I-TASSER results

I-TASSER results for job id Rv3811

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (539 residues)
MAATVVIVAWIANRPPASSHEPSPTPNTQLAEQPLIGLGGGVTVRELTQDTPFSLVALTG
DLAGTSARVRAKRPDGDWGPWYQTEYETEPRDPAGTDGSVELGGLNPGPRSTDPVFVGTT
TTVQVAVTRPIDAPITQPPAGRPPNDLLDSGLGYRPATKEQPFGQNISAILISPPQAPPG
TQWTPPTAVTMAGQPPAIISRAEWGADESLRCETPEYDRGVRAAVVHHTAGSNDYSPLES
AGIVKAIYTYHSKTLGWCDIAYNALVDKYGQVFEGSAGGLTKPVEGFHTGGFNRNTWGVA
MIGNFDDVAPTPIQIRTVGRLLGWRLGMDDVDPRSMVDLQSAGSSYTTFPGGAIARLPAI
FTHRDVGNTDCPGNAAYAVMDEIRDIAAHFNDPPEELIKALEGGAIYQRWQALGGMNSAL
GAPTSPEADAADGARYATFAKGAMYWSPVTDAQPITGAIYEAWASQSYERGPLGLPTSAE
IQEPLQITQNFQHGTLNFERLTGNVTEVVDGITTPLATRPPSGPTVPPEHFTLPTHPIT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAATVVIVAWIANRPPASSHEPSPTPNTQLAEQPLIGLGGGVTVRELTQDTPFSLVALTGDLAGTSARVRAKRPDGDWGPWYQTEYETEPRDPAGTDGSVELGGLNPGPRSTDPVFVGTTTTVQVAVTRPIDAPITQPPAGRPPNDLLDSGLGYRPATKEQPFGQNISAILISPPQAPPGTQWTPPTAVTMAGQPPAIISRAEWGADESLRCETPEYDRGVRAAVVHHTAGSNDYSPLESAGIVKAIYTYHSKTLGWCDIAYNALVDKYGQVFEGSAGGLTKPVEGFHTGGFNRNTWGVAMIGNFDDVAPTPIQIRTVGRLLGWRLGMDDVDPRSMVDLQSAGSSYTTFPGGAIARLPAIFTHRDVGNTDCPGNAAYAVMDEIRDIAAHFNDPPEELIKALEGGAIYQRWQALGGMNSALGAPTSPEADAADGARYATFAKGAMYWSPVTDAQPITGAIYEAWASQSYERGPLGLPTSAEIQEPLQITQNFQHGTLNFERLTGNVTEVVDGITTPLATRPPSGPTVPPEHFTLPTHPIT
Prediction	CCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEHCCCCCCCCCEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHCCCCEEEHCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCCEEEHCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHCCCCEEEHCCCCCCCEHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHCCEEEEEHCCCCEEEEEHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98753443445678888888888888877666677778887654565567867999999768997699999858998888666578888888888888776667788877777666578875688764688888777777667666667777777777667766666654457777777666677666667888877986445798888888888788899889998689999999889999999999999998599888765788799859987889887777775568888885899997689999998999999999999999986999875578776578876678885665445656777777778876556555554454455567777777777776456566665787788888877776788886676547885887678887555458999999989877888888888754688689977587999976898799985645665667888888888887788888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAATVVIVAWIANRPPASSHEPSPTPNTQLAEQPLIGLGGGVTVRELTQDTPFSLVALTGDLAGTSARVRAKRPDGDWGPWYQTEYETEPRDPAGTDGSVELGGLNPGPRSTDPVFVGTTTTVQVAVTRPIDAPITQPPAGRPPNDLLDSGLGYRPATKEQPFGQNISAILISPPQAPPGTQWTPPTAVTMAGQPPAIISRAEWGADESLRCETPEYDRGVRAAVVHHTAGSNDYSPLESAGIVKAIYTYHSKTLGWCDIAYNALVDKYGQVFEGSAGGLTKPVEGFHTGGFNRNTWGVAMIGNFDDVAPTPIQIRTVGRLLGWRLGMDDVDPRSMVDLQSAGSSYTTFPGGAIARLPAIFTHRDVGNTDCPGNAAYAVMDEIRDIAAHFNDPPEELIKALEGGAIYQRWQALGGMNSALGAPTSPEADAADGARYATFAKGAMYWSPVTDAQPITGAIYEAWASQSYERGPLGLPTSAEIQEPLQITQNFQHGTLNFERLTGNVTEVVDGITTPLATRPPSGPTVPPEHFTLPTHPIT
Prediction	61000000000022223444444544545335441455254542452446320000000032641402010225715123024044434334344454434444444434212102124143142323444524344344443444234442444444454332441332213324134222211333242424200000122011422343522415340400000000024132242023123101200144240310000000033020010121323331200101011110000000010443313420040012002100422420131012012122321212222214210000013122240122212222221121112212222222222222222322232223332212123341414410111204301000024344221212014203632134020000001124364222030130202022651210201320343126433412215423212143248
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEHCCCCCCCCCEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHCCCCEEEHCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCCEEEHCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHCCCCEEEHCCCCCCCEHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHCCEEEEEHCCCCEEEEEHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCC
MAATVVIVAWIANRPPASSHEPSPTPNTQLAEQPLIGLGGGVTVRELTQDTPFSLVALTGDLAGTSARVRAKRPDGDWGPWYQTEYETEPRDPAGTDGSVELGGLNPGPRSTDPVFVGTTTTVQVAVTRPIDAPITQPPAGRPPNDLLDSGLGYRPATKEQPFGQNISAILISPPQAPPGTQWTPPTAVTMAGQPPAIISRAEWGADESLRCETPEYDRGVRAAVVHHTAGSNDYSPLESAGIVKAIYTYHSKTLGWCDIAYNALVDKYGQVFEGSAGGLTKPVEGFHTGGFNRNTWGVAMIGNFDDVAPTPIQIRTVGRLLGWRLGMDDVDPRSMVDLQSAGSSYTTFPGGAIARLPAIFTHRDVGNTDCPGNAAYAVMDEIRDIAAHFNDPPEELIKALEGGAIYQRWQALGGMNSALGAPTSPEADAADGARYATFAKGAMYWSPVTDAQPITGAIYEAWASQSYERGPLGLPTSAEIQEPLQITQNFQHGTLNFERLTGNVTEVVDGITTPLATRPPSGPTVPPEHFTLPTHPIT

