I-TASSER results

I-TASSER results for job id Rv3707c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (336 residues)
MLRIGPTAGTGTPTGDYGIGATDLCEFVEFPSQLLQVCGDSFAGQGVGFGGWYAPVALHV
DTESIDDPAGVRYTGVTGVGTPLLADPTPPGDSQLPAGVVQINRRNYLMVTTTKDLQPQN
SRLVRAEAARGGWQTVSGSRRNAAYQDGRQTQISGYYDPVPTPDSPTGWVYIVADSFTRG
EPAVLYRATPESFTDRSRWQGWAGGPDGGWNKPPTPLWPDQLGEMSIRQIDGQTVLSYFN
ASTGNMEVRVAHHPTSLGAAPVTTVVRHDEWPEPAESLPPPYDNRLAQPYGGYISPGSTI
DELRIFVSQWDTRARQNGPYRVIQFAVNPFKPWSDP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLRIGPTAGTGTPTGDYGIGATDLCEFVEFPSQLLQVCGDSFAGQGVGFGGWYAPVALHVDTESIDDPAGVRYTGVTGVGTPLLADPTPPGDSQLPAGVVQINRRNYLMVTTTKDLQPQNSRLVRAEAARGGWQTVSGSRRNAAYQDGRQTQISGYYDPVPTPDSPTGWVYIVADSFTRGEPAVLYRATPESFTDRSRWQGWAGGPDGGWNKPPTPLWPDQLGEMSIRQIDGQTVLSYFNASTGNMEVRVAHHPTSLGAAPVTTVVRHDEWPEPAESLPPPYDNRLAQPYGGYISPGSTIDELRIFVSQWDTRARQNGPYRVIQFAVNPFKPWSDP
Prediction	CCCHCCCCCCCCCCCCCCCCCCCCEEEEHCCCEEEEEHCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCEEEHCCEEEHCCEEEEEEEEHCCCCCCCEEEEEHCCCCCCEEHCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCEEEEEHCCCCCCCCEEEEEHCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCEEEEEEHCCCCCCEEEEHCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCEEEEEEHCCCCCCCCC
Conf.Score	985456789998766668765554578775998999995789999999998877589997579988876566588888765556888899856665667998998999999976888876699999699986677688756888888876544344555554457898699996889999877999878788798555778888998888889865557997567899989989999886999968999869999999888578766788888877778888887777666655899888848999998589988998866899997688898899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLRIGPTAGTGTPTGDYGIGATDLCEFVEFPSQLLQVCGDSFAGQGVGFGGWYAPVALHVDTESIDDPAGVRYTGVTGVGTPLLADPTPPGDSQLPAGVVQINRRNYLMVTTTKDLQPQNSRLVRAEAARGGWQTVSGSRRNAAYQDGRQTQISGYYDPVPTPDSPTGWVYIVADSFTRGEPAVLYRATPESFTDRSRWQGWAGGPDGGWNKPPTPLWPDQLGEMSIRQIDGQTVLSYFNASTGNMEVRVAHHPTSLGAAPVTTVVRHDEWPEPAESLPPPYDNRLAQPYGGYISPGSTIDELRIFVSQWDTRARQNGPYRVIQFAVNPFKPWSDP
Prediction	734104011344334311010000000022541000000000225425343000000000224424312203133343323410355345220100000000433100000001302343000020144243043344332224344132111222332233353630000000022414110000103365153352002112343142453000015241000001325320000000244210000004406334344333113314134443432444543111000000002132420000000011445441200000010343524768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHCCCCCCCCCCCCCCCCCCCCEEEEHCCCEEEEEHCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCEEEHCCEEEHCCEEEEEEEEHCCCCCCCEEEEEHCCCCCCEEHCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCEEEEEHCCCCCCCCEEEEEHCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCEEEEEEHCCCCCCEEEEHCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCEEEEEEHCCCCCCCCC
MLRIGPTAGTGTPTGDYGIGATDLCEFVEFPSQLLQVCGDSFAGQGVGFGGWYAPVALHVDTESIDDPAGVRYTGVTGVGTPLLADPTPPGDSQLPAGVVQINRRNYLMVTTTKDLQPQNSRLVRAEAARGGWQTVSGSRRNAAYQDGRQTQISGYYDPVPTPDSPTGWVYIVADSFTRGEPAVLYRATPESFTDRSRWQGWAGGPDGGWNKPPTPLWPDQLGEMSIRQIDGQTVLSYFNASTGNMEVRVAHHPTSLGAAPVTTVVRHDEWPEPAESLPPPYDNRLAQPYGGYISPGSTIDELRIFVSQWDTRARQNGPYRVIQFAVNPFKPWSDP

