I-TASSER results

I-TASSER results for job id Rv3694c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (330 residues)
MDVDAFLLTNRGTWDRLDHLIKKRHSLSGAEIDELVELYQRVSTHLSMLRSASSDQLMTG
RLSSLVARARSAVTGAHAPLTRTFIRFWTVSFPVVAYRTWRWWLATAVAFFAVVVLIGFW
VAGSHEVQSAIGTPTEIDELVSHDVQSYYSEHPAASFALQVWVNNSWVATTCIAMSVVLG
LPIPLVLFDNAANVGLIAGLMFQAGKGDFLLGLLLPHGLLELTAVFLAAAIGMRLGWSVI
SAGNRPRGQVLAEQGRGVVSVAVGLVGVFLVAGLIEAVVTPSPLPTFVRIAVGIIAEAVF
LSYIGYFGRRAAQAGETGDMEDAPDVVPTG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDVDAFLLTNRGTWDRLDHLIKKRHSLSGAEIDELVELYQRVSTHLSMLRSASSDQLMTGRLSSLVARARSAVTGAHAPLTRTFIRFWTVSFPVVAYRTWRWWLATAVAFFAVVVLIGFWVAGSHEVQSAIGTPTEIDELVSHDVQSYYSEHPAASFALQVWVNNSWVATTCIAMSVVLGLPIPLVLFDNAANVGLIAGLMFQAGKGDFLLGLLLPHGLLELTAVFLAAAIGMRLGWSVISAGNRPRGQVLAEQGRGVVSVAVGLVGVFLVAGLIEAVVTPSPLPTFVRIAVGIIAEAVFLSYIGYFGRRAAQAGETGDMEDAPDVVPTG
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCC
Conf.Score	979999999999999999999986579988899999999999999999998789989999999999999999986887467899999999999999999999999999999999999999985967888877979999998565566546787789999999999999999999999999999999999999999999999997979999999998758999999999999999999998668887899999999999999999999999999999975666678999999999999999999999587545457777744455678999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDVDAFLLTNRGTWDRLDHLIKKRHSLSGAEIDELVELYQRVSTHLSMLRSASSDQLMTGRLSSLVARARSAVTGAHAPLTRTFIRFWTVSFPVVAYRTWRWWLATAVAFFAVVVLIGFWVAGSHEVQSAIGTPTEIDELVSHDVQSYYSEHPAASFALQVWVNNSWVATTCIAMSVVLGLPIPLVLFDNAANVGLIAGLMFQAGKGDFLLGLLLPHGLLELTAVFLAAAIGMRLGWSVISAGNRPRGQVLAEQGRGVVSVAVGLVGVFLVAGLIEAVVTPSPLPTFVRIAVGIIAEAVFLSYIGYFGRRAAQAGETGDMEDAPDVVPTG
Prediction	753640355137405402510553671547304401510240031002025302545014202300230133024444531430010021100100133322000112333333332010000113112101335314412553235224734211002113320331023132323331331333133203210200010033431221111133023301200210000013002000223635324202510130021012122213200320010013412330010003212333222211022313544652426425533258
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCC
MDVDAFLLTNRGTWDRLDHLIKKRHSLSGAEIDELVELYQRVSTHLSMLRSASSDQLMTGRLSSLVARARSAVTGAHAPLTRTFIRFWTVSFPVVAYRTWRWWLATAVAFFAVVVLIGFWVAGSHEVQSAIGTPTEIDELVSHDVQSYYSEHPAASFALQVWVNNSWVATTCIAMSVVLGLPIPLVLFDNAANVGLIAGLMFQAGKGDFLLGLLLPHGLLELTAVFLAAAIGMRLGWSVISAGNRPRGQVLAEQGRGVVSVAVGLVGVFLVAGLIEAVVTPSPLPTFVRIAVGIIAEAVFLSYIGYFGRRAAQAGETGDMEDAPDVVPTG

