I-TASSER results

I-TASSER results for job id Rv3813c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (273 residues)
MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHFILATGRPPRWVRPIVDAL
GFAPMAVCANGAVIYDPGTDRVMSVRTLPVDALATLAEVATRVIPGAGLAVERIGERAHD
TATPQFVSSPGYEHAWLNPDNTEVSIDHLLSAPAIKLLIRKAGAASADMAAELAKHVGFE
GDITYSTNNGLVEIVPLGISKATGVDEIARPLGISDAEVVAFGDMPNDVPMLLRAGLGVA
MGNAHPDALAVADEVTAPNSEDGVARVLERWWS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHFILATGRPPRWVRPIVDALGFAPMAVCANGAVIYDPGTDRVMSVRTLPVDALATLAEVATRVIPGAGLAVERIGERAHDTATPQFVSSPGYEHAWLNPDNTEVSIDHLLSAPAIKLLIRKAGAASADMAAELAKHVGFEGDITYSTNNGLVEIVPLGISKATGVDEIARPLGISDAEVVAFGDMPNDVPMLLRAGLGVAMGNAHPDALAVADEVTAPNSEDGVARVLERWWS
Prediction	CCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEHCCCCCHHHHHHHHHHHCCCCEEEHCCCCEEEHCCCCEEEEHCCCCHHHHHHHHHHHHHHCCCEEEEEEEHCCEEEHCCCCHHHHHHHHHHHCCCCCCEHCCHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCEEEEHCCCCCHHHHHHHHHHHHCCCHHHEEEHCCCCHHHHHHHHHCCEEHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHC
Conf.Score	999875799995889988899989999999999999989979995899958999999998999859975885999889997999758999999999999999899879999875664665577556555556554567775567999976689879999869789999999999985997799998699779985899998999999999989998876764699756899987597677588899999987934699876579999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHFILATGRPPRWVRPIVDALGFAPMAVCANGAVIYDPGTDRVMSVRTLPVDALATLAEVATRVIPGAGLAVERIGERAHDTATPQFVSSPGYEHAWLNPDNTEVSIDHLLSAPAIKLLIRKAGAASADMAAELAKHVGFEGDITYSTNNGLVEIVPLGISKATGVDEIARPLGISDAEVVAFGDMPNDVPMLLRAGLGVAMGNAHPDALAVADEVTAPNSEDGVARVLERWWS
Prediction	855531313131324324347553174126104503744144233520024103300652704100110322131227543001533532620340051046222300000110233223243451253242443314253342305402744000000003753145016303740646210001023205434333112032032007416241641326225241041432141021343127331400410212215203544765358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEHCCCCCHHHHHHHHHHHCCCCEEEHCCCCEEEHCCCCEEEEHCCCCHHHHHHHHHHHHHHCCCEEEEEEEHCCEEEHCCCCHHHHHHHHHHHCCCCCCEHCCHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCEEEEHCCCCCHHHHHHHHHHHHCCCHHHEEEHCCCCHHHHHHHHHCCEEHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHC
MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHFILATGRPPRWVRPIVDALGFAPMAVCANGAVIYDPGTDRVMSVRTLPVDALATLAEVATRVIPGAGLAVERIGERAHDTATPQFVSSPGYEHAWLNPDNTEVSIDHLLSAPAIKLLIRKAGAASADMAAELAKHVGFEGDITYSTNNGLVEIVPLGISKATGVDEIARPLGISDAEVVAFGDMPNDVPMLLRAGLGVAMGNAHPDALAVADEVTAPNSEDGVARVLERWWS

1rkqA

0.26

0.97

3.81

MUSTER

L---AIKLIAIDMDGTLLLPDHTISPAVKNAIAAARARGVNVVLTTGRPYAGVHNYLKELHMEDYCITYNGALVQKAADGSTVAQTALSYDDYRFLEKLSREVGSHFHALDR----TTLYTANRDISYYTVHESFVATIPLVFCEAEKMPNTQFLKVMMIDEPAILDQAIARIPQEVKEK-YTVLKSAPYFLEILDKRVNKGTGVKSLADVLGIKPEEIMAIGDQENDIAMIEYAGVGVAVDNAIPSVKEVANFVTKSNLEDGVAFAIEKYVN

