I-TASSER results

I-TASSER results for job id Rv3693

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (440 residues)
MILTGRTGLLALICVLPIALSPWPARAFVMLLVALAVAVTVDTLLAASTRKLRFTRSPYT
SARLGQPVDASLLLCNGGRRRFRGQVRDAWPPSARAQPHTHDVDVAAGQRQQVHTALRPV
RRGDQRAAMVTARSIGPLGLAGRQSSQSVPGLVRVLPPFLSRKHLPSRLAKLREIDGLLP
TLIRGQGTEFDSLREYVVGDDVRSIDWRASARRADVMVRTWRPERDRRVVIVLDTGRMAA
GRVGVDPTAADPAGWPRLDWSMDAALLLAALASRAGDHVDFLAHDRISRAGVFGASRSEL
LAQLVDAMAPLRPALIESDWHAMIATILRRTRRRSLVVLLTDLNATALDEGLLPVLPQLS
ARHHVLVAAVADPRVDQLAAGRSDAAAVYDAAAAERARNDRRAIASQLRRGGVDVIDAPP
AEIAPGLADRYLAMKATGRL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MILTGRTGLLALICVLPIALSPWPARