I-TASSER results

I-TASSER results for job id Rv3701c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (321 residues)
MRVSVANHLGEDAGHLALRRDVYSGLQKTPKSLPPKWFYDTVGSELFDQITRLPEYYPTR
AEAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDALRHRGSLRRFVPFDVDASVLS
ATATAIQREYSGVEINAVCGDFEEHLTEIPRGGRRLFVFLGSTIGNLTPGPRAQFLTALA
GVMRPGDSLLLGTDLVKDAARLVRAYDDPGGVTAQFNRNVLAVINRELEADFDVDAFQHV
ARWNSAEERIEMWLRADGRQRVRVGALDLTVDFDAGEEMLTEVSCKFRPQAVGAELAAAG
LHRIRWWTDEAGDFGLSLAAK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRVSVANHLGEDAGHLALRRDVYSGLQKTPKSLPPKWFYDTVGSELFDQITRLPEYYPTRAEAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDALRHRGSLRRFVPFDVDASVLSATATAIQREYSGVEINAVCGDFEEHLTEIPRGGRRLFVFLGSTIGNLTPGPRAQFLTALAGVMRPGDSLLLGTDLVKDAARLVRAYDDPGGVTAQFNRNVLAVINRELEADFDVDAFQHVARWNSAEERIEMWLRADGRQRVRVGALDLTVDFDAGEEMLTEVSCKFRPQAVGAELAAAGLHRIRWWTDEAGDFGLSLAAK
Prediction	CEEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHHCCCEEEEEEHCCHHHHHHHHHHHHHHCCCCEEEEEHCCCCHHHHHCCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHCCCCCEEEEEEEHCCCEEEEHCCCCCEEEHCCCEEEEEEEEHCCCHHHHHHHHHHHCCEEEEEEHCCCCCEEEEEEHC
Conf.Score	967887657876678999999999975899988845546768999999999898878748999999999999999869985999689997799999999999799869999978999999999999998999689999756655666578889859998798767899999999999999997999779999867888889998757988767999999999999998899985447999998688988999999856689998469967997799689999875799999999999989989999978999789999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRVSVANHLGEDAGHLALRRDVYSGLQKTPKSLPPKWFYDTVGSELFDQITRLPEYYPTRAEAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDALRHRGSLRRFVPFDVDASVLSATATAIQREYSGVEINAVCGDFEEHLTEIPRGGRRLFVFLGSTIGNLTPGPRAQFLTALAGVMRPGDSLLLGTDLVKDAARLVRAYDDPGGVTAQFNRNVLAVINRELEADFDVDAFQHVARWNSAEERIEMWLRADGRQRVRVGALDLTVDFDAGEEMLTEVSCKFRPQAVGAELAAAGLHRIRWWTDEAGDFGLSLAAK
Prediction	441404422447434540251025003542240001000163005103400623720113102300462244104303532003122330400220041037354502000000035104401540374046040200000034005304753210000000000004272034004302610454120200122353342023002265221330021003202530435042730412030255431020102033514030433634030444130100101103272035005714041253031573200000046
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHHCCCEEEEEEHCCHHHHHHHHHHHHHHCCCCEEEEEHCCCCHHHHHCCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHCCCCCEEEEEEEHCCCEEEEHCCCCCEEEHCCCEEEEEEEEHCCCHHHHHHHHHHHCCEEEEEEHCCCCCEEEEEEHC
MRVSVANHLGEDAGHLALRRDVYSGLQKTPKSLPPKWFYDTVGSELFDQITRLPEYYPTRAEAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDALRHRGSLRRFVPFDVDASVLSATATAIQREYSGVEINAVCGDFEEHLTEIPRGGRRLFVFLGSTIGNLTPGPRAQFLTALAGVMRPGDSLLLGTDLVKDAARLVRAYDDPGGVTAQFNRNVLAVINRELEADFDVDAFQHVARWNSAEERIEMWLRADGRQRVRVGALDLTVDFDAGEEMLTEVSCKFRPQAVGAELAAAGLHRIRWWTDEAGDFGLSLAAK

