I-TASSER results

I-TASSER results for job id Rv3700c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (390 residues)
MRRSGANSPAGDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHARHEAEVGGYV
AAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGSLHALDLLLGSWPGENRTLACLPGEYGP
NLAVMAAHGFDVRPLPTLQDGRVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQ
LCTELKLPLVVDAAQGLGHVDCAVGADVTYASSRKWIAGPRGVGVLAVRPELMERLRARL
PAPDWMPPLTVAQQLGFGEANVAARVGFSVALGEHLACGPQAIRARLAELGDIARTVLAD
VSGWRVVEAVDEPSAITTLAPIDGADPAAVRAWLLSQRRIVTTYAGVERAPLELPAPVLR
ISPHVDNTADDLDAFAEALVAATAATSGER

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRRSGANSPAGDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHARHEAEVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGSLHALDLLLGSWPGENRTLACLPGEYGPNLAVMAAHGFDVRPLPTLQDGRVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQLCTELKLPLVVDAAQGLGHVDCAVGADVTYASSRKWIAGPRGVGVLAVRPELMERLRARLPAPDWMPPLTVAQQLGFGEANVAARVGFSVALGEHLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLAPIDGADPAAVRAWLLSQRRIVTTYAGVERAPLELPAPVLRISPHVDNTADDLDAFAEALVAATAATSGER
Prediction	CCCCCCCCCCCHHHHHHHHHHCCCCCCEHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCHHHHHHHHHHCCCCCCEEEEHCCCCHHHHHHHHHHCCEEEEEHCCCCCCCCHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCEEEEHCHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCEEEEEEHCCCCCHHHHHHHHHHCCCCEEEHCCCCCCHHHHHCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	988778888878999999997999975655778888999999999999999757657999999999999999999999989996538985995689999999858999899996786566899999889689999769998889999999857899589999878888788777999999999989989997887777777656887899847788767899789987888998789988898887756655655678885899999999999999989899999999999999999985999999878888856899865799999999999997579789967765576665478589985457999999999999999999986779
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRRSGANSPAGDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHARHEAEVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGSLHALDLLLGSWPGENRTLACLPGEYGPNLAVMAAHGFDVRPLPTLQDGRVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQLCTELKLPLVVDAAQGLGHVDCAVGADVTYASSRKWIAGPRGVGVLAVRPELMERLRARLPAPDWMPPLTVAQQLGFGEANVAARVGFSVALGEHLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLAPIDGADPAAVRAWLLSQRRIVTTYAGVERAPLELPAPVLRISPHVDNTADDLDAFAEALVAATAATSGER
Prediction	655463542335610530174131042010000001242440040025006400010003003300520250052015106054610000110000000002002554100000200010001104634040310203750302163046104763000000000010100021043005103724000000000000203000000000000001011121000000154006504021021310441511310102022000000001003103722163025104400520261047154030202375310000002064110320112024432000000000000023320000000030014400320050044016305768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHHHHHHHCCCCCCEHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCHHHHHHHHHHCCCCCCEEEEHCCCCHHHHHHHHHHCCEEEEEHCCCCCCCCHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCEEEEHCHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCEEEEEEHCCCCCHHHHHHHHHHCCCCEEEHCCCCCCHHHHHCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHHCCC
MRRSGANSPAGDSLADRWRAARPPVAGLHLDSAACSRQSFAALDAAAQHARHEAEVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGSLHALDLLLGSWPGENRTLACLPGEYGPNLAVMAAHGFDVRPLPTLQDGRVALDDAAFMLADDPPDLVHLTVVASHRGVAQPLAMVAQLCTELKLPLVVDAAQGLGHVDCAVGADVTYASSRKWIAGPRGVGVLAVRPELMERLRARLPAPDWMPPLTVAQQLGFGEANVAARVGFSVALGEHLACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLAPIDGADPAAVRAWLLSQRRIVTTYAGVERAPLELPAPVLRISPHVDNTADDLDAFAEALVAATAATSGER

4lw2A

0.24

0.22

0.95

3.48

MUSTER

----------NVFNPAQFRAQFPALAGVYLDSAATALKPEAVVEATQQFYAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDKTIVWTRGTTESINMVAQCYAQPGDEIIVSVAEHHANLVPWLMV-AKVVKLPLNAQRLPDVDLLPELITP-RSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVDIDFYAFSGHKL-YGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRC--QDSSLLAFDF-AGVHHSDMVTLLAE-YGIALRAGQHCAQPLLAELGTLRASFAPYNTKSDVDALVNAVDRALELLV---

