I-TASSER results

I-TASSER results for job id Rv3695

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (310 residues)
MSEVVTGDAVVLDVQIAQLPVRAVSAVIDITIIFIGYILGLMLWATALTQFDEALTTAFL
IIFTVLALVGYPLVWETATRGRSVGKIVMGLRVVSDDGGPERFRQALFRALASVVEIWML
LGSPAVICSMLSPKAKRVGDVFAGTVVVSERGPRLGPPPVMPPSLAWWASSLQLSGLTAG
QAEVARQFLVRAPQLDPALREQMAYRIAGDVVARIAPPPPPGVPPQLVLAAVLAERHRRE
LLRLRPTLPPAGQAPWAQMAPHRGWPPGLSGATPWSPQQPVIPWPEPDPPPQAAPWPQQA
PDGPGFSPPG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSEVVTGDAVVLDVQIAQLPVRAVSAVIDITIIFIGYILGLMLWATALTQFDEALTTAFLIIFTVLALVGYPLVWETATRGRSVGKIVMGLRVVSDDGGPERFRQALFRALASVVEIWMLLGSPAVICSMLSPKAKRVGDVFAGTVVVSERGPRLGPPPVMPPSLAWWASSLQLSGLTAGQAEVARQFLVRAPQLDPALREQMAYRIAGDVVARIAPPPPPGVPPQLVLAAVLAERHRRELLRLRPTLPPAGQAPWAQMAPHRGWPPGLSGATPWSPQQPVIPWPEPDPPPQAAPWPQQAPDGPGFSPPG
Prediction	CCEHCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9855577757887556878999999999999999999999999998755555789999999999999999999999857899978887687899789998899999999999999999999999999886379998545555595999857877778888987655544456666799999999999999998789999999999999999998689999999999999999999999999998656777878887888888888888888998888888888999998888899998889999999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSEVVTGDAVVLDVQIAQLPVRAVSAVIDITIIFIGYILGLMLWATALTQFDEALTTAFLIIFTVLALVGYPLVWETATRGRSVGKIVMGLRVVSDDGGPERFRQALFRALASVVEIWMLLGSPAVICSMLSPKAKRVGDVFAGTVVVSERGPRLGPPPVMPPSLAWWASSLQLSGLTAGQAEVARQFLVRAPQLDPALREQMAYRIAGDVVARIAPPPPPGVPPQLVLAAVLAERHRRELLRLRPTLPPAGQAPWAQMAPHRGWPPGLSGATPWSPQQPVIPWPEPDPPPQAAPWPQQAPDGPGFSPPG
Prediction	7540523530404152022012210322132023223333332321222323333333333333333333331110133312000020020000234454020200000121333213213333210000014621000020040100235446445433345625422432414503460042034004315504562044004300540273051424672424300100020024212441455554455343444425433124344443343444434434243446433425644627244348
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEHCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSEVVTGDAVVLDVQIAQLPVRAVSAVIDITIIFIGYILGLMLWATALTQFDEALTTAFLIIFTVLALVGYPLVWETATRGRSVGKIVMGLRVVSDDGGPERFRQALFRALASVVEIWMLLGSPAVICSMLSPKAKRVGDVFAGTVVVSERGPRLGPPPVMPPSLAWWASSLQLSGLTAGQAEVARQFLVRAPQLDPALREQMAYRIAGDVVARIAPPPPPGVPPQLVLAAVLAERHRRELLRLRPTLPPAGQAPWAQMAPHRGWPPGLSGATPWSPQQPVIPWPEPDPPPQAAPWPQQAPDGPGFSPPG

4ke2A

0.12

0.07

0.63

1.17

dPPAS2

-------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIAT-INAASAAAKSI---------AAAAAMAAKDTAAAAASAAAAAVASAAKALET-----------------------INVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATA-------AAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------

1jvrA

0.14

0.06

0.43

1.17

dPPAS2

------------------------------------------------------------------------------------------------------------------------------------------------------HMGQIHGLSPTPIPKAPRGLS----------THHWLNFLQAAYRLQPGPSDFDFQQLRRFLKLALKTPIWLNPIDYSLLASLIPKRVVEIINILVKNQVSPSAPAAPVPTPICPTTTPPPPPPPSPEAHVPPPYVEPTTTQCF-----------------

