I-TASSER results

I-TASSER results for job id Rv3802c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (336 residues)
MAKNSRRKRHRILAWIAAGAMASVVALVIVAVVIMLRGAESPPSAVPPGVLPPGPTPAHP
HKPRPAFQDASCPDVQMISVPGTWESSPQQNPLNPVQFPKALLLKVTGPIAQQFAPARVQ
TYTVAYTAQFHNPLTTDNQMSYNDSRAEGTRAMVAAMTDMNNRCPLTSYVLIGFSQGAVI
AGDVASDIGNGRGPVDEDLVLGVTLIADGRRQQGVGNQVPPSPRGEGAEITLHEVPVLSG
LGLTMTGPRPGGFGALDGRTNEICAQGDLICAAPAQAFSPANLPTTLNTLAGGAGQPVHA
MYATPEFWNSDGEPATEWTLNWAHQLIENAPHPKHR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAKNSRRKRHRILAWIAAGAMASVVALVIVAVVIMLRGAESPPSAVPPGVLPPGPTPAHPHKPRPAFQDASCPDVQMISVPGTWESSPQQNPLNPVQFPKALLLKVTGPIAQQFAPARVQTYTVAYTAQFHNPLTTDNQMSYNDSRAEGTRAMVAAMTDMNNRCPLTSYVLIGFSQGAVIAGDVASDIGNGRGPVDEDLVLGVTLIADGRRQQGVGNQVPPSPRGEGAEITLHEVPVLSGLGLTMTGPRPGGFGALDGRTNEICAQGDLICAAPAQAFSPANLPTTLNTLAGGAGQPVHAMYATPEFWNSDGEPATEWTLNWAHQLIENAPHPKHR
Prediction	CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEHCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCHCCCCCCCCCHHHHHHHHHHHHHHHCCCEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
Conf.Score	987665665456678999999999999999999986567777777777666777777778888877788999988999978999999888988887777646778999999986888689999578876688888888877678899999999999999999899985999985789999999999976888988766567899877999888888778888888755555567887777788888888878887764346663899964689998887566788888888765654444357887778888874477999999999868898899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAKNSRRKRHRILAWIAAGAMASVVALVIVAVVIMLRGAESPPSAVPPGVLPPGPTPAHPHKPRPAFQDASCPDVQMISVPGTWESSPQQNPLNPVQFPKALLLKVTGPIAQQFAPARVQTYTVAYTAQFHNPLTTDNQMSYNDSRAEGTRAMVAAMTDMNNRCPLTSYVLIGFSQGAVIAGDVASDIGNGRGPVDEDLVLGVTLIADGRRQQGVGNQVPPSPRGEGAEITLHEVPVLSGLGLTMTGPRPGGFGALDGRTNEICAQGDLICAAPAQAFSPANLPTTLNTLAGGAGQPVHAMYATPEFWNSDGEPATEWTLNWAHQLIENAPHPKHR
Prediction	656645452320101010100000001100000000223333433334233333333344443444445650220000000001033344424323322312123004203741455403112020000122324244433144123401430251045117503503000000010010013003302454441334200000000002234435442233143312211223122122311323313333123033101000064000000245242022122002202432121000012245324473430131124103410752451658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEHCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCHCCCCCCCCCHHHHHHHHHHHHHHHCCCEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
MAKNSRRKRHRILAWIAAGAMASVVALVIVAVVIMLRGAESPPSAVPPGVLPPGPTPAHPHKPRPAFQDASCPDVQMISVPGTWESSPQQNPLNPVQFPKALLLKVTGPIAQQFAPARVQTYTVAYTAQFHNPLTTDNQMSYNDSRAEGTRAMVAAMTDMNNRCPLTSYVLIGFSQGAVIAGDVASDIGNGRGPVDEDLVLGVTLIADGRRQQGVGNQVPPSPRGEGAEITLHEVPVLSGLGLTMTGPRPGGFGALDGRTNEICAQGDLICAAPAQAFSPANLPTTLNTLAGGAGQPVHAMYATPEFWNSDGEPATEWTLNWAHQLIENAPHPKHR

3ajaA

0.73

0.57

0.77

2.31

MUSTER

---------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDRCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGFGALDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSG----PVHALYNTPQFWVENGQTATQWTLEWARNLVENAPHP---

3ajaA

0.73

0.57

0.77

2.90

dPPAS

---------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDRCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGFGALDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSG----PVHALYNTPQFWVENGQTATQWTLEWARNLVENAPHP---

3ajaA

0.73

0.57

0.77

4.43

wdPPAS

---------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDRCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGFGALDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSG----PVHALYNTPQFWVENGQTATQWTLEWARNLVENAPHP---

