I-TASSER results

I-TASSER results for job id Rv3835

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (449 residues)
MLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVT
AIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEH
RFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISM
LWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQP
IDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTT
LTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEE
RLNLPPIPLQLPTPRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQ
PPPPDAGAPPATQSPEATPPGPAEPAPAG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVTAIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEHRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPTPRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCEHCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHCCCHHHHHHCCCEEEEEEEEHCCCCCCEEEEEEEHHHCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHCCCCCHHHHHCCCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98887666788888888888888888888888876566556899999999999999999865678888888888888888887777777776678998555689998887666688998589999887567788766889999999999999999988999999859988888866899976898888775876899887875899966667765455445677788777657888888877778888886578999986788889999998999999887789999998587666666656765788957775588689999998589987555557888888788889999999999889999999999999999999999999999999999999999999999999999999999999999999999999999999999999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVTAIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEHRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPTPRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG
Prediction	74544653446556464365355653454442444232320000000000000000000000122243444344424544345445445431441430201305524254144041744020101231404413354226634114361035014630452036104361224010000001034610452120000000122267443342434045234441131120021535555425230413440221000103035416542144640352046203510461134651444101111321437104411110101002327533233143525451416654246556426654535444556454445566654455446545346553454346435464356553556543546355244565367544735636568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCEHCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHCCCHHHHHHCCCEEEEEEEEHCCCCCCEEEEEEEHHHCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHCCCCCHHHHHCCCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRALLLTALGGLLIAGLVTAIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLMWPDGTPESAAIVSCADEHRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQDGFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWATLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPTPRPAPPAQQLPSTPPGTQHLPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG

5gaoE

0.12

0.09

0.75

1.30

dPPAS

--------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------------------------------

4nl6A

0.16

0.08

0.52

0.96

wPPAS

-----------------------------------------------------------------------MAMSSGGSGGGVPEQEDSVLFRR-GTGQ---WDDTA----KAVA-----SFK-----ALKNGDICE--TSGKPKTTPKRKPAK------------KNKSQKKNT-------ASLQQW-KVGDK---C-----SEDGC----PATIASIDFKR----ETCV-------------V------------------VYTG----------------------Y-------------------------GNREE-------QNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLP--PFPSGPPIIPPPPPICPDSLD

5gaoE

0.12

0.09

0.75

2.30

dPPAS2

---------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAA---------------AAAAAAAAAAAAAAAAAAAAAAAAAAA--AAAAAAAAAAAAAAA---------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------------------------------

5gaoE

0.14

0.10

0.75

1.49

PPAS

-----------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------AAAAA---------AAAAAAAAAAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAAAAA---------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------AAAAAAAA----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-----

5fmwA

0.10

0.92

1.05

dPPAS

RCTDAVGDRRQCVPTEPCECGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNASLIYETKGEKNFRTEHYEEQIEAFKS---------------------IIQEKTSNFNAAISLKFTPGKG-----------SFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELI-YVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLI-SQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDG

1mv3A

0.12

0.03

0.27

1.83

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPA

1w0sA

0.13

0.12

0.87

1.20

PPAS

GGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSEGSQLRYRR-----------------------VGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCS---VTCSKGTRTRR-----ACNHPAPKCGGHCPGQAQES------EACDTQQVCPTHGAWATWGPWT-----PCSASCHGGPHRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRT---HIC----------NTAVPCPVDGEWDSWGE--WSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTGLCMPPCGPNPTRTPLLPKYPPTVSMVEGQGEKNVTFGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEE

1w0rA

0.10

0.09

0.90

1.02

dPPAS

LNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLR------------------YRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMG---GWSGWGPWEPCSVTCSKG----TRTRRRACNHPAPKCGGHCPGQAQES------EACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRT---------------HICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPAC

4nl6A

0.13

0.06

0.47

1.45

dPPAS2

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMSSGGSG----GGVPEQEDSVLFRRG---TGQSDDSASFKHALKNGD-----------ICETSGKPKTTPK-------------------RKPAKKNKSQKKNTAASLQQWKVGDKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPIC

1w0rA

0.13

0.12

0.87

1.20

PPAS

GGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSEGSQLRYRR-----------------------VGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCS---VTCSKGTRTRR-----ACNHPAPKCGGHCPGQAQES------EACDTQQVCPTHGAWATWGPWT-----PCSASCHGGPHRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRT---HIC----------NTAVPCPVDGEWDSWGE--WSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTGLCMPPCGPNPTRTPLLPKYPPTVSMVEGQGEKNVTFGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEE

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.26

Estimated TM-score = 0.35±0.12

Estimated RMSD = 15.2±3.5Å

Download Model 2

C-score=-4.29

Download Model 3

C-score=-4.44

Download Model 4

C-score=-4.83

Download Model 5

C-score=-4.72

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1w0rA	0.787	3.08	0.085	0.891
2	4g1eA	0.328	6.03	0.031	0.479
3	1sjjA	0.298	7.78	0.049	0.528
4	5l56A	0.296	7.25	0.039	0.497
5	5cskA	0.295	7.20	0.041	0.488
6	3q2wA	0.289	7.49	0.031	0.488
7	1cwvA	0.286	6.72	0.057	0.441
8	3q2vA	0.286	7.30	0.032	0.479
9	5iryA	0.284	6.99	0.043	0.466
10	1q5cA	0.282	7.13	0.029	0.466