5ijoJ

0.10

1.00

0.79

MUSTER

FEELYKTEAPTWETHGNLMTERQVSRWFVQCLREQSMLLEIIFLYYAYFEMAPSDLLVLTKMFKEQGFGSRQTNRLVDETMDPFVDRIGYFSALILV-EGMDIESLHKCALHQFAQDGLICQDMDCLMLTFGDIPHHAPVLLAWALLRHTLNPEETSSVVRKTRLLQSLASGGNDCTTSTACMCVYGLLSFVLTSLTLGNQQDIIDTACEVLADPSLPELPTSGLGIILDSVCGMHLLSPLLQLLRALVSGKSTAKKVYSFLDKMSFYNELYKHKPHDVISHEDGTLWRRQTPKLLYPLGGQTNLRIPQG

5gaoE

0.13

0.11

0.86

0.71

dPPAS

--------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------AAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

2mu3A

0.16

0.10

0.62

0.67

wdPPAS

-------------------------------------------------------------------------------AGPQGG------------GATGGASAGLISRVANALA-------TSTLRTVL---RTGVSQQIASS-VVQRAAQSLASTLGVDGNNLARFAVQAVSRLPSAYAQAFSSALFNAGVLNASNIDTLGSRVLSALLNGVSSAAQGGIN----VDSGSVQSDISSSSSFLSTSSSSASYSQASASSTSGA----GYTGPSGPSTGPSGYPGPL--GGGAPFGQSGFGG-------

4rdqA

0.15

0.14

0.97

0.67

wMUSTER

TNRVADGTFSQLLLQ-GSIYKLLYSEFLIFISLYFAISLVYRLILSESQRLMNSYLIPVSFVLGFYVSLVVSRWWAQYESIPWPDRIMNLVSCNVDGEDE--YGRLLRRTLMRYSNLCSVLILRSVSTAVY-KRFPSMEHVVRAGLMTPEEHKSLNSPHNKFWIPCVWFSNLLLQGI-LNELNTLRSQCGRLYGYDPLVYTQVVTVAVYSFFLAC-LDPEKAVPVFTFLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNLQVEMHQDLPILEKDLYWNEPDPQPPYTAATAEYKRPSFLGST--F

2mu3A

0.16

0.10

0.62

0.76

wPPAS

-------------------------------------------------------------------------------AGPQGG------------GATGGASAGLISRVANALA-------TSTLRTVL---RTGVSQQIASS-VVQRAAQSLASTLGVDGNNLARFAVQAVSRLPSAYAQAFSSALFNAGVLNASNIDTLGSRVLSALLNGVSSAAQGGIN----VDSGSVQSDISSSSSFLSTSSSSASYSQASASSTSGA----GYTGPSGPSTGPSGYPGPL--GGGAPFGQSGFGG-------

2mxxA

0.09

0.05

0.49

1.11

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------MADEATDAARNNDGAYYLQTQFTN---ADKVNEYLAQHDG-EIRAEAAADPAVVAAKAALDAVEGGSHAAYEAAFNNAFNAVRNKYVQRFQATYNNATEQEGKTYIQGLKRVGAANNQNPAAEDKGATTPASKEEAKKSEAAAKNAGKAAGKALPK

5gaoE

0.13

0.12

0.92

0.97

PPAS

----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------AAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

4l9mA2

0.10

0.09

0.92

0.72

Env-PPAS

KRKVS--------LLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSR-PTPQLRAE-------------VFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPI--LGVHLKDLISLYEAMPVHKLLALYNHISELVQLQEVAPPANKDLVHLLTLSLEDEIYELSYAREPRPVVVDWASGVSPKPDPQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLIS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.34

