I-TASSER results

I-TASSER results for job id Rv3728

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (1065 residues)
MHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQPSSSAVLLVAAFGAFLAFLDSTIV
NVAFPDIQRHFHSDISDLSWMLNAYNIVFAAFLVAAGRLADLMGRKRVFILGVALFTVAS
GLCAIAESVGELVAFRVLQGIGAAVLVPASLGLVVEAFPAERRAHGVNLWGAAGAIAAGL
GPPIGGALIEADGWRWVFLVNLPLGVFAVLAARRALVENRAAGRRRVPDVRGAVLLAFAL
GLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVMSSRHHPAPMVEPTLLRIQSFVAGT
GLTAVASAGFYAYLLTHVLFLNYVWGYTLLEAGMAVAPAALVAAVVAAVLGRVADRHGYR
FIVGIGALIWAASLLWYLKVVGSQPDFLGEWLPGQILQGIGVGATFPLLGSAALARLAKG
GSYATASAVTGTIRQVGAVIGVAVLVILVGTPAPGAAEEALRHGWALAAICFVAVGIGAL
SLGRIRPVPAAVEPPPGPPVAPLGARRPPRPAPVASPAAAVAPTPKTSREVNLLEALRFA
RPDTQQIELQAGSYLFHAGDVSDALYVVRSGRLQVLAGDGAKDEVVAELGRGQVVGELGV
LLDAPRSASVRAVRDSSLMRVTKAEFAKIADAGVLGALAGVLAKRQHQTRVASQRTTPEV
VVAVVGVDANAPVAMVATELCRALSTRLRAVAPGRVDCDGLERAEQTADRVVLHAAVGDA
RWREFCLRVADRVVLVASNPAVPVAPLPTRATGADLVLAGRPAGREHRRAWEQLITPRSM
HVVRREFVADDLRVLATRIAGRSVGLVLSGGAARACAHLGVLEELEAAGVTVDRFAGTSM
GAIIAALAASGLDAAGVDAQIYEHFVRKSHGDYTLPSKGLIRGKRTQSTLRTIFGDHLVE
ELPKHFRCVSVDLLARRPVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVP
VTTLVGKDGPLIAVNVASGGNPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEKVLA
QADLVIKPNPIGVGLMEYHQIDRAREAGRIAAREALPQIMELVHG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQPSSSAVLLVAAFGAFLAFLDSTIVNVAFPDIQRHFHSDISDLSWMLNAYNIVFAAFLVAAGRLADLMGRKRVFILGVALFTVASGLCAIAESVGELVAFRVLQGIGAAVLVPASLGLVVEAFPAERRAHGVNLWGAAGAIAAGLGPPIGGALIEADGWRWVFLVNLPLGVFAVLAARRALVENRAAGRRRVPDVRGAVLLAFALGLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVMSSRHHPAPMVEPTLLRIQSFVAGTGLTAVASAGFYAYLLTHVLFLNYVWGYTLLEAGMAVAPAALVAAVVAAVLGRVADRHGYRFIVGIGALIWAASLLWYLKVVGSQPDFLGEWLPGQILQGIGVGATFPLLGSAALARLAKGGSYATASAVTGTIRQVGAVIGVAVLVILVGTPAPGAAEEALRHGWALAAICFVAVGIGALSLGRIRPVPAAVEPPPGPPVAPLGARRPPRPAPVASPAAAVAPTPKTSREVNLLEALRFARPDTQQIELQAGSYLFHAGDVSDALYVVRSGRLQVLAGDGAKDEVVAELGRGQVVGELGVLLDAPRSASVRAVRDSSLMRVTKAEFAKIADAGVLGALAGVLAKRQHQTRVASQRTTPEVVVAVVGVDANAPVAMVATELCRALSTRLRAVAPGRVDCDGLERAEQTADRVVLHAAVGDARWREFCLRVADRVVLVASNPAVPVAPLPTRATGADLVLAGRPAGREHRRAWEQLITPRSMHVVRREFVADDLRVLATRIAGRSVGLVLSGGAARACAHLGVLEELEAAGVTVDRFAGTSMGAIIAALAASGLDAAGVDAQIYEHFVRKSHGDYTLPSKGLIRGKRTQSTLRTIFGDHLVEELPKHFRCVSVDLLARRPVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVPVTTLVGKDGPLIAVNVASGGNPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEKVLAQADLVIKPNPIGVGLMEYHQIDRAREAGRIAAREALPQIMELVHG
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEHCCCCEEHCCCCCCCEEEEEHCCEEEEEHCCCCCCEEEEEHCCCCCCEEEEEHCCCCCCCEEEEEHCCEEEEHCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHEEEHCCCCCCHHHHHHHHHHHCEEEEEHCCCCCHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCHHHHHHHCCCEEEEEHCCCCHHHHHHHHHHHHCCCEEEEEHCHHHHHHHHHHHHHHHHHHCCCEEEHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEHCCCCCCEEEEHCCHHHHHHHHHHHCCCCCCCCHCCCCEEEEEEHCCCCCHHHHHCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
