I-TASSER results

I-TASSER results for job id Rv3776

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (519 residues)
MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGARRLSAIAELTSRRTGNDQRADWAC
DGWDCAAAEVAAALTVSHRKASGQMHLSLTLNRLPQVAALFLAGQLSARLVSIIAWRTYL
VRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIG
DPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGALAAGADRL
TCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLSGPEPALAPEAPATPAVKP
PAALISGGGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRF
PGCDQPTEFCDIDHTLPYPLGPTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIWTAP
NGHTYTTHPDSRIFLPSWHTTTAALPPAPSPPAIGPTHTLLMPRRRRTRAAELAHRIKRE
RAHVTQRNKPPPSGGDTAVAEGFEPPDGVSRLSLSRRVH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGARRLSAIAELTSRRTGNDQRADWACDGWDCAAAEVAAALTVSHRKASGQMHLSLTLNRLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLSGPEPALAPEAPATPAVKPPAALISGGGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYPLGPTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPSPPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDTAVAEGFEPPDGVSRLSLSRRVH
Prediction	CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEHCCCCCCEEEEEEEHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHCCCCEEEEHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
Conf.Score	998878877664569989999999999999999999999999999998545444566665568899999999999999999999999865555599999999899999999999999966995888999999999987764678889999999999998687777766788876575898658999689999997899999999999998765588999997775445666776556677766677777777777777766566654565545678888777776655555566566677765657888788999999998786677655788888877889999999999996787899999999755556667778999999888555556555555578857887589985999889996787699998778877888888899988998888876678865666899999999999999998656888877788888899987466554434459
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGARRLSAIAELTSRRTGNDQRADWACDGWDCAAAEVAAALTVSHRKASGQMHLSLTLNRLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLSGPEPALAPEAPATPAVKPPAALISGGGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYPLGPTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPSPPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDTAVAEGFEPPDGVSRLSLSRRVH
Prediction	513333433230440423201400340120100010100000000142124544444111420210000002116002320221032033133001001002012001400100030044044641133013201530441451315201410330043122422453565045332221324310000000000001000001300231023224635133211200000101221121312133441433444344322010101122311442442424232221012111111121211001000000010001002101002101211312422211003100100000120021010210031010000131440100041011002100212334421222114501000001311312131512222251422435333444333444523443354333245423431440154254446445543544336645136335325244548
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEHCCCCCCEEEEEEEHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHCCCCEEEEHCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGARRLSAIAELTSRRTGNDQRADWACDGWDCAAAEVAAALTVSHRKASGQMHLSLTLNRLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLSGPEPALAPEAPATPAVKPPAALISGGGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYPLGPTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPSPPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDTAVAEGFEPPDGVSRLSLSRRVH

5gaoE

0.16

0.10

0.65

1.48

dPPAS2

----------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------AAAAAAARAAAAAAAAA-----------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------------------------------

5gaoE

0.16

0.10

0.65

1.31

PPAS

----------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------AAARAAAAAAAAAAAAA--------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-------------------------------------

4ke2A

0.18

0.07

0.38

1.14

dPPAS2

-------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAA--------ATAATA---------------------AAVAAATLEAAAAKAAATA-------VSAAAAAAAAAIAFAAAP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4b2nA

0.08

0.95

1.03

PPAS

QFNAYFVDLHNPPPPFVNRLPPRPTTCGQFRASATRGRVNLEER-------QFFQPMALATSYHFIFLQWGYLIRPPDFEEQVSKRYGEDPNQTNGSCSACHDSRLGTASEASFKWGLPNSANDAGLLASDMFRTTPITALGNLLPLPWIGLISLLPALFDMETLTLAPSLLEYVADAPHAGMTKDGSLSANIFRDANARRGLEDEFEDINNFLISLSPATYPKTINTALAEQGAVIYHERDLWASGANGAIPKPAGNGSCAS---GVYSPRHAADPNYLPDPRLKGVAAVVTPIETIRTDPRRMRLMADERQRRAWNSGWWAYNNLSPSWTGYPSDNIVASELRRVPRAIYNNGGPIYSPLGPNIWEEPTGYIAPPLYGAWATAPYF------HNGSVPNLWGVLKPSDRPKLWKRPYTAAGIGGKNAGYDYSFASYDWQKLGWKYTAVACNNSIFTSPFLPCTHNMATIDILYSMWDNVAAQYLN---------LAYQSPPPITDQQIKSRMVYNSY

5cwqA

0.10

0.04

0.45

1.13

dPPAS2

--------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEARE--QGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4r1dA