Estimated TM-score = 0.44±0.14

Estimated RMSD = 11.8±4.5Å

Download Model 2

C-score=-3.67

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5ijoJ	0.889	2.56	0.094	0.997
2	4kf7A	0.881	2.50	0.089	0.984
3	4knhA	0.589	4.86	0.068	0.832
4	5hb4B	0.581	4.79	0.067	0.813
5	4ifqA	0.561	5.01	0.066	0.803
6	3s4wA	0.557	4.86	0.063	0.784
7	3p8cB	0.503	5.87	0.063	0.781
8	3msvA	0.498	4.73	0.048	0.697
9	3m1iC	0.497	6.31	0.051	0.848
10	4n5cA	0.490	5.79	0.060	0.771

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	4fe1F	CLA	Rep, Mult	24,28
2	0.07	4	3ai7A	CA	Rep, Mult	97,140,142
3	0.06	3	1w9c0	III	Rep, Mult	50,54,55,58,61,62,69,85,88,89,91,92,95,108
4	0.04	2	3oheA	CA	Rep, Mult	143,145
5	0.04	2	3bvdA	XE	Rep, Mult	25,28,76,77
6	0.04	2	1mz9B	VDY	Rep, Mult	32,35,39
7	0.02	1	3knhK	MG	Rep, Mult	22,25
8	0.02	1	2q69A	CA	Rep, Mult	83,84,85
9	0.02	1	2qvwB	MN	Rep, Mult	136,140
10	0.02	1	1c7kA	CA	Rep, Mult	29,31
11	0.02	1	1f59A	III	Rep, Mult	36,39,40,43,44,90,94,98
12	0.02	1	4ej7B	CA	Rep, Mult	96,127
13	0.02	1	1f59B	III	Rep, Mult	26,30,33,34,84,88
14	0.02	1	2h8pC	GOA	Rep, Mult	70,71
15	0.02	1	2dftB	MG	Rep, Mult	83,97