4lgnA

0.12

0.11

0.97

1.09

MUSTER

WNNWGYNGVVSIAADPINTNKAVGMYTNSWDPNDGITPLPFKLGGNMPGRGMGERLAVDPNNDNI-LYFGAPSGKGLWATWSQMTNFPDVGTYIANPTD--TTGYQSDIQGVVWVAFDKSSS----SLGQASKTIFVGVADPNNPVFWSRDGGATWQAVPGAPTGFIPHKGVFDPVNHVLYIATSNTGGPYDGSSGDVWKFSVWTRISPVPSTDTANDYFGYSGLTIDRQHPNTIMVATQISWWPDTIIFRSTDGGWTRIWLRYVLDISAEPW-LTFGVQPNPPVPSPKLGWMDEAMAIDPFNSDRMLYGTGATLYATNDLTKWDSGGQIHIAPMVKGLEETAVNDLISPPSGAPLISALGDLGGFTHADVTAVPSTIFTSPVFTTGTSVDYAELNPSIIVRAGSFDPSSQPNDRDGGKNWFQGSEPGGVTTGGTVAASADGRFVWAPGDPGQPVV------YAVGFGNS----WAASQGVPANAQIRSDRVNPKTFYALSNGTFYRSTDGGVTFVAAGLPSSGAVGVMFHAVPGKEGD

2xz4A

0.27

0.08

0.31

1.26

dPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HILDRSEWLGEPP-SGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNFLVGGDGQIYVGRGWH----IQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHR-----------------------LQPDYHIYAHRQLSPTESPGQKLFELMQNWPRFTQD------------------------------------------------------------------------------------------------------------------------------------------------------

1sxrA

0.29

0.09

0.32

2.26

wdPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPTIKLKRQWGGKPSLG--LHYQVRPIRYVVIHHTVTGECSGLLKCAEILQNMQAYHQNELDFNDISYNFLIGNDGIVYEGTGWG----LRGAHTYGYNAIGTGIAFIGNFVDKLPSDAALQAAKDLLACGVQQGELSEDYALIAGSQVIS-TQSPGLTLYNEIQEWPHW----LSNPHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------

