I-TASSER results

I-TASSER results for job id Rv3738c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (315 residues)
MTTAYASALAAMPTLTELAANHTSHAVLLGTNFFGINTIPIALNEADYARMWIQAATTMS
IYEGTSDAALASAPQTTPAPVLFNGGAGVASALPAISAATLDPASIIGIIIEILIQLFLI
SLEILFAIVAYTIIIVLILPLVIFAYAIVFAVLAIIFGPPLLVIASPFVLTGSVIAVPTS
LSTSLSTAVPIGVGQYLADLASADAQAIEVGLKTADVAPVAVRPAAAPPLRESAAVRPEA
RLVSAVAPAPAGTSASVLASDRGAGVLGFAGTAGKESVGRPAGLTTLAGGEFGGSPSVPM
VPASWEQLVGAGEAG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTAYASALAAMPTLTELAANHTSHAVLLGTNFFGINTIPIALNEADYARMWIQAATTMSIYEGTSDAALASAPQTTPAPVLFNGGAGVASALPAISAATLDPASIIGIIIEILIQLFLISLEILFAIVAYTIIIVLILPLVIFAYAIVFAVLAIIFGPPLLVIASPFVLTGSVIAVPTSLSTSLSTAVPIGVGQYLADLASADAQAIEVGLKTADVAPVAVRPAAAPPLRESAAVRPEARLVSAVAPAPAGTSASVLASDRGAGVLGFAGTAGKESVGRPAGLTTLAGGEFGGSPSVPMVPASWEQLVGAGEAG
Prediction	CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHCCCCCCHHHHHHHHCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	976677678868999999999999999999865687589999999999999999899888777899999987788999987788875444444445567787655788899999998887776655555666554444554444566545566666555666654555444455554555555555555556666666666666667777777777776667777777777788888877777788888888887777777887777878888888888887765568888888889988888888888888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTAYASALAAMPTLTELAANHTSHAVLLGTNFFGINTIPIALNEADYARMWIQAATTMSIYEGTSDAALASAPQTTPAPVLFNGGAGVASALPAISAATLDPASIIGIIIEILIQLFLISLEILFAIVAYTIIIVLILPLVIFAYAIVFAVLAIIFGPPLLVIASPFVLTGSVIAVPTSLSTSLSTAVPIGVGQYLADLASADAQAIEVGLKTADVAPVAVRPAAAPPLRESAAVRPEARLVSAVAPAPAGTSASVLASDRGAGVLGFAGTAGKESVGRPAGLTTLAGGEFGGSPSVPMVPASWEQLVGAGEAG
Prediction	703013202223032120110142013011120000000000312230330103313122211210120143144342323234543432433344433434334332312330342123323312323333233333332333333333333333333331332333333332333222223323322313223323333333233233333333213232322322223323322333333333333333343333234422433223222345443311111203434215213300001004465555668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHCCCCCCHHHHHHHHCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MTTAYASALAAMPTLTELAANHTSHAVLLGTNFFGINTIPIALNEADYARMWIQAATTMSIYEGTSDAALASAPQTTPAPVLFNGGAGVASALPAISAATLDPASIIGIIIEILIQLFLISLEILFAIVAYTIIIVLILPLVIFAYAIVFAVLAIIFGPPLLVIASPFVLTGSVIAVPTSLSTSLSTAVPIGVGQYLADLASADAQAIEVGLKTADVAPVAVRPAAAPPLRESAAVRPEARLVSAVAPAPAGTSASVLASDRGAGVLGFAGTAGKESVGRPAGLTTLAGGEFGGSPSVPMVPASWEQLVGAGEAG

2g38B

0.23

0.06

0.26

1.96

wdPPAS

IVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.19

0.17

0.88

1.84

dPPAS2

-------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

2g38B

0.23

0.06

0.26

3.28

wPPAS

IVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.19

0.18

0.94

2.33

PPAS

---------------AAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

2g38B

0.23

0.06

0.26

1.12

Env-PPAS

IVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.21

0.19

0.90

1.33

wPPAS

-------AAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

2g38B

0.23

0.06

0.26

1.81

dPPAS2

IVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2mu3A

0.08

0.05

0.62

1.11

dPPAS2

---------------------------------------------------------------------------------------------AGPQGGFGATGGASAGLISRVANALANTSTLRTVLRTGVSQQIASSVVQRAAASTLGVDGNNLARFAVQAVSRLPAGSDTSAYAQAFSSALFNAGVLNASNIDTLGSRVLSALLNGVSSAAQGLGINVDSGSVQSDISSSSSFLSTSSSSASYSQASASSTSGAGYTGPSGPSTGPSGYPGPLGGGAPFGQSGFGG--------------------------