3ajaA

0.73

0.56

0.77

2.83

wMUSTER

----------------------------------------------------------------------DCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDRCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGFGALDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSG----PVHALYNTPQFWVENGQTATQWTLEWARNLVENAPHP---

3ajaA

0.73

0.57

0.77

5.52

wPPAS

---------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDRCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGFGALDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSG----PVHALYNTPQFWVENGQTATQWTLEWARNLVENAPHP---

3ajaA

0.73

0.57

0.77

6.20

dPPAS2

---------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDRCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGFGALDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSG----PVHALYNTPQFWVENGQTATQWTLEWARNLVENAPHP---

3ajaA

0.73

0.57

0.77

4.39

PPAS

---------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDRCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGFGALDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSG----PVHALYNTPQFWVENGQTATQWTLEWARNLVENAPHP---

3ajaA

0.73

0.57

0.77

5.56

Env-PPAS

---------------------------------------------------------------------ADCPDVMMVSIPGTWESSPTDDPFNPTQFPLSLMSNISKPLAEQFGPDRLQVYTTPYTAQFHNPFAADKQMSYNDSRAEGMRTTVKAMTDMNDRCPLTSYVIAGFSQGAVIAGDIASDIGNGRGPVDEDLVLGVTLIADGRRQMGVGQDVGPNPAGQGAEITLHEVPALSALGLTMTGPRPGGFGALDNRTNQICGSGDLICSAPEQAFSVFNLPKTLETLSG----PVHALYNTPQFWVENGQTATQWTLEWARNLVENAPHP---

4pscA

0.17

0.11

0.65

1.36

MUSTER

-----------------------WPSINEFLSELAKVMPIGDTITAACDLISDGEDAAASLFGISETENDPCGDVTVLFARGTCDPGN---------VGVLVGPWFFDSLQTALGSRTLGVKGVPYPASVQD---------FLSGSVQNGINMANQIKSVLQSCPNTKLVLGGYSQGSMVVHNAASNLDAA----TMSKISAVVLFGDPYYGKPVA-------------------------------------NFDAAKTLVVCHDGDNICQGGDIIL--------------LP----HLTYA------EDADTAAAFVVPLVS---------HH-

1bs9A

0.20

0.12

0.59

1.61

dPPAS

----------------------------------------------------------------------SCPAIHVFGARETTASPGY-----------GSSSTVVNGVLSAYPGS--TAEAINYPACGGQSSC--GGASYSSSVAQGIAAVASAVNSFNSQCPSTKIVLVGYSQGGEIMDVALCGGGVQLSSSAVNMVKAAIFMGDPMFRAGLSYEVGTCAAGG------------------FDQRPAGFSCPSAAKIKSYCDASDPYCC---NGSNAATHQGYGSEYGSQALAFVKSKLG---------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.50

Estimated TM-score = 0.65±0.13

Estimated RMSD = 7.5±4.3Å

Download Model 2

C-score=-2.84

Download Model 3

C-score=-2.92

Download Model 4

C-score=-2.39

Download Model 5

C-score=-3.46

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ajaA	0.762	0.79	0.727	0.771
2	4hxeB	0.555	5.20	0.048	0.768
3	3azoA	0.554	4.63	0.088	0.735
4	5l8sA	0.553	5.19	0.072	0.765
5	1ve6A	0.552	5.01	0.109	0.759
6	2xe4A	0.548	5.08	0.096	0.750
7	4hvtA	0.547	5.44	0.047	0.783
8	1xfdA	0.546	5.24	0.066	0.762
9	5jrlA	0.544	5.25	0.074	0.774
10	2bklB	0.543	5.29	0.065	0.765

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.21	9	3deaA	HZH	Rep, Mult	82,83,142,175,176,270
2	0.09	3	1oxmA	TC4	Rep, Mult	83,84,174,175,176,294,299,301
3	0.07	3	1u8eA	UUU	Rep, Mult	161,164,167,168,169
4	0.07	3	2bgnB	UUU	Rep, Mult	124,126,145,150,153
5	0.02	1	2buaC	UUU	Rep, Mult	143,147,183,249
6	0.02	1	3esaA	NXC	Rep, Mult	82,83,175,176,275,277,283
7	0.02	1	2ripA	UUU	Rep, Mult	200,201,202