4g1eA

0.10

0.92

1.03

MUSTER

PIEFDATGNRDYAKDDPLEFKSHFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTV---EYAPCRSQDIDADGQGFCQGGFSIDFTK----ADRVLLGGP---GSFYWQGQLISDQVAEIVSKYDPNVYSIKYNN-----QLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVP--RAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATD-------INGDDYADVFIGAPLFMDRGSDGKLQVSVSLQRASGDFQTTKLNGFEVFARFGSAIADLDQDGFNDIAIAAPYGGEDKKG--IVYIFNGRSTGLNAVP

3c7gA1

0.09

0.94

1.77

dPPAS

TSTTIAKHIGNSNPLIDHHLGADPVALTYNGRVYIYMSSDDYEYNSNGFANLNRVFVISSADMVNWTDHGAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFAN-SGGGIGVLTADSPIGPWTDPIGKPLVTPSTPGMSGV-VWLFDPAVFVDDDGTGYLYAGGGVPGVSNPT---QGQWANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFN--------------FKNEWYVVYHAQSALFGAGKGYRSPHINKLVHNADGSI

4hbsA

0.12

0.11

0.92

2.51

wdPPAS

LPNRSGQYWK---TRSLGWNGGDGVFTTGLDGNIFWSFNDSFYGVINENRSFPRNSIVQTPGEDPNADRYYQVRTHIRHPKATLSGEIDQDYLYWAGDATIYNNQQLWGAVDNTDLRRFGTCLATYSLEGKPGDATYKLISRNDNFNDHT------LGYGDTWEDEDGHIYLYTTS---NYKVAVARTATRDLG--SQWEYYVADPWTTQYPSTQDASTIIPLESACSPWVFKKTYYIGQSWFGRDVLFRSKHPYGPFVDQKTLFTLPEFLD--------KIGEQRYQHVYVNIHP-SRTGELVISTNT-FNAPGSADFYRPYFYRV-LYD-NDAP

4hbsA

0.14

0.12

0.92

1.23

wMUSTER

VFKYNALF-----TRSLGWNGGDGVFTTGLPGNIFWSFNDSFYGVINENRSFPRNSIVQTPGEKDADRYYQVRTHIRHPKATLSDGEIDQDYLYWAGDATIYNNQQLWGAVDNTDLRRFGTCLATYSLEGKP------GDATYKLISRNDNFNDHTLGYGDTWEDEDGHIYLYTTS---NYKVAVARTATRDLG--SQWEYYVADSWTTQYPSTSTIIPLESACSPWVFKKGDTYYIGQS-WFGRDVLFRSKHPYGPFVDQKTLFTLPEFLD--------KIGEQRYQHVYVNIHPASRTGELVISTNT-DCAPGSADFYRPYFYRV-LYD-NDAP

4hbsA

0.12

0.11

0.92

1.80

wPPAS

VKELPNRSGQYWKTRSLGWNGGDGVFTTGLPGNIFWSFNDSFENRSRGNCSFPRNSIVQTPTNDPNADRYYQVRTHIRHPKATLSGEIDQDYLYWAGDATIYNNQQLWGAVDNTDLRRFGTCLATYSLEGKPGDATYKLISRNDNFNDHTLGYG------DTWEDEDGHIYLYTTSNYK---VAVARTATRDLG--SQWEYYVADSWTTQYPSTQDASTIIPLESACSPWVFKKTYYIGQSWFGRDVLFRSKHPYGPFVDQKTLFTLPEFLD--------KIGEQRYQHVYVNIHP-SRTGE--LVIST-DCSPGSADFYRPYFYRV-LYD--DAP

4hbsA

0.13

0.11

0.83

2.27

dPPAS2

LP----------------------------DGNIFWSFNDSFENRSRGNCSFPRNSIVQTPTNDPNADRYYQVRTHIRHPKATLSGEIDQDYLYWAGDATIYNNQQLWGAVDNTDLRRFGTCLATYS--------LEGKPGDATYKLISRNDNFNDHTLGDTWEDEDGHIYLYTTS---NYKVAVARTATRDLG--SQWEYYVADPQGHFTQYPSTIIPLESACSPWVFKKGDTYYIGQS-WFGRDVLFRSKHPYGPFVDQKTLFTLPEFLDKIGEQRYQSRTGEL---------------VISTNTDCSNNAPGSADFYRPYFYRVFLYD-NDAP