Conf.Score	998889889998888999988888888888888888766899999999999999999999999999999989986677889999999999999999999887666799999999999999999986999999999999999999999999999998789888788999999999999999999999999875557889999999999999999973688898888888889999999999999999863688898757999999999999999999997589988777884677558999999999999999999999999887688889999999999999999999999998875885699999999999999999965899876999999999999999999999999999858856665688999999999999999999999998667776578999999999999999999999998765677777778877777777888888887777777777888777655566666666665445665699577467988876999985779999758998668998689976444444358888657999974578986799999997888999999999999975778888888886999995888888799999999999875566647778879999999985989998668997588888766788999958999998888755677569997788888875789998756479999768757899999999987865899846677788999999999999995778756468999999998789999999999999997598866643566554589999999998686456656664678765788976887555588888866546776577545897898655334676577765799699998688889887656777887789869999999987556567899998766898688676775447899999999999999999998765789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQPSSSAVLLVAAFGAFLAFLDSTIVNVAFPDIQRHFHSDISDLSWMLNAYNIVFAAFLVAAGRLADLMGRKRVFILGVALFTVASGLCAIAESVGELVAFRVLQGIGAAVLVPASLGLVVEAFPAERRAHGVNLWGAAGAIAAGLGPPIGGALIEADGWRWVFLVNLPLGVFAVLAARRALVENRAAGRRRVPDVRGAVLLAFALGLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVMSSRHHPAPMVEPTLLRIQSFVAGTGLTAVASAGFYAYLLTHVLFLNYVWGYTLLEAGMAVAPAALVAAVVAAVLGRVADRHGYRFIVGIGALIWAASLLWYLKVVGSQPDFLGEWLPGQILQGIGVGATFPLLGSAALARLAKGGSYATASAVTGTIRQVGAVIGVAVLVILVGTPAPGAAEEALRHGWALAAICFVAVGIGALSLGRIRPVPAAVEPPPGPPVAPLGARRPPRPAPVASPAAAVAPTPKTSREVNLLEALRFARPDTQQIELQAGSYLFHAGDVSDALYVVRSGRLQVLAGDGAKDEVVAELGRGQVVGELGVLLDAPRSASVRAVRDSSLMRVTKAEFAKIADAGVLGALAGVLAKRQHQTRVASQRTTPEVVVAVVGVDANAPVAMVATELCRALSTRLRAVAPGRVDCDGLERAEQTADRVVLHAAVGDARWREFCLRVADRVVLVASNPAVPVAPLPTRATGADLVLAGRPAGREHRRAWEQLITPRSMHVVRREFVADDLRVLATRIAGRSVGLVLSGGAARACAHLGVLEELEAAGVTVDRFAGTSMGAIIAALAASGLDAAGVDAQIYEHFVRKSHGDYTLPSKGLIRGKRTQSTLRTIFGDHLVEELPKHFRCVSVDLLARRPVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVPVTTLVGKDGPLIAVNVASGGNPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEKVLAQADLVIKPNPIGVGLMEYHQIDRAREAGRIAAREALPQIMELVHG
Prediction	644544644434444424424444444443445434210000000000001101101100000011014304143420100000000000011010000001211200000010100100000000000000000001001000110000000012104362000000000010010011101100000020121000000100000000000000121445635320000001100101101100000024110000000000000100101000000115100000000101000000000011111321121220011000000000000000001010111000000000011201000000011001011000000000000000011010110111000000000000110334210000000000000100010101100000011121011001000000000000001000000011134344544444444444464444244444444344442434443313451544554134122543330143222010000000000000244544320002022420000001003202301020011000010025104400123002100200041024445344442210000000131212043004200410432021022631235104400441010000032444400310011000000002262214340343212000000024232522420330010000000234223500110011001200000000010000000000200452400000000000000000000010225301320130004321200000000002042014203410242203402210000000023033301241301400100000000000001432000000002101040033460100000004444254343234524432010020000001001444344034201000204042010110420340042014102400440452058
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060