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.415	1bs9A	0.513	2.99	0.193	0.583	3.1.1.72	83,175,176,268,299
2	0.317	3dcnA	0.470	3.18	0.178	0.548	3.1.1.74	175,176,268,299
3	0.072	2czqA	0.515	2.71	0.230	0.577	3.1.1.-	83,175,176,268,299
4	0.067	3gbsA	0.468	3.00	0.193	0.539	3.1.1.74	175,176,268,299
5	0.060	1hlgB	0.491	4.56	0.089	0.640	3.1.1.3	155
6	0.060	1hlgA	0.491	4.64	0.089	0.646	3.1.1.3	NA
7	0.060	1r9mB	0.534	5.26	0.069	0.750	3.4.14.5	NA
8	0.060	2fj0A	0.484	5.25	0.069	0.676	3.1.1.1	NA
9	0.060	2ecfA	0.542	5.20	0.060	0.759	3.4.14.5	268,299
10	0.060	3esbA	0.482	3.22	0.211	0.562	3.1.1.74	175,176,268
11	0.060	2c7bA	0.483	4.72	0.087	0.643	3.1.1.1	79
12	0.060	2qr5A	0.555	4.91	0.094	0.756	3.4.19.1	71
13	0.060	2o7rA	0.482	5.10	0.097	0.661	3.1.1.1	NA
14	0.060	1k8qA	0.492	4.84	0.087	0.661	3.1.1.3	175,176
15	0.060	1crlA	0.496	5.39	0.060	0.691	3.1.1.3	NA
16	0.060	1qz3A	0.495	5.04	0.109	0.684	3.1.1.1	79
17	0.060	2jbwD	0.525	4.80	0.094	0.696	3.7.1.-	175
18	0.060	1cleA	0.496	5.35	0.063	0.688	3.1.1.3	NA
19	0.060	1gz7C	0.503	5.34	0.085	0.699	3.1.1.3	190,201
20	0.060	3hlkB	0.482	4.60	0.079	0.637	3.1.2.2	156
21	0.060	1z68A	0.535	5.35	0.073	0.747	3.4.21.-	79
22	0.060	3ga7A	0.488	4.79	0.084	0.655	3.1.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.53	0.771	0.96	0.72	0.78	3ajaB	GO:0008152 GO:0016020 GO:0016021 GO:0016787
1	0.28	0.510	2.96	0.21	0.58	1qozA	GO:0000272 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0030245 GO:0030248 GO:0045493 GO:0046555 GO:0052689
2	0.26	0.470	3.18	0.21	0.55	4oyyC	GO:0005576 GO:0008152 GO:0016787 GO:0050525 GO:0052689
3	0.24	0.513	2.99	0.19	0.58	1bs9A	GO:0000272 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0030245 GO:0045493 GO:0046555 GO:0052689
4	0.21	0.482	3.22	0.21	0.56	3esbA	GO:0005576 GO:0008152 GO:0016787 GO:0050525 GO:0052689
5	0.21	0.468	3.00	0.19	0.54	3gbsA	GO:0005576 GO:0008152 GO:0016042 GO:0016787 GO:0050525 GO:0052689
6	0.20	0.526	3.76	0.17	0.65	4psdA	GO:0005576 GO:0008152 GO:0016787 GO:0050525 GO:0052689
7	0.18	0.483	3.21	0.23	0.56	5ajhA	GO:0005576 GO:0008152 GO:0016787 GO:0050525 GO:0052689
8	0.17	0.470	3.18	0.18	0.55	3dcnA	GO:0005576 GO:0008152 GO:0009405 GO:0016787 GO:0050525 GO:0052689
9	0.15	0.473	4.94	0.06	0.63	3f98A	GO:0003847 GO:0005543 GO:0005576 GO:0005615 GO:0005737 GO:0006629 GO:0016042 GO:0016787 GO:0016788 GO:0034362 GO:0034374 GO:0034440 GO:0034441 GO:0047499 GO:0050729 GO:0090026
10	0.09	0.546	5.24	0.07	0.76	1xfdA	GO:0005886 GO:0006508 GO:0008076 GO:0008236 GO:0008239 GO:0009986 GO:0015459 GO:0016020 GO:0016021 GO:0043025 GO:0043268 GO:0070062 GO:0072659 GO:1901379
11	0.07	0.527	3.15	0.13	0.61	3hc7A	GO:0008152 GO:0016787
12	0.07	0.552	5.23	0.04	0.77	4hxgF	GO:0006508 GO:0008236 GO:0046872
13	0.07	0.547	5.44	0.05	0.78	4hvtA	GO:0004252 GO:0006508 GO:0008236 GO:0016787 GO:0070008
14	0.07	0.544	5.37	0.06	0.77	3munA	GO:0004252 GO:0006508 GO:0008236 GO:0070008
15	0.07	0.543	5.29	0.07	0.76	2bklB	GO:0004252 GO:0006508 GO:0008236 GO:0070008
