I-TASSER results

I-TASSER results for job id Rv3732

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (352 residues)
MAVLPACRLGLVVCVATAVITATMVLATPSYACACGAAVTAHGSQATLNHEVALLHWDGT
TETIVMQLAMNADTDNVALVVPTPTPAIVTTADQSTFGELDTLSAPLIEHQRHWSLRRGV
GASGPQEAAARAPHVLNQVRLGPLEATTLTGGDLSGLQTWLSDNGYAIRPAVSAALDPYV
RDGWAFVAIRLTSTDLIVGGLDPVRMTFRSSRLVYPMRLSVAAQEPQHVTIFTLSDHRQQ
RTDADAATQTTHVRFAGDMSTAVRDPLLRELIGNHGSYLTKVEVDIYQTSRISSDFTFGN
APNDDPYRQVVTVYDDVALPPLLLVVVSAIAVGAAGGAVVVVLRRRRRAHTG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAVLPACRLGLVVCVATAVITATMVLATPSYACACGAAVTAHGSQATLNHEVALLHWDGTTETIVMQLAMNADTDNVALVVPTPTPAIVTTADQSTFGELDTLSAPLIEHQRHWSLRRGVGASGPQEAAARAPHVLNQVRLGPLEATTLTGGDLSGLQTWLSDNGYAIRPAVSAALDPYVRDGWAFVAIRLTSTDLIVGGLDPVRMTFRSSRLVYPMRLSVAAQEPQHVTIFTLSDHRQQRTDADAATQTTHVRFAGDMSTAVRDPLLRELIGNHGSYLTKVEVDIYQTSRISSDFTFGNAPNDDPYRQVVTVYDDVALPPLLLVVVSAIAVGAAGGAVVVVLRRRRRAHTG
Prediction	CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEHCCCCCEEEHCCEEEEEEHCCCEEEEEEEEHCCCCCCCEEEEHCCCCCCEEEHCCHHHHHHHHHHHCCCEEHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCEEEEEEHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEEEHCCCCCCCCCCEEEEEHCCCCCEEEEEHCCCCCCCCEEEEEEHCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEEHCCCCCCCCCHHHHCCCCCCCEEEEEEEEHCCCCCEEHHHHHHHHHHHHCCCCEEEEEEEHCCCCCC
Conf.Score	9876654679999999999999998866567655766767888757766779999986988999999745788775799976999857886898999999998688557647788878888888888888896899999867758999986998999999999899999669999999999897899999857877778777599998799857888875678898679999985874546788766788876655444445677677676478876678887666687666688567548999865789999857777644456777776654455457888765455679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAVLPACRLGLVVCVATAVITATMVLATPSYACACGAAVTAHGSQATLNHEVALLHWDGTTETIVMQLAMNADTDNVALVVPTPTPAIVTTADQSTFGELDTLSAPLIEHQRHWSLRRGVGASGPQEAAARAPHVLNQVRLGPLEATTLTGGDLSGLQTWLSDNGYAIRPAVSAALDPYVRDGWAFVAIRLTSTDLIVGGLDPVRMTFRSSRLVYPMRLSVAAQEPQHVTIFTLSDHRQQRTDADAATQTTHVRFAGDMSTAVRDPLLRELIGNHGSYLTKVEVDIYQTSRISSDFTFGNAPNDDPYRQVVTVYDDVALPPLLLVVVSAIAVGAAGGAVVVVLRRRRRAHTG
Prediction	7321421310000000110211100022122000000001454251435322000011453100101231625263000000024434053145510530251024214244424254434424364465441412343401311001030743730350056241523760452044005440300001023563535403002020526300000100232645120100000532233551541322341402330443235420441266430100312441341531323330252364520331033146350000000010020011231000000113245468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEHCCCCCEEEHCCEEEEEEHCCCEEEEEEEEHCCCCCCCEEEEHCCCCCCEEEHCCHHHHHHHHHHHCCCEEHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCEEEEEEHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEEEHCCCCCCCCCCEEEEEHCCCCCEEEEEHCCCCCCCCEEEEEEHCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEEHCCCCCCCCCHHHHCCCCCCCEEEEEEEEHCCCCCEEHHHHHHHHHHHHCCCCEEEEEEEHCCCCCC
MAVLPACRLGLVVCVATAVITATMVLATPSYACACGAAVTAHGSQATLNHEVALLHWDGTTETIVMQLAMNADTDNVALVVPTPTPAIVTTADQSTFGELDTLSAPLIEHQRHWSLRRGVGASGPQEAAARAPHVLNQVRLGPLEATTLTGGDLSGLQTWLSDNGYAIRPAVSAALDPYVRDGWAFVAIRLTSTDLIVGGLDPVRMTFRSSRLVYPMRLSVAAQEPQHVTIFTLSDHRQQRTDADAATQTTHVRFAGDMSTAVRDPLLRELIGNHGSYLTKVEVDIYQTSRISSDFTFGNAPNDDPYRQVVTVYDDVALPPLLLVVVSAIAVGAAGGAVVVVLRRRRRAHTG