4lw2A

0.23

0.22

0.95

6.71

dPPAS

----------NVFNPAQFRAQFPALAGVYLDSAATALKPEAVVEATQQFYAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDKTIVWTRGTTESINMVAQCYAQPGDEIIVSVAEHHANLVPWLMVAAKVVKLPLNAQRLPDVDLLPELITP-RSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVDIDFYAFSGHKL-YGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRC--QDSSLLAFDF-AGVHHSDMVTLLAE-YGIALRAGQHCAQPLLAELGTLRASFAPYNTKSDVDALVNAVDRALELLV---

4lw2A

0.24

0.22

0.95

5.90

wdPPAS

----------NVFNPAQFRAQFPALAGVYLDSAATALKPEAVVEATQQFYAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDKTIVWTRGTTESINMVAQCYAQPGDEIIVSVAEHHANLVPWLMV-AKVVKLPLNAQRLPDVDLLPELITP-RSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVDIDFYAFSGHKL-YGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSFPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRC--QDSSLLAFDF-AGVHHSDMVTLLAE-YGIALRAGQHCAQPLLAELGTLRASFAPYNTKSDVDALVNAVDRALELLV---

4lw2A

0.24

0.22

0.95

4.05

wMUSTER

V-----------FNPAQFRAQFPALAGVYLDSAATALKPEAVVEATQQFYAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDKTIVWTRGTTESINMVAQCYAQPGDEIIVSVAEHHANLVPWLMV-AKVVKLPLNAQRLPDVDLLPELITP-RSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVDIDFYAFSGHKL-YGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRC--QDSSLLAFDF-AGVHHSDMVTLLAE-YGIALRAGQHCAQPLLAELGTLRASFAPYNTKSDVDALVNAVDRALELLV---

4lw2A

0.24

0.22

0.95

4.08

wPPAS

----------NVFNPAQFRAQFPALAGVYLDSAATALKPEAVVEATQQFYAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDKTIVWTRGTTESINMVAQCYAQPGDEIIVSVAEHHANLVPWLMV-AKVVKLPLNAQRLPDVDLLPELIT-PRSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVQIDFYAFSGHKL-YGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSFPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRC--QDSSLLAFDF-AGVHHSDMVTLLAE-YGIALRAGQHCAQPLLAELGTLRASFAPYNTKSDVDALVNAVDRALELLV---

4lw2A

0.23

0.22

0.95

7.03

dPPAS2

----------NVFNPAQFRAQFPALAGVYLDSAATALKPEAVVEATQQFYAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDKTIVWTRGTTESINMVAQCYAQPGDEIIVSVAEHHANLVPWLMVAAKVVKLPLNAQRLPDVDLLPELITP-RSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVDIDFYAFSGHKL-YGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSFPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRC--QDSSLLAFDF-AGVHHSDMVTLLAE-YGIALRAGQHCAQPLLAELGTLRASFAPYNTKSDVDALVNAVDRALELLV---

4lw2A

0.24

0.22

0.95

4.06

PPAS

----------NVFNPAQFRAQFPALAGVYLDSAATALKPEAVVEATQQFYAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDKTIVWTRGTTESINMVAQCYAQPGDEIIVSVAEHHANLVPWLMV-AKVVKLPLNAQRLPDVDLLPELITP-RSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVDIDFYAFSGHKL-YGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSFPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRC--QDSSLLAFDF-AGVHHSDMVTLLAE-YGIALRAGQHCAQPLLAELGTLRASFAPYNTKSDVDALVNAVDRALELLV---

4lw2A

0.23

0.22

0.95

5.86

Env-PPAS

----------NVFNPAQFRAQFPALAGVYLDSAATALKPEAVVEATQQFYAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDKTIVWTRGTTESINMVAQCYAQPGDEIIVSVAEHHANLVPWLMVAAKVVKLPLNAQRLPDVDLLPELITP-RSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVDIDFYAFSGHKL-YGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRC--QDSSLLAFDF-AGVHHSDMVTLLAE-YGIALRAGQHCAQPLLAELGTLRASFAPYNTKSDVDALVNAVDRALELLV---

4w91A

0.22

0.21

0.95

3.48

MUSTER

------------YDVEAIRRDFPILTLVYLDNGASAQKPQSVIDAVTHAYANEVHRGLHFLSNAATDAYEKSRETVRRFLNAGSDEIVFTKNATEAINTVAYGYGGEGDEILLSIMEHHSNIVPWHFI-AKLVFTPVDDNGVFHIEEFEKRLS-ERTKLVAITHMSNTLGTVVPIKKIVELAHARGIPVLVDGSQGAVHLPVDVGCDWYVFTGHV--YGPSGIGVLYGRAQMLEKMRPFQGGGEMIEEVTPPHRFEAGTPPIVQAIGLGAALEYMEKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAPDKGAIISFAL-EGIHAHDVSMVIDR-AGVAVRAGTHCAQPLLKRFSTCRASFALYNTRAEVDALAEALEKARKFFG---