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Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEHCCCCEEHCCCCCCCEEEEEHCCEEEEEHCCCCCCEEEEEHCCCCCCEEEEEHCCCCCCCEEEEEHCCEEEEHCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHEEEHCCCCCCHHHHHHHHHHHCEEEEEHCCCCCHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCHHHHHHHCCCEEEEEHCCCCHHHHHHHHHHHHCCCEEEEEHCHHHHHHHHHHHHHHHHHHCCCEEEHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEHCCCCCCEEEEHCCHHHHHHHHHHHCCCCCCCCHCCCCEEEEEEHCCCCCHHHHHCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQPSSSAVLLVAAFGAFLAFLDSTIVNVAFPDIQRHFHSDISDLSWMLNAYNIVFAAFLVAAGRLADLMGRKRVFILGVALFTVASGLCAIAESVGELVAFRVLQGIGAAVLVPASLGLVVEAFPAERRAHGVNLWGAAGAIAAGLGPPIGGALIEADGWRWVFLVNLPLGVFAVLAARRALVENRAAGRRRVPDVRGAVLLAFALGLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVMSSRHHPAPMVEPTLLRIQSFVAGTGLTAVASAGFYAYLLTHVLFLNYVWGYTLLEAGMAVAPAALVAAVVAAVLGRVADRHGYRFIVGIGALIWAASLLWYLKVVGSQPDFLGEWLPGQILQGIGVGATFPLLGSAALARLAKGGSYATASAVTGTIRQVGAVIGVAVLVILVGTPAPGAAEEALRHGWALAAICFVAVGIGALSLGRIRPVPAAVEPPPGPPVAPLGARRPPRPAPVASPAAAVAPTPKTSREVNLLEALRFARPDTQQIELQAGSYLFHAGDVSDALYVVRSGRLQVLAGDGAKDEVVAELGRGQVVGELGVLLDAPRSASVRAVRDSSLMRVTKAEFAKIADAGVLGALAGVLAKRQHQTRVASQRTTPEVVVAVVGVDANAPVAMVATELCRALSTRLRAVAPGRVDCDGLERAEQTADRVVLHAAVGDARWREFCLRVADRVVLVASNPAVPVAPLPTRATGADLVLAGRPAGREHRRAWEQLITPRSMHVVRREFVADDLRVLATRIAGRSVGLVLSGGAARACAHLGVLEELEAAGVTVDRFAGTSMGAIIAALAASGLDAAGVDAQIYEHFVRKSHGDYTLPSKGLIRGKRTQSTLRTIFGDHLVEELPKHFRCVSVDLLARRPVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVPVTTLVGKDGPLIAVNVASGGNPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEKVLAQADLVIKPNPIGVGLMEYHQIDRAREAGRIAAREALPQIMELVHG