4uxeA

0.09

0.07

0.78

1.09

dPPAS2

NRTFTIRNTGAPTSIVFEKGPASGANPAQSSI---RVWGNQFGGGSDTTRSTVFEVGDDTSHHFYSQRNKDG---NIAFNINGTVPININASG-----------------LNVNGTATFGRSVTANGEFISKSANAFRAINGDYGFFIRNDAS-------------------------------NTYFLLTAAGDQTGNGLRPLLINNQSGQ----ITIGEGLIIAKGVTI---------NSGGLTVNSRIRSQGTKTSDLYTRAPT-----SDTVGFWSIDINDSATYNQFPGYFKVEKTNEVTGL-PYLERGEEVKSPGTLTQFGNT-----LDSLYQDWITYPTTPEAR

2wpxA

0.12

0.09

0.76

1.01

dPPAS2

-------------------------------------------------------------------------AGELEFVPLAAN-------DDETVGQWLDLMALAAETGPRAAPPCNVDMVGSLRFAPPAVVRSGGRVVGALRLALPDGAPTARVDQLLVHPGRRRRALWAHARELARKHDRTTLTATVVESLPSGPAQDPMGAHRSDIPAGTHQWLDLDRHDPLADGVPAVPAGTITPDEYAVPVSELELRAAQEVRTSYARQFETMRVGRGRRAYHTGAVHDAT-GALAGYTSVSKTTGNPAYALQGMTVVHREHRTLLKLANLEYVLRHEPEVRLVETANA--EDNH

1ddoA

0.13

0.11

0.86

0.64

MUSTER

MVVIGAGVIGLSTALCIHERYH------------------------VLQPLDVKVYADRF-------TPFTTTDVAAGLWQPYPSNPQEANWNQQTFNYLLSHISPNLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELFPNTSLILEGRKLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINGVLQPDPLLQPGRGQIIKVDAPWL--NFIITHDLERGIYNSPYIIPGL-------QAVTLGGTFQVGNW-NEINNIQDHNTIWEG----CCRLEPTLKDAKIVGEYTGFRPVRPQVRLEREQLRFGSSNTEVIHLTIHWGCALEVAKLFGKVLEERNL-----

3txaA1

0.08

0.07

0.95

0.82

dPPAS

MNNERANNSQRALKAGEAVEKLIDKITSNKDNR---VALVTYASTIFDGTEATVSKGVADQNGKALNDSVSWDYHKTTFTATTHNYSYLNLTNDANEVNILKSRIPKEAEHINGDRTLYQFGATFTQSSNARKKLIFHVTDGVSYAINFNPYISTSYQNQFNSFLNKIPDRSGILQEDFIINGDDYQIVKGDGESFKLFSDRKVPVTGGTTQAAYRVPQNMSNEGYAINSGYIYLYWRDYNWVYPFDPKTKKVSATKQIKTHGEPTTLYFNGNIRPKGYDIFTVGIGVNGDPGATPLEAEKFMQSISSKTENYTNVDDTNKIYDELNKYFKTIVEEK---------------

