I-TASSER results

I-TASSER results for job id Rv3785

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (357 residues)
MVTVARRPVCPVTLTPGDPALASVRDLVDAWSAHDALAELVTMFGGAFPQTDHLEARLAS
LDKFSTAWDYRARARAARALHGEPVRCQDSGGGARWLIPRLDLPAKKRDAIVGLAQQLGL
TLESTPQGTTFDHVLVIGTGRHSNLIRARWARELAKGRQVGHIVLAAASRRLLPSEDDAV
AVCAPGARTEFELLAAAARDAFGLDVHPAVRYVRQRDDNPHRDSMVWRFAADTNDLGVPI
TLLEAPSPEPDSSRATSADTFTFTAHTLGMQDSTCLLVTGQPFVPYQNFDALRTLALPFG
IQVETVGFGIDRYDGLGELDQQHPAKLLQEVRSTIRAARALLERIEAGERMATDPRR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVTVARRPVCPVTLTPGDPALASVRDLVDAWSAHDALAELVTMFGGAFPQTDHLEARLASLDKFSTAWDYRARARAARALHGEPVRCQDSGGGARWLIPRLDLPAKKRDAIVGLAQQLGLTLESTPQGTTFDHVLVIGTGRHSNLIRARWARELAKGRQVGHIVLAAASRRLLPSEDDAVAVCAPGARTEFELLAAAARDAFGLDVHPAVRYVRQRDDNPHRDSMVWRFAADTNDLGVPITLLEAPSPEPDSSRATSADTFTFTAHTLGMQDSTCLLVTGQPFVPYQNFDALRTLALPFGIQVETVGFGIDRYDGLGELDQQHPAKLLQEVRSTIRAARALLERIEAGERMATDPRR
Prediction	CCCCCCCCCCCEHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCEHCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHCCCCCCCHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
Conf.Score	987677887765568886899999999999866889999999989989998888999999887765455555555677656766555566666555566667775789999999999899766788888886899984445678889999999997787887999856777767777777765899875466766666554466777545545566888864444444566888777877999779999987777657899999875578998589997787555456789999867665655676568655455545788888999999999999999999999857888888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVTVARRPVCPVTLTPGDPALASVRDLVDAWSAHDALAELVTMFGGAFPQTDHLEARLASLDKFSTAWDYRARARAARALHGEPVRCQDSGGGARWLIPRLDLPAKKRDAIVGLAQQLGLTLESTPQGTTFDHVLVIGTGRHSNLIRARWARELAKGRQVGHIVLAAASRRLLPSEDDAVAVCAPGARTEFELLAAAARDAFGLDVHPAVRYVRQRDDNPHRDSMVWRFAADTNDLGVPITLLEAPSPEPDSSRATSADTFTFTAHTLGMQDSTCLLVTGQPFVPYQNFDALRTLALPFGIQVETVGFGIDRYDGLGELDQQHPAKLLQEVRSTIRAARALLERIEAGERMATDPRR
Prediction	733234321020302343500220052033125351033004313242243540331032025104203134445346445544233462433332202424344442410130042121034243643401100000103301232142044144344002000001335045244421121134242303001101331141544533542434464444433114226347413130200203455465543434410210053161471200000030101133140022012235040310012143353155155630250053024003303302531533644455568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCEHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCEHCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHCCCCCCCHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
MVTVARRPVCPVTLTPGDPALASVRDLVDAWSAHDALAELVTMFGGAFPQTDHLEARLASLDKFSTAWDYRARARAARALHGEPVRCQDSGGGARWLIPRLDLPAKKRDAIVGLAQQLGLTLESTPQGTTFDHVLVIGTGRHSNLIRARWARELAKGRQVGHIVLAAASRRLLPSEDDAVAVCAPGARTEFELLAAAARDAFGLDVHPAVRYVRQRDDNPHRDSMVWRFAADTNDLGVPITLLEAPSPEPDSSRATSADTFTFTAHTLGMQDSTCLLVTGQPFVPYQNFDALRTLALPFGIQVETVGFGIDRYDGLGELDQQHPAKLLQEVRSTIRAARALLERIEAGERMATDPRR