2xz4A

0.27

0.08

0.31

1.15

wMUSTER

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HILDRSEWLGEPP-SGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNFLVGGDGQIYVGRGWH----IQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHR-----------------------LQPDYHIYAHRQLSPTESPGQKLFELMQNWPRFTQD------------------------------------------------------------------------------------------------------------------------------------------------------

2xz4A

0.27

0.08

0.31

2.75

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HILDRSEWLGEPP-SGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNFLVGGDGQIYVGRGWH----IQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHR-----------------------LQPDYHIYAHRQLSPTESPGQKLFELMQNWPRFTQD------------------------------------------------------------------------------------------------------------------------------------------------------

2xz4A

0.27

0.08

0.31

3.23

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HILDRSEWLGEPP-SGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNFLVGGDGQIYVGRGWH----IQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHR-----------------------LQPDYHIYAHRQLSPTESPGQKLFELMQNWPRFTQD------------------------------------------------------------------------------------------------------------------------------------------------------

2xz4A

0.27

0.08

0.31

2.21

PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HILDRSEWLGEPP-SGKYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNFLVGGDGQIYVGRGWH----IQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHR-----------------------LQPDYHIYAHRQLSPTESPGQKLFELMQNWPRFTQD------------------------------------------------------------------------------------------------------------------------------------------------------

2xz4A

0.27

0.08

0.31

3.74

Env-PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HILDRSEWLGEPPSG-KYPHLKLPVSNIIIHHTATEGCEQEDVCIYRMKTIQAFHMKSFGWVDIGYNFLVGGDGQIYVGRGWH----IQGQHVNGYGAISVSIAFIGTFVNMEPPARQIEAAKRLMDEGVRLHR-----------------------LQPDYHIYAHRQLSPTESPGQKLFELMQNWPRFTQD------------------------------------------------------------------------------------------------------------------------------------------------------

5jwzA

0.11

0.10

0.95

1.05

MUSTER

ARIDGGGFVPGIVFNRSEKNLAYKPLLDWVDWDRWGWTGVVSLASDTVDPDNVYAAVGTYTNSWTDGAVLRSSDRGA---WKAATLPFKLGGNPGRGGERLAVDPNKNSV----LYLGAPSGNGLWRSTDAGVSWSEVTAFPNPGNYAQDPSDTSGYGNDNQGI----VWVTFDERSGSAGSATQDIYVGVADKENTVYRSTDGGATWSRIPGQPTGYSATGHLYLTLSDTGGPYDGGKG-----RIWRYDTASGAWQDVSPVAE-AYYGFSGLSVDRQKPGTLATAYSSWWPDTQIFRSTDSAWDYTGYPNRSNRYTLDVSSVPWLSWGASPAPPETAPKLGLEIDPFDSDRYGTGATVYGTEDLTSWDSGGTFRITPVKGIEETAVNDLASPPSGAPLLSALGDIGGFRHTDLDAVP-DLYTSPNLDSTTSLDFAESSPGTVVRVGNSDAA---PHIG--FSTDNGANW---FQGSEPSGVTGGGTVAADGSGFVWSPEGAGVHHTTGFGTSW---TASTGIPAGATVESDRKNPEK

1sxrA

0.29

0.09

0.32

1.23

dPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CPTIKLKRQWGGKPSLGL--HYQVRPIRYVVIHHTVTGECSGLLKCAEILQNMQAYHQNELDFNDISYNFLIGNDGIVYEGTGWG----LRGAHTYGYNAIGTGIAFIGNFVDKLPSDAALQAAKDLLACGVQQGE-----------------------LSEDYALIAGSQVISTQSPGLTLYNEIQEWPHWLSNPHHHHHH-----------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.49

Estimated TM-score = 0.78±0.10

Estimated RMSD = 6.4±3.9Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4lgnA	0.869	2.89	0.106	0.963
2	5fkqA	0.846	3.16	0.074	0.950
3	5jwzA	0.831	3.11	0.103	0.935
4	2cn2A	0.779	3.35	0.079	0.883
5	2ebsB	0.777	3.86	0.087	0.913
6	3a0fA	0.772	3.78	0.073	0.907
7	5hy7A	0.638	4.99	0.057	0.818
8	3ei2A	0.619	4.98	0.041	0.803
9	5lqwX	0.610	5.40	0.049	0.816
10	5m11A	0.593	4.64	0.067	0.744