5ezmA

0.09

0.97

1.00

wMUSTER

GEWQARLAVALSGLLGIGVSMMAARRWFGARAAAFTGLALLAAPMWSVAAHFNTLDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTKG--LVGIALPGLVLVVYTLVTRDWGLWRRLHLALGVVVMLV--FYLVSVRNPEFPNFFFYFLPLVIGGFLPWAGIFPKLWTAMRPALMAGIWAIAIFVFFSISRSAGVALDRLPRSWGKQLIGMAIVAACGLLASPVVATLNANHIPNSFYRAYAVWVAVAFVVMLLGIAVARLLLRRGVLPSVAVYAMGMYLGFTVALLGHETVG-ADIAPQ-----AQKLTPEMPLY

4zowA2

0.09

0.05

0.58

1.60

dPPAS2

--------------------------------------------------------------------------------------LSLKELGRDYKLVLGRFVAGALALGFVSLPLLAWIAQSPIIIITGE------------------QLSSYEYGLLQVPIFGALIAGNLLLARLTTVRSLIIMGGWPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFA------SDMSKGTVSAAMGMLQMLIFTVGIEISKHAWLNGG---NGLFNLFNLVNGILWLSLMVIFLK------------------------

4wgvA

0.11

0.98

1.10

PPAS

LFVILISSLAAMLLQSMTVRLGIATGKD--LAQMTRHFLSKPVAIIFWIIAELAIIATDIAEVIGSAIALDLIFGIPLIVGALITVFDVFLLLFIMRFRKIEAIVGTLIFTVLAIFVFEVFISSPQLTDILNGVTNQGILYIALGIIGATIMPHNLYLHSSIVDNEEKAQAIKYATIDSNLQLSIAFVVNCLLLTLGAALFFGTKTTEPVLGATLGGVMSTLFAVALLASGQNSTITGTLAGQIVMEGFLIPNWLRRLITRSLAVIPVIICLIIF-NSEKIEQLLVFSQVFLSIALPFSLIPLQLATSNK----KLMGPFINKTWVNIIS

4ke2A

0.09

0.05

0.59

1.56

dPPAS2

----------------------------------------------------------------------------------------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATID-----NAAAAKAAAVATAVSDAAATAATAAAVAAATLE--AAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------

4kjsA

0.10

0.09

0.88

1.09

PPAS

AGVPLSVIGSLMHWPSAVLFAVYCVTI-IALASYMGRATESLSIRIGGLLNATFGNAVELIISMFALKELTGIVLASLTGSVLGNLLLVAGLSFFVGYARQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIM----ILLYVAALYFKSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFGW-------ELFIGVIIVAIVGNAAEHASAIIMAFK-----------KMDIAVEIAVGSTLQIAMFVAPVLVICSIF--FPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG--------------A

4k5yA2

0.09

0.06

0.67

1.53

dPPAS2

-------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVV----QLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLWDAYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASIQARKAVKATLVLLPLLGITYMLAFVNEVSR---------------VV

4w6vA2

0.12

0.09

0.76

1.03

PPAS

--------------------------------------GRWVTAIMAVVVVIIALISQGVIPINPVMIASLLVY-----AASVTLYFIYLFAFAKMSRKDRARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTDRMVMGFETVWFQSINALFIILLAPVFSWAPSSITKFVIGILCAAAGFAVMMYAAQHVLSSG------GAGVSPLWLVMSILLLTLGELCLS--IGLATMTLLAPDRMRG-----QVMGLWFCASSLGNLAAGLIGGHVK--ADQLDMLPTLFARCSIALVICAAVLILLIVP---------------------

4bwzA2

0.13

0.08

0.60

1.48

dPPAS2

--------------------------------------------------------------------------------------------LKDILAVGKEAFLVAVLGVALPFLGGYLYG---LEIG--------------------FETLPALFLGTALVVGITARVLQELGVLPYSRIILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMRGEVGLIVAALGLKAGAV----NEEEYAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE-------------

4k5yA2

0.11

0.08

0.75

1.03

PPAS

--------------------------------------HYHVAAIINYLGHC---ISLVALLVAFVLFLRARSIRC--------------LRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLWDAYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTT-----SETIQARKAVKATLVLLPLLGITYMLAFVVSRVVFIYFNAFLESFQGFFVSVFACFLNS----------------------

