I-TASSER results

I-TASSER results for job id Rv3730c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (346 residues)
MAAAAEELDVDGIAVRLTSPDRMYFPKLGSHGTKRRLVEYYFAVAGGPMLTALRDRPTHL
QRFPDGVDGEQIYQKRIPRHRPDYLQTCRVTFPSGRMADALKVTHPAAIVWAAQMGTITL
HPWQVRCPDTEHPDELRIDLDPQPGTGFVEARTVAVDVLRSVLDDLGLVGYPKTSGGRGI
HVFLRIATDWDFVEVRRAGIALAREVERRAPDAVTTSWWKEERGARIFIDFNQNARDRTM
ASAYSVRPTPIATVSMPLTWEELAGADPDDYTMTTVPELVKIRDDPWAGMDDVAQSIAPL
LDLAAADEERGLGDMPYPPNYPKMPGEPKRVQPSRDTDLKGGNTSK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAAAAEELDVDGIAVRLTSPDRMYFPKLGSHGTKRRLVEYYFAVAGGPMLTALRDRPTHLQRFPDGVDGEQIYQKRIPRHRPDYLQTCRVTFPSGRMADALKVTHPAAIVWAAQMGTITLHPWQVRCPDTEHPDELRIDLDPQPGTGFVEARTVAVDVLRSVLDDLGLVGYPKTSGGRGIHVFLRIATDWDFVEVRRAGIALAREVERRAPDAVTTSWWKEERGARIFIDFNQNARDRTMASAYSVRPTPIATVSMPLTWEELAGADPDDYTMTTVPELVKIRDDPWAGMDDVAQSIAPLLDLAAADEERGLGDMPYPPNYPKMPGEPKRVQPSRDTDLKGGNTSK
Prediction	CCCCCEEEEHCCEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCEEEEHCCCCCCCCCEEHCCCCCCCCCCEEEEEEHCCCCCCCCEEEHCCHHHHHHHHHHCCEEHCCCCCCCCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHCHHHCCCCEEEHCCCCCCCCCEEEHCCCCCCCCCCEEEHCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9998758999568999758986556667888889999999999866578888849975899868998887656557999999875799986789986656876899999999998675876888778888999789998699999999999999999999999998998657756999589999889999999999999999999999898737754547876996999856778998678754678899987677578888578985569987999999986998755655678889999999776756887899999888999999887765554567677889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAAAAEELDVDGIAVRLTSPDRMYFPKLGSHGTKRRLVEYYFAVAGGPMLTALRDRPTHLQRFPDGVDGEQIYQKRIPRHRPDYLQTCRVTFPSGRMADALKVTHPAAIVWAAQMGTITLHPWQVRCPDTEHPDELRIDLDPQPGTGFVEARTVAVDVLRSVLDDLGLVGYPKTSGGRGIHVFLRIATDWDFVEVRRAGIALAREVERRAPDAVTTSWWKEERGARIFIDFNQNARDRTMASAYSVRPTPIATVSMPLTWEELAGADPDDYTMTTVPELVKIRDDPWAGMDDVAQSIAPLLDLAAADEERGLGDMPYPPNYPKMPGEPKRVQPSRDTDLKGGNTSK
Prediction	7656545140453604012131000264425200210030024004320021027010001000512735301113236321520430404267654231020431400000000000000012032732530010000002467340430040014103400551604010000322100000004471417201400320042006420420004113751631000000112420000000000025402020103163065051640205301500673520044037364304400520534475425634213723624752623421454567866568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCEEEEHCCEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCEEEEHCCCCCCCCCEEHCCCCCCCCCCEEEEEEHCCCCCCCCEEEHCCHHHHHHHHHHCCEEHCCCCCCCCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHCHHHCCCCEEEHCCCCCCCCCEEEHCCCCCCCCCCEEEHCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MAAAAEELDVDGIAVRLTSPDRMYFPKLGSHGTKRRLVEYYFAVAGGPMLTALRDRPTHLQRFPDGVDGEQIYQKRIPRHRPDYLQTCRVTFPSGRMADALKVTHPAAIVWAAQMGTITLHPWQVRCPDTEHPDELRIDLDPQPGTGFVEARTVAVDVLRSVLDDLGLVGYPKTSGGRGIHVFLRIATDWDFVEVRRAGIALAREVERRAPDAVTTSWWKEERGARIFIDFNQNARDRTMASAYSVRPTPIATVSMPLTWEELAGADPDDYTMTTVPELVKIRDDPWAGMDDVAQSIAPLLDLAAADEERGLGDMPYPPNYPKMPGEPKRVQPSRDTDLKGGNTSK