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ho8A	0.426	6.30	0.050	0.716	3.6.3.14	86,91
2	0.060	2jgdA	0.410	6.15	0.076	0.668	1.2.4.2	NA
3	0.060	1b90A	0.430	6.58	0.043	0.748	3.2.1.2	96
4	0.060	2f6dA	0.440	5.70	0.032	0.681	3.2.1.3	74,131
5	0.060	1iq8A	0.423	6.39	0.057	0.719	2.4.2.29	NA
6	0.060	1f1sA	0.414	5.78	0.048	0.655	4.2.2.1	NA
7	0.060	3evhA	0.447	5.57	0.050	0.664	4.2.2.3	NA
8	0.060	1r9jB	0.414	6.56	0.054	0.719	2.2.1.1	81,83
9	0.060	1w6jA	0.417	6.02	0.053	0.668	5.4.99.7	NA
10	0.060	2eabA	0.434	5.71	0.028	0.661	3.2.1.63	NA
11	0.060	3figB	0.429	6.03	0.069	0.694	2.3.3.13	141,150
12	0.060	2qnoA	0.425	5.66	0.060	0.661	3.2.1.4	NA
13	0.060	1ay0A	0.422	6.49	0.035	0.723	2.2.1.1	NA
14	0.060	1hn0A	0.430	6.23	0.055	0.713	4.2.2.20	NA
15	0.060	2sqcA	0.414	5.95	0.057	0.668	5.4.99.17	NA
16	0.060	1ut9A	0.415	5.62	0.062	0.639	3.2.1.4	NA
17	0.060	1i8qA	0.418	5.74	0.045	0.652	4.2.2.1	NA
18	0.060	2gtqA	0.416	5.85	0.084	0.664	3.4.11.2	40
19	0.060	1f13A	0.421	6.16	0.058	0.700	2.3.2.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.889	2.56	0.09	1.00	5ijoJ	GO:0005634 GO:0005635 GO:0005643 GO:0006405 GO:0006406 GO:0006409 GO:0006606 GO:0006810 GO:0007077 GO:0010827 GO:0015031 GO:0016020 GO:0016032 GO:0016925 GO:0017056 GO:0019083 GO:0031047 GO:0044611 GO:0051028 GO:0075733 GO:1900034
1	0.07	0.589	4.86	0.07	0.83	4knhA	GO:0005634 GO:0005643 GO:0006810 GO:0015031 GO:0051028
2	0.07	0.581	4.79	0.07	0.81	5hb4B	GO:0005634 GO:0005643 GO:0006810 GO:0015031 GO:0051028
3	0.07	0.566	5.12	0.06	0.82	4ifqA	GO:0000059 GO:0005634 GO:0005643 GO:0006810 GO:0006999 GO:0015031 GO:0017056 GO:0044611 GO:0046822 GO:0051028
4	0.07	0.460	5.87	0.05	0.72	5ijnD	GO:0000059 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0006406 GO:0006409 GO:0006810 GO:0006913 GO:0007077 GO:0010827 GO:0015031 GO:0016020 GO:0016032 GO:0016925 GO:0017056 GO:0019083 GO:0031047 GO:0031965 GO:0034399 GO:0044611 GO:0051028 GO:0051292 GO:0075733 GO:1900034
5	0.07	0.586	4.77	0.06	0.82	4knhB	GO:0005634 GO:0005643 GO:0006810 GO:0015031 GO:0051028
6	0.07	0.881	2.50	0.09	0.98	4kf7A	GO:0005643 GO:0006406 GO:0006606 GO:0006999 GO:0017056 GO:0031990 GO:0044611
7	0.06	0.409	5.10	0.06	0.60	4f7rD	GO:0019904
8	0.06	0.348	5.93	0.06	0.54	1k9xA	GO:0004180 GO:0004181 GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0046872 GO:0050897
9	0.06	0.359	6.06	0.04	0.58	1n1zA	GO:0000287 GO:0008152 GO:0009507 GO:0009536 GO:0010333 GO:0016829 GO:0016853 GO:0046211 GO:0046872 GO:0047926
10	0.06	0.368	6.52	0.04	0.62	3qiaA	GO:0000166 GO:0004518 GO:0004519 GO:0005524 GO:0006314 GO:0006754 GO:0006810 GO:0006811 GO:0015991 GO:0015992 GO:0016539 GO:0016787 GO:0016820 GO:0033178 GO:0046034 GO:0090305
11	0.06	0.361	5.47	0.03	0.55	4eqfA	GO:0000268 GO:0005052 GO:0005737 GO:0005778 GO:0005829 GO:0016020 GO:0016560 GO:0030425 GO:0031267 GO:0042391 GO:0043235 GO:0043949 GO:0045185
12	0.06	0.332	6.97	0.03	0.60	1bagA	GO:0003824 GO:0004556 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0043169 GO:0046872
13	0.06	0.325	6.04	0.04	0.53	2ptxA	GO:0000015 GO:0000287 GO:0004634 GO:0006096 GO:0016829 GO:0046872
14	0.06	0.295	5.64	0.04	0.45	4dozA	GO:0000166 GO:0003723 GO:0005737 GO:0046872 GO:0051607
15	0.06	0.241	6.47	0.03	0.41	1p9pA	GO:0000287 GO:0002939 GO:0005737 GO:0005829 GO:0006400 GO:0008033 GO:0008168 GO:0008685 GO:0009019 GO:0016740 GO:0030488 GO:0032259 GO:0042802 GO:0052906
16	0.06	0.250	6.79	0.03	0.44	1w62A	GO:0005576 GO:0005737 GO:0007275 GO:0016020 GO:0016853 GO:0018112
17	0.06	0.275	5.54	0.06	0.42	4wnlC	GO:0003723 GO:0003729 GO:0005634 GO:0005737 GO:0005789 GO:0005934 GO:0006810 GO:0007533 GO:0008289 GO:0008298 GO:0051028
18	0.06	0.293	6.69	0.02	0.51	4q0mA	GO:0004067 GO:0006520

Consensus prediction of GO terms

Molecular Function	GO:0017056
GO-Score	0.31
Biological Processes	GO:0051049	GO:1903047	GO:0032774	GO:0018205	GO:1902583	GO:0032446	GO:0080135	GO:0019080	GO:0071431	GO:0006405	GO:0051081	GO:0034605	GO:0051031	GO:0071427	GO:0046794	GO:0016458	GO:0015758	GO:0044744	GO:0017038	GO:1902593	GO:0051028
GO-Score	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.52	0.41	0.41	0.41	0.40
Cellular Component	GO:0044611
GO-Score	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.