3wdoA

0.16

0.07

0.42

1.43

MUSTER

-------------------------------DYKMTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA--IAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNRES--------------------------------------------------GMVKGSF--SKVLAEPRLLKLNFGIMCLHMLLMSTFVALPGQLADAGFPEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA------QTQFWQLVVGVQLFFVAFNLMEALLPSLISK-ESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMF-----------DGQGVFLAGAMLAAVWLAVASTMKEPPYVSSLRIEIPADIAA------------------------NEALKVRLLET--------------------------------------------------EG--VKEVLIAEEE---HSAYVKIDSKV--TNRFEVEQAIRQAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5dlqB

0.12

0.11

0.89

1.29

MUSTER

----AALGPPEVIAQAPPSMVSNEQRQHA-LSFRKSKSPFAVCRHILETDYVLFQAATAIMEAVVREWVLLEKGIESLRTFLLTYVLQRPNL------------KYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISSPTVQTLACSILTALLSEFSNCKRVFQEEDLRQIFMLTVGVLQEFSRENLSAQMSSVFQRYLALANQVLSWNFLPPTES--------WREALLDSRVMELFFTVHRKIREDS----------DMAQDSLQCLAQLAS-LHGPIFP-------DEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVPRNVLTAIPSELFSSFVNCL---THLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVRFTQHAVQVFNSYIQCHLAARDQFSDQLASVGMLGRIAAEHCMPLLTSLLEERV-TRLHGQLQRHNKMLDDLYEDIHWLILVTGYLLADDTQGETPLIPPESIKHSSEVDINTTLQILGSPGEKASSIPGYSRTDSVIRLLSAVLRVSEVE--SRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPLSTAFGADTEGSQWII--GYLLQKVISNLSVWSEQDLANDTVQLLVTLVERRERANLVIQCENWWNLAFASRSPPLNFLSSPVQRTLMKALVLGGFAHMDTEVLQPLQQRFLRVIFQQMCQQEEVKQEITATLEALCGIAEA-------TQIDNVAILFNFLM--------DFLNNCIGLMEVYKNTPETVNLIIEVFVEVAHKQICYL----GESKAMHLYEACLTLLQVYSKNEQYQDLLLIMELLTNLLSKVSAADVVLYGVNLILPLMSQDLLFPTLCNQYYKLITFICEIFPE--KIPQLPEDLF-----------------SLMYSLELGMT---------SMSSEVCQLCLLTPLTRHFLK----LVFDMLVLQNTEMTT-------------AAGEAFYTLVCLYQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASSRKQKMAFLKSLEEFMANVGG

4zowA

0.17

0.06

0.37

2.29

dPPAS

---------------------------------RLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIRESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLS--------------------------------LKELGRDYKLVLK-------------------NGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASD--MSKGTVSAAMGMLQMLIFTVGIEISKHAWL------NGGNGLFNLFNLVNGILWLSLMVIFLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3w3tA

0.10

0.09

0.88

1.28

MUSTER

FASDNQIRSV-WENNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAEWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDAVTAFVGYFKQLPKSEGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKLFKDMFDQIIQFTDMVIKN-PPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYL-QQMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKIL---MVIPLIN--PHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLT----SECTSRVQTHAAAALVNFSEKDILEPYLDSLLTNLLVLLQLYVQEQALTTIAFIAEAAKNKFIKYYDT--LMPLLLNVLKVNSVLKGKCMECATLIGFAVGKEKFHEHSQE---SILVALQNSDDDALRSYLEQSWSRICRILGDDFVPLLPIVIPPLLITAK---ATQDVGLIEEEE---------------AANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSA-MELL--QSYATLLRGQFAVYV-KEVMEEIALPSLDF----------------------YLHDGVRAAGATLIPILLSCLLAATEE--LVLLWHKASSKL--IGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANL----------TDTYERMQDR----YNEFTDEDLLDEINKSIAAVLKTT--GHYLKNLENIWPMINTFLLDNEPILV----IFALVVIGDLIQYEQTASMKNAFIPKVTECISPDARIRQAASYIIGVCAQYAPSTYAD-VCIPTLDTLVQIVDGSKLEENRSSTENASAAIAKILYAYDTYTANW------------FKTLPT----------------------------ITDKEAASFNYQFLSQLIENSNISAVVDSVIQA---LNERSLTVISSVKKLLGFLPSSDAMAIFNRYADIMEKVHK