2z0mA

0.12

0.10

0.85

0.91

MUSTER

--------------------------------MNEKIEQAIREMGFTEVQSKTIPLMLQGKNVVVRAKTGSGKTAAYAIPILEL------GMKSLVVTPTRELTRQVASHIRDIGRYMDTKMPYKAQINR-ADIVVATPGRLLDLWSKGVI----DLSSFEIVIIDEADLMFEMGFIDDIKIILASNRKITGLFSATIPEEIRKVVKDFITNYEEIEACIGLANVEHKFVHVKDDWRSKVQALRENKDKGVIVFVRTRNRVAKLVRLFD----NAIELRGPQSVRNRNIDAFREGEYDMLITTDVASRGLDIPLVEKVINPQDLRTYIHRIGRTGRMGRKGEAITFI-----LNEYW

5gaoE

0.13

0.12

0.92

0.57

dPPAS

-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------

3p2mA

0.19

0.14

0.72

0.56

wdPPAS

------------ELTGLDEF-ALLAENAEQAGVNGPLPEVERVWGGSAPNAHTWDTVIVGLGEPALAVDLPG--------HGH----SAWREDGNYSP------QLNSETLAPVLRELAPGAE-----------FVVG---MSLGGLTAIRLAAMAPDLVGELVLVDVT---SALQRHAELTAEREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNWVWRY-------------------DAIRTFGDFAGLWDDVDA-----SAPITLVRGGGFVTDQDTAELHRRA-THFRGVHIVKSG-------HSVQSDQPRALIEIVRGVLDT--------------------

1s2mA

0.13

0.11

0.90

0.82

wMUSTER

-------------------------NTFEDFYLKRELLMGIFEAGFEKPQEEAIPVAITGRDILARAKNGTGKTAAFVIPTLEKVKPKLNKIQALIMVPTRELALQTSQVVRTLGKHCGILRDDILRLNETVHILVGTPGRVLDLASRKVA----DLSDCSLFIMDEADKMLSRDFKTIIEQILPP-THQSLLFSATFPLTVKEFMVKHLHKPYMEELTLKGITQYYAFVEERQKLHCLNTLFSKLQIN-----CNSTNRVELLAKKITDLGYSCYYSHAKQQERNKVFHEFRQGKVRTLVCSDLLTRGIDIQAVNVVINPKTAETYLHRIGRSGRFGHLGLAINLINWNDRFNLYK

1q0zA

0.18

0.13

0.71

0.65

wPPAS

IVPSG------VEL--GDP-------------ADPAL--LVMGGNLSWP--DEFARRLAD---L--RYDHRD--------TGR---TTRDFAAHPYGF------GELAADAVAVLDGWGVDRAH-HDR---SSLTMLLGGGLDIDFDANIERVMRGEPTLD------GLPGPQQPFLDALALMNQPAEGRAAEVAKRVSKWRILSGT------GVPFDDAEYARWEERAIDHAGGV--------LAEPYAHYSLTLPPPSRAAELREVTV---PTLVIQAEPIAPAPHGKHLAGL-IP-TARLAEIGMG---------LPSSVHGPLAEVILAHTRSAA------------------

1rrvA

0.15

0.13

0.84

0.63

dPPAS2

LSVCG---------TRGDIGVALADRLKALMCAPPAAEERLAEVGVPHPVGLPQHMML--------------------------------------QEGMPPPPPEEEQRLAAMTVEM-QFDAVPGAAEGCAAVVAVGD-----LAAATGVRSVAEKLGLPFFYSVPASPHLPPAYDEPTTPGVTDIRVLWEERAARFADRYGPTLNRRRAEIGLPPVEDHGERPLLAADPVLAPLQPDVDAVQTGAWLLSDERPLPPELEAFLAA----GSPPVHIGFGSSSGIADAAKVAVEAIRAQGRRILSRGWTELVLPDDRDIDEVNFQALFRRVAAVIHSAGTEHVATRAGVPQLVIPRN

4rieA

0.13

0.10

0.82

0.70

PPAS

MILFV---ASG---SPATALAPLATAARNAMGAVEDMVPYIASAGIPASIAPSSIRRYATMDREGNPVRMPETPEEELDF------------AGHWF-------GRMAAGSMDALREV--TANWRP--------LVVGGSMS------FAAALIAAELGVPYVRQAWDTGDAWELRPELRALGLDRLPDPALFVDICPPSLPATAPPAQMMRWVPANGQRRLEPWMYTKGNRP--AALDAEVVIALDEVAEEVRAGWVP-LDVVVPTCD------VVVHH------TALTAMNALIVPQGGNISDFGAAITVDEAVEK----ACGELIGN-PSYAERARELSAEIAA-LPLPAE-EN

