I-TASSER results

I-TASSER results for job id Rv3821

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (237 residues)
MWSTVLVLALSVICEPVRIGLVVLMLNRRRPLLHLLTFLCGGYTMAGGVAMVTLVVLGAT
PLAGHFSVAEVQIGTGLIALLIAFALTTNVIGKHVRRATHARVGDDGGRVLRESVPPSGA
HKLAVRARCFLQGDSLYVAGVSGLGAALPSANYMGAMAAILASGATPATQALAVVTFNVV
AFTVAEVPLVSYLAAPRKTRAFMAALQSWLRSRSRRDAALLVAAGGCLMLTLGLSNL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MWSTVLVLALSVICEPVRIGLVVLMLNRRRPLLHLLTFLCGGYTMAGGVAMVTLVVLGATPLAGHFSVAEVQIGTGLIALLIAFALTTNVIGKHVRRATHARVGDDGGRVLRESVPPSGAHKLAVRARCFLQGDSLYVAGVSGLGAALPSANYMGAMAAILASGATPATQALAVVTFNVVAFTVAEVPLVSYLAAPRKTRAFMAALQSWLRSRSRRDAALLVAAGGCLMLTLGLSNL
Prediction	CCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	956799999999747757899999977987556899999999999999999999986434567777777545779999999999999987654455666666678876655567888757889999999865786588999888874898888999999998688578999999999999999999999999975788999999999999998967899999999999999977659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MWSTVLVLALSVICEPVRIGLVVLMLNRRRPLLHLLTFLCGGYTMAGGVAMVTLVVLGATPLAGHFSVAEVQIGTGLIALLIAFALTTNVIGKHVRRATHARVGDDGGRVLRESVPPSGAHKLAVRARCFLQGDSLYVAGVSGLGAALPSANYMGAMAAILASGATPATQALAVVTFNVVAFTVAEVPLVSYLAAPRKTRAFMAALQSWLRSRSRRDAALLVAAGGCLMLTLGLSNL
Prediction	523301320301033332000000000334223102012111211122332110100220333443424301001023113310111021324434445445444544443445543431440353034216541020000212021323330000001112243431120001311323133111112000001143044004302400443412000000133112101322244
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
MWSTVLVLALSVICEPVRIGLVVLMLNRRRPLLHLLTFLCGGYTMAGGVAMVTLVVLGATPLAGHFSVAEVQIGTGLIALLIAFALTTNVIGKHVRRATHARVGDDGGRVLRESVPPSGAHKLAVRARCFLQGDSLYVAGVSGLGAALPSANYMGAMAAILASGATPATQALAVVTFNVVAFTVAEVPLVSYLAAPRKTRAFMAALQSWLRSRSRRDAALLVAAGGCLMLTLGLSNL

4bwzA2

0.16

0.14

0.84

1.05

wMUSTER

VGKEAFLVAVLGVALPFLGGYLYGLEI---GFETLPALFLGTALVATSVGITARVLQELGVLSRPYS--RIILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGA-VNEEEYAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE--------------------------------

2n4xA

0.11

0.08

0.74

1.71

wPPAS

LM--AFALGILSVFSP------VLVVGSRGRALDAFLIVAGLTISMLILGYTASLFFGFF----------RVVAMLFLLIFALILLSDELDEK--------------------------VSIFASRMTSGLSWKSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN--------PLVMLSYGLGMAVTIAAVFKMGEK----------FVKANFRKVTGAIVLLYLAYFALTEVLLL

4bwzA2

0.16

0.14

0.84

1.57

dPPAS2

VGKEAFLVAVLGVALPFLGGYLYGLEI---GFETLPALFLGTALVATSVGITARVLQELGVLSRPYSR--IILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGA-VNEEEYAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE--------------------------------

4bwzA2

0.16

0.14

0.84

1.47

PPAS

VGKEAFLVAVLGVALPFLGGYLYGLEIGFE---TLPALFLGTALVATSVGITARVLQELGVLSRPYS--RIILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGA-VNEEEYAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE--------------------------------

4cadC

0.08

0.97

0.98

wMUSTER

--NPKLYFLSTFVVTILWFTGAYLSFSSTYSGIYMLIMLPGLMAPFIISTILIAKKKDFINRLFNLKLINLKTIPVVFLLMPAVILLSILLSIPFGGSISQFQFSGGDFVPVLFLLLLAFDSLQSRYS--LFKASILFGIFWSLWHF-PLIFVSYQYEIFNQSIWYGLNFFLSILPMGIIITWMCLKNIILAIIFHFLINLNQELL---ITQDTKIIETGVLFLVAAAIILYDKKMF

4bwzA2

0.17

0.14

0.83

1.37

wPPAS

VGKEAFLVAVLGVALPFLGGYLYGLE----GFETLPALFLGTALVATSVGITARVLQELGVLSRPYS--RIILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMA-PRGEVGLIVAALGLKGA--NEEEYAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE--------------------------------