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	4dmzA	MG	Rep, Mult	281,285
2	0.06	3	4ap9C	1PS	Rep, Mult	285,286,287
3	0.04	2	2c9sA	ZN	Rep, Mult	317,318
4	0.04	2	1kqrA	MNA	Rep, Mult	235,258,276,280,281
5	0.02	1	2c5rF	NUC	Rep, Mult	295,301
6	0.02	1	3zvwC	MG	Rep, Mult	398,399
7	0.02	1	1y77I	ZN	Rep, Mult	158,198,247,251
8	0.02	1	1focA	HEM	Rep, Mult	100,116
9	0.02	1	2ecwA	ZN	Rep, Mult	116,120,198,230
10	0.02	1	3mcoA	MG	Rep, Mult	218,220
11	0.02	1	3cmvB	ANP	Rep, Mult	255,256,257,258,270
12	0.02	1	3qsvA	ZN	Rep, Mult	198,230,247,251
13	0.02	1	2g02A	ZN	Rep, Mult	100,116,120
14	0.02	1	3r6nB	D1D	Rep, Mult	260,262,270,271
15	0.02	1	2vl1C	III	Rep, Mult	183,185,207
16	0.02	1	5cjnA	MG	Rep, Mult	84,85
17	0.02	1	4cinB	CA	Rep, Mult	277,281
18	0.02	1	3ojyB	BMA	Rep, Mult	313,318

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ynnD	0.245	7.49	0.034	0.412	2.7.7.6	NA
2	0.060	1mo7A	0.107	6.18	0.048	0.160	3.6.3.9	194,220
3	0.060	2e1rA	0.223	7.32	0.020	0.372	3.6.5.3	118
4	0.060	1z1wA	0.203	6.40	0.021	0.305	3.4.11.-	NA
5	0.060	2vumA	0.257	7.07	0.032	0.416	2.7.7.6	NA
6	0.060	1w36C	0.230	7.82	0.022	0.403	3.1.11.5	NA
7	0.060	3b8eA	0.177	7.75	0.015	0.312	3.6.3.9	NA
8	0.060	1ug9A	0.220	7.24	0.032	0.367	3.2.1.70	NA
9	0.060	1kfxL	0.213	7.67	0.060	0.374	3.4.22.53	NA
10	0.060	3gm8A	0.234	6.11	0.018	0.345	3.2.1.-	NA
11	0.060	3b43A	0.262	6.42	0.063	0.405	2.7.11.1	362
12	0.060	2uv8G	0.264	7.07	0.047	0.428	2.3.1.86	NA
13	0.060	3dnyT	0.223	7.21	0.031	0.374	3.6.5.3	NA
14	0.060	2vkzG	0.261	7.03	0.034	0.421	2.3.1.38,3.1.2.14	NA
15	0.060	2nqaB	0.115	5.63	0.026	0.163	3.4.22.53,3.4.22.52	NA
16	0.060	2pmzQ	0.254	7.25	0.026	0.421	2.7.7.6	NA
17	0.060	1yq2A	0.228	6.97	0.031	0.367	3.2.1.23	159
18	0.060	2cseW	0.233	7.39	0.016	0.392	3.6.4.13	NA
19	0.060	3eqlD	0.250	6.99	0.014	0.399	2.7.7.6	377,383,417