3u1tA

0.17

0.13

0.78

0.82

Env-PPAS

---SSEFPFAKRTVEVEGATIA-----YVDEGSGQPV---LFLHG--NPTSRNIIPYVVAAGYRAVAPDLIGG---------------------DSAKPDIEYRLQDHVAYDGFIDALGLDD----------VLVIHDWGSVIGRHARLNP------DRVAAVAFEALVPPALPPSYEA----GPQLGPLFRDLRTADVGEKVLDGNFFVETILPEGVVRSLSEAEAAYRAPFPTRQSRLPTLQWPREVPGGEPAFAEAEVLKNGEWLASPI-PKLLFHAEALAPKPVVDYLSEN-VP---NLEVRFVG----AGTHFLQEDHPHLIGQGIADWLRRNKP----------HAS----

1s2mA

0.12

0.11

0.90

0.86

MUSTER

-------------------------NTFEDFYLKRELLMGIFEAGPSPIQEEAIPVAITGRDILARAKNGTGKTAAFVIPTLEKVKPKLNKIQALIMVPTRELALQTSQVVRTLGKHCGISRDDILRLNETVHILVGTPGRVLDLASRKVA----DLSDCSLFIMDEADKMLSRDFKTIIEQILSPPTHQSLLFSATFPLTVKEFMVKHLHKPYMEELTLKGITQYYAFVEERQKLHCLNTLFSKLQIN-----CNSTNRVELLAKKITDLGYSCYYSHAKQQERNKVFHEFRQGKVRTLVCSDLLTRGIDIQAVNVVINPKTAETYLHRIGRSGRFGHLGLAINLINWNDRFNLYK

5f2hA

0.08

0.07

0.83

0.54

dPPAS

------------------TYIQLLNETLHCYASKGSLEAYTYIEHAKGIVGNEAQIYNFKYALASAAGLEEEAHVKEAIIEKGFWYGNEYLISDDDLKPLHKFEEFHQVQLCKEREELATERADVKYIDSKEKLFIAHGDQENIAIVEPYWKSVLD---QDYTLALPQSSQIQFSD----GFVWDDIQRGKEELKEHYVKFIENHRGESVIIGGFSAGA-----RVALYTILHKDIDVDGFIFAPWLPEI-------DEWNELLEVLQDKNIKGYVVCGDQDEDCFECTQQFVQVLKDKNIEHEFKVV-----PNLKHDYPEDFDELLKEAIKYIED--------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.91

Estimated TM-score = 0.38±0.13

Estimated RMSD = 13.6±4.0Å

Download Model 2

C-score=-3.40

Download Model 3

C-score=-4.05

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1s2mA	0.829	2.45	0.113	0.916
2	1xtkA	0.631	5.06	0.076	0.880
3	3eiqD	0.617	5.17	0.093	0.877
4	2eyqA	0.608	5.26	0.082	0.880
5	3ewsA	0.583	5.21	0.079	0.809
6	4xqkA	0.571	5.41	0.071	0.826
7	5lb3B	0.567	5.37	0.078	0.807
8	1hv8A	0.558	5.67	0.105	0.843
9	2i4iA	0.557	4.09	0.071	0.686
10	4qqxA	0.546	5.34	0.094	0.779

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	3mwyW	ATG	Rep, Mult	46,47,50,70,71,72,73,74,166,167
2	0.05	3	3r3qA	ZN	Rep, Mult	259,262
3	0.03	2	5anrB	III	Rep, Mult	227,228,229,232,233,236,237,238,240,241,242,244,259,260,263,264,267,271
4	0.03	2	1bpeA	DTP	Rep, Mult	169,175,177
5	0.03	2	3ly5A	MG	Rep, Mult	73,167,195,196
6	0.03	2	2wayA	III	Rep, Mult	227,228,229,230,234,237,238,241,242,245,271,352,353,356
7	0.03	2	3hc8A	MG	Rep, Mult	257,259
8	0.03	2	2xb2A	III	Rep, Mult	254,256,260,264,267,318,319
9	0.02	1	3f1yA	MG	Rep, Mult	287,290
10	0.02	1	2q7sA	ZN	Rep, Mult	34,69,207
11	0.02	1	5agaA	MG	Rep, Mult	73,166
12	0.02	1	2jk8B	CL	Rep, Mult	138,140,141
13	0.02	1	1aicB	UUU	Rep, Mult	70,336
14	0.02	1	4h83F	BCT	Rep, Mult	57,213
15	0.02	1	4ewlB	GOL	Rep, Mult	291,307,309
16	0.02	1	2xb2X	III	Rep, Mult	229,230,237,241,244
17	0.02	1	1wuuC	MG	Rep, Mult	143,176

