKLSEYGV------------FRGEKRIAGETEEEVYAALG--LPWIPPPLREDQGEVEAALELPQVKGDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFNETHGPPYLLAGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLL----GRRAPIEADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNTLDYEDLLSWLKAR

3au2A3

0.37

0.27

0.73

3.00

dPPAS

---------------------------------------------------------------------------------------PKLLELPQVKGDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFNETHGPPYLLAGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLL----GRRAPIEADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNTLDYEDLLSWLKAR

3au2A3

0.36

0.27

0.73

3.56

wdPPAS

---------------------------------------------------------------------------------------PKLLELPQVKGDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFNETHGPPYLLAGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLLG----RRAPIEADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNTLDYEDLLSWLKAR

2w9mB2

0.43

0.32

0.73

3.61

wPPAS

-------------------------------------------------------------------------PD-PAEL----------VTVGDLRGMIHTHSTWSDGGASIREMAEATLTLGHEFLGTADHSRAAYYANGLTIERLREQLKEIRELQRA--GLPIVAGSEVDILDDGSLDFPDDVLGELDYVVVSVHSNFTLDAARQTERLIRAVSHPLVTVLGHATGRLLLR----RPGYALDLDAVLGACEANGTVVEINANAARLDLD-WREALRWRERLKFAINTDAHVPGGLRDARYGVMQARKAGLTPAHVVNSLGRAEFLDFVARQ

3au2A3

0.37

0.27

0.73

7.36

dPPAS2

---------------------------------------------------------------------------------------PKLLELPQVKGDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFNETHGPPYLLAGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLL----GRRAPIEADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNTLDYEDLLSWLKAR

2w9mB2

0.42

0.30

0.73

3.20

PPAS

------------------------------------------------------------------------------------PDPAELVTVGDLRGMIHTHSTWSDGGASIREMAEATLTLGHEFLGTADHSRAAYYANGLTIERLREQLKEIRELQRA--GLPIVAGSEVDILDDGSLDFPDDVLGELDYVVVSVHSNFTLDAARQTERLIRAVSHPLVTVLGHATGRLL----LRRPGYALDLDAVLGACEANGTVVEINANAARLDLD-WREALRWRERLKFAINTDAHVPGGLRDARYGVMQARKAGLTPAHVVNSLGRAEFLDFVARQ

2w9mB2

0.43

0.31

0.73

5.16

Env-PPAS

--------------------------------------------------------------------------PDPAEL----------VTVGDLRGMIHTHSTWSDGGASIREMAEATLTLGHEFLGTADHSRAAYYANGLTIERLREQLKEIRELQRA--GLPIVAGSEVDILDDGSLDFPDDVLGELDYVVVSVHSNFTLDAARQTERLIRAVSHPLVTVLGHATGRLL----LRRPGYALDLDAVLGACEANGTVVEINANAARLDLD-WREALRWRERLKFAINTDAHVPGGLRDARYGVMQARKAGLTPAHVVNSLGRAEFLDFVARQ

3au2A3

0.37

0.27

0.73

1.84

MUSTER

---------------------------------------------------------------------------------------PKLLELPQVKGDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVAGGPSPEEALKRVGEIRRFNETHGPPYLLAGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALENPFVHVLAHPTARLL----GRRAPIEADWEAVFQKAKEKGVAVEIDGYYDRMDLPDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNTLDYEDLLSWLKAR

2w9mB2

0.42

0.31

0.73

2.94

dPPAS

------------------------------------------------------------------------------------PDPAELVTVGDLRGMIHTHSTWSDGGASIREMAEATLTLGHEFLGTADHSRAAYYANGLTIERLREQLKEIRELQRA--GLPIVAGSEVDILDDGSLDFPDDVLGELDYVVVSVHSNFTLDAARQTERLIRAVSHPLVTVLGHATGRLL----LRRPGYALDLDAVLGACEANGTVVEINANAARLDLDWREALRWRE-RLKFAINTDAHVPGGLRDARYGVMQARKAGLTPAHVVNSLGRAEFLDFVARQ

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.24

Estimated TM-score = 0.45±0.15

Estimated RMSD = 11.7±4.5Å

Download Model 2

C-score=-2.15

Download Model 3

C-score=-2.76

Download Model 4

C-score=-3.15

Download Model 5

C-score=-3.30

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2w9mB	0.765	2.25	0.342	0.809
2	3au2A	0.755	3.15	0.286	0.851
3	1pb0A	0.603	2.23	0.259	0.657
4	2yxoB	0.589	2.72	0.195	0.663
5	3umuA	0.571	3.58	0.180	0.681
6	3la4A	0.547	5.11	0.112	0.758
7	3dcpA	0.540	3.13	0.167	0.624
8	3lggA	0.535	5.40	0.085	0.776
9	2x0sA	0.534	4.97	0.076	0.752
10	2p50A	0.534	4.53	0.136	0.696