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.16	0.787	3.08	0.09	0.89	1w0rA	GO:0002376 GO:0005576 GO:0005615 GO:0005788 GO:0006955 GO:0006956 GO:0006957 GO:0030449 GO:0031012 GO:0036066 GO:0042742 GO:0045087
1	0.06	0.250	7.42	0.05	0.42	3t5oA	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
2	0.06	0.239	7.50	0.03	0.41	4a5wB	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
3	0.06	0.245	7.26	0.05	0.41	4e0sB	GO:0001701 GO:0001970 GO:0002376 GO:0005576 GO:0005579 GO:0006955 GO:0006956 GO:0006958 GO:0019835 GO:0030449 GO:0045087 GO:0045766 GO:0045917 GO:0070062
4	0.06	0.207	3.76	0.08	0.25	3r6bA	GO:0000187 GO:0001666 GO:0001786 GO:0001937 GO:0001948 GO:0001953 GO:0001968 GO:0002040 GO:0002544 GO:0002576 GO:0002581 GO:0002605 GO:0005178 GO:0005509 GO:0005576 GO:0005577 GO:0005615 GO:0005783 GO:0005788 GO:0006954 GO:0006955 GO:0006986 GO:0007050 GO:0007155 GO:0008201 GO:0009749 GO:0009897 GO:0009986 GO:0010595 GO:0010596 GO:0010748 GO:0010751 GO:0010754 GO:0010757 GO:0010759 GO:0010763 GO:0016477 GO:0016525 GO:0016529 GO:0017134 GO:0018149 GO:0030141 GO:0030169 GO:0030194 GO:0030198 GO:0030335 GO:0030511 GO:0030823 GO:0031012 GO:0031091 GO:0031093 GO:0032026 GO:0032570 GO:0032695 GO:0032914 GO:0034605 GO:0034976 GO:0036066 GO:0040037 GO:0042327 GO:0042493 GO:0042535 GO:0042802 GO:0043032 GO:0043066 GO:0043154 GO:0043236 GO:0043394 GO:0043536 GO:0043537 GO:0043652 GO:0045727 GO:0045766 GO:0048266 GO:0050431 GO:0050840 GO:0050921 GO:0051592 GO:0051895 GO:0051897 GO:0051918 GO:0070051 GO:0070052 GO:0070062 GO:1902043 GO:2000353 GO:2000379 GO:2001027 GO:2001237
5	0.06	0.199	5.67	0.03	0.28	4v2aA	GO:0005886 GO:0006915 GO:0007165 GO:0007275 GO:0007411 GO:0016020 GO:0016021 GO:0031175 GO:0031226 GO:0032589 GO:0032809 GO:0033564 GO:0038007 GO:0042995 GO:0045121
6	0.06	0.181	6.63	0.04	0.29	5fttA	GO:0005886 GO:0006915 GO:0007165 GO:0007275 GO:0007411 GO:0009986 GO:0016020 GO:0016021 GO:0021859 GO:0098609 GO:2001222
7	0.06	0.159	6.30	0.03	0.24	4hqoB	GO:0016020 GO:0016021 GO:0046872
8	0.06	0.147	7.49	0.02	0.25	5foeB	GO:0000187 GO:0001666 GO:0001786 GO:0001937 GO:0001948 GO:0001953 GO:0001968 GO:0002040 GO:0002544 GO:0002576 GO:0002581 GO:0002605 GO:0005178 GO:0005509 GO:0005576 GO:0005577 GO:0005615 GO:0005783 GO:0005788 GO:0005794 GO:0005975 GO:0006004 GO:0006486 GO:0006954 GO:0006955 GO:0006986 GO:0007050 GO:0007155 GO:0008201 GO:0009749 GO:0009897 GO:0009986 GO:0010595 GO:0010596 GO:0010748 GO:0010751 GO:0010754 GO:0010757 GO:0010759 GO:0010763 GO:0016477 GO:0016525 GO:0016529 GO:0016740 GO:0016757 GO:0017134 GO:0018149 GO:0030141 GO:0030169 GO:0030194 GO:0030198 GO:0030335 GO:0030511 GO:0030823 GO:0031012 GO:0031091 GO:0031093 GO:0032026 GO:0032570 GO:0032695 GO:0032914 GO:0034605 GO:0034976 GO:0036066 GO:0040037 GO:0042327 GO:0042493 GO:0042535 GO:0042802 GO:0043032 GO:0043066 GO:0043154 GO:0043236 GO:0043394 GO:0043536 GO:0043537 GO:0043652 GO:0045727 GO:0045766 GO:0046922 GO:0048266 GO:0050431 GO:0050840 GO:0050921 GO:0051592 GO:0051895 GO:0051897 GO:0051918 GO:0070051 GO:0070052 GO:0070062 GO:1902043 GO:2000353 GO:2000379 GO:2001027 GO:2001237
9	0.06	0.149	5.48	0.04	0.20	3vn4A	GO:0004175 GO:0004222 GO:0005178 GO:0005509 GO:0005576 GO:0005578 GO:0005615 GO:0005788 GO:0006508 GO:0007160 GO:0007229 GO:0007596 GO:0007599 GO:0008233 GO:0008237 GO:0008270 GO:0009100 GO:0009636 GO:0009986 GO:0016485 GO:0016787 GO:0030168 GO:0034341 GO:0034612 GO:0036066 GO:0043171 GO:0046872 GO:0070670
10	0.06	0.110	3.05	0.09	0.12	1vexA	GO:0005576 GO:0005578 GO:0007155 GO:0046872
11	0.06	0.102	5.41	0.04	0.14	2ifwA	GO:0004190 GO:0006508 GO:0008233 GO:0016787
12	0.06	0.091	3.27	0.04	0.10	2bbxA	GO:0005886 GO:0007155 GO:0008201 GO:0016020 GO:0016021

Consensus prediction of GO terms

Molecular Function	GO:0005178	GO:0017134	GO:0030169	GO:0050431	GO:0043236	GO:0001968	GO:0001786	GO:0043394	GO:0070051	GO:0070052	GO:0005509	GO:0008201	GO:0042802
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0045765	GO:1904018	GO:0036065	GO:0006493	GO:0002455	GO:2000259	GO:0002922	GO:0043009	GO:0001969	GO:0010954	GO:0002699	GO:0098542	GO:0009617	GO:0045087
GO-Score	0.46	0.46	0.43	0.43	0.35	0.35	0.35	0.35	0.35	0.35	0.35	0.32	0.32	0.31
Cellular Component	GO:1903561	GO:0031988	GO:0044432	GO:0070013	GO:0098797	GO:0005887	GO:0046930
GO-Score	0.46	0.46	0.43	0.43	0.35	0.35	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.