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.067	3iuyA	0.466	2.73	0.113	0.524	3.6.4.13	103,195
2	0.066	1hv8A	0.558	5.67	0.105	0.843	3.6.4.13	51,103
3	0.060	3fhoB	0.473	5.44	0.057	0.689	3.6.4.13	99,139,172
4	0.060	2is4B	0.478	5.48	0.057	0.692	3.6.1.-	NA
5	0.060	1uaaA	0.500	5.36	0.073	0.720	3.6.4.12	NA
6	0.060	3pjrA	0.494	5.53	0.063	0.723	3.6.4.12	NA
7	0.060	1s2mA	0.829	2.45	0.113	0.916	3.6.4.13	196,311
8	0.060	2wwyA	0.518	5.34	0.077	0.740	3.6.4.12	195,197
9	0.060	1fuuB	0.526	4.21	0.108	0.655	3.6.4.13	97,99,140,165,172,193,196
10	0.060	1fa9A	0.459	6.54	0.061	0.759	2.4.1.1	216
11	0.060	1oyyA	0.508	5.40	0.065	0.734	3.6.4.12	NA
12	0.060	3eiqD	0.617	5.17	0.093	0.877	3.6.4.13	103
13	0.060	2hyiI	0.523	4.58	0.100	0.672	3.6.4.13	NA
14	0.060	3kx2B	0.506	6.16	0.074	0.804	3.6.4.13	140
15	0.060	1w36B	0.495	5.58	0.080	0.737	3.1.11.5	NA
16	0.060	2is6A	0.485	5.43	0.057	0.700	3.6.4.12	NA
17	0.060	1xtkA	0.631	5.06	0.076	0.880	3.6.4.13	311
18	0.060	2vdcA	0.467	6.97	0.079	0.818	1.4.1.13	NA
19	0.060	3i62A	0.521	4.60	0.081	0.678	3.6.4.13	188
20	0.060	2gblA	0.449	6.48	0.056	0.737	2.7.11.1	NA
21	0.060	2qllA	0.430	6.68	0.061	0.726	2.4.1.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.474	2.86	0.12	0.54	3ly5B	GO:0000166 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005694 GO:0005730 GO:0010501 GO:0016020 GO:0016787 GO:0044822
1	0.17	0.829	2.45	0.11	0.92	1s2mA	GO:0000166 GO:0000290 GO:0000932 GO:0003676 GO:0003682 GO:0003723 GO:0003729 GO:0004004 GO:0004386 GO:0005524 GO:0005737 GO:0006397 GO:0006417 GO:0006810 GO:0010494 GO:0010501 GO:0016787 GO:0017148 GO:0033962 GO:0034063 GO:0045900 GO:0051028 GO:0090079
2	0.16	0.472	2.56	0.12	0.52	3b7gA	GO:0000122 GO:0000166 GO:0000244 GO:0000387 GO:0003676 GO:0003677 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0006396 GO:0006397 GO:0008285 GO:0008380 GO:0010501 GO:0016020 GO:0016787 GO:0017053 GO:0019904 GO:0030674 GO:0032797 GO:0034719 GO:0042826 GO:0043065 GO:0045892 GO:0048477 GO:0050810 GO:0051170 GO:0070491 GO:0090571 GO:0097504
3	0.12	0.499	4.72	0.10	0.66	2zu6F	GO:0000166 GO:0000289 GO:0000339 GO:0003676 GO:0003723 GO:0003725 GO:0003729 GO:0003743 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006413 GO:0006446 GO:0008135 GO:0010468 GO:0010501 GO:0016020 GO:0016032 GO:0016281 GO:0016787 GO:0016887 GO:0031012 GO:0031100 GO:0044822 GO:0070062
4	0.07	0.480	2.45	0.10	0.53	1q0uB	GO:0003676 GO:0005524
5	0.07	0.631	5.06	0.08	0.88	1xtkA	GO:0000166 GO:0000245 GO:0000346 GO:0000398 GO:0001889 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005681 GO:0005687 GO:0005688 GO:0005737 GO:0006369 GO:0006397 GO:0006405 GO:0006406 GO:0006810 GO:0008186 GO:0008380 GO:0010501 GO:0016363 GO:0016607 GO:0016787 GO:0016887 GO:0017070 GO:0030621 GO:0031124 GO:0032403 GO:0032786 GO:0043008 GO:0043234 GO:0044822 GO:0045727 GO:0046784 GO:0051028 GO:0061051 GO:1904707 GO:2000002 GO:2000573