4uy5A

0.71

0.70

0.98

3.00

MUSTER

-TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRLLD--ARDAELLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEWLRAR-TAQHVRVAALDLEVDFAAGEELT-EVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR

4uy5A

0.71

0.70

0.98

4.43

dPPAS

-TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRLLD--ARDAELLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEWLRAR-TAQHVRVAALDLEVDFAAGEELT-EVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR

4uy5A

0.71

0.69

0.98

4.33

wdPPAS

-TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRLLDARDAE--LLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEWLRA--TAQHVRVAALDLEVDFAAGEELT-EVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR

4uy5A

0.71

0.70

0.98

3.53

wMUSTER

-TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRLLD--ARDAELLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEWLRAR-TAQHVRVAALDLEVDFAAGEELT-EVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR

4uy5A

0.71

0.69

0.98

4.77

wPPAS

-TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRLLDARDAE--LLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEWLRA--TAQHVRVAALDLEVDFAAGEELT-EVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR

4uy5A

0.71

0.70

0.98

10.14

dPPAS2

-TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRLLD--ARDAELLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEWLRAR-TAQHVRVAALDLEVDFAAGEELT-EVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR

4uy5A

0.71

0.69

0.98

4.50

PPAS

-TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRLLDARDAE--LLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEWLRAR-TAQHVRVAALDLEVDFAAGEELT-EVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR

4uy5A

0.71

0.69

0.98

6.49

Env-PPAS

-TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRLLDARDAE--LLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEWLRAR-TAQHVRVAALDLEVDFAAGEELT-EVSCKFRPENVVAELAEAGLRQTHWWTDPAGDFGLSLAVR

3pfgA

0.18

0.13

0.73

1.02

MUSTER

----------------------------------PQADYSGEIAELYDLVHQGKGK-DYHREAADLAALVRRHSP--KAASLLDVACGTGMHLRHLAD------SFGTVEGLELSADMLAIARRRN----PDA--VLHHGDMRD----FSLGRRSAVTCMFSSIGHLAQAELDAALERFAAHVLPDGVVVVEPWWFPE--------------------------------NFTPGYVAAGTVEAGGTTVTRVSHSSREGEATRI-EVHYLVAGPDRGITHHEESHRFTREQYERAFTAAGLSVEFMPGGPSGR-GLFTGLP

3pfgA

0.17

0.12

0.73

1.22

dPPAS

----------------------------------PQADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHS---PKAASLLDVACGTGMHLRHLAD------SFGTVEGLELSADMLAIARRRNPD------AVLHHGDMRD---FSLGRRFSAVTCMFSSIGHLAQAELDAALERFAAHVLPDGVVVVEPWWFPE--------------------------------NFTPGYVAAGTVEAGGTTVTRVSHSSREGEATRI-EVHYLVAGPDRGITHHEESHRFTREQYERAFTAAGLSVEFMPGGPSGR-GLFTGLP

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.79

Estimated TM-score = 0.97±0.05

Estimated RMSD = 2.8±2.0Å

Download Model 2

C-score=-2.51

Download Model 3

C-score=-3.57

Download Model 4

C-score=-3.23

Download Model 5

C-score=-3.28

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4uy5A	0.973	0.75	0.722	0.984
2	1m6eX	0.580	3.88	0.090	0.729
3	5hyzA	0.569	3.84	0.105	0.710
4	5f2kA	0.567	3.98	0.142	0.723
5	2eg5E	0.557	3.73	0.104	0.689
6	4ckbA	0.552	4.21	0.063	0.707
7	2vdwA	0.551	4.15	0.082	0.704
8	4f3nA	0.548	4.53	0.093	0.720
9	1y8cA	0.546	3.32	0.076	0.654
10	2aoxA	0.545	3.65	0.074	0.670