4w91A

0.22

0.21

0.95

6.69

dPPAS

------------YDVEAIRRDFPILTLVYLDNGASAQKPQSVIDAVTHAYANEVHRGLHFLSNAATDAYEKSRETVRRFLNAGSDEIVFTKNATEAINTVAYGYGGEGDEILLSIMEHHSNIVPWHFIRAKLVFTPVDDNGVFHIEEFEKRLSE-RTKLVAITHMSNTLGTVVPIKKIVELAHARGIPVLVDGSQGAVHLPVDVGCDWYVFTGH--VYGPSGIGVLYGRAQMLEKMRPFQGGGEMIEEVHPPHRFEAGTPPIVQAIGLGAALEYMEKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAPDKGAIISFAL-EGIHAHDVSMVIDR-AGVAVRAGTHCAQPLLKRFGTCRASFALYNTRAEVDALAEALEKARKFFG---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 4 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.13

Estimated TM-score = 0.87±0.07

Estimated RMSD = 4.4±2.9Å

Download Model 2

C-score=-1.68

Download Model 3

C-score=-1.02

Download Model 4

C-score=-0.43

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4lw2A	0.927	1.25	0.232	0.951
2	1t3iA	0.889	2.23	0.199	0.946
3	5j8qA	0.888	2.27	0.202	0.946
4	1jf9A	0.886	2.20	0.208	0.941
5	4q75A	0.885	2.44	0.203	0.951
6	4w91A	0.882	2.29	0.208	0.941
7	3caiA	0.852	2.39	0.175	0.915
8	1n31A	0.832	2.64	0.159	0.913
9	5i90A	0.821	2.77	0.188	0.913
10	1p3wB	0.807	2.71	0.187	0.890

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.74	189	2ycnB	P61	Rep, Mult	92,93,94,97,118,120,167,192,194,195,212,214,215,360
2	0.19	61	1eqbA	GLY	Rep, Mult	33,118,167,195,215,360
3	0.03	12	2ch2C	KY1	Rep, Mult	33,34,118,343,346,360
4	0.02	8	4eb7B	PLP	Rep, Mult	258,259
5	0.02	6	3e9kA	3XH	Rep, Mult	34,118,195,214,215,360
6	0.01	4	3fz7A	PO4	Rep, Mult	92,93,94,212,214,215
7	0.01	3	1t3iA	2OS	Rep, Mult	137,138,139,141,305,307,352,353
8	0.01	3	3a9xB	PO4	Rep, Mult	34,118,215,347,348
9	0.00	1	2e7iB	SO4	Rep, Mult	60,274,278,283,367
10	0.00	2	3lvk0	III	Rep, Mult	29,31,34,35,37,38,43,47,50,51,52,91,94,95,98,101,119,120,123,127,221,222,240,241,242,256,258,259,261,263,264,342,343
11	0.00	1	1eluB	CSS	Rep, Mult	243
12	0.00	1	2e7iB	SO4	Rep, Mult	37,274,283,366
13	0.00	2	1n31A	CYS	Rep, Mult	56,243
14	0.00	1	4obvC	2SU	Rep, Mult	37,38,39,40,218,366
15	0.00	3	1pmoA	TRS	Rep, Mult	36,38,40,43,218,219,220,271
16	0.00	1	1pmoA	TRS	Rep, Mult	86,87,88,233,238,254,255,256
17	0.00	2	2e7jA	SO4	Rep, Mult	60,274,278,281
18	0.00	2	4r2nC	PHE	Rep, Mult	94,118,119,120,345
19	0.00	1	3kgxA	MG	Rep, Mult	293,297,373
20	0.00	1	1eluA	PDA	Rep, Mult	56,243,258,259