1p35A

0.10

0.08

0.76

0.60

wdPPAS

----------------------------------C--VIFPVEIDVSQT-IIRDCQVDKQRELVYINKIMNTQLTKMMFNIPI----SVTRKNNNLRDRIKSKVDEQFDQLERDYSDQMDGFHDSIKYFKD------------YSVSCQNGSVKSKFAKILKSHDYTDKKSIEAYEKYCLPKNDYYVAVCVLKPGFENGSNQVLSFEYNGNKVIVPFAHEINDTGLYEYDVVAYVDS-VQFDGEQFEEFVQSLILPSSFKNS--EKVL---ASKNKSMIYKALEFTTESSWGKSE--IYDKKSKVLYVKLHNVTSALNKNVILNTIKA------------------------

1ddoA

0.13

0.11

0.84

0.63

wMUSTER

VVVIGAGVIGLSTALCIHERYH-----------------------VLQPLDVKVYADRF--------TPFTTTDVAAGLWQPYPSNPQEANWNQQTFNYLLSHISPNLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELFPNTSLILEGR-LQWLTERLTERGVKFFLRKVESFEEVARGGADVIIN-VWAGVQPDPLLQPGRGQI-APWLKNFIITHDLERGIYNS-PYIIPGL-------QAVTLGGTFQVGNW-NEINNIQDHNTIWEKDAKIVGEYTGFR--PVRPQVRLEREQLRFGSSNTEVIHNY--HGGYGLTIHWGCALEVAKLFGKVL-------ERNL-

4m8rA2

0.13

0.09

0.71

0.65

wPPAS

---------------------------TPKD-----YGINETD-----KTIERAYAEETVTG----KKTWDSAHPDFRSVVNLQKT-AEENGVQQPF----DFCT---GEWKALSFYDYNTLALVIGSGND---IAAIQQRGKYSLYNVSAGEQSNYATKTRSNQFELPEGFPEQFGDYVFQGNEIILLSARKGN---GKWVPLYNYRNGEGIIIPFYFGALPDSLQKKVGYIY----YSSGD------------------------------NRGSSFRLLEPD-KESSKLQLQEPFAQLSD----KKVVSITNRLDRIGTITVL---------SDRTTSDFDWNSKEYTD

5gaoE

0.15

0.12

0.81

0.95

dPPAS2

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAA----AAAAAAAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAAAAAAAAAAA-----------------AAAAAAAAAAAAAAAAAAAAAAAA-----------------AAAAAAAAAAA-----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

3txaA1

0.07

0.93

0.81

PPAS

MNNERANNSQRALKAGEAVEKLIDKITSNKDN----VALVTYASTIFDGTEATVSKGVADQNGKALNDSVSWDYHKTTFTATTHNYSYLNLTNDANEVNILKSRIPKEAEHINGDRTLYQFGATQSSNARKKLIFHVT---GAINFNPYISTSYQNQFNSFLNK---IPDRSGILQEDFIINGDDYQIVKGDGESFKLFSDRKVPVTGGTTQAAYRVPQNMSNEGYAINSGYIYLYWRDYNWVYPFDPKTKKVSATKQIKTHGEPTTLYFNGNIRPKGYDIFTVGIGVNGDPGATPLEAEKFMQSISSKTENYTNVDDTNKIYDELNKYFKTIVEEK---------------

1p35A

0.10

0.09

0.82

0.84

Env-PPAS

----------------------------------C--VIFPVEIDVSQTIIRDCQVDKQTRELVYINKIMNTQLTKMMFNISGPIR-SVTRKNNNLRDRIKSKVDEQFDQLERDYSDQMDGFHDSIKY----------FKDEHYSVSCQNGSVKSKFAKILKSHDYTDKKSIEAYEKYCLPKNDYYVAVCVLKPGFENGSNQVLSFEYNGNKVIVPFAHEINDTGLYEYDVVAYVDS-VQFDGEQFEEFVQSLILPSSFKNSEKVLYYNEASKNKSMIYKALEFTTESSWGKSEKYNWK-------IFCNGFIYDKKSK--VLYVKLH----NVTSALNKNVILNTIKA---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.65