2g38B

0.23

0.06

0.26

2.19

PPAS

IVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3wpaA

0.09

0.08

0.90

1.36

PPAS

-------------------------------NVAQGNQTNVGDALTALDNAINTAATTSKSTVSNGQNIVVSKSKNADGSDNYEVSTAKDLTVDSVKAGDTVLNNAGITIGNNAVVLNNTGLTISGGPSVTLAGIDAGNKTIQNVANAVNATDAVNKGQLDSAINNVNNNVNELANNAVKYDDASKDKITLGGGATGTTITNVKDGTVAQGSKDAVNGGQQQVDQNTTDISNIKNDINNGTVGLVQQAGKDAPVTVAKDTGGTTVNVAGTDGNRVVTGVKEGAVNATSKDALGGGAGYDNITGSFTAPSYTVGDS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.17

Estimated TM-score = 0.36±0.12

Estimated RMSD = 14.0±3.9Å

Download Model 2

C-score=-3.33

Download Model 3

C-score=-3.64

Download Model 4

C-score=-4.90

Download Model 5

C-score=-3.83

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wpaA	0.571	4.67	0.075	0.759
2	1xi5A	0.471	5.86	0.045	0.740
3	1sjjA	0.467	6.30	0.041	0.743
4	3wprA	0.432	3.68	0.085	0.521
5	4oj5A	0.385	5.84	0.062	0.603
6	1e07A	0.374	6.68	0.039	0.648
7	3gqnA	0.364	5.68	0.081	0.543
8	2yo3A	0.357	5.66	0.068	0.556
9	2dfsA	0.355	5.42	0.042	0.524
10	3p8cA	0.352	6.16	0.056	0.575

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3nwfB	MRY	Rep, Mult	18,20,25,26,29,30
2	0.06	3	4zzbA	XE	Rep, Mult	18,48,51,52
3	0.06	3	1pthA	NAG	Rep, Mult	45,48
4	0.04	2	3rj1A	SE	Rep, Mult	51,54
5	0.04	2	3mylX	POP	Rep, Mult	29,30,31,42,45
6	0.04	2	4e6eA	MG	Rep, Mult	58,61
7	0.04	2	2q68A	CA	Rep, Mult	35,37
8	0.04	2	1izlC	III	Rep, Mult	52,55,56,59
9	0.02	1	2zd9A	K	Rep, Mult	14,34
10	0.02	1	3rj8A	ZN	Rep, Mult	63,67
11	0.02	1	2xqtD	CVM	Rep, Mult	158,161,165
12	0.02	1	4l6vK	CLA	Rep, Mult	41,42,45
13	0.02	1	3jcuD	FE2	Rep, Mult	25,45
14	0.02	1	1z08D	MG	Rep, Mult	12,14
15	0.02	1	3r6nB	D1D	Rep, Mult	15,16,19,52,55
16	0.02	1	2yvvA	LBT	Rep, Mult	11,12,13,36,44