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.407	1pffA	0.642	3.13	0.122	0.736	4.4.1.11	118,192,215
2	0.397	1p3wA	0.808	2.69	0.187	0.890	2.8.1.7,4.4.1.-	192,215
3	0.382	1i29A	0.886	2.20	0.210	0.941	4.4.1.16	192,215
4	0.338	1bt4A	0.726	3.74	0.147	0.869	2.6.1.52	192,215
5	0.336	3kgxB	0.766	3.50	0.173	0.897	2.6.1.51,2.6.1.44	192,215
6	0.335	1j04A	0.763	3.60	0.177	0.897	2.6.1.44	192
7	0.329	1qz9A	0.802	2.91	0.152	0.903	3.7.1.3	192,215
8	0.317	2z9xB	0.774	3.32	0.159	0.887	2.6.1.30	97,118,192,215,220,222,360
9	0.316	2hdyA	0.805	2.79	0.179	0.892	4.4.1.16	192,215
10	0.307	1bjnA	0.719	3.75	0.114	0.867	2.6.1.52	192
11	0.307	1p3wB	0.807	2.71	0.187	0.890	2.8.1.7	34,92,217
12	0.255	1bjoA	0.719	3.73	0.112	0.864	2.6.1.52	92,217,220,222,360
13	0.254	3m5uA	0.688	3.95	0.115	0.841	2.6.1.52	33,92,219,222,360
14	0.125	2fyfA	0.708	3.85	0.132	0.859	2.6.1.52	192,215
15	0.120	3e77A	0.712	3.97	0.121	0.864	2.6.1.52	192,215
16	0.108	1v72A	0.670	3.64	0.122	0.803	4.1.2.26	327
17	0.060	1w23A	0.725	3.79	0.138	0.867	2.6.1.52	192,215
18	0.060	3caiA	0.852	2.39	0.175	0.915	2.6.1.-	265
19	0.060	2yriA	0.750	3.34	0.187	0.867	2.6.-.-	192,215
20	0.060	1iugA	0.740	3.35	0.179	0.851	2.6.1.1	NA
21	0.060	1js6A	0.734	3.46	0.118	0.864	4.1.1.28	194,215
22	0.060	2z9uA	0.771	3.38	0.156	0.890	2.6.1.30	215
23	0.060	1c7gA	0.732	3.88	0.111	0.887	4.1.99.2	40
24	0.060	2jisB	0.757	3.52	0.130	0.890	4.1.1.29	192,215
25	0.060	2vmzA	0.732	3.64	0.143	0.864	2.1.2.1	166,194,215,221
26	0.060	2okkA	0.755	3.37	0.137	0.882	4.1.1.15	95
27	0.060	2jg2A	0.728	3.37	0.139	0.846	2.3.1.50	192
28	0.060	2hzpA	0.799	3.06	0.102	0.915	3.7.1.3	NA
29	0.060	3a2bA	0.725	3.31	0.121	0.831	2.3.1.50	192,215
30	0.060	3h7fB	0.726	3.60	0.158	0.859	2.1.2.1	NA
31	0.060	2okjB	0.768	3.28	0.114	0.892	4.1.1.15	NA
32	0.060	1n31A	0.832	2.64	0.159	0.913	4.4.1.-	192,194,195
33	0.060	2e7iA	0.746	2.86	0.138	0.833	2.5.1.73	212,215
34	0.060	1t3iA	0.889	2.23	0.199	0.946	2.8.1.7	192,215
35	0.060	3hbxA	0.745	3.60	0.106	0.890	4.1.1.15	93,212