5dmuA

0.31

0.27

0.85

3.34

MUSTER

RGSHMEVLHIEGHDIKVTNPDKVLFPEDG--ITKGELVDYYRRIS-GVMVPLVRGRPMTMQRFPDGIGKEGFFQKEASDYFPDWVHRATLELGKGGIQHQVVCDDAATLVYLASQAMITPHVFLSRIDKVHYPDRLIFDLDPPDNN--FETVRSAAKTIREALDAEGYPVYLMTTGSRGLHVVVPLDRSADFDTVRAFARGFGEKLTKKYPDRFTIELSKEKRRGRLFLDYLRNSYGQTGVAPYGVRARSGAPVATPITWDELDDIGSQEYNIRNIMGRMDKRGDAWKYIDKDRTSIKNL----------------------------------------------

5dmuA

0.31

0.27

0.85

9.39

dPPAS

GSHMTEVLHIEGHDIKVTNPDKVLFPEDG--ITKGELVDYYRRIS-GVMVPLVRGRPMTMQRFPDGIGKEGFFQKEASDYFPDWVHRATLELGKGGIQHQVVCDDAATLVYLASQAMITPHVFLSRIDKVHYPDRLIFDLDPPDNN--FETVRSAAKTIREALDAEGYPVYLMTTGSRGLHVVVPLDRSADFDTVRAFARGFGEKLTKKYPDRFTIELSKEKRRGRLFLDYLRNSYGQTGVAPYGVRARSGAPVATPITWDELDDIGSQEYNIRNIMGRMDKRGDAWKYIDKDRTSIKNL----------------------------------------------

5dmuA

0.31

0.27

0.85

7.34

wdPPAS

GSHMTEVLHIEGHDIKVTNPDKVLFPEDG--ITKGELVDYYRRIS-GVMVPLVRGRPMTMQRFPDGIGKEGFFQKEASDYFPDWVHRATLELGKGGIQHQVVCDDAATLVYLASQAMITPHVFLSRIDKVHYPDRLIFDLDPPDNN--FETVRSAAKTIREALDAEGYPVYLMTTGSRGLHVVVPLDRSADFDTVRAFARGFGEKLTKKYPDRFTIELSKEKRRGRLFLDYLRNSYGQTGVAPYGVRARSGAPVATPITWDELDDIGSQEYNIRNIMGRMDKRGDAWKYIDKDRTSIKNL----------------------------------------------

5dmuA

0.32

0.27

0.85

3.92

wMUSTER

RGSHMEVLHIEGHDIKVTNPDKVLFPEDG--ITKGELVDYYRRIS-GVMVPLVRGRPMTMQRFPDGIGKEGFFQKEASDYFPDWVHRATLELGKGGIQHQVVCDDAATLVYLASQAMITPHVFLSRIDKVHYPDRLIFDLDP-PDNN-FETVRSAAKTIREALDAEGYPVYLMTTGSRGLHVVVPLDRSADFDTVRAFARGFGEKLTKKYPDRFTIELSKEKRRGRLFLDYLRNSYGQTGVAPYGVRARSGAPVATPITWDELDDIGSQEYNIRNIMGRMDKRGDAWKYIDKDRTSIKNL----------------------------------------------

5dmuA

0.32

0.27

0.85

4.93

wPPAS

RGSHMEVLHIEGHDIKVTNPDKVLFPEDG--ITKGELVDYYRRIS-GVMVPLVRGRPMTMQRFPDGIGKEGFFQKEASDYFPDWVHRATLELGKGGIQHQVVCDDAATLVYLASQAMITPHVFLSRIDKVHYPDRLIFDLDP-PDNN-FETVRSAAKTIREALDAEGYPVYLMTTGSRGLHVVVPLDRSADFDTVRAFARGFGEKLTKKYPDRFTIELSKEKRRGRLFLDYLRNSYGQTGVAPYGVRARSGAPVATPITWDELDDIGSQEYNIRNIMGRMDKRGDAWKYIDKDRTSIKNL----------------------------------------------