1rkqA

0.27

0.26

0.97

5.17

dPPAS

--SLAIKLIAIDMDGTLLLPDHTISPAVKNAIAAARARGVNVVLTTGRPYAGVHNYLKELHMEQYCITYNGALVQKAADGSTVAQTALSYDDYRFLEKLSREVGSHFHALDRT----TLYTANRDISYYTVHESFVATIPLVFCEAEKMPNTQFLKVMMIDEPAILDQAIARIPQEVKEKYTVLKS-APYFLEILDKRVNKGTGVKSLADVLGIKPEEIMAIGDQENDIAMIEYAGVGVAVDNAIPSVKEVANFVTKSNLEDGVAFAIEKYVL

1rkqA

0.26

0.97

5.73

wdPPAS

--SLAIKLIAIDMDGTLLLPDHTISPAVKNAIAAARARGVNVVLTTGRPYAGVHNYLKELHMEQYCITYNGALVQKAADGSTVAQTALSYDDYRFLEKLSREVGSHFHALDRT----TLYTANRDISYYTVHESFVATIPLVFCEAEKMPNTQFLKVMMIDEPAILDQAIARIPQEVKEK-YTVLKSAPYFLEILDKRVNKGTGVKSLADVLGIKPEEIMAIGDQENDIAMIEYAGVGVAVDNAIPSVKEVANFVTKSNLEDGVAFAIEKYVL

1rkqA

0.26

0.97

4.30

wMUSTER

L---AIKLIAIDMDGTLLLPDHTISPAVKNAIAAARARGVNVVLTTGRPYAGVHNYLKELHMEDYCITYNGALVQKAADGSTVAQTALSYDDYRFLEKLSREVGSHFHALDRT----TLYTANRDISYYTVHESFVATIPLVFCEAEKMPNTQFLKVMMIDEPAILDQAIARIPQEVKEK-YTVLKSAPYFLEILDKRVNKGTGVKSLADVLGIKPEEIMAIGDQENDIAMIEYAGVGVAVDNAIPSVKEVANFVTKSNLEDGVAFAIEKYVN

1rkqA

0.26

0.97

3.97

wPPAS

L---AIKLIAIDMDGTLLLPDHTISPAVKNAIAAARARGVNVVLTTGRPYAGVHNYLKELHMEDYCITYNGALVQKAADGSTVAQTALSYDDYRFLEKLSREVGSHFHALDRT----TLYTANRDISYYTVHESFVATIPLVFCEAEKMPNTQFLKVMMIDEPAILDQAIARIPQEVKEK-YTVLKSAPYFLEILDKRVNKGTGVKSLADVLGIKPEEIMAIGDQENDIAMIEYAGVGVAVDNAIPSVKEVANFVTKSNLEDGVAFAIEKYVN

1rkqA

0.27

0.26

0.97

6.61

dPPAS2

--SLAIKLIAIDMDGTLLLPDHTISPAVKNAIAAARARGVNVVLTTGRPYAGVHNYLKELHMEQYCITYNGALVQKAADGSTVAQTALSYDDYRFLEKLSREVGSHFHALDRT----TLYTANRDISYYTVHESFVATIPLVFCEAEKMPNTQFLKVMMIDEPAILDQAIARIPQEVKEKYTVLKS-APYFLEILDKRVNKGTGVKSLADVLGIKPEEIMAIGDQENDIAMIEYAGVGVAVDNAIPSVKEVANFVTKSNLEDGVAFAIEKYVL