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.45	0.886	2.20	0.21	0.94	1i29A	GO:0001887 GO:0003824 GO:0005737 GO:0006534 GO:0006790 GO:0009000 GO:0016226 GO:0016740 GO:0016829 GO:0030170 GO:0031071 GO:0031162
1	0.40	0.888	2.43	0.20	0.95	4q76A	GO:0001887 GO:0003824 GO:0006534 GO:0006790 GO:0009000 GO:0009507 GO:0009536 GO:0009570 GO:0010269 GO:0016740 GO:0016829 GO:0018283 GO:0030170 GO:0031071
2	0.39	0.927	1.25	0.23	0.95	4lw2A	GO:0000096 GO:0003824 GO:0009000 GO:0016226 GO:0016740 GO:0016783 GO:0016829 GO:0030170 GO:0031071
3	0.38	0.889	2.23	0.20	0.95	1t3iA	GO:0003824 GO:0006534 GO:0016740 GO:0030170 GO:0031071
4	0.37	0.761	3.51	0.18	0.89	2hufA	GO:0003824 GO:0004760 GO:0008453 GO:0008483 GO:0016740
5	0.37	0.805	2.79	0.18	0.89	3a9yA	GO:0003824 GO:0005737 GO:0005829 GO:0009000 GO:0016740 GO:0016829
6	0.36	0.806	2.82	0.18	0.89	3lvmB	GO:0003824 GO:0005737 GO:0008033 GO:0016740 GO:0030170 GO:0031071 GO:0044571 GO:0046872 GO:0051536 GO:0051537
7	0.35	0.883	2.31	0.21	0.94	4w91B	GO:0003824 GO:0006534 GO:0008483 GO:0016740 GO:0030170 GO:0031071
8	0.34	0.832	2.64	0.16	0.91	1n31A	GO:0003824 GO:0016829
9	0.34	0.806	2.80	0.18	0.89	3gzcA	GO:0001887 GO:0003824 GO:0005737 GO:0005829 GO:0006520 GO:0009000 GO:0016740 GO:0016829
10	0.34	0.794	2.56	0.20	0.87	1ecxB	GO:0003824 GO:0008483 GO:0016740 GO:0031071
11	0.33	0.802	2.91	0.15	0.90	1qz9A	GO:0003824 GO:0005737 GO:0006569 GO:0009435 GO:0016787 GO:0019363 GO:0019805 GO:0030170 GO:0030429 GO:0034354 GO:0043420 GO:0097053
12	0.32	0.771	3.38	0.16	0.89	2z9uA	GO:0003824 GO:0008483 GO:0016740 GO:0030170 GO:0047300
13	0.32	0.746	2.86	0.14	0.83	2e7iA	GO:0003824 GO:0006412 GO:0016740 GO:0043766 GO:0071952
14	0.31	0.777	2.66	0.17	0.86	4ixoB	GO:0003824
15	0.31	0.852	2.39	0.17	0.92	3caiA	GO:0003824 GO:0005618 GO:0005886 GO:0040007
16	0.31	0.720	3.47	0.21	0.83	3vaxA	GO:0003824
17	0.31	0.771	2.36	0.20	0.83	4w91J	GO:0003824 GO:0006534 GO:0008483 GO:0016740 GO:0030170 GO:0031071
18	0.29	0.799	2.78	0.23	0.88	4isyC	GO:0003824 GO:0008483 GO:0016226 GO:0016740 GO:0031071 GO:0040007 GO:0046872 GO:0051536
19	0.29	0.821	2.77	0.19	0.91	5i90A	GO:0003824
20	0.29	0.766	3.50	0.17	0.90	3kgxB	GO:0003824 GO:0004760 GO:0005102 GO:0005739 GO:0005759 GO:0005777 GO:0005782 GO:0007219 GO:0008453 GO:0008483 GO:0009436 GO:0010498 GO:0016597 GO:0016740 GO:0019265 GO:0019448 GO:0030170 GO:0042803 GO:0042853 GO:0042866 GO:0043621 GO:0046487 GO:0046724 GO:0051384 GO:0051591
21	0.28	0.687	4.20	0.16	0.86	2ogaA	GO:0003824 GO:0008483 GO:0016740 GO:0017000 GO:0030170 GO:0033068
22	0.26	0.664	3.70	0.17	0.80	1v2eA	GO:0003824 GO:0008483 GO:0009058 GO:0016740 GO:0030170
23	0.25	0.766	3.63	0.18	0.90	4kyoC	GO:0003824 GO:0004760 GO:0005102 GO:0005739 GO:0005759 GO:0005777 GO:0005782 GO:0007219 GO:0008453 GO:0008483 GO:0009436 GO:0010498 GO:0016597 GO:0016740 GO:0019265 GO:0019448 GO:0030170 GO:0042803 GO:0042853 GO:0042866 GO:0043621 GO:0046487 GO:0046724 GO:0051384 GO:0051591
24	0.25	0.802	2.70	0.20	0.88	4eb5A	GO:0003824 GO:0005737 GO:0016740 GO:0030170 GO:0031071 GO:0044571 GO:0046872 GO:0051536 GO:0051537
25	0.24	0.697	3.69	0.11	0.84	2gmsA	GO:0003824 GO:0008483 GO:0016740
26	0.21	0.739	3.43	0.13	0.86	5eudA	GO:0003824 GO:0016829 GO:0016831 GO:0019752 GO:0030170
27	0.21	0.659	3.82	0.12	0.80	1b5oA	GO:0003824 GO:0004069 GO:0005737 GO:0008483 GO:0009058 GO:0016740 GO:0030170 GO:0080130

Consensus prediction of GO terms

Molecular Function	GO:0030170	GO:0031071	GO:0009000	GO:0008453	GO:0004760
GO-Score	0.88	0.88	0.80	0.37	0.37
Biological Processes	GO:0006534	GO:0001887	GO:0031162	GO:0010269	GO:0018283	GO:0000096
GO-Score	0.80	0.67	0.46	0.40	0.40	0.39
Cellular Component	GO:0009570
GO-Score	0.40

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.