4hbsA

0.12

0.11

0.93

1.34

PPAS

LPNRSGQYWKVFVTRSLGWNGGDGVFTTGLPGNIFWSFNDSFENRSRGNCSFPRNSIVQTPTNDPNADRYYQVRTHIRHPKATLSGEIDQDYLYWAGDATIYNNQQLWGAVDNTDLRRFGTCLATYSLEGKPGDATYKLISRNDNFNDHT------LGYGDTWEDEDGHIYLYTTSNYK---VAVARTATRDLG--SQWEYYVADPQGHFSTQYPSIIPLESACSPWVFKKGDTYYIGQS-WFGRDVLFRSKHPYGPFVDQKTLFTLPEFLDKI--------GEQRYQHVYVNIHP-SRTGVISTNTDCSNNAPGSADFYRPYFYRV-LYDN-DAP

4hbsA

0.12

0.11

0.94

1.76

Env-PPAS

LPNRSGQYWKALFTRSLGWNGGDGVFTTGLPGNIFWSFNDSFENRSRGNCSFPRNSIVQTPTNDPNADRYYQVRTHIRHPKATLSGEIDQDYLYWAGDATIYNNQQLWGAVDNTDLRRFGTCLATYSLEGKPGDATYKLISRNDNFNDHT------LGYGDTWEDEDGHIYLYTTSNYK---VAVARTATRDLG--SQWEYYVADPQGHFSTQYPSIIPLESACSPWVFKKGDTYYIGQS-WFGRDVLFRSKHPYGPFVDQKTLFTLPEFLDK--------IGEQRYQHVYVNIHPALSRTVISTNTDCSNNAPGSADFYRPYFYRVFNWESLDAP

4g1eA1

0.10

0.09

0.93

1.02

MUSTER

PIEFDATGNRDYAKDDPLEFKSHFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGT----KTVEYAPCRSQDIDADGQGFCQGGF---SIDFTKADRVLLGGPGSFYWQ----GQLISDQVAEIVSKYDPNVYSIKYNN----QLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVP--RAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATD-------INGDDYADVFIGAPLFDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVP

2jkbA3

0.08

0.07

0.91

1.61

dPPAS

-FQLIFQSGDSTQANYFRI-----PTLYTLSSGRVLSSIDARYGGTHDSKSKINIATSYSDDNGKTWSEPIFAMKFNDYEEQLVYWPRISGSASFIDSSIVESGKTILLADVMPAGIGNNIAMTTSQNRGESW--EQFKLLPPFLGEKHNGTYLCPGQGLALKSSNRLIFATYT-----SGELTYLISD-------------DSGQTWKKSSASIP-FKNATAEAQMVELRDGVIRTFFRTTTGKIAYMTSRDSGETWSKVSYIDGIQQTSYGTQVSAIKYSQLIDGKEAVILSTPNSRSGRKGGQLVVGLVNKEDDS---IDWKYHYDIDLPSYG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.06

Estimated TM-score = 0.58±0.14

Estimated RMSD = 8.8±4.6Å

Download Model 2

C-score=-3.55

Download Model 3

C-score=-2.55

Download Model 4

C-score=-2.16

Download Model 5

C-score=-3.65

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4hbsA	0.791	3.10	0.135	0.923
2	2yfrA	0.679	3.77	0.107	0.848
3	3bykA	0.670	4.02	0.047	0.848
4	1w18B	0.668	4.37	0.077	0.869
5	3vsrA	0.667	4.46	0.085	0.875
6	3c7gA	0.665	4.12	0.068	0.845
7	4d47A	0.651	4.07	0.078	0.833
8	5annA	0.648	3.93	0.085	0.827
9	3sc7X	0.644	3.75	0.070	0.798
10	5a8cA	0.643	3.87	0.074	0.801