3wdoA

0.16

0.07

0.42

2.44

wdPPAS

-------------------------------DYKMTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA--IAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNRE----------------------SGMV----------------------------------SKVLAEPRLLKLNFGIMCLHMLLMSTFVALPGQLADAGF-EHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA------QTQFWQLVVGVQLFFVAFNLMEALLPSLISK-ESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMF-----------DGQGVFLAGAMLAAVWLAVASTMKEPPYVSSLRIEIPADIAAN---------------------------EALKVRLLE------------------------------------------------EG--VKEVLIAEEE---HSAYVKIDSK--VTNRFEVEQAIRQAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3wajA

0.12

0.08

0.70

1.15

wMUSTER

----------------------------------------SVLVIAALISVKLRILN---------PWNSVFTWTVRLG--NDPWYYYRLIENTIHN---D-YGSYTHFPFLVYLGSIAGIIFSATSGESLRAVLAFIPAIGGVLAILPVYLLTREVF-----DKRAAVIAAFLIAIV---P---GQFLQRLGFNDHHIWEAFWQVSALGTFLLAYNRWKGHDLTARQ------MAYPVIAGITIGLYV---LSWGAGFIIAPIILAFMFFAFVLA--------------FVNADRKNLSLVAVVTFAVSALIYLPFAF---NYPGFSTIFYSPFQLLVLLGSAVIAAAFYQIEKWNDVGFFERVGLKGMPLAVIVLTALI---MGLFFVLTNAVLHFGALFFFGMAGILYSAYRFLKRRS-------------FPEMALLIWAIAMFIALWGQ----------NRFAYYFAAVSAVYSALALSVVFDKLHFRVAFALLIALAAIYPTYILADAQSSYAGGPNKQWYDALTWMRENTGEKYDEYYLQLYPTPQSNKEPFSYPFETYGVIS-------------------------G-IEAVAHRM----PIA--NP---------F--------------------QAGIGNKYNNVPGASSFFTAEN-----ESYAEFVAEKLNVKYVVSDI-EMETGKYYAMAVWAE--------GDLPLAEKYYG---GYFYYSPTGTFGYANSIPLNSIIIPLRIPSELYYSTMEAKLHLFDGSGYRMIYESDYPAEWKSYSSQVNLNN-------ESQVLQTALYEAVMRARYGVS------PTMGTQEVLYKYA---YTQLYEKKMGIPVKIAPSGYVK-IFERVKGAVVT-------GKVSANVTE---VSVNATIKQNRTFEYWQGTY------TVVLP--YSPVKPITPYHIKAGVVKTIYESQVQN--GEIIQLDL-----------------------------------------------------------------------------------------

3wdoA

0.17

0.07

0.42

1.53

wMUSTER

--------------------------------YKMTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA--IAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNRES--------------------------------------------------GMVKGSF--SKVLAEPRLLKLNFGIMCLHMLLMSTFVALPGQLADAGF-EHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA------QTQFWQLVVGVQLFFVAFNLMEALLPSLISK-ESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMF-----------DGQGVFLAGAMLAAVWLAVASTMKEPPYVSSLRIEIPADIAA------------------------NEALKVRLLET--------------------------------------------------EG--VKEVLIAEEE---HSAYVKIDSKV--TNRFEVEQAIRQAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3wdoA

0.16

0.07

0.42

2.13

wPPAS

-------------------------------DYKMTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA--IAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNRESG--------------------------------------------------MVKGSF--SKVLAEPRLLKLNFGIMCLHMLLMSTFVALPGQLADAGFPAHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA------QTQFWQLVVGVQLFFVAFNLMEALLPSLISK-ESPAGYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMF-----------DGQGVFLAGAMLAAVWLAVASTMKEPPYVSSLRIEIPADIAAN---------------------------EALKVRLLE------------------------------------------------EG--VKEVLIAEEE---HSAYVKIDSKV--TNRFEVEQAIRQAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4zowA