5dmuA

0.31

0.27

0.85

11.51

dPPAS2

RGSHMEVLHIEGHDIKVTNPDKVLFPEDG--ITKGELVDYYRRIS-GVMVPLVRGRPMTMQRFPDGIGKEGFFQKEASDYFPDWVHRATLELGKGGIQHQVVCDDAATLVYLASQAMITPHVFLSRIDKVHYPDRLIFDLDPPDNN--FETVRSAAKTIREALDAEGYPVYLMTTGSRGLHVVVPLDRSADFDTVRAFARGFGEKLTKKYPDRFTIELSKEKRRGRLFLDYLRNSYGQTGVAPYGVRARSGAPVATPITWDELDDIGSQEYNIRNIMGRMDKRGDAWKYIDKDRTSIKNL----------------------------------------------

5dmuA

0.32

0.27

0.85

4.64

PPAS

RGSHMEVLHIEGHDIKVTNPDKVLFPEDG--ITKGELVDYYRRIS-GVMVPLVRGRPMTMQRFPDGIGKEGFFQKEASDYFPDWVHRATLELGKGGIQHQVVCDDAATLVYLASQAMITPHVFLSRIDKVHYPDRLIFDLDP-PDNN-FETVRSAAKTIREALDAEGYPVYLMTTGSRGLHVVVPLDRSADFDTVRAFARGFGEKLTKKYPDRFTIELSKEKRRGRLFLDYLRNSYGQTGVAPYGVRARSGAPVATPITWDELDDIGSQEYNIRNIMGRMDKRGDAWKYIDKDRTSIKNL----------------------------------------------

2faoA

0.29

0.25

0.84

7.47

Env-PPAS

--------RAATAGVRISHPQRLIDPSIQ--ASKLELAEFHARYA-DLLLRDLRERPVSLVRGPDGIGGELFFQKHAARLKIPGIVQLDPALDPGHP-PLLQIRSAEALVGAVQMGSIEFHTWNASLANLERPDRFVLDLDPDPALP-WKRMLEATQLSLTLLDELGLRAFLKTSGGKGMHLLVPLERRHGWDEVKDFAQAISQHLARLMPERFSAVSGPRNRVGKIFVDYLRNSRGASTVAAYSVRAREGLPVSVPVFREELDSLGANQWNLRSLPQRLDELADPWADYAGTRQRISAAMRRQL-----------------------------------------

2faoA

0.29

0.25

0.84

3.29

MUSTER

--------RAATAGVRISHPQRLIDPSIQ--ASKLELAEFHARYA-DLLLRDLRERPVSLVRGPDGIGGELFFQKHAARLKIPGIVQLDPALDPGHP-PLLQIRSAEALVGAVQMGSIEFHTWNASLANLERPDRFVLDLDPDPALP-WKRMLEATQLSLTLLDELGLRAFLKTSGGKGMHLLVPLERRHGWDEVKDFAQAISQHLARLMPERFSAVSGPRNRVGKIFVDYLRNSRGASTVAAYSVRAREGLPVSVPVFREELDSLGANQWNLRSLPQRLDELADPWADYAGTRQRISAAMRRQL-----------------------------------------

2faoA

0.29

0.25

0.84

9.10

dPPAS

--------RAATAGVRISHPQRLIDPSIQ--ASKLELAEFHARYA-DLLLRDLRERPVSLVRGPDGIGGELFFQKHAARLKIPGIVQLDPALDPG-HPPLLQIRSAEALVGAVQMGSIEFHTWNASLANLERPDRFVLDLDPDPALP-WKRMLEATQLSLTLLDELGLRAFLKTSGGKGMHLLVPLERRHGWDEVKDFAQAISQHLARLMPERFSAVSGPRNRVGKIFVDYLRNSRGASTVAAYSVRAREGLPVSVPVFREELDSLGANQWNLRSLPQRLDELADPWADYAGTRQRISAAMRRQL-----------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.27