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	6	1s18A	CA	Rep, Mult	25,26,97,159,226,293
2	0.07	4	3gvkB	UUU	Rep, Mult	226,227,228,230,234,235,236,237
3	0.07	4	1gyeB	AHR	Rep, Mult	21,22,39,40,93,320
4	0.04	2	3mbrX	CA	Rep, Mult	27,226,227,228,295
5	0.02	1	2qquA	ZN	Rep, Mult	38,40,95
6	0.02	1	2vk6A	MG	Rep, Mult	207,258
7	0.02	1	3a9gA	TRE	Rep, Mult	191,195
8	0.02	1	3qqzA	CA	Rep, Mult	96,308
9	0.02	1	3qefB	AHR	Rep, Mult	116,240,290,291
10	0.02	1	1b3aA	AOP	Rep, Mult	289,290
11	0.02	1	3o1jC	IPA	Rep, Mult	195,202,238
12	0.02	1	1cq1A	CA	Rep, Mult	203,204,205,207,251
13	0.02	1	3hzbA	CA	Rep, Mult	19,40
14	0.02	1	3gvjA	UUU	Rep, Mult	23,25,36,58
15	0.02	1	2x8sB	AHR	Rep, Mult	115,117,118,176,177,178,220,224
16	0.02	1	2tnfA	IPA	Rep, Mult	236,290