0.17

0.06

0.37

4.30

dPPAS2

---------------------------------RLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGYAAIRESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAISFFGLQRAMPETATRIGEKLS--------------------------------LKELGRDYKLVLK-------------------NGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASD--MSKGTVSAAMGMLQMLIFTVGIEISKHAWL------NGGNGLFNLFNLVNGILWLSLMVIFLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3wdoA

0.16

0.07

0.42

2.34

PPAS

-------------------------------DYKMTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALGASEALIGIAIGIYGLTQAVFQIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGA--IAAAVMALLSDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIWVVPNSSTHVLNRESG--------------------------------------------------MVKGSF--SKVLAEPRLLKLNFGIMCLHMLLMSTFVALPGQLADAGFPAHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNA------QTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPA-GYKGTAMGVYSTSQFLGVAIGGSLGGWIDGMF-----------DGQGVFLAGAMLAAVWLAVASTMKEPPYVSSLRIEIPADIAA------------------------NEALKVRLLET--------------------------------------------------EG--VKEVLIAEEE---HSAYVKIDSKV--TNRFEVEQAIRQAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.98

Estimated TM-score = 0.48±0.15

Estimated RMSD = 14.1±3.9Å

Download Model 2

C-score=-1.31

Download Model 3

C-score=-1.53

Download Model 4

C-score=-1.96

Download Model 5

C-score=-2.05

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wdoA	0.415	1.53	0.162	0.422
2	5c65A	0.346	3.58	0.122	0.377
3	4gbyA	0.342	3.88	0.123	0.378
4	4ybqA	0.339	3.97	0.105	0.376
5	4m64A	0.330	4.67	0.102	0.383
6	3o7pA	0.328	3.12	0.106	0.353
7	5aymA	0.322	3.32	0.123	0.349
8	4pypA	0.314	4.53	0.097	0.361
9	4zowA	0.312	4.33	0.166	0.356
10	4j05A	0.310	4.61	0.064	0.357

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	6	2gzwB	CMP	Rep, Mult	575,587,595,596,597,598,599,606,607,608,610,645,649
2	0.08	4	5c65B	Y01	Rep, Mult	94,300,304,308,433,436
3	0.04	2	3v2d2	MG	Rep, Mult	132,136
4	0.04	2	4zwbA	MAL	Rep, Mult	171,174,175,178,306,307,311,402,403,410,438
5	0.02	1	1n35A	CH1	Rep, Mult	96,103,108,109,149
6	0.02	1	1izlA	CLA	Rep, Mult	45,46
7	0.02	1	4fyiB	6C6	Rep, Mult	79,81
8	0.02	1	1n38A	CH1	Rep, Mult	93,94,98,99,100,149
9	0.02	1	3p2rB	FAH	Rep, Mult	424,425
10	0.02	1	3lw54	CLA	Rep, Mult	85,88
11	0.02	1	3g61A	0JZ	Rep, Mult	58,61,83
12	0.02	1	2bhwA	CLA	Rep, Mult	149,151
13	0.02	1	3c46A	2HP	Rep, Mult	155,166,167,168
14	0.02	1	1j59B	CMP	Rep, Mult	575,596,597,598,606,607,608,645,649
15	0.02	1	2rddA	AIC	Rep, Mult	438,439,440,441