Estimated TM-score = 0.68±0.12

Estimated RMSD = 7.1±4.1Å

Download Model 2

C-score=-0.95

Download Model 3

C-score=-1.58

Download Model 4

C-score=-2.52

Download Model 5

C-score=-2.54

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5dmuA	0.840	0.88	0.308	0.853
2	2faoA	0.783	2.05	0.291	0.844
3	2iryA	0.753	1.73	0.269	0.795
4	4bpuA	0.555	3.37	0.160	0.662
5	4limA	0.543	3.51	0.114	0.653
6	1v34A	0.513	3.50	0.091	0.616
7	1zt2A	0.507	3.08	0.114	0.587
8	2gmhA	0.430	6.48	0.026	0.697
9	3m1mA	0.409	5.20	0.071	0.569
10	3h20A	0.406	3.81	0.077	0.506

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.47	21	3pkyA	UTP	Rep, Mult	73,121,139,141,175,177,178,179,181,233,239,240,241,247
2	0.38	16	2faqA	MN	Rep, Mult	139,141,230,233
3	0.16	9	3pkyB	NUC	Rep, Mult	19,22,34,62,64,80,114
4	0.08	5	2r9lB	NUC	Rep, Mult	72,73,75,76,91,92,93,94,98,218,237,238
5	0.06	4	3pkyB	QNA	Rep, Mult	72,73,74,75,76,93,94,98