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.26	14	4pioA	SAH	Rep, Mult	36,47,86,87,88,92,112,113,114,115,118,140,141,142,161,163
2	0.20	8	4pipD	TRP	Rep, Mult	37,38,47,56,161,163,166,206,213,216,282,284
3	0.07	4	1qzzA	SAM	Rep, Mult	37,86,87,88,113,114,140,141,142,160,162,166,167
4	0.02	1	4fs8A	CA	Rep, Mult	56,86
5	0.02	1	3jwgA	MG	Rep, Mult	86,160
6	0.02	1	1yz30	III	Rep, Mult	69,195,289,290,293,307,308

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.081	3hnrA	0.473	3.32	0.130	0.573	2.1.1.-	NA
2	0.071	2h11B	0.484	3.82	0.090	0.608	2.1.1.67	NA
3	0.067	2ex4A	0.513	3.59	0.152	0.629	2.1.1.-	165
4	0.066	2opbB	0.527	3.83	0.120	0.654	2.1.1.28	86,88,113,146
5	0.066	2iipA	0.538	3.71	0.123	0.664	2.1.1.1	36,86,88,115,141
6	0.066	3lccA	0.477	3.45	0.107	0.583	2.1.1.-	48,86,119,138
7	0.066	1xcjA	0.482	3.97	0.127	0.608	2.1.1.2	37,143
8	0.066	3bgdA	0.483	3.68	0.080	0.598	2.1.1.67	NA
9	0.066	2pxxA	0.452	3.62	0.155	0.554	3.4.24.71	NA
10	0.066	1ri5A	0.504	4.10	0.098	0.645	2.1.1.56	86
11	0.066	1ri1A	0.504	4.14	0.093	0.648	2.1.1.56	86,113
12	0.060	1im8A	0.523	3.60	0.158	0.651	2.1.1.-	NA
13	0.060	1kphC	0.508	4.25	0.087	0.660	2.1.1.79	40
14	0.060	1kpiA	0.505	4.39	0.115	0.660	2.1.1.79	NA
15	0.060	1tpyA	0.511	4.30	0.110	0.660	2.1.1.79	NA
16	0.060	2i62C	0.530	3.55	0.111	0.645	2.1.1.1	38,86,88,115,284
17	0.060	2ve5H	0.491	5.53	0.070	0.732	1.2.1.8	114,157,193,295
18	0.060	2qyoA	0.485	4.18	0.088	0.617	2.1.1.46	NA
19	0.060	2ve5A	0.492	5.48	0.070	0.729	1.2.1.8	NA
20	0.060	2aovA	0.541	3.72	0.074	0.670	2.1.1.8	86,91,116
21	0.060	1a4sA	0.490	5.47	0.053	0.720	1.2.1.8,1.2.1.3	NA
22	0.060	1wznA	0.529	3.46	0.127	0.642	2.1.1.-	NA
23	0.060	1wnbA	0.493	5.47	0.062	0.735	1.2.1.19,1.2.1.8	NA
24	0.060	1o01C	0.494	5.44	0.054	0.735	1.2.1.3	NA
25	0.060	2a14A	0.532	3.57	0.135	0.645	2.1.1.49	86,88,115,138,160
26	0.060	3fg0C	0.499	5.44	0.046	0.738	1.2.1.8	NA
27	0.060	3b4wA	0.496	5.35	0.048	0.729	1.2.1.-	NA
28	0.060	1wndA	0.493	5.41	0.050	0.732	1.2.1.19	NA
29	0.060	2fk8A	0.492	4.06	0.087	0.629	2.1.1.-	167
30	0.060	3i58A	0.522	3.41	0.127	0.626	2.1.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.69	0.980	0.91	0.74	1.00	4uy7A	GO:0006479 GO:0008168 GO:0008276 GO:0016740 GO:0030745 GO:0032259 GO:0052699 GO:0052704 GO:0052707
1	0.19	0.538	3.82	0.10	0.67	4kifB	GO:0008168 GO:0016740 GO:0017000 GO:0032259