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2v0hA	0.236	6.38	0.082	0.406	2.3.1.157,2.7.7.23	NA
2	0.060	3c8xA	0.127	5.48	0.012	0.187	2.7.10.1	14
3	0.060	3hmjA	0.260	6.13	0.064	0.422	2.3.1.86	NA
4	0.060	2z6bA	0.266	6.88	0.048	0.479	3.2.1.17	63
5	0.060	1q5nA	0.246	6.12	0.046	0.403	5.5.1.2	56
6	0.060	2vd4A	0.234	6.62	0.041	0.406	2.3.1.157,2.7.7.23	23,25
7	0.060	3btaA	0.248	6.38	0.036	0.416	3.4.24.69	NA
8	0.060	2uv8G	0.243	6.80	0.035	0.419	2.3.1.86	NA
9	0.060	2iw5A	0.225	5.76	0.019	0.343	1.-.-.-	14
10	0.060	1f1sA	0.271	5.85	0.065	0.429	4.2.2.1	NA
11	0.060	2dq3A	0.252	5.62	0.062	0.387	6.1.1.11	17
12	0.060	1i8qA	0.261	5.98	0.063	0.413	4.2.2.1	NA
13	0.060	2e9bA	0.266	5.97	0.084	0.429	3.2.1.41	10
14	0.060	3b2vA	0.221	6.03	0.047	0.352	2.7.10.1	5
15	0.060	2v5yA	0.293	7.00	0.022	0.533	3.1.3.48	70,88,90
16	0.060	3lssB	0.259	5.86	0.042	0.406	6.1.1.11	19
17	0.060	3c09A	0.145	5.09	0.051	0.206	2.7.10.1	NA
18	0.060	1wleB	0.250	6.23	0.048	0.406	6.1.1.11	NA
19	0.060	3h09B	0.263	5.59	0.062	0.406	3.4.21.72	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.571	4.67	0.07	0.76	3wpaA	GO:0009405 GO:0019867
1	0.06	0.432	3.68	0.09	0.52	3wprA	GO:0009405 GO:0019867
2	0.06	0.416	6.28	0.05	0.70	3lvhA	GO:0005198 GO:0005739 GO:0005905 GO:0006886 GO:0016020 GO:0016192 GO:0030117 GO:0030130 GO:0030132 GO:0030659 GO:0031410 GO:0042470 GO:1900126
3	0.06	0.418	4.16	0.07	0.55	3wqaA	GO:0009405 GO:0019867
4	0.06	0.305	4.25	0.04	0.40	2yo2A	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0009405 GO:0010691 GO:0019867 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
5	0.06	0.238	4.42	0.08	0.31	3ntnB	GO:0009405 GO:0019867
6	0.06	0.286	5.13	0.08	0.41	3pr7A	GO:0009405 GO:0019867
7	0.06	0.241	3.37	0.05	0.29	3d9xA	GO:0009405 GO:0019867
8	0.06	0.227	5.06	0.09	0.32	4usxC	GO:0009405 GO:0019867
9	0.06	0.230	3.79	0.03	0.29	4lgoA	GO:0009405 GO:0019867
10	0.06	0.235	4.08	0.09	0.30	2ynzA	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0009405 GO:0010691 GO:0019867 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
11	0.06	0.259	3.44	0.06	0.31	3zmfA	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0009405 GO:0010691 GO:0019867 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
12	0.06	0.260	6.44	0.05	0.44	4pa0B	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006091 GO:0006936 GO:0006941 GO:0007512 GO:0008218 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0018298 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0055010 GO:0060048
13	0.06	0.176	5.67	0.03	0.26	3q15A	GO:0004721 GO:0006470 GO:0016787
14	0.06	0.200	4.17	0.09	0.26	2ynyA	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0009405 GO:0010691 GO:0019867 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
15	0.06	0.191	3.19	0.09	0.23	3emoA	GO:0009405 GO:0019867
16	0.06	0.239	6.16	0.03	0.39	4p7hB	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006091 GO:0006936 GO:0006941 GO:0007512 GO:0008218 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0018298 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0055010 GO:0060048
17	0.06	0.172	6.69	0.02	0.30	4w5tA	GO:0000340 GO:0000932 GO:0000993 GO:0001047 GO:0003676 GO:0003723 GO:0003725 GO:0003727 GO:0003729 GO:0003743 GO:0004518 GO:0004519 GO:0004521 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005844 GO:0005845 GO:0006351 GO:0006355 GO:0006412 GO:0006413 GO:0006417 GO:0007223 GO:0008022 GO:0009791 GO:0010501 GO:0010586 GO:0010628 GO:0016020 GO:0016442 GO:0016787 GO:0016891 GO:0030425 GO:0030529 GO:0031047 GO:0031054 GO:0035068 GO:0035087 GO:0035194 GO:0035196 GO:0035197 GO:0035198 GO:0035278 GO:0035279 GO:0035280 GO:0044822 GO:0045944 GO:0045947 GO:0046872 GO:0048015 GO:0060213 GO:0070551 GO:0070578 GO:0090502 GO:0090624 GO:0090625 GO:1900153
18	0.06	0.147	6.92	0.02	0.27	1kfdA	GO:0003676 GO:0003677 GO:0003824 GO:0003887 GO:0004518 GO:0004527 GO:0005737 GO:0005829 GO:0006139 GO:0006260 GO:0006261 GO:0006281 GO:0006284 GO:0006974 GO:0008408 GO:0008409 GO:0016740 GO:0016779 GO:0016787 GO:0071897 GO:0090305

Consensus prediction of GO terms

Molecular Function	GO:0005198	GO:0001135	GO:0000981	GO:0001190	GO:0000978	GO:0003682	GO:0042802	GO:0001084
GO-Score	0.07	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0051704
GO-Score	0.47
Cellular Component	GO:0016020
GO-Score	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.