4o6yA

0.16

0.10

0.59

1.47

dPPAS2

----------------------------------------------------------------------------------------------------PIFMVVRVLGFIIAALVLTWTVHYRGGLA----------LSSDNKDHIFNVHPVMMVIGLILFNGEAMLAYKSKNLKKLVHLTLQLTAFILSLIGVWAALKFHIDKGIENFYS--LHSWLGLACLFLFAFQWAAGFVTYWYPGGSNSRASLMPWHVFLGISIYALALVTATTGILEKVTFSTEAMLVNTMGVLILILGGFVILGVVT-----------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.50

Estimated TM-score = 0.33±0.11

Estimated RMSD = 15.0±3.5Å

Download Model 2

C-score=-3.19

Download Model 3

C-score=-3.76

Download Model 4

C-score=-4.79

Download Model 5

C-score=-4.97

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2ewfA	0.442	6.14	0.063	0.700
2	1jqnA	0.418	6.18	0.054	0.667
3	1t0rA	0.416	6.08	0.059	0.664
4	1j3uA	0.411	5.24	0.031	0.582
5	1z45A	0.409	6.33	0.061	0.651
6	1mhzD	0.408	6.58	0.062	0.688
7	1vdkA	0.407	5.24	0.058	0.573
8	3gtdA	0.406	5.26	0.054	0.585
9	1jswB	0.405	5.28	0.064	0.591
10	1l2aA	0.404	6.56	0.055	0.661

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	2	3u32N	DCW	Rep, Mult	219,226
2	0.05	2	1fz8B	2BM	Rep, Mult	114,117,118,191
3	0.05	2	2o011	CLA	Rep, Mult	275,276
4	0.03	1	1xvgB	BRJ	Rep, Mult	173,174,223,228
5	0.03	1	2a6hC	STD	Rep, Mult	174,178,181,209
6	0.03	1	1xvgA	BRJ	Rep, Mult	66,67,70,107,110,111
7	0.03	1	5ezmA	MPG	Rep, Mult	48,52,296,300,303
8	0.03	1	1xvgB	BRJ	Rep, Mult	165,166,170,210
9	0.03	1	3a0bk	CLA	Rep, Mult	261,266
10	0.03	1	5ezmA	MPG	Rep, Mult	38,41,286
11	0.03	1	1xveA	3BB	Rep, Mult	233,236,237,260,261
12	0.03	1	2r9rB	PGW	Rep, Mult	156,157
13	0.03	1	1frfL	SF4	Rep, Mult	41,217
14	0.03	1	1xvfA	3CL	Rep, Mult	46,65,194,197,198
15	0.03	1	3f1f2	MG	Rep, Mult	27,31
16	0.03	1	1brrC	ARC	Rep, Mult	264,267,275