6	0.07	0.608	5.26	0.08	0.88	2eyqA	GO:0000166 GO:0000716 GO:0003676 GO:0003677 GO:0003684 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0006281 GO:0006355 GO:0006974 GO:0008026 GO:0015616 GO:0016787 GO:0043175
7	0.07	0.617	5.17	0.09	0.88	3eiqD	GO:0000166 GO:0000289 GO:0000339 GO:0003676 GO:0003723 GO:0003725 GO:0003729 GO:0003743 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006413 GO:0006446 GO:0008135 GO:0010468 GO:0010501 GO:0016020 GO:0016032 GO:0016281 GO:0016787 GO:0016887 GO:0031012 GO:0031100 GO:0044822 GO:0070062
8	0.07	0.478	2.95	0.13	0.54	3berA	GO:0000166 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0006397 GO:0006915 GO:0008380 GO:0008625 GO:0010501 GO:0016020 GO:0016787 GO:0044822
9	0.07	0.480	2.92	0.11	0.55	2pl3A	GO:0000166 GO:0003676 GO:0003723 GO:0003724 GO:0004004 GO:0004386 GO:0005524 GO:0010501 GO:0016787 GO:0044822
10	0.07	0.466	2.73	0.11	0.52	3iuyA	GO:0000166 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0010501 GO:0016787
11	0.07	0.583	5.21	0.08	0.81	3ewsA	GO:0000166 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005635 GO:0005643 GO:0005737 GO:0006406 GO:0006810 GO:0010501 GO:0015031 GO:0016020 GO:0016787 GO:0031965 GO:0051028 GO:0070062
12	0.07	0.471	2.80	0.11	0.53	1wrbA	GO:0000166 GO:0003676 GO:0004386 GO:0005524 GO:0016787
13	0.07	0.570	5.59	0.12	0.85	1hv8A	GO:0000166 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0010501 GO:0016787
14	0.07	0.481	3.18	0.08	0.55	4a4dA	GO:0000122 GO:0000166 GO:0000381 GO:0000398 GO:0003676 GO:0003713 GO:0003723 GO:0003724 GO:0004004 GO:0004386 GO:0005516 GO:0005524 GO:0005634 GO:0005654 GO:0005681 GO:0005730 GO:0006351 GO:0006355 GO:0006397 GO:0008380 GO:0009299 GO:0010501 GO:0016020 GO:0016049 GO:0016787 GO:0019899 GO:0030331 GO:0030529 GO:0031012 GO:0033148 GO:0036002 GO:0043517 GO:0044822 GO:0045069 GO:0045667 GO:0045944 GO:0048306 GO:0048511 GO:0050681 GO:0060765 GO:0070062 GO:0071013 GO:0072332 GO:2001014
15	0.07	0.471	3.04	0.10	0.55	3dkpA	GO:0000166 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0010501 GO:0016020 GO:0016787 GO:0044822
16	0.07	0.554	4.48	0.09	0.71	4ljyA	GO:0000166 GO:0000348 GO:0003676 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0006397 GO:0008186 GO:0008380 GO:0010468 GO:0010501 GO:0016787
17	0.07	0.548	4.08	0.11	0.68	1fuuB	GO:0000166 GO:0003676 GO:0003723 GO:0003743 GO:0004004 GO:0004386 GO:0005524 GO:0005737 GO:0005840 GO:0006412 GO:0006413 GO:0006446 GO:0008186 GO:0010468 GO:0010501 GO:0016281 GO:0016787
18	0.07	0.511	5.51	0.10	0.73	4q47A	GO:0000166 GO:0003676 GO:0003677 GO:0003824 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005694 GO:0005737 GO:0006260 GO:0006281 GO:0006310 GO:0008026 GO:0009378 GO:0009432 GO:0032508 GO:0043140 GO:0043590 GO:0044237 GO:0046872