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2akzA	0.374	5.60	0.070	0.543	4.2.1.11	NA
2	0.060	3i39X	0.376	6.49	0.051	0.619	1.2.99.2	105
3	0.060	1eg7A	0.371	6.78	0.067	0.650	6.3.4.3	NA
4	0.060	1p0fA	0.371	6.25	0.067	0.590	1.1.1.2	NA
5	0.060	1t7nA	0.365	6.17	0.081	0.587	2.3.1.7	40
6	0.060	1ahpA	0.391	6.49	0.053	0.636	2.4.1.1	NA
7	0.060	1ahuA	0.380	6.57	0.044	0.627	1.1.3.38,1.1.3.13	NA
8	0.060	1mc1B	0.369	6.94	0.051	0.639	6.3.3.4	NA
9	0.060	1d1tA	0.370	6.09	0.029	0.584	1.1.1.1	101
10	0.060	2azdB	0.337	6.75	0.057	0.572	2.4.1.1	NA
11	0.060	1c4aA	0.392	6.09	0.043	0.624	1.12.7.2	60
12	0.060	1a47A	0.374	6.74	0.033	0.642	2.4.1.19	270
13	0.060	1ygpA	0.380	6.63	0.049	0.630	2.4.1.1	156,157
14	0.060	1qhoA	0.375	6.92	0.041	0.653	3.2.1.133	NA
15	0.060	1ciuA	0.374	6.69	0.041	0.639	2.4.1.19	233,235
16	0.060	1e9iD	0.372	5.81	0.072	0.552	4.2.1.11	NA
17	0.060	1qlhA	0.367	6.06	0.053	0.584	1.1.1.1	NA
18	0.060	1cdgA	0.368	6.64	0.034	0.621	2.4.1.19	NA
19	0.060	1dehA	0.367	6.15	0.053	0.578	1.1.1.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.54	0.753	1.73	0.27	0.79	2iryA	GO:0000166 GO:0000287 GO:0003677 GO:0003824 GO:0003887 GO:0003896 GO:0003899 GO:0003909 GO:0003910 GO:0004518 GO:0004527 GO:0004652 GO:0005524 GO:0005886 GO:0006266 GO:0006269 GO:0006281 GO:0006303 GO:0006310 GO:0006974 GO:0008152 GO:0008310 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016874 GO:0030145 GO:0046872 GO:0071897 GO:0090305
1	0.52	0.783	2.05	0.29	0.84	2faoA	GO:0000166 GO:0003677 GO:0003824 GO:0003887 GO:0003910 GO:0004518 GO:0004527 GO:0004532 GO:0005524 GO:0006266 GO:0006281 GO:0006310 GO:0006974 GO:0008152 GO:0016740 GO:0016779 GO:0016787 GO:0016874 GO:0046872 GO:0071897 GO:0090305 GO:0090503
2	0.06	0.291	6.29	0.03	0.46	1telB	GO:0000287 GO:0015977 GO:0016984 GO:0046872
3	0.06	0.309	6.41	0.05	0.51	3bihA	GO:0005737 GO:0005975 GO:0006071 GO:0006094 GO:0016311 GO:0016787 GO:0030145 GO:0042132 GO:0046872
4	0.06	0.230	6.48	0.02	0.38	2yzsB	GO:0003677 GO:0004518 GO:0004519 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
5	0.06	0.257	6.98	0.03	0.44	5crvB	GO:0004721 GO:0004725 GO:0005634 GO:0005654 GO:0005737 GO:0005768 GO:0005769 GO:0005856 GO:0005929 GO:0006470 GO:0006810 GO:0010633 GO:0015031 GO:0016023 GO:0016311 GO:0016787 GO:0016791 GO:0019901 GO:0030030 GO:0030334 GO:0031410 GO:0035335 GO:0036064 GO:0042995 GO:0043162 GO:0060271 GO:0070062 GO:1903387 GO:1903393 GO:2000643
6	0.06	0.265	6.54	0.04	0.44	1ni9A	GO:0005737 GO:0005975 GO:0006071 GO:0006094 GO:0016311 GO:0016787 GO:0030145 GO:0042132 GO:0046872
7	0.06	0.289	6.55	0.04	0.49	1zjcA	GO:0004177 GO:0006508
8	0.06	0.299	6.94	0.06	0.52	2qryC	GO:0005215 GO:0005524 GO:0006810 GO:0015888 GO:0030288 GO:0030975 GO:0042597 GO:0048502 GO:0055085
9	0.06	0.295	6.45	0.06	0.48	1k7hA	GO:0003824 GO:0004035 GO:0008152 GO:0016311 GO:0016787 GO:0016791 GO:0046872
10	0.06	0.280	6.11	0.05	0.45	4d8yA	GO:0003824 GO:0004731 GO:0006139 GO:0009116 GO:0016740 GO:0016757 GO:0016763 GO:0042278
11	0.06	0.270	5.56	0.07	0.40	2pyuA	GO:0000166 GO:0000287 GO:0005829 GO:0006163 GO:0009117 GO:0009143 GO:0016787 GO:0017111 GO:0046872 GO:0047429
12	0.06	0.262	6.40	0.04	0.42	3b5iA	GO:0000287 GO:0008168 GO:0009944 GO:0010252 GO:0016740 GO:0032259 GO:0042802 GO:0046872 GO:0051749
13	0.06	0.260	6.83	0.05	0.45	1hm7B	GO:0016829 GO:0017000 GO:0046872 GO:0050467
14	0.06	0.255	6.18	0.04	0.40	4wd2A	GO:0003824 GO:0006520 GO:0008483 GO:0008793 GO:0009058 GO:0016740 GO:0030170 GO:0080130
15	0.06	0.216	7.35	0.04	0.39	3letB	GO:0000166 GO:0005524 GO:0005576 GO:0006464 GO:0009405 GO:0016740 GO:0016779 GO:0018117 GO:0018178 GO:0034260 GO:0035024 GO:0043087 GO:0044054 GO:0048365 GO:0070733
16	0.06	0.201	5.86	0.04	0.32	1s7fA	GO:0005737 GO:0008080 GO:0016740 GO:0016746 GO:0017198
17	0.06	0.246	6.35	0.06	0.40	1gz0F	GO:0000453 GO:0003723 GO:0005737 GO:0005829 GO:0006364 GO:0006396 GO:0008168 GO:0008173 GO:0016740 GO:0032259 GO:0070039
18	0.06	0.194	5.00	0.04	0.27	4gcyA	GO:0000287 GO:0004170 GO:0005737 GO:0006220 GO:0006226 GO:0009117 GO:0016787 GO:0040007 GO:0046080 GO:0046081 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0003677	GO:0005524	GO:0003887	GO:0003910	GO:0030145	GO:0000287	GO:0003896	GO:0008310	GO:0004652	GO:0004532
GO-Score	0.79	0.78	0.78	0.78	0.57	0.57	0.54	0.54	0.54	0.52
Biological Processes	GO:0071897	GO:0006310	GO:0006266	GO:0006303	GO:0016032	GO:0006269	GO:0090503
GO-Score	0.78	0.78	0.78	0.54	0.54	0.54	0.52
Cellular Component	GO:0005886
GO-Score	0.54

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.