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1clqA	0.378	6.51	0.032	0.621	2.7.7.7	180
2	0.060	1cdgA	0.390	6.68	0.041	0.676	2.4.1.19	NA
3	0.060	1jswB	0.405	5.28	0.064	0.591	4.3.1.1	NA
4	0.060	1jqnA	0.418	6.18	0.054	0.667	4.1.1.31	NA
5	0.060	2hvgA	0.385	5.36	0.055	0.567	4.3.2.2	NA
6	0.060	3hmjA	0.388	6.77	0.048	0.667	2.3.1.86	NA
7	0.060	1l2aE	0.402	6.57	0.047	0.654	3.2.1.4	39
8	0.060	3iydC	0.395	6.06	0.050	0.633	2.7.7.6	227,263
9	0.060	3gtdA	0.406	5.26	0.054	0.585	4.2.1.2	NA
10	0.060	3e04D	0.400	5.38	0.051	0.576	4.2.1.2	258
11	0.060	1a47A	0.383	6.74	0.052	0.670	2.4.1.19	NA
12	0.060	1mhyD	0.410	6.56	0.062	0.688	1.14.13.25	NA
13	0.060	2occN	0.402	6.63	0.059	0.688	1.9.3.1	NA
14	0.060	1z45A	0.409	6.33	0.061	0.651	5.1.3.2,5.1.3.3	NA
15	0.060	1fftA	0.403	6.55	0.051	0.679	1.10.3.-	26
16	0.060	9cgtA	0.381	6.89	0.044	0.673	2.4.1.19	NA
17	0.060	3eqlM	0.399	5.94	0.036	0.624	2.7.7.6	42
18	0.060	1yfeA	0.403	5.31	0.058	0.576	4.2.1.2	NA
19	0.060	3i4zA	0.402	5.68	0.047	0.597	2.5.1.34	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.443	5.86	0.05	0.68	4wl5A	GO:0004519 GO:0090305
1	0.06	0.410	6.56	0.06	0.69	1mhyD	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0016491 GO:0046872 GO:0055114
2	0.06	0.314	5.94	0.07	0.48	3odmC	GO:0000287 GO:0003824 GO:0006099 GO:0006107 GO:0008964 GO:0015977 GO:0016829
3	0.06	0.311	6.84	0.07	0.55	2hg4D	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016788 GO:0017000 GO:0031177 GO:0033068 GO:0047879 GO:0048037
4	0.06	0.332	7.01	0.03	0.60	2z1kA	GO:0003824 GO:0005975
5	0.06	0.383	6.47	0.05	0.64	2innA	GO:0006725 GO:0016491 GO:0046872 GO:0055114
6	0.06	0.287	6.54	0.03	0.48	5ej4A	GO:0000287 GO:0003824 GO:0009234 GO:0016740 GO:0030145 GO:0030976 GO:0046872 GO:0070204
7	0.06	0.404	6.65	0.05	0.68	1fziA	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0015050 GO:0015947 GO:0016491 GO:0046872 GO:0055114
8	0.06	0.415	6.11	0.07	0.67	2incA	GO:0004497 GO:0006725 GO:0016491 GO:0046872 GO:0055114
9	0.06	0.310	6.36	0.08	0.51	3vatA	GO:0004177 GO:0005576 GO:0005634 GO:0005654 GO:0005737 GO:0006508 GO:0006518 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872 GO:0070006 GO:0072562
10	0.06	0.418	6.18	0.05	0.67	1jqnA	GO:0000287 GO:0003824 GO:0005829 GO:0006099 GO:0006107 GO:0008152 GO:0008964 GO:0015977 GO:0016829
11	0.06	0.304	5.25	0.04	0.44	4fj0D	GO:0000166 GO:0016491 GO:0055114
12	0.06	0.338	6.13	0.04	0.54	1booA	GO:0003677 GO:0006306 GO:0008168 GO:0008170 GO:0009307 GO:0015667 GO:0016740 GO:0032259 GO:0090124
13	0.06	0.293	6.60	0.05	0.51	5ff2A	GO:0003824 GO:0016491 GO:0016765 GO:0046872 GO:0051188 GO:0051536 GO:0051537 GO:0051539 GO:0055114
14	0.06	0.278	6.47	0.04	0.46	1v9nA	GO:0005737 GO:0006099 GO:0008152 GO:0016491 GO:0030060 GO:0055114
15	0.06	0.409	6.56	0.07	0.69	4uolA	GO:0003824 GO:0005737 GO:0006099 GO:0008152 GO:0008964 GO:0015977 GO:0015979 GO:0016829
16	0.06	0.417	6.19	0.05	0.68	4bxcA	GO:0003824 GO:0005737 GO:0006099 GO:0008152 GO:0008964 GO:0009760 GO:0015977 GO:0015979 GO:0016829
17	0.06	0.268	6.73	0.06	0.47	2xy4A	GO:0005886 GO:0010043 GO:0030001 GO:0046872
18	0.06	0.269	7.25	0.03	0.49	3flmA	GO:0000287 GO:0003824 GO:0009234 GO:0016740 GO:0030145 GO:0030976 GO:0046872 GO:0070204

Consensus prediction of GO terms

Molecular Function	GO:0015049	GO:0004519	GO:0000287	GO:0008964	GO:0047879	GO:0048037	GO:0031177
GO-Score	0.07	0.07	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0090305	GO:0006730	GO:0033068	GO:0015977	GO:0006107	GO:0005975	GO:0006099
GO-Score	0.07	0.07	0.06	0.06	0.06	0.06	0.06
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.