19	0.07	0.521	5.85	0.06	0.78	4u7dC	GO:0000166 GO:0000724 GO:0000733 GO:0003676 GO:0003677 GO:0003678 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0005737 GO:0006281 GO:0006310 GO:0008026 GO:0009378 GO:0016020 GO:0016787 GO:0032508 GO:0036310 GO:0043140
20	0.07	0.522	4.49	0.11	0.66	3ex7C	GO:0000166 GO:0000184 GO:0000289 GO:0000398 GO:0003676 GO:0003723 GO:0003729 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005681 GO:0005737 GO:0005829 GO:0006364 GO:0006369 GO:0006397 GO:0006405 GO:0006406 GO:0006417 GO:0006810 GO:0008143 GO:0008306 GO:0008380 GO:0010501 GO:0010629 GO:0014070 GO:0016020 GO:0016259 GO:0016607 GO:0016787 GO:0017148 GO:0030425 GO:0030529 GO:0031124 GO:0035145 GO:0035368 GO:0035613 GO:0035640 GO:0043021 GO:0043025 GO:0044822 GO:0045727 GO:0048701 GO:0051028 GO:0071013 GO:0072715 GO:0090394 GO:1902415 GO:1904570 GO:1904574 GO:1990416
21	0.07	0.492	5.49	0.08	0.71	2zj8A	GO:0000166 GO:0003676 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0006974 GO:0016787 GO:0016818
22	0.07	0.493	5.74	0.05	0.71	1d2mA	GO:0000166 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009381 GO:0009432 GO:0016787 GO:0090305
23	0.07	0.524	4.05	0.10	0.64	2db3A	GO:0000166 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005737 GO:0007275 GO:0008104 GO:0016787 GO:0030154 GO:0048477
24	0.07	0.503	5.64	0.06	0.73	5jc3A	GO:0003677 GO:0005524 GO:0016787 GO:0016817
25	0.07	0.517	5.42	0.06	0.75	1oywA	GO:0000166 GO:0003676 GO:0003677 GO:0003824 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005737 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0008026 GO:0008094 GO:0008270 GO:0009378 GO:0009432 GO:0016787 GO:0016887 GO:0017116 GO:0017117 GO:0030894 GO:0032508 GO:0043140 GO:0043590 GO:0044237 GO:0046914
26	0.07	0.520	4.62	0.09	0.68	3i5xA	GO:0000166 GO:0000372 GO:0000373 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005739 GO:0005759 GO:0006392 GO:0006397 GO:0006417 GO:0008380 GO:0010501 GO:0016787 GO:0033592 GO:0034337
27	0.07	0.521	5.40	0.07	0.73	4d26A	GO:0000166 GO:0003676 GO:0004386 GO:0005524 GO:0016787
28	0.07	0.517	4.52	0.11	0.66	5elxA	GO:0000166 GO:0003676 GO:0003723 GO:0004386 GO:0005524 GO:0005634 GO:0005643 GO:0005737 GO:0006810 GO:0015031 GO:0016020 GO:0016787 GO:0031965 GO:0051028

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0004004	GO:0003723	GO:0045182	GO:0044877	GO:0060090	GO:0008134	GO:0019899
GO-Score	0.54	0.51	0.42	0.34	0.34	0.33	0.33	0.33
Biological Processes	GO:0010501	GO:0070925	GO:0000288	GO:0006448	GO:0032269	GO:0022618	GO:0034249	GO:0050658	GO:0000398	GO:0042127	GO:0006913	GO:0046890	GO:0043068	GO:0007281	GO:0006357	GO:0042981	GO:0045892	GO:0007292	GO:0019218	GO:0006694
GO-Score	0.51	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33
Cellular Component	GO:0016020	GO:0036464	GO:0016604	GO:0090568
GO-Score	0.41	0.34	0.33	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.