0.09

0.08

0.88

1.00

PPAS

KADKSEVWRPPNGLWPMDDLFASIGALWTWAWRGPKARQELLKAEQVEVDDQGTIDVGQSGLSEEAARLRGWGKVMRSAYNPVMGLMERRLDNIVSRRELQAWWNDEALSPPGDQGEEQGKVGPIDEEELLRASRYQFDQSNRQSALDVRDYIENTVLPFYQKECGLDPEQMRRMKVILVT-GYERVLGVVHGVQPATGSSTIYHHMRCGYEGIAQVVLG----RNAGEVTAIVANSAEYREGRPWLFLCDAQGQVLKDIDGKPRAYPQNQDPYEEIYKNTTWYGLVPEQNSQYLDMSDKK----EGLRVGPRDNFEDLIDSIA--------------------NFHGELSAAGYHSETYAHYGADDSRHSWRDLI-WKGDPTPLETPGATLNDDENGTYNSWF----RRGLPTIVQGPLETGNPLDASGSGTDSGQAPALAGVKASFRHGSKGKGQANTKRGYEHQESYNDARAQWAALYGVIKITQLADW---------------------------

5cwoA

0.10

0.04

0.42

1.10

dPPAS2

---------------------PELEEWIRRAKEVAKEVEKVAQRAEEEGNPDLRDSAKELRRAVEEAIEEAKKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGN--RDLFRAALELVRAVIEAIEEAVKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRAALELVRAVIEAIEEAVKQGNPELVERVAAKKAAELIKRAIRAEKEGNRDERREALERVREVIERIEELVRQG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5cwmA

0.11

0.05

0.44

1.10

dPPAS2

------------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGD-PEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALR----AVELVVRVAELLLRIAKESGSEEALERALR---------------------VAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5dlqB

0.11

1.00

0.91

MUSTER

VSQLISSGNPTVQTLACSILTALLSEFSNCKRVFQEEDLRQIFMLTVGVLQEFSRRENLSAQMSSVFQRYLALANPPTESWREALLDSRVMELFFTVHRKIRDSDMAQDSLQCLAQLAPIFPDEGSQVDYLAHFIEGLLNTEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSNCLTHLTCSFGRSAALEEVLDMVYMEAYDKLLESWLTLVRKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISQEDDRDQFSDQLASVGMLGRIAAEHCMPLLTSLLEERVTRLHGQLQRHQQDNKMLDDLYEDIHWLILVTGYLLADDTQGETPLIPPEIMEYSIKHVDINTTLQILGSPGEKASIPGYSRTDSVIRLLSAVLRVSEVESRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPLSTAFGADTEGSQWIIGSVWSSEQDLANDTVQLLVTLVERRERANLVIQCENKQFASRSPPLNFLSSPVQRTLMKALVL

5gaoE

0.16

0.10

0.65

0.87

dPPAS

----------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------AAAAAAARAAAAAAAAA-----------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.41

Estimated TM-score = 0.43±0.14

Estimated RMSD = 13.3±4.1Å

Download Model 2

C-score=-3.32

Download Model 3

C-score=-2.44

Download Model 4

C-score=-4.75

Download Model 5

C-score=-4.92

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4b2nA	0.915	1.96	0.085	0.954
2	4r04A	0.370	7.54	0.045	0.607
3	4f91B	0.364	7.55	0.020	0.599
4	2j5wA	0.363	7.72	0.030	0.607
5	4av3A	0.362	8.11	0.034	0.636
6	3dx4A	0.355	7.79	0.053	0.603
7	1llwA	0.353	7.62	0.054	0.592
8	4zhjA	0.349	7.74	0.029	0.588
9	4a01A	0.346	7.61	0.043	0.572
10	1aorA	0.346	7.14	0.071	0.547

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	7	2ro1A	ZN	Rep, Mult	358,363,374,392
2	0.06	3	1ofdB	F3S	Rep, Mult	315,320,349,350,351,352,358
3	0.04	2	3gl6A	ZN	Rep, Mult	358,363
4	0.02	1	3llxA	ZN	Rep, Mult	374,392
5	0.02	1	5fywR	NUC	Rep, Mult	124,126
6	0.02	1	5eulY	TBR	Rep, Mult	26,29
7	0.02	1	1swiC	BNZ	Rep, Mult	32,36
8	0.02	1	3e0dB	DTP	Rep, Mult	105,106,107,114
9	0.02	1	5elcC	GAL	Rep, Mult	413,415
10	0.02	1	3my9A	MG	Rep, Mult	237,240
11	0.02	1	2uwdA	MG	Rep, Mult	341,344
12	0.02	1	3toyA	CA	Rep, Mult	37,40
13	0.02	1	5kzmB	CA	Rep, Mult	354,355
14	0.02	1	1llwA	F3S	Rep, Mult	88,89,90,93,94,95,100
15	0.02	1	4b2nA	HEM	Rep, Mult	260,261,293,297,298,300,373,374,375,376,378,387,388,395,402,405,406
16	0.02	1	3htwA	MG	Rep, Mult	352,357