1rkqA

0.26

0.97

3.86

PPAS

L---AIKLIAIDMDGTLLLPDHTISPAVKNAIAAARARGVNVVLTTGRPYAGVHNYLKELHMEDYCITYNGALVQKAADGSTVAQTALSYDDYRFLEKLSREVGSHFHALDRT----TLYTANRDISYYTVHESFVATIPLVFCEAEKMPNTQFLKVMMIDEPAILDQAIARIPQEVKEK-YTVLKSAPYFLEILDKRVNKGTGVKSLADVLGIKPEEIMAIGDQENDIAMIEYAGVGVAVDNAIPSVKEVANFVTKSNLEDGVAFAIEKYVL

4qjbA

0.19

0.97

5.00

Env-PPAS

LN-DEIKIIFTDLDGTLLNSENKVSEQNLESLIRAQEKGIKVVIATGRSIFSVENVIGEHVKKNPGIYMNGCVTFDE-KGSRVIDRIMNNDLKMEIHEFSKQINISKYAIWFCLEKTYCFEINDCIREYMEVEALNP----DVIEDNMLEGLTVYKVLFSLPENILENTLKLCREKFSHRI-NVANTFQSYVELFHQHTNKFEGVKEICKYYNISLNNALAMGDGENDIEMLSGLTHSVGVHNASEKVKNSAAYVGPSNNEHAISHVLKTFCD

4qjbA

0.19

0.97

3.67

MUSTER

LN-DEIKIIFTDLDGTLLNSENKVSEQNLESLIRAQEKGIKVVIATGRSIFSVENVIGEHVKKNPGIYMNGCVTFDE-KGSRVIDRIMNNDLKMEIHEFSKQINISKYAIWFCLEKTYCFEINDCIREYMEVEA----LNPDVIEDNMLEGLTVYKVLFSLPENILENTLKLCREKFSHRI-NVANTFQSYVELFHQHTNKFEGVKEICKYYNISLNNALAMGDGENDIEMLSGLTHSVGVHNASEKVKNSAAYVGPSNNEHAISHVLKTFCD

4qjbA

0.19

0.97

5.01

dPPAS

LN-DEIKIIFTDLDGTLLNSENKVSEQNLESLIRAQEKGIKVVIATGRSIFSVENVIGEHVKKNPGIYMNGCVTFDE-KGSRVIDRIMNNDLKMEIHEFSKQINISKYAIWFCLEKTYCFEINDCIREYMEVEA----LNPDVIEDNMLEGLTVYKVLFSLPENILENTLKLCREKFSHRI-NVANTFQSYVELFHQHTNKFEGVKEICKYYNISLNNALAMGDGENDIEMLSGLTHSVGVHNASEKVKNSAAYVGPSNNEHAISHVLKTFCD

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.51

Estimated TM-score = 0.92±0.06

Estimated RMSD = 3.0±2.1Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1rkqA	0.960	0.78	0.263	0.974
2	4qjbA	0.889	2.01	0.200	0.971
3	3l7yA	0.865	2.08	0.205	0.945
4	2b30A	0.865	2.35	0.230	0.971
5	1nrwA	0.843	2.29	0.265	0.927
6	2ravA	0.841	2.46	0.254	0.938
7	3dnpA	0.827	2.66	0.266	0.934
8	3pgvA	0.826	2.13	0.244	0.897
9	3r4cA	0.826	2.70	0.245	0.938
10	3niwA	0.783	2.98	0.246	0.938

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.79	123	4rn3A	MG	Rep, Mult	12,14,224,228
2	0.40	54	1rltC	AF3	Rep, Mult	12,13,14,46,47,201,227
3	0.07	16	1u2tA	SUP	Rep, Mult	12,13,14,46,47,70,156,187,190,191,193,201,227
4	0.02	8	3zw7B	2M8	Rep, Mult	14,47,48,56,123,153,158,186,187,188,192,194
5	0.01	2	1nf2C	SO4	Rep, Mult	27,30,34,269
6	0.01	3	2amyA	GLY	Rep, Mult	232,233,234,236,238
7	0.01	3	3ztyB	GD	Rep, Mult	20,224,225
8	0.00	1	1l6rB	CA	Rep, Mult	48,49,52,111
9	0.00	1	1wr80	III	Rep, Mult	22,23,24,26,33,54,58,59,79,81
10	0.00	1	1kytA	CA	Rep, Mult	47,48,188,189,190,193
11	0.00	1	1l6r0	III	Rep, Mult	181,197,198,203,210,229,233,247,250,251
12	0.00	1	1kytB	CA	Rep, Mult	22,189