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.63	41	3qy6A	FE	Rep, Mult	101,103,133,172,292,294
2	0.35	23	3e38A	ZN	Rep, Mult	108,133,294
3	0.22	17	3dcpC	FE	Rep, Mult	133,172,199,227
4	0.02	3	3au2A	DGT	Rep, Mult	12,13,14,15,17
5	0.02	3	3auoB	NUC	Rep, Mult	12,23,27,28,32,33,35,36,88

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.194	3dcpA	0.540	3.13	0.167	0.624	3.1.3.15	133,192,226,287,292
2	0.180	1v77A	0.477	3.32	0.058	0.567	3.1.26.5	193,223,266
3	0.067	1xrtA	0.483	5.32	0.091	0.684	3.5.2.3	291,292
4	0.067	2wjfA	0.519	3.82	0.137	0.654	3.1.3.48	167
5	0.060	2gq3A	0.526	4.99	0.047	0.731	2.3.3.9	NA
6	0.060	2a3lA	0.508	5.00	0.089	0.713	3.5.4.6	NA
7	0.060	1ie7C	0.517	5.28	0.104	0.731	3.5.1.5	294
8	0.060	1j5sA	0.512	4.51	0.082	0.693	5.3.1.12	292
9	0.060	1onxA	0.512	4.65	0.084	0.690	3.4.19.-	292
10	0.060	1a5lC	0.521	4.96	0.083	0.716	3.5.1.5	NA
11	0.060	2uz9A	0.519	4.99	0.072	0.713	3.5.4.3	308
12	0.060	1e9yB	0.518	5.10	0.108	0.719	3.5.1.5	NA
13	0.060	2gokA	0.508	5.05	0.136	0.693	3.5.2.7	292
14	0.060	3iv8D	0.530	4.61	0.132	0.696	3.5.1.25	242
15	0.060	1qbaA	0.518	5.32	0.074	0.743	3.2.1.52	194
16	0.060	1vbgA	0.533	4.83	0.053	0.743	2.7.9.1	NA
17	0.060	2p50A	0.534	4.53	0.136	0.696	3.5.1.25	NA
18	0.060	3d6nA	0.522	4.80	0.109	0.713	3.5.2.3	NA
19	0.060	2ftwA	0.512	5.37	0.077	0.734	3.5.2.2	292
20	0.060	1kraC	0.522	5.01	0.086	0.719	3.5.1.5	109,115
21	0.060	2puzA	0.484	5.03	0.069	0.678	3.5.2.7	299
22	0.060	2g3fA	0.521	4.30	0.094	0.672	3.5.2.7	267