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2vycA	0.324	7.23	0.055	0.518	4.1.1.19	NA
2	0.060	2rnpC	0.278	7.59	0.022	0.461	2.7.7.6	NA
3	0.060	1aorB	0.346	7.13	0.071	0.547	1.2.7.5	NA
4	0.060	3hkzJ	0.323	7.92	0.036	0.559	2.7.7.6	398
5	0.060	1q16A	0.320	7.64	0.052	0.528	1.7.99.4	NA
6	0.060	1ofdA	0.362	7.55	0.051	0.601	1.4.7.1	NA
7	0.060	1fo4A	0.289	8.13	0.033	0.505	1.17.1.4	NA
8	0.060	1l5jA	0.342	7.94	0.041	0.584	4.2.1.3	41,103
9	0.060	1ej6A	0.322	7.64	0.053	0.543	2.7.7.50	NA
10	0.060	3g4dA	0.320	7.35	0.035	0.512	4.2.3.13	63
11	0.060	1h0hA	0.320	7.59	0.047	0.528	1.2.1.2	NA
12	0.060	1yq2A	0.317	7.68	0.043	0.530	3.2.1.23	NA
13	0.060	2dqmA	0.320	7.56	0.038	0.532	3.4.11.2	NA
14	0.060	2hpiA	0.295	7.68	0.046	0.493	2.7.7.7	NA
15	0.060	1n1hA	0.316	7.70	0.042	0.518	2.7.7.48	NA
16	0.060	1ea0A	0.313	8.14	0.055	0.541	1.4.1.13	NA
17	0.060	2vdcF	0.297	8.21	0.037	0.526	1.4.1.13	104
18	0.060	1s76D	0.280	6.96	0.040	0.432	2.7.7.6	NA
19	0.060	1mswD	0.284	8.25	0.040	0.497	2.7.7.6	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.915	1.96	0.09	0.95	4b2nA	GO:0009055 GO:0020037 GO:0046872
1	0.06	0.307	7.87	0.04	0.52	5a9jA	GO:0000166 GO:0000724 GO:0003676 GO:0003677 GO:0003682 GO:0003684 GO:0003887 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0006260 GO:0006261 GO:0006281 GO:0006284 GO:0006302 GO:0006974 GO:0016446 GO:0016740 GO:0016779 GO:0043142 GO:0051260 GO:0051575 GO:0071897 GO:0097681 GO:2000042
2	0.06	0.312	7.62	0.06	0.52	4a4zA	GO:0000166 GO:0003676 GO:0003677 GO:0003723 GO:0003724 GO:0004386 GO:0005524 GO:0005737 GO:0006401 GO:0006417 GO:0016787 GO:0034427 GO:0051607 GO:0055087 GO:0070478 GO:0070481
3	0.06	0.311	7.88	0.05	0.54	2xgjA	GO:0000166 GO:0000467 GO:0003676 GO:0003723 GO:0003724 GO:0003824 GO:0004386 GO:0005524 GO:0005634 GO:0005730 GO:0006364 GO:0006401 GO:0008143 GO:0016075 GO:0016491 GO:0016787 GO:0031499 GO:0034459 GO:0034475 GO:0034476 GO:0043629 GO:0055114 GO:0071031 GO:0071035 GO:0071038 GO:0071042 GO:0071049 GO:0071051
4	0.06	0.264	7.67	0.05	0.44	2xgjB	GO:0000166 GO:0000467 GO:0003676 GO:0003723 GO:0003724 GO:0003824 GO:0004386 GO:0005524 GO:0005634 GO:0005730 GO:0006364 GO:0006401 GO:0008143 GO:0016075 GO:0016491 GO:0016787 GO:0031499 GO:0034459 GO:0034475 GO:0034476 GO:0043629 GO:0055114 GO:0071031 GO:0071035 GO:0071038 GO:0071042 GO:0071049 GO:0071051
5	0.06	0.264	7.72	0.04	0.44	1qhoA	GO:0003824 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0043169 GO:0043897 GO:0046872 GO:2001070
6	0.06	0.310	7.58	0.04	0.51	4bujA	GO:0000166 GO:0003676 GO:0003677 GO:0003723 GO:0003724 GO:0004386 GO:0005524 GO:0005737 GO:0006401 GO:0006417 GO:0016787 GO:0034427 GO:0051607 GO:0055087 GO:0070478 GO:0070481
7	0.06	0.287	7.70	0.06	0.48	2p6rA
8	0.06	0.311	7.72	0.07	0.52	2zj8A	GO:0000166 GO:0003676 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0006974 GO:0016787 GO:0016818