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.330	1l6rA	0.704	2.76	0.183	0.821	3.1.3.18	15,202,227,230
2	0.317	1rltC	0.849	2.34	0.181	0.952	3.1.3.23	202,243
3	0.293	2q4rA	0.584	4.07	0.171	0.766	5.4.2.8	47,186,224
4	0.281	1wr8B	0.702	2.92	0.179	0.821	3.1.3.18	15,47,227,252
5	0.262	1f5sA	0.499	2.86	0.237	0.564	3.1.3.3	12,14,47,228
6	0.258	2r8zP	0.489	1.88	0.250	0.527	3.1.3.45	14,17,19,244,252,255
7	0.211	1wzcB	0.699	3.19	0.123	0.832	3.1.3.70	184
8	0.203	1s2oA	0.618	3.88	0.159	0.802	3.1.3.24	47,227
9	0.114	3f9rA	0.653	3.44	0.176	0.780	5.4.2.8	13,15
10	0.067	2gmwB	0.481	2.65	0.166	0.549	3.1.3.-	NA
11	0.060	2x4dA	0.565	4.34	0.119	0.747	3.6.1.1	224,234
12	0.060	3ewiB	0.473	1.83	0.173	0.509	2.7.7.43	15,244
13	0.060	1l8oB	0.481	3.21	0.126	0.575	3.1.3.3	47,243
14	0.060	2feaA	0.462	3.37	0.140	0.557	3.1.3.-	15,47,224,228
15	0.060	2azdB	0.463	5.19	0.065	0.674	2.4.1.1	NA
16	0.060	2hszA	0.453	2.57	0.170	0.516	3.1.3.18	15
17	0.060	3b8cB	0.481	3.32	0.160	0.560	3.6.3.6	202
18	0.060	2vkqA	0.479	3.70	0.103	0.601	3.1.3.5	14,224
19	0.060	1cjyA	0.458	5.02	0.061	0.667	3.1.1.4,3.1.1.5	15
20	0.060	2iyeA	0.454	2.20	0.197	0.502	3.6.1.10	224,240,243,251,259
21	0.060	2hjhB	0.455	4.81	0.086	0.656	3.5.1.-	NA
22	0.060	3b8cA	0.481	3.32	0.160	0.560	3.6.3.6	12
23	0.060	1xviB	0.621	3.68	0.153	0.773	3.1.3.70	9,15,17,70,224,226,230
24	0.060	1ygpA	0.456	5.31	0.052	0.674	2.4.1.1	NA
25	0.060	1eg7A	0.458	5.66	0.075	0.747	6.3.4.3	NA
26	0.060	2d1fA	0.452	5.20	0.081	0.670	4.2.3.1	NA
27	0.060	1k1eK	0.492	1.81	0.188	0.527	3.1.3.45	14,17,19,244,253,255
28	0.060	1l8lA	0.485	3.18	0.126	0.575	3.1.3.3	NA
29	0.060	2fueA	0.625	3.44	0.138	0.766	5.4.2.8	15,47,198