4ke2A

0.12

0.10

0.83

1.24

dPPAS2

MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-----------------------------------------

2n4xA

0.11

0.08

0.75

1.29

PPAS

LM--AFALGILSVFSP------VLVVGSRGRALDAFLIVAGLTISMLILGY----------TASLFFGFFRVVAMLFLLIFALILLSDELDEK--------------------------VSIFASRMTSGLSWKSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN--------PLVMLSYGLGMAVTIAAVFKMGEKF------VKANFQLIR-KVTGAIVLLYLAYFALTEVLLL

4czbA2

0.13

0.10

0.80

1.31

wPPAS

VIKTVVRLDITFLITLLISGFIFNMVLN--PYTSPVGYLFGAITA-----ATLIPVFSRVRTNPEVAI--ESIFNDPLGIVSTSVILGLFG---------------------LFSLSMLENYFIPGLLVAL--GSIFLARPLGVFLGIGSKHSFKEKLYFALEGP-------------VVPAALAVTVGIEILKNADKIPASITKYITPTDIAG-TIIIGTFMTILLSVILEASW-L

4zowA2

0.10

0.08

0.82

1.17

dPPAS2

-------------LSLKELGRDYKLVLK------NGRFVAGALALGFVSLPLLAWIAQSIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRT--------------------VRSLIIMGGWPI--MIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASKGTVSAAMGMLQMLIFTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLK--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.53

Estimated TM-score = 0.42±0.14

Estimated RMSD = 11.6±4.5Å

Download Model 2

C-score=-3.25

Download Model 3

C-score=-3.80

Download Model 4

C-score=-3.91

Download Model 5

C-score=-4.28

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1zcdA2	0.630	2.72	0.084	0.730
2	1mhzD	0.437	5.38	0.077	0.717
3	2x42A	0.417	5.59	0.061	0.679
4	2o78A	0.415	5.32	0.098	0.646
5	1zhyA	0.406	5.81	0.062	0.679
6	1xmgC	0.402	5.53	0.055	0.650
7	1gkmA	0.401	5.86	0.055	0.671
8	2f8zF	0.392	4.80	0.024	0.557
9	2zt6A	0.392	6.02	0.032	0.675
10	2f6dA	0.390	6.06	0.067	0.675

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	4	3a0bZ	CLA	Rep, Mult	187,190
2	0.05	3	1xvbD	3BR	Rep, Mult	218,221,222,224
3	0.04	2	3wmoS	BCL	Rep, Mult	8,19
4	0.04	2	1xvgA	BRJ	Rep, Mult	13,14,17,79,82,83
5	0.04	2	1fz8D	2BM	Rep, Mult	175,178,179,182
6	0.02	1	3wmnQ	BCL	Rep, Mult	8,19,23
7	0.02	1	3ojcA	CA	Rep, Mult	134,164
8	0.02	1	4n7wB	MPG	Rep, Mult	26,118,121,122,124,125,128,193
9	0.02	1	1xvgB	BRJ	Rep, Mult	9,10,14,79
10	0.02	1	4ryrA	MPG	Rep, Mult	130,224
11	0.02	1	1izlA	CLA	Rep, Mult	180,181
12	0.02	1	1mhy1	III	Rep, Mult	14,15,18,19,21,22,25,26,114,118,121
13	0.02	1	2wscA	CLA	Rep, Mult	2,6
14	0.02	1	4brbB	78N	Rep, Mult	91,95
15	0.02	1	4q54z	CLA	Rep, Mult	187,195
16	0.02	1	3ue8A	09M	Rep, Mult	143,192
17	0.02	1	2y04A	2CV	Rep, Mult	52,72,76
18	0.02	1	2aj4A	MG	Rep, Mult	41,114
19	0.02	1	1jb0M	CLA	Rep, Mult	79,83
20	0.02	1	2r9rB	PGW	Rep, Mult	206,221

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1s76D	0.349	5.29	0.060	0.548	2.7.7.6	NA
2	0.060	1gnxA	0.364	5.28	0.047	0.561	3.2.1.21	NA
3	0.060	1occA	0.377	5.23	0.086	0.582	1.9.3.1	15
4	0.060	1ej6A	0.374	5.74	0.059	0.629	2.7.7.50	NA
5	0.060	2gl9C	0.248	5.40	0.023	0.405	3.5.1.26	214
6	0.060	1ygyA	0.372	5.40	0.089	0.587	1.1.1.95	18
7	0.060	2wyhA	0.366	5.95	0.041	0.625	3.2.1.24	NA
8	0.060	2o2rC	0.346	6.02	0.059	0.616	1.5.1.6	NA
9	0.060	1v5yA	0.368	4.98	0.049	0.540	1.6.99.-	NA
10	0.060	1ug9A	0.386	5.53	0.076	0.633	3.2.1.70	70
11	0.060	2rnpC	0.382	5.09	0.056	0.570	2.7.7.6	NA
12	0.060	1hrkA	0.371	5.40	0.089	0.591	4.99.1.1	NA
13	0.060	2occN	0.376	5.77	0.043	0.633	1.9.3.1	148
14	0.060	1o01C	0.377	5.50	0.057	0.603	1.2.1.3	NA
15	0.060	1cb8A	0.368	5.17	0.039	0.557	4.2.2.5	NA
16	0.060	2gl9D	0.240	4.97	0.050	0.363	3.5.1.26	73
17	0.060	1b8fA	0.369	6.04	0.066	0.654	4.3.1.3	NA
18	0.060	1g87B	0.388	5.78	0.050	0.650	3.2.1.4	NA
19	0.060	2de3B	0.366	4.98	0.072	0.565	3.13.1.3	3