9	0.06	0.311	7.84	0.04	0.54	2eyqA	GO:0000166 GO:0000716 GO:0003676 GO:0003677 GO:0003684 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0006281 GO:0006355 GO:0006974 GO:0008026 GO:0015616 GO:0016787 GO:0043175
10	0.06	0.268	8.02	0.04	0.47	5jb2A	GO:0003677 GO:0005524 GO:0016787 GO:0016817
11	0.06	0.279	7.70	0.02	0.47	2ykgA	GO:0000166 GO:0002230 GO:0002376 GO:0003676 GO:0003690 GO:0003723 GO:0003725 GO:0003727 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005923 GO:0008270 GO:0009597 GO:0009615 GO:0010628 GO:0015629 GO:0016020 GO:0016032 GO:0016787 GO:0016817 GO:0030054 GO:0030334 GO:0032480 GO:0032587 GO:0032725 GO:0032727 GO:0032728 GO:0032755 GO:0032757 GO:0034344 GO:0039528 GO:0039529 GO:0042802 GO:0042993 GO:0042995 GO:0043330 GO:0045087 GO:0045944 GO:0046872 GO:0051091 GO:0051607
12	0.06	0.269	8.16	0.07	0.47	2cfmA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0007049 GO:0016874 GO:0046872 GO:0051103 GO:0051301 GO:0071897
13	0.06	0.264	7.80	0.04	0.45	5f9fI	GO:0000166 GO:0002230 GO:0002376 GO:0003676 GO:0003690 GO:0003723 GO:0003725 GO:0003727 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005923 GO:0008270 GO:0009597 GO:0009615 GO:0010628 GO:0015629 GO:0016020 GO:0016032 GO:0016787 GO:0016817 GO:0030054 GO:0030334 GO:0032480 GO:0032587 GO:0032725 GO:0032727 GO:0032728 GO:0032755 GO:0032757 GO:0034344 GO:0039528 GO:0039529 GO:0042802 GO:0042993 GO:0042995 GO:0043330 GO:0045087 GO:0045944 GO:0046872 GO:0051091 GO:0051607
14	0.06	0.264	7.60	0.05	0.44	4q47A	GO:0000166 GO:0003676 GO:0003677 GO:0003824 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005694 GO:0005737 GO:0006260 GO:0006281 GO:0006310 GO:0008026 GO:0009378 GO:0009432 GO:0032508 GO:0043140 GO:0043590 GO:0044237 GO:0046872
15	0.06	0.273	6.95	0.03	0.42	4ljyA	GO:0000166 GO:0000348 GO:0003676 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0006397 GO:0008186 GO:0008380 GO:0010468 GO:0010501 GO:0016787
16	0.06	0.283	8.01	0.04	0.49	2va8B
17	0.06	0.263	8.18	0.02	0.46	5f9hG	GO:0000166 GO:0002230 GO:0002376 GO:0003676 GO:0003690 GO:0003723 GO:0003725 GO:0003727 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005923 GO:0008270 GO:0009597 GO:0009615 GO:0010628 GO:0015629 GO:0016020 GO:0016032 GO:0016787 GO:0016817 GO:0030054 GO:0030334 GO:0032480 GO:0032587 GO:0032725 GO:0032727 GO:0032728 GO:0032755 GO:0032757 GO:0034344 GO:0039528 GO:0039529 GO:0042802 GO:0042993 GO:0042995 GO:0043330 GO:0045087 GO:0045944 GO:0046872 GO:0051091 GO:0051607
18	0.06	0.260	7.98	0.05	0.45	5jbjA	GO:0003677 GO:0005524 GO:0016787 GO:0016817

Consensus prediction of GO terms

Molecular Function	GO:0032550	GO:0035639	GO:0032559	GO:0043169	GO:0046906	GO:0017111
GO-Score	0.46	0.46	0.46	0.43	0.43	0.36
Biological Processes	GO:0034655	GO:0044265	GO:0016070
GO-Score	0.36	0.36	0.36
Cellular Component	GO:0043231
GO-Score	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.