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.56	0.765	2.25	0.34	0.81	2w9mB	GO:0003677 GO:0003824 GO:0003887 GO:0006260 GO:0006281 GO:0046872 GO:0071897
1	0.48	0.603	2.23	0.26	0.66	1pb0A	GO:0003677 GO:0003824 GO:0003887 GO:0005829 GO:0006260 GO:0008270 GO:0016311 GO:0016787 GO:0016791 GO:0042578 GO:0046872 GO:0071897 GO:0071978
2	0.47	0.589	2.72	0.20	0.66	2yxoB	GO:0000105 GO:0003677 GO:0003824 GO:0003887 GO:0004401 GO:0006260 GO:0016311 GO:0016787 GO:0046872 GO:0071897
3	0.45	0.755	3.15	0.29	0.85	3au2A	GO:0003677 GO:0003824 GO:0003887 GO:0006260 GO:0006281 GO:0046872 GO:0071897
4	0.38	0.447	4.28	0.15	0.57	3o0fA	GO:0000166 GO:0003677 GO:0003824 GO:0003887 GO:0006260 GO:0016787 GO:0046872 GO:0071897
5	0.21	0.496	3.43	0.10	0.59	3wyzA	GO:0001682 GO:0003824 GO:0004518 GO:0004519 GO:0004526 GO:0004540 GO:0005737 GO:0008033 GO:0016787 GO:0030677 GO:0090305 GO:0090501 GO:0090502
6	0.13	0.493	3.33	0.07	0.59	2czvA	GO:0001682 GO:0003824 GO:0004518 GO:0004519 GO:0004526 GO:0004540 GO:0005737 GO:0008033 GO:0016787 GO:0030677 GO:0090305 GO:0090501 GO:0090502
7	0.07	0.498	5.61	0.06	0.74	4s3kA	GO:0004553 GO:0004568 GO:0005975 GO:0006032 GO:0008152 GO:0016787 GO:0016798
8	0.06	0.425	4.29	0.07	0.56	2a21A	GO:0003824 GO:0005737 GO:0008152 GO:0008676 GO:0009058 GO:0009103 GO:0016740 GO:0019294
9	0.06	0.308	6.03	0.07	0.48	3ew9A	GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0006259 GO:0006281 GO:0006310 GO:0006974 GO:0008094
10	0.06	0.299	6.23	0.05	0.48	3fyhA	GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0006259 GO:0006281 GO:0006310 GO:0006974 GO:0008094
11	0.06	0.316	6.21	0.08	0.50	1xu4A	GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0006259 GO:0006281 GO:0006310 GO:0006974 GO:0008094
12	0.06	0.278	7.53	0.05	0.53	4i27A	GO:0003677 GO:0003887 GO:0003912 GO:0005634 GO:0005654 GO:0005737 GO:0006259 GO:0006304 GO:0016740 GO:0016779 GO:0034061 GO:0046872 GO:0071897
13	0.06	0.291	6.94	0.04	0.50	5b16A	GO:0001530 GO:0003723 GO:0003725 GO:0004518 GO:0004519 GO:0004521 GO:0004525 GO:0005634 GO:0005654 GO:0005730 GO:0006396 GO:0010468 GO:0010586 GO:0010628 GO:0016075 GO:0016787 GO:0030422 GO:0031047 GO:0031053 GO:0031054 GO:0042254 GO:0042803 GO:0044822 GO:0046872 GO:0050829 GO:0050830 GO:0070877 GO:0070878 GO:0090305 GO:0090501 GO:0090502 GO:2000628
14	0.06	0.270	7.59	0.05	0.53	2ihmB	GO:0003677 GO:0003887 GO:0005634 GO:0006281 GO:0006310 GO:0006974 GO:0016446 GO:0016740 GO:0016779 GO:0030183 GO:0034061 GO:0046872 GO:0071897
15	0.06	0.276	6.65	0.06	0.47	4lzdA	GO:0003677 GO:0003887 GO:0005634 GO:0005654 GO:0006281 GO:0006303 GO:0006310 GO:0006974 GO:0016446 GO:0016740 GO:0016779 GO:0030183 GO:0034061 GO:0046872 GO:0071897
16	0.06	0.288	4.50	0.07	0.38	2p5sB	GO:0000166 GO:0005509 GO:0005525 GO:0005737 GO:0007264 GO:0046872 GO:0048471
17	0.06	0.286	6.45	0.03	0.47	4rq2A	GO:0003677 GO:0003684 GO:0003887 GO:0003906 GO:0005634 GO:0005654 GO:0005737 GO:0005874 GO:0005876 GO:0006260 GO:0006261 GO:0006281 GO:0006284 GO:0006286 GO:0006287 GO:0006288 GO:0006290 GO:0006297 GO:0006915 GO:0006954 GO:0006974 GO:0007435 GO:0007568 GO:0008017 GO:0008630 GO:0010332 GO:0016445 GO:0016446 GO:0016740 GO:0016779 GO:0016829 GO:0019899 GO:0034061 GO:0043234 GO:0045471 GO:0046872 GO:0048535 GO:0048536 GO:0048872 GO:0051402 GO:0055093 GO:0071707 GO:0071897
18	0.06	0.261	6.42	0.03	0.42	4k4iA	GO:0003677 GO:0003887 GO:0005634 GO:0005654 GO:0006260 GO:0006281 GO:0006289 GO:0006303 GO:0006974 GO:0016446 GO:0016740 GO:0016779 GO:0016829 GO:0034061 GO:0046872 GO:0071897
19	0.06	0.269	7.60	0.04	0.52	4i2iA	GO:0003677 GO:0003887 GO:0003912 GO:0005634 GO:0005654 GO:0005737 GO:0006259 GO:0006304 GO:0016740 GO:0016779 GO:0034061 GO:0046872 GO:0071897
20	0.06	0.262	7.27	0.04	0.47	1t3nA	GO:0003677 GO:0003684 GO:0003887 GO:0005622 GO:0005634 GO:0005654 GO:0006260 GO:0006281 GO:0006974 GO:0016740 GO:0016779 GO:0019985 GO:0042276 GO:0043231 GO:0046872 GO:0071897
21	0.06	0.237	6.01	0.04	0.37	3mf2A	GO:0000166 GO:0004812 GO:0005524 GO:0006418 GO:0016874 GO:0016878 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0003887	GO:0003677	GO:0008270	GO:0004401	GO:0000166
GO-Score	0.96	0.96	0.48	0.47	0.38
Biological Processes	GO:0006260	GO:0071897	GO:0006281	GO:0016311	GO:0071978	GO:0000105
GO-Score	0.96	0.96	0.76	0.72	0.48	0.47
Cellular Component	GO:0005829
GO-Score	0.48

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.