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ti6A	0.221	8.46	0.073	0.330	1.97.1.2	52
2	0.060	2pffB	0.255	9.58	0.040	0.411	2.3.1.86	140,142
3	0.060	3gtgB	0.203	9.15	0.030	0.315	2.7.7.6	NA
4	0.060	2vz9B	0.218	9.60	0.050	0.354	2.3.1.85	NA
5	0.060	1t3tA	0.222	9.12	0.045	0.347	6.3.5.3	NA
6	0.060	3g61A	0.233	9.05	0.051	0.354	3.6.3.44	41
7	0.060	3ikmD	0.217	8.97	0.040	0.333	2.7.7.7	53,58
8	0.060	2vdcF	0.214	8.93	0.037	0.325	1.4.1.13	152
9	0.060	1fo4A	0.234	9.38	0.035	0.373	1.17.1.4	NA
10	0.060	2ckjA	0.224	9.24	0.038	0.354	1.17.1.4,1.17.3.2	NA
11	0.060	1z0hB	0.143	7.33	0.035	0.197	3.4.24.69	NA
12	0.060	3c46B	0.218	9.18	0.054	0.342	2.7.7.6	121
13	0.060	3b9jJ	0.117	6.51	0.061	0.152	1.17.1.4,1.17.3.2	NA
14	0.060	3b8eA	0.208	8.76	0.030	0.313	3.6.3.9	NA
15	0.060	1ti2A	0.221	8.38	0.068	0.328	1.97.1.2	NA
16	0.060	2vumB	0.191	9.33	0.028	0.304	2.7.7.6	155,423
17	0.060	1ea0A	0.214	9.45	0.038	0.342	1.4.1.13	NA
18	0.060	3b8eC	0.206	8.97	0.032	0.316	3.6.3.9	46,351
19	0.060	3ffzA	0.208	9.12	0.030	0.324	3.4.24.69	162