16	0.07	0.523	5.06	0.07	0.72	3fnbA	GO:0004252 GO:0006508
17	0.07	0.529	5.32	0.07	0.74	4q1vA	GO:0006508 GO:0008236 GO:0016787 GO:0046872
18	0.07	0.515	2.71	0.23	0.58	2czqA	GO:0008152 GO:0016787
19	0.07	0.494	4.90	0.07	0.66	3dohA	GO:0002084 GO:0005737 GO:0008474 GO:0016787 GO:0052689
20	0.07	0.473	5.52	0.07	0.68	3bl8A	GO:0001966 GO:0002087 GO:0004872 GO:0005615 GO:0005886 GO:0005887 GO:0007155 GO:0007158 GO:0007416 GO:0007630 GO:0009986 GO:0016020 GO:0016021 GO:0019233 GO:0030054 GO:0032024 GO:0032230 GO:0035176 GO:0035418 GO:0035641 GO:0042043 GO:0042734 GO:0045202 GO:0045211 GO:0050804 GO:0050808 GO:0050839 GO:0050885 GO:0051965 GO:0051968 GO:0052689 GO:0060076 GO:0060077 GO:0072553 GO:0097104 GO:0097105 GO:0097116 GO:0097119 GO:0097151 GO:1902474 GO:1904862 GO:2000311 GO:2000463 GO:2000809
21	0.07	0.496	4.66	0.07	0.65	4e15B	GO:0004061 GO:0006569 GO:0008152 GO:0016272 GO:0016787 GO:0019441
22	0.07	0.475	5.27	0.06	0.67	3biwA	GO:0002087 GO:0004872 GO:0005615 GO:0005794 GO:0005829 GO:0005886 GO:0005887 GO:0006605 GO:0007155 GO:0007157 GO:0007158 GO:0007399 GO:0007416 GO:0009897 GO:0009986 GO:0010841 GO:0014069 GO:0016020 GO:0016021 GO:0016080 GO:0016339 GO:0017146 GO:0030054 GO:0030165 GO:0030425 GO:0031175 GO:0032230 GO:0032433 GO:0035418 GO:0042043 GO:0043197 GO:0043198 GO:0045161 GO:0045184 GO:0045202 GO:0045211 GO:0045664 GO:0046983 GO:0048489 GO:0048511 GO:0048789 GO:0050804 GO:0050808 GO:0050839 GO:0051260 GO:0051290 GO:0051491 GO:0051965 GO:0051968 GO:0052689 GO:0060076 GO:0060080 GO:0060291 GO:0060999 GO:0061002 GO:0072553 GO:0097091 GO:0097104 GO:0097105 GO:0097110 GO:0097113 GO:0097114 GO:0097115 GO:0097119 GO:0097120 GO:0098793 GO:1900029 GO:1900244 GO:1902474 GO:1902533 GO:2000302 GO:2000310 GO:2000311 GO:2000463 GO:2000809
23	0.07	0.473	5.46	0.05	0.68	3vkfA	GO:0002087 GO:0004872 GO:0005615 GO:0005794 GO:0005829 GO:0005886 GO:0005887 GO:0006605 GO:0007155 GO:0007157 GO:0007158 GO:0007399 GO:0007416 GO:0009897 GO:0009986 GO:0010841 GO:0014069 GO:0016020 GO:0016021 GO:0016080 GO:0016339 GO:0017146 GO:0030054 GO:0030165 GO:0030425 GO:0031175 GO:0032230 GO:0032433 GO:0035418 GO:0042043 GO:0043197 GO:0043198 GO:0045161 GO:0045184 GO:0045202 GO:0045211 GO:0045664 GO:0046983 GO:0048489 GO:0048511 GO:0048789 GO:0050804 GO:0050808 GO:0050839 GO:0051260 GO:0051290 GO:0051491 GO:0051965 GO:0051968 GO:0052689 GO:0060076 GO:0060080 GO:0060291 GO:0060999 GO:0061002 GO:0072553 GO:0097091 GO:0097104 GO:0097105 GO:0097110 GO:0097113 GO:0097114 GO:0097115 GO:0097119 GO:0097120 GO:0098793 GO:1900029 GO:1900244 GO:1902474 GO:1902533 GO:2000302 GO:2000310 GO:2000311 GO:2000463 GO:2000809

Consensus prediction of GO terms

Molecular Function	GO:0016798	GO:0030247	GO:0046555	GO:0050525
GO-Score	0.56	0.56	0.45	0.42
Biological Processes	GO:0030245	GO:0045493
GO-Score	0.45	0.45
Cellular Component	GO:0005576	GO:0016021
GO-Score	0.68	0.53

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.