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	1lbaA	ZN	Rep, Mult	227,363,371
2	0.04	2	3nnoC	RAM	Rep, Mult	257,290,293
3	0.04	2	2cn3A	GLC	Rep, Mult	46,50,343,362
4	0.04	2	5fksA	BGC	Rep, Mult	191,292,293,312,385
5	0.04	2	2qoeA	UUU	Rep, Mult	226,236,238,239
6	0.02	1	4h5jB	K	Rep, Mult	56,57,115,116
7	0.02	1	5fksA	XYS	Rep, Mult	2
8	0.02	1	1tk3B	NDG	Rep, Mult	231,233,252,253,254
9	0.02	1	2cn3A	CA	Rep, Mult	296,298
10	0.02	1	3qv4B	CTO	Rep, Mult	228,229,230,251,262,304,370
11	0.02	1	2f2lX	MLD	Rep, Mult	228,229,230,251,257,258,262,276,287,288,290,291,293,363,367,369,370,371
12	0.02	1	3nw3C	MU2	Rep, Mult	255,257,287,288,290,293,367
13	0.02	1	5fksA	BGC	Rep, Mult	46
14	0.02	1	3cxaA	TRE	Rep, Mult	228,229,230,262,363,368,369,371
15	0.02	1	2eaxC	UUU	Rep, Mult	228,229,251,262,368,369
16	0.02	1	2xz4A	CU	Rep, Mult	198,203
17	0.02	1	2cn3A	BGC	Rep, Mult	46,343
18	0.02	1	1sqj0	III	Rep, Mult	231,253,257,258,261,320,321
19	0.02	1	5fksA	XYS	Rep, Mult	46,50,105,191
20	0.02	1	2gbcA	NDG	Rep, Mult	226,234,236,238,253

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1kb0A	0.437	6.00	0.047	0.605	1.1.99.-	NA
2	0.060	2gc7A	0.396	4.12	0.083	0.475	1.4.99.3	226,231,303,321
3	0.060	1vcuB	0.394	4.50	0.065	0.488	3.2.1.18	239
4	0.060	3g0bB	0.492	6.66	0.037	0.722	3.4.14.5	NA
5	0.060	1lrwA	0.397	5.80	0.035	0.532	1.1.99.8	NA
6	0.060	1eusA	0.389	4.56	0.073	0.482	3.2.1.18	NA
7	0.060	1euuA	0.410	6.85	0.075	0.623	3.2.1.18	172
8	0.060	1eurA	0.391	4.53	0.076	0.484	3.2.1.18	261
9	0.060	1yr2A	0.539	5.66	0.069	0.727	3.4.21.26	NA
10	0.060	2ebsB	0.777	3.86	0.087	0.913	3.2.1.150	255
11	0.060	1c9uB	0.397	4.68	0.038	0.495	1.1.5.2,1.1.99.17	NA
12	0.060	1eutA	0.411	6.90	0.075	0.627	3.2.1.18	NA
13	0.060	1w6sC	0.408	6.23	0.056	0.571	1.1.99.8	NA
14	0.060	1yifA	0.430	5.95	0.053	0.590	3.2.1.37	210,230,234,251,253,257,261
15	0.060	1orvA	0.491	6.62	0.045	0.722	3.4.14.5	306
16	0.060	1st8A	0.395	6.02	0.039	0.557	3.2.1.80	NA
17	0.060	2qr5A	0.464	5.72	0.075	0.627	3.4.19.1	236
18	0.060	1e5tA	0.493	5.96	0.058	0.685	3.4.21.26	236,306
19	0.060	2bklB	0.486	5.90	0.064	0.666	3.4.21.26	276