2	0.13	0.522	3.79	0.13	0.66	3b5iA	GO:0000287 GO:0008168 GO:0009944 GO:0010252 GO:0016740 GO:0032259 GO:0042802 GO:0046872 GO:0051749
3	0.07	0.580	3.88	0.09	0.73	1m6eX	GO:0008168 GO:0016740 GO:0032259 GO:0046872
4	0.07	0.516	3.89	0.15	0.65	5cvdA	GO:0005634 GO:0005654 GO:0005737 GO:0006480 GO:0007051 GO:0007059 GO:0008168 GO:0008276 GO:0016740 GO:0018011 GO:0018012 GO:0018016 GO:0032259 GO:0035572 GO:0035573 GO:0071885
5	0.07	0.580	3.85	0.11	0.72	5hyzA	GO:0003700 GO:0005634 GO:0006351 GO:0006355 GO:0043565
6	0.07	0.567	3.98	0.14	0.72	5f2kA	GO:0008168 GO:0032259
7	0.07	0.479	3.84	0.08	0.60	4iv8A	GO:0000234 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
8	0.07	0.557	3.73	0.10	0.69	2eg5E	GO:0008168 GO:0009820 GO:0016740 GO:0032259
9	0.07	0.555	3.99	0.11	0.72	2efjA	GO:0008168 GO:0009820 GO:0016740 GO:0032259
10	0.07	0.501	4.02	0.10	0.64	3uj7A	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
11	0.07	0.468	3.46	0.13	0.57	3dliA
12	0.06	0.365	6.05	0.07	0.57	2y4oA	GO:0000166 GO:0003824 GO:0008152 GO:0010124 GO:0016874 GO:0046872 GO:0047475
13	0.06	0.305	7.06	0.05	0.55	1xtfA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
14	0.06	0.315	6.45	0.06	0.54	5ab5A	GO:0003824 GO:0008152 GO:0016747
15	0.06	0.298	6.28	0.05	0.49	2hx1A	GO:0046872
16	0.06	0.296	5.33	0.04	0.43	4m7tA	GO:0003824 GO:0016491 GO:0017000 GO:0046872 GO:0051536 GO:0051539 GO:0055114
17	0.06	0.299	6.74	0.04	0.52	2imcB	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
18	0.06	0.299	6.64	0.04	0.51	4dxbA	GO:0005215 GO:0005363 GO:0006810 GO:0006974 GO:0008643 GO:0008800 GO:0015768 GO:0016787 GO:0030288 GO:0030655 GO:0034289 GO:0042597 GO:0042956 GO:0043190 GO:0046677 GO:0055052 GO:0060326 GO:1901982 GO:1990060
19	0.06	0.286	5.09	0.04	0.40	4m7sA	GO:0003824 GO:0016491 GO:0017000 GO:0046872 GO:0051536 GO:0051539 GO:0055114
20	0.06	0.269	6.45	0.03	0.45	4v94B	GO:0000166 GO:0005524 GO:0005737 GO:0005832 GO:0006457 GO:0051082
21	0.06	0.269	6.97	0.04	0.47	3oftA	GO:0004497 GO:0005506 GO:0016491 GO:0016705 GO:0020037 GO:0046872 GO:0055114
22	0.06	0.341	6.81	0.05	0.58	3v0aA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806

Consensus prediction of GO terms

Molecular Function	GO:0008276	GO:0030745	GO:0043169
GO-Score	0.71	0.69	0.38
Biological Processes	GO:0052704	GO:0006479	GO:0052707	GO:0016999
GO-Score	0.69	0.69	0.69	0.37
Cellular Component	GO:0005737	GO:0005654
GO-Score	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.