Estimated TM-score = 0.32±0.10

Estimated RMSD = 15.6±3.3Å

Download Model 2

C-score=-4.29

Download Model 3

C-score=-4.58

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3txaA1	0.729	4.10	0.077	0.923
2	2ww8A	0.709	4.21	0.066	0.903
3	3eg9A	0.445	4.71	0.042	0.594
4	1cjyA2	0.442	5.92	0.081	0.679
5	3efoB	0.441	4.96	0.079	0.608
6	1pcxA	0.430	4.39	0.055	0.560
7	3eh1A	0.430	4.63	0.094	0.574
8	2qtvA1	0.422	4.37	0.078	0.548
9	1jeqA	0.417	4.58	0.065	0.551
10	4a01A	0.413	7.19	0.070	0.730

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	3	1l5gB	UUU	Rep, Mult	59,61,63,65,69
2	0.05	3	1rd4A	L08	Rep, Mult	18,22,35,135,137,279,282,283,284,310,311,312,313,325,328
3	0.03	2	2xr9A	ZN	Rep, Mult	58,96,236,237
4	0.03	2	4q9lA	PHE	Rep, Mult	20,24
5	0.03	2	5li3B	9RB	Rep, Mult	157,160
6	0.03	2	1dw2C	NO	Rep, Mult	160,161,164
7	0.03	2	2buqA	CAQ	Rep, Mult	178,179
8	0.03	2	4bzzA	ACT	Rep, Mult	21,25,330
9	0.02	1	3wmoP	BCL	Rep, Mult	26,27
10	0.02	1	3u7eB	MG	Rep, Mult	58,236
11	0.02	1	2vdoB	III	Rep, Mult	241,243,245
12	0.02	1	2vc2B	180	Rep, Mult	27,33,34,35,36,37,39
13	0.02	1	1u8cB	UUU	Rep, Mult	204,206,214,233,235
14	0.02	1	1e08A	HEM	Rep, Mult	35,59
15	0.02	1	1l5gB	III	Rep, Mult	91,92,94,99
16	0.02	1	1kj4B	III	Rep, Mult	84,89
17	0.02	1	1gz7A	GOL	Rep, Mult	76,220,221,224
18	0.02	1	2islB	OXY	Rep, Mult	142,201
19	0.02	1	2ww8A	CA	Rep, Mult	206,209,212,214,236
20	0.02	1	4iqdA	PYR	Rep, Mult	10,11

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1cleA	0.404	6.62	0.052	0.670	3.1.1.3	NA
2	0.060	1k4yA	0.397	6.00	0.068	0.605	3.1.1.1	NA
3	0.060	1f6wA	0.370	6.44	0.027	0.594	3.1.1.13,3.1.1.3	NA
4	0.060	2fj0A	0.389	6.71	0.031	0.648	3.1.1.1	NA
5	0.060	1e1eB	0.400	6.57	0.057	0.665	3.2.1.21	NA
6	0.060	1gz7C	0.401	6.55	0.038	0.665	3.1.1.3	NA
7	0.060	1ahpA	0.392	6.09	0.085	0.622	2.4.1.1	NA
8	0.060	2b4kA	0.404	6.04	0.028	0.619	3.1.1.43	202
9	0.060	1dwaM	0.394	6.92	0.052	0.679	3.2.1.147	NA
10	0.060	1ygpA	0.385	6.63	0.048	0.645	2.4.1.1	NA
11	0.060	1l7qA	0.405	6.06	0.053	0.622	3.1.1.1	NA
12	0.060	2hihA	0.408	5.98	0.037	0.622	3.1.1.3	NA
13	0.060	1lpsA	0.404	6.86	0.051	0.685	3.1.1.3	NA
14	0.060	2i6qA	0.394	4.71	0.063	0.534	3.4.21.43	NA
15	0.060	2jlgC	0.386	6.80	0.048	0.648	2.7.7.48	NA
16	0.060	1thgA	0.397	6.47	0.042	0.656	3.1.1.3	36,337
17	0.060	1itwB	0.385	6.34	0.038	0.611	1.1.1.42	NA
18	0.060	1eveA	0.395	6.49	0.056	0.645	3.1.1.7	NA
19	0.060	1aknA	0.405	6.24	0.034	0.642	3.1.1.13,3.1.1.3	237