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.124	1gydB	0.614	3.89	0.068	0.771	3.2.1.99	171
2	0.081	1pjxA	0.541	4.40	0.093	0.717	3.1.8.2	NA
3	0.079	1uv4A	0.608	3.70	0.090	0.759	3.2.1.99	NA
4	0.067	2xcyA	0.616	4.71	0.086	0.833	3.2.1.18	122,155,157
5	0.067	1rwlA	0.513	3.82	0.105	0.649	2.7.11.1	28
6	0.067	2iwaA	0.531	3.85	0.048	0.670	2.3.2.5	162,249
7	0.067	2fpcA	0.556	4.21	0.074	0.723	4.3.3.2	116
8	0.067	1vcuB	0.606	4.68	0.077	0.821	3.2.1.18	NA
9	0.066	1simA	0.602	4.84	0.062	0.839	3.2.1.18	295
10	0.066	2f10A	0.600	4.71	0.072	0.816	3.2.1.18	NA
11	0.066	1v04A	0.570	4.13	0.079	0.735	3.1.1.2,3.1.8.1	NA
12	0.066	2uvkB	0.561	4.45	0.075	0.741	5.1.3.-	97,102,107
13	0.066	2h2nA	0.535	4.02	0.078	0.676	3.6.1.6	91,118
14	0.066	3dr2A	0.510	4.07	0.080	0.652	3.1.1.17	NA
15	0.060	1eurA	0.597	4.67	0.078	0.809	3.2.1.18	140
16	0.060	1ncaN	0.586	4.93	0.063	0.821	3.2.1.18	NA
17	0.060	3gvjA	0.629	4.72	0.060	0.848	3.2.1.129	100,103,134
18	0.060	1y4wA	0.641	3.88	0.071	0.812	3.2.1.80	NA
19	0.060	1eutA	0.581	5.05	0.049	0.804	3.2.1.18	NA
20	0.060	3h71B	0.604	5.16	0.074	0.854	3.2.1.18	NA
21	0.060	1w18B	0.668	4.37	0.077	0.869	2.4.1.10	231
22	0.060	2aeyA	0.633	4.22	0.081	0.821	3.2.1.80	NA
23	0.060	1oygA	0.670	3.96	0.047	0.845	2.4.1.10	NA
24	0.060	1st8A	0.633	4.25	0.077	0.824	3.2.1.80	NA
25	0.060	1a4gA	0.610	4.47	0.064	0.816	3.2.1.18	NA
26	0.060	2jkbA	0.614	4.89	0.065	0.848	3.2.1.18,4.2.2.15	NA
27	0.060	1s0kA	0.611	4.32	0.040	0.809	3.2.1.18	199
28	0.060	1yifA	0.629	4.02	0.096	0.798	3.2.1.37	107
29	0.060	1cvmA	0.585	4.53	0.067	0.774	3.1.3.8	126
30	0.060	2vsmA	0.595	5.17	0.082	0.842	3.2.1.18	177
31	0.060	1yrzA	0.629	4.07	0.096	0.804	3.2.1.37	227
32	0.060	1sllA	0.602	4.85	0.070	0.827	4.2.2.15	242
33	0.060	1usrA	0.586	5.01	0.080	0.821	3.2.1.18	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.17	0.606	4.17	0.07	0.78	3p2nA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0033954 GO:0102253 GO:0102254 GO:0102256
1	0.10	0.679	3.77	0.11	0.85	2yfrA	GO:0005576 GO:0005618 GO:0005975 GO:0009758 GO:0016740 GO:0016757 GO:0046872 GO:0047725 GO:0050053
2	0.09	0.663	4.53	0.09	0.88	3wpuA	GO:0009758 GO:0050053
3	0.09	0.531	3.85	0.05	0.67	2iwaA	GO:0016603 GO:0016740 GO:0016746 GO:0046872
4	0.09	0.669	3.96	0.05	0.85	3om2A	GO:0009758 GO:0016740 GO:0016757 GO:0046872 GO:0050053
5	0.09	0.668	4.37	0.08	0.87	1w18B	GO:0005576 GO:0009758 GO:0016740 GO:0016757 GO:0050053
6	0.09	0.670	4.02	0.05	0.85	3byjA	GO:0005576 GO:0009758 GO:0016740 GO:0016757 GO:0050053
7	0.08	0.556	3.60	0.06	0.68	3qqzA	GO:0016020 GO:0016021
8	0.07	0.621	3.90	0.07	0.78	1gyhA	GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031222 GO:0046558 GO:0046872
9	0.07	0.533	3.66	0.10	0.66	3mbrX	GO:0016740 GO:0046872
10	0.07	0.533	3.77	0.09	0.66	3nolA	GO:0016020 GO:0016021 GO:0016740
11	0.07	0.521	3.78	0.06	0.65	3nokA	GO:0016603 GO:0046872
12	0.07	0.557	5.18	0.06	0.80	4unmB	GO:0016020 GO:0016021 GO:0046872
13	0.06	0.436	6.24	0.08	0.70	1hn0A	GO:0003824 GO:0005576 GO:0005975 GO:0016829 GO:0016837 GO:0030246 GO:0034000 GO:0042597 GO:0046872
14	0.06	0.338	6.41	0.06	0.55	2y6eB	GO:0000244 GO:0004843 GO:0005634 GO:0005737 GO:0005764 GO:0005886 GO:0006508 GO:0006511 GO:0008233 GO:0008234 GO:0016579 GO:0016787 GO:0031397 GO:0031647 GO:0031685 GO:0034394 GO:0036459 GO:0042802 GO:0046872
15	0.06	0.303	6.88	0.06	0.54	2h84A	GO:0003824 GO:0004871 GO:0005622 GO:0007165 GO:0008152 GO:0009813 GO:0010628 GO:0010629 GO:0016210 GO:0016491 GO:0016740 GO:0016746 GO:0019505 GO:0030639 GO:0031149 GO:0031152 GO:0043327 GO:0043949 GO:0044671 GO:0048837 GO:0055114
16	0.06	0.311	6.55	0.04	0.52	2bcgG	GO:0005092 GO:0005093 GO:0005096 GO:0005737 GO:0006810 GO:0007264 GO:0015031 GO:0016192 GO:0016491 GO:0043547 GO:0050790 GO:0055114
17	0.06	0.282	6.99	0.06	0.50	1v33A	GO:0003896 GO:0003899 GO:0006260 GO:0006269 GO:0016740 GO:0016779 GO:0046872 GO:1990077
18	0.06	0.227	6.98	0.05	0.40	3hvnA	GO:0009405 GO:0015485
19	0.06	0.257	7.45	0.04	0.48	1g71A	GO:0003896 GO:0003899 GO:0006260 GO:0006269 GO:0016740 GO:0016779 GO:0046872 GO:1990077
20	0.06	0.269	5.18	0.07	0.39	3mh9A	GO:0005576 GO:0005618 GO:0005886 GO:0006810 GO:0006869 GO:0008289 GO:0009405 GO:0016020 GO:0035091 GO:0046677 GO:0051861 GO:0097691
21	0.06	0.253	7.11	0.04	0.45	3rtkA	GO:0000166 GO:0001666 GO:0005524 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006457 GO:0009408 GO:0040007 GO:0042026 GO:0044406 GO:0051082
22	0.06	0.235	5.43	0.07	0.35	1ncwH
23	0.06	0.238	5.64	0.04	0.36	2gpyB	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0016758	GO:0043169	GO:0004553
GO-Score	0.51	0.51	0.34
Biological Processes	GO:0044699	GO:0044238	GO:0071704
GO-Score	0.45	0.43	0.41
Cellular Component	GO:0005618	GO:0005576
GO-Score	0.10	0.10

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.