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.62	0.855	2.10	0.24	0.93	3pgvA	GO:0016787 GO:0046872
1	0.60	0.844	2.42	0.25	0.94	2rarA	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872
2	0.60	0.960	0.78	0.26	0.97	1rkqA	GO:0000287 GO:0005829 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872 GO:0050308
3	0.60	0.865	2.08	0.20	0.95	3l7yA	GO:0016787 GO:0046872
4	0.59	0.865	2.35	0.23	0.97	2b30A	GO:0016787 GO:0046872
5	0.52	0.699	3.19	0.12	0.83	1wzcB	GO:0005737 GO:0016311 GO:0016787 GO:0046872 GO:0050531 GO:0051479
6	0.52	0.613	3.66	0.14	0.77	2i54A	GO:0004615 GO:0005737 GO:0009298 GO:0016853 GO:0046872
7	0.50	0.864	2.30	0.27	0.95	1nrwA	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872
8	0.49	0.794	3.11	0.15	0.93	3fzqA	GO:0016787
9	0.48	0.602	4.75	0.16	0.81	3gygA
10	0.47	0.847	2.57	0.28	0.95	3dnpA	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283
11	0.47	0.772	3.44	0.22	0.95	1nf2A	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872
12	0.47	0.798	2.97	0.26	0.96	3mpoB	GO:0016787
13	0.47	0.890	1.99	0.20	0.97	4zevA	GO:0005737 GO:0010323 GO:0016311 GO:0016787 GO:0044283 GO:0046872 GO:0050308
14	0.45	0.859	2.29	0.26	0.96	4dwoA	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872
15	0.42	0.489	1.89	0.25	0.53	2r8xH	GO:0009103 GO:0016311 GO:0016787 GO:0019143 GO:0046872
16	0.39	0.480	1.92	0.20	0.52	3e81A	GO:0005829 GO:0008781 GO:0016311 GO:0016740 GO:0016779 GO:0016787 GO:0019143 GO:0046872
17	0.38	0.753	3.60	0.26	0.93	2qyhB	GO:0016787
18	0.33	0.704	2.72	0.19	0.82	1kytA	GO:0000287 GO:0005975 GO:0008967 GO:0016311 GO:0016787 GO:0046872
19	0.32	0.700	3.09	0.14	0.83	2b1qA	GO:0000287 GO:0005986 GO:0016311 GO:0046872 GO:0050307
20	0.32	0.757	3.46	0.20	0.95	3daoB	GO:0016787
21	0.31	0.718	3.86	0.20	0.95	2hf2B	GO:0000287 GO:0005737 GO:0016311 GO:0016787 GO:0044283 GO:0046872 GO:0050308
22	0.30	0.489	1.89	0.26	0.53	4hgnA	GO:0005829 GO:0008781 GO:0016311 GO:0016787 GO:0019143 GO:0046872
23	0.28	0.487	1.87	0.20	0.52	3mmzD	GO:0016740 GO:0046872
24	0.27	0.487	1.93	0.20	0.53	2p9jB	GO:0005829 GO:0008781 GO:0016311 GO:0016787 GO:0019143 GO:0046872
25	0.23	0.499	2.86	0.24	0.56	1f5sA	GO:0000287 GO:0004647 GO:0005737 GO:0006564 GO:0008152 GO:0008652 GO:0016311 GO:0016787 GO:0016791 GO:0046872
26	0.22	0.490	1.84	0.24	0.53	3ij5A	GO:0005829 GO:0008781 GO:0009103 GO:0016311 GO:0016787 GO:0019143 GO:0046872
27	0.20	0.702	2.92	0.18	0.82	1wr8B	GO:0000287 GO:0005975 GO:0008967 GO:0016311 GO:0016787 GO:0046872
28	0.19	0.826	2.70	0.24	0.94	3r4cA	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872
29	0.07	0.494	1.73	0.24	0.53	3n1uA	GO:0016311 GO:0016787 GO:0019143 GO:0046872
30	0.07	0.489	1.87	0.24	0.53	3mn1A	GO:0016311 GO:0019143 GO:0046872
31	0.07	0.487	1.92	0.24	0.53	3n07A	GO:0005829 GO:0008781 GO:0016311 GO:0019143 GO:0046872
32	0.07	0.560	4.12	0.11	0.73	1vjrA	GO:0016311 GO:0016791 GO:0046872
33	0.07	0.544	3.67	0.18	0.67	3gygB
34	0.07	0.568	4.35	0.17	0.74	3gygD

Consensus prediction of GO terms

Molecular Function	GO:0000287	GO:0050308
GO-Score	0.60	0.60
Biological Processes	GO:0044283	GO:0016311
GO-Score	0.84	0.84
Cellular Component	GO:0005829
GO-Score	0.60

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.