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.349	3.74	0.12	0.38	4zw9A	GO:0005215 GO:0005355 GO:0005536 GO:0005886 GO:0005887 GO:0005975 GO:0006810 GO:0008643 GO:0015758 GO:0016020 GO:0016021 GO:0019852 GO:0022857 GO:0022891 GO:0033300 GO:0055056 GO:0055085 GO:0070062 GO:0070837 GO:1904659
1	0.06	0.346	4.15	0.11	0.39	4ybqB	GO:0003044 GO:0005215 GO:0005353 GO:0005355 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0015755 GO:0015758 GO:0016020 GO:0016021 GO:0016324 GO:0022857 GO:0022891 GO:0042383 GO:0055085 GO:0070061 GO:0071332 GO:1904659 GO:1990539
2	0.06	0.342	3.88	0.12	0.38	4gbyA	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0015293 GO:0015519 GO:0015753 GO:0016020 GO:0016021 GO:0022857 GO:0022891 GO:0055085
3	0.06	0.330	4.67	0.10	0.38	4m64A	GO:0005215 GO:0005886 GO:0006810 GO:0006814 GO:0008643 GO:0015293 GO:0016020 GO:0016021 GO:0055085
4	0.06	0.309	4.52	0.08	0.35	4yb9D	GO:0003044 GO:0005215 GO:0005353 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0009750 GO:0015755 GO:0016020 GO:0016021 GO:0016324 GO:0022857 GO:0022891 GO:0042383 GO:0055085 GO:0070061 GO:0071332 GO:1990539
5	0.06	0.313	4.33	0.10	0.36	4m64B	GO:0005215 GO:0005886 GO:0006810 GO:0006814 GO:0008643 GO:0015293 GO:0016020 GO:0016021 GO:0055085
6	0.06	0.314	4.54	0.10	0.36	5eqgA	GO:0000139 GO:0001939 GO:0005215 GO:0005355 GO:0005622 GO:0005737 GO:0005829 GO:0005886 GO:0005887 GO:0005901 GO:0005911 GO:0005989 GO:0006461 GO:0006810 GO:0006970 GO:0008643 GO:0015758 GO:0016020 GO:0016021 GO:0016323 GO:0016324 GO:0019852 GO:0019900 GO:0022857 GO:0022891 GO:0030496 GO:0030864 GO:0031982 GO:0033300 GO:0042149 GO:0042470 GO:0042802 GO:0042908 GO:0042910 GO:0043621 GO:0045121 GO:0050796 GO:0055056 GO:0055085 GO:0070062 GO:0070837 GO:0072562 GO:1904659
7	0.06	0.303	4.93	0.10	0.36	4ja4A	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0015293 GO:0015519 GO:0015753 GO:0016020 GO:0016021 GO:0022857 GO:0022891 GO:0055085
8	0.06	0.311	4.52	0.17	0.36	4zp0A	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015385 GO:0015386 GO:0016020 GO:0016021 GO:0030641 GO:0035725 GO:0046677 GO:0055085 GO:0071805
9	0.06	0.310	4.61	0.06	0.36	4j05A	GO:0005215 GO:0016020 GO:0016021 GO:0022857 GO:0055085
10	0.06	0.302	4.98	0.08	0.36	4ldsA	GO:0005215 GO:0006810 GO:0016020 GO:0016021 GO:0022857 GO:0022891 GO:0055085
11	0.06	0.290	4.31	0.10	0.33	4m64D	GO:0005215 GO:0005886 GO:0006810 GO:0006814 GO:0008643 GO:0015293 GO:0016020 GO:0016021 GO:0055085
12	0.06	0.291	5.85	0.10	0.36	2cfpA	GO:0005351 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0015293 GO:0015528 GO:0015767 GO:0015992 GO:0016020 GO:0016021 GO:0030395 GO:0055085
13	0.06	0.278	5.26	0.09	0.34	2gfpA	GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0015893 GO:0016020 GO:0016021 GO:0055085
14	0.06	0.158	6.81	0.05	0.21	5i1mV	GO:0000220 GO:0000324 GO:0000329 GO:0005773 GO:0005774 GO:0006461 GO:0006797 GO:0006810 GO:0006811 GO:0007035 GO:0015078 GO:0015986 GO:0015991 GO:0015992 GO:0016020 GO:0016021 GO:0016049 GO:0033179 GO:0046961 GO:0051117 GO:0070072
15	0.06	0.169	7.97	0.06	0.24	2d0oA	GO:0000166 GO:0005524 GO:0046872
16	0.06	0.135	7.34	0.06	0.19	4jevB	GO:0003824 GO:0003992 GO:0005737 GO:0005829 GO:0006520 GO:0006525 GO:0006526 GO:0008483 GO:0008652 GO:0009016 GO:0009085 GO:0009089 GO:0016740 GO:0030170 GO:0042802
17	0.06	0.119	6.69	0.05	0.16	1pquA	GO:0003942 GO:0004073 GO:0005737 GO:0006520 GO:0008652 GO:0009085 GO:0009086 GO:0009088 GO:0009089 GO:0009097 GO:0016491 GO:0016620 GO:0019877 GO:0046983 GO:0050661 GO:0051287 GO:0055114 GO:0071266
18	0.06	0.116	6.48	0.06	0.15	3kexA	GO:0000165 GO:0000166 GO:0003197 GO:0004672 GO:0004713 GO:0004888 GO:0005088 GO:0005524 GO:0005576 GO:0005615 GO:0005622 GO:0005886 GO:0005887 GO:0006468 GO:0007162 GO:0007165 GO:0007169 GO:0007422 GO:0007507 GO:0009968 GO:0014037 GO:0014065 GO:0014066 GO:0014068 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016323 GO:0016324 GO:0016328 GO:0016740 GO:0018108 GO:0019838 GO:0021545 GO:0030296 GO:0038128 GO:0038132 GO:0042060 GO:0042127 GO:0042802 GO:0042803 GO:0043235 GO:0043524 GO:0043547 GO:0046854 GO:0046934 GO:0046982 GO:0048015 GO:0051048 GO:0051402 GO:0061098 GO:0070886 GO:0097192 GO:2000145

Consensus prediction of GO terms

Molecular Function	GO:0022892
GO-Score	0.46
Biological Processes	GO:0044763	GO:0071702	GO:0044765
GO-Score	0.56	0.56	0.56
Cellular Component	GO:0031226
GO-Score	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.