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.727	4.05	0.07	0.92	3txaA	GO:0016020 GO:0016021 GO:0046872
1	0.12	0.709	4.21	0.07	0.90	2ww8A	GO:0016020 GO:0016021
2	0.06	0.291	6.96	0.06	0.51	3mjmA	GO:0004151 GO:0006221 GO:0008270 GO:0016787 GO:0016812 GO:0019856 GO:0044205 GO:0046872
3	0.06	0.441	4.96	0.08	0.61	3efoB	GO:0000139 GO:0001701 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0048208 GO:0048471
4	0.06	0.295	6.19	0.03	0.47	3pnuA	GO:0004151 GO:0006221 GO:0016787 GO:0016812 GO:0019856 GO:0044205 GO:0046872
5	0.06	0.295	7.27	0.04	0.52	1ytmA	GO:0000166 GO:0004611 GO:0004612 GO:0005524 GO:0005737 GO:0006094 GO:0016829 GO:0016831 GO:0017076 GO:0046872
6	0.06	0.264	7.34	0.04	0.49	2xidB	GO:0016020 GO:0016021
7	0.06	0.265	4.95	0.04	0.37	1j8dA	GO:0005829 GO:0008781 GO:0009103 GO:0016311 GO:0016787 GO:0019143 GO:0046872
8	0.06	0.278	5.39	0.06	0.41	3c3yA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0042409 GO:0046872
9	0.06	0.255	6.15	0.04	0.40	2b69A	GO:0005739 GO:0005794 GO:0016020 GO:0016021 GO:0016829 GO:0016831 GO:0032580 GO:0033320 GO:0042803 GO:0048040 GO:0051262 GO:0070062 GO:0070403
10	0.06	0.246	6.37	0.03	0.39	3mydA	GO:0005886 GO:0006810 GO:0009306 GO:0015031 GO:0016020 GO:0016021 GO:0044780 GO:0044781
11	0.06	0.226	6.07	0.04	0.35	4lk3B	GO:0005739 GO:0005794 GO:0016020 GO:0016021 GO:0016829 GO:0016831 GO:0032580 GO:0033320 GO:0042803 GO:0048040 GO:0051262 GO:0070062 GO:0070403
12	0.06	0.231	6.81	0.03	0.39	4p0dA	GO:0005576 GO:0005618
13	0.06	0.194	6.22	0.03	0.31	3h7tA	GO:0004252 GO:0006508 GO:0046872
14	0.06	0.232	6.11	0.08	0.37	3p56D	GO:0003676 GO:0003723 GO:0004518 GO:0004519 GO:0004523 GO:0004540 GO:0005634 GO:0005654 GO:0005737 GO:0006260 GO:0006298 GO:0006401 GO:0016070 GO:0016787 GO:0032299 GO:0043137 GO:0046872 GO:0090305 GO:0090501 GO:0090502
15	0.06	0.277	7.03	0.06	0.48	1twaA	GO:0001055 GO:0001172 GO:0003677 GO:0003899 GO:0003968 GO:0005634 GO:0005665 GO:0006351 GO:0006366 GO:0016740 GO:0016779 GO:0019985 GO:0043566 GO:0046872
16	0.06	0.198	6.78	0.05	0.34	3kptB	GO:0016020 GO:0016021
17	0.06	0.225	6.31	0.06	0.36	4oq1A	GO:0016020 GO:0016021
18	0.06	0.190	6.39	0.04	0.31	4v96AA	GO:0098025

Consensus prediction of GO terms

Molecular Function	GO:0043169
GO-Score	0.46
Biological Processes	GO:0044205	GO:0019856	GO:0002474	GO:0001701	GO:0019886	GO:0048208	GO:0006886
GO-Score	0.12	0.12	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0031224
GO-Score	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.