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.579	3.76	0.05	0.76	4atvA	GO:0005886 GO:0006810 GO:0006811 GO:0006814 GO:0006885 GO:0015081 GO:0015297 GO:0015491 GO:0015992 GO:0016020 GO:0016021 GO:0035725 GO:0055085 GO:0098655
1	0.06	0.447	5.86	0.06	0.76	2innA	GO:0006725 GO:0016491 GO:0046872 GO:0055114
2	0.06	0.420	4.72	0.08	0.63	2f6hX	GO:0000001 GO:0000011 GO:0000131 GO:0000132 GO:0000146 GO:0000166 GO:0000329 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005934 GO:0005935 GO:0006810 GO:0007049 GO:0007107 GO:0007118 GO:0009826 GO:0015031 GO:0016192 GO:0016459 GO:0030050 GO:0030133 GO:0031941 GO:0031982 GO:0032432 GO:0043332 GO:0045033 GO:0048313 GO:0051015 GO:0051301 GO:0071563
3	0.06	0.388	5.92	0.03	0.67	4zo6A	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
4	0.06	0.416	5.60	0.06	0.68	2x41A	GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0102483
5	0.06	0.375	6.27	0.04	0.68	3abzB	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0030245 GO:0102483
6	0.06	0.339	6.27	0.04	0.61	4d0jA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0030245 GO:0102483
7	0.06	0.379	6.23	0.06	0.69	4i8dB	GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0102483
8	0.06	0.376	6.38	0.05	0.70	3abzA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0030245 GO:0102483
9	0.06	0.339	5.65	0.08	0.55	2oxnA	GO:0004553 GO:0004563 GO:0005737 GO:0005975 GO:0007049 GO:0008152 GO:0008360 GO:0009252 GO:0009254 GO:0009273 GO:0016787 GO:0016798 GO:0046677 GO:0051301 GO:0071555
10	0.06	0.338	6.09	0.04	0.59	5fjiA	GO:0000272 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0030245 GO:0102483
11	0.06	0.325	5.79	0.04	0.55	4kqxB	GO:0000166 GO:0004455 GO:0008652 GO:0009082 GO:0009097 GO:0009099 GO:0016491 GO:0016853 GO:0046872 GO:0055114
12	0.06	0.399	5.98	0.01	0.68	4iibA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0030245 GO:0102483
13	0.06	0.351	5.74	0.07	0.59	4gnvB	GO:0004553 GO:0004563 GO:0005737 GO:0005975 GO:0007049 GO:0008152 GO:0008360 GO:0009252 GO:0009254 GO:0016787 GO:0016798 GO:0051301 GO:0071555
14	0.06	0.308	5.69	0.03	0.49	3dhiB	GO:0004497 GO:0006725 GO:0016491 GO:0016709 GO:0019439 GO:0042203 GO:0055114
15	0.06	0.451	5.42	0.04	0.74	1mhyD	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0016491 GO:0046872 GO:0055114
16	0.06	0.420	5.33	0.06	0.69	3dhiA	GO:0004497 GO:0006725 GO:0016491 GO:0019439 GO:0042203 GO:0046872 GO:0055114
17	0.06	0.432	5.58	0.10	0.73	1fziA	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0015050 GO:0015947 GO:0016491 GO:0046872 GO:0055114
18	0.06	0.373	5.84	0.03	0.62	5fjjA	GO:0000272 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008422 GO:0016052 GO:0016787 GO:0016798 GO:0030245 GO:0102483

Consensus prediction of GO terms

Molecular Function	GO:0015081	GO:0015491	GO:0016491	GO:0046872	GO:0005516	GO:0102483	GO:0000146	GO:0008422	GO:0051015	GO:0005524
GO-Score	0.07	0.07	0.07	0.07	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0005975	GO:0015992	GO:0035725	GO:0006885	GO:0055114	GO:0006725	GO:0015031	GO:0030050	GO:0007107	GO:0016192	GO:0000011	GO:0009826	GO:0000001	GO:0048313	GO:0007118	GO:0045033	GO:0000132
GO-Score	0.12	0.07	0.07	0.07	0.07	0.07	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0005886	GO:0016021	GO:0032432	GO:0071563	GO:0031941	GO:0000329	GO:0016459	GO:0005934	GO:0000131	GO:0043332	GO:0005935	GO:0030133
GO-Score	0.07	0.07	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.