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.844	3.08	0.10	0.95	5jwzA	GO:0004553 GO:0005975 GO:0030246 GO:0030247
1	0.20	0.869	2.89	0.11	0.96	4lgnA	GO:0004553 GO:0005975 GO:0030246 GO:0030247 GO:0030248
2	0.19	0.846	3.16	0.07	0.95	5fkqA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0030247 GO:0030248
3	0.18	0.837	3.18	0.08	0.95	2cn3A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033946 GO:0043263 GO:2000899
4	0.16	0.800	3.28	0.08	0.90	2cn2A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033946 GO:0043263 GO:2000899
5	0.15	0.777	3.86	0.09	0.91	2ebsB	GO:0000272 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033945
6	0.06	0.425	3.84	0.07	0.50	3b7fA	GO:0016787
7	0.06	0.387	4.70	0.06	0.49	5f9tA	GO:0004308 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0052794 GO:0052795 GO:0052796
8	0.06	0.355	5.39	0.05	0.47	4kc7A	GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031222 GO:0046558 GO:0046872
9	0.06	0.341	6.91	0.03	0.52	4po7A	GO:0001503 GO:0005634 GO:0005764 GO:0005765 GO:0005768 GO:0005769 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0005886 GO:0005905 GO:0006810 GO:0006895 GO:0006897 GO:0007186 GO:0007218 GO:0007275 GO:0008333 GO:0008625 GO:0009986 GO:0010008 GO:0010465 GO:0010468 GO:0014902 GO:0016020 GO:0016021 GO:0016023 GO:0016050 GO:0019899 GO:0030136 GO:0030140 GO:0030154 GO:0030379 GO:0030425 GO:0031965 GO:0032509 GO:0032580 GO:0032868 GO:0038180 GO:0043025 GO:0043231 GO:0045599 GO:0046323 GO:0048011 GO:0048227 GO:0048406 GO:0048471 GO:0051005 GO:1904037
10	0.06	0.253	7.04	0.05	0.39	3gg8A	GO:0000287 GO:0003824 GO:0004743 GO:0006096 GO:0016301 GO:0016310 GO:0016740 GO:0030955
11	0.06	0.203	6.90	0.04	0.31	4m0xA	GO:0003824 GO:0008152 GO:0016853 GO:0018849 GO:0018850 GO:0030145 GO:0046872
12	0.06	0.225	7.13	0.03	0.35	3p3yA	GO:0002175 GO:0005622 GO:0005886 GO:0005925 GO:0007155 GO:0007411 GO:0007422 GO:0016020 GO:0016021 GO:0019226 GO:0019904 GO:0030424 GO:0030913 GO:0033010 GO:0033268 GO:0033270 GO:0034113 GO:0042552 GO:0043194 GO:0043209 GO:0045162 GO:0050808 GO:0070062 GO:0071205 GO:0072661 GO:0086080 GO:0097454
13	0.06	0.182	7.29	0.03	0.29	4atvA	GO:0005886 GO:0006810 GO:0006811 GO:0006814 GO:0006885 GO:0015081 GO:0015297 GO:0015491 GO:0015992 GO:0016020 GO:0016021 GO:0035725 GO:0055085 GO:0098655
14	0.06	0.194	7.20	0.07	0.31	3eoeD	GO:0000287 GO:0003824 GO:0004743 GO:0006096 GO:0016301 GO:0016310 GO:0016740 GO:0030955
15	0.06	0.247	7.29	0.03	0.40	4yt2B	GO:0015948 GO:0016491 GO:0018537 GO:0047068 GO:0055114
16	0.06	0.204	6.97	0.04	0.32	1dapA	GO:0008652 GO:0009085 GO:0009089 GO:0016491 GO:0019877 GO:0047850 GO:0055114
17	0.06	0.189	7.18	0.01	0.30	1z1bB	GO:0003676 GO:0003677 GO:0006310 GO:0008907 GO:0015074 GO:0016740 GO:0016787 GO:0046718 GO:0075713
18	0.06	0.152	6.19	0.02	0.22	1w2wA	GO:0005634 GO:0005737 GO:0008652 GO:0009086 GO:0016853 GO:0019284 GO:0019509 GO:0044237 GO:0044249 GO:0046523

Consensus prediction of GO terms

Molecular Function	GO:0030248	GO:0033946
GO-Score	0.35	0.31
Biological Processes	GO:0030245	GO:2000899
GO-Score	0.31	0.31
Cellular Component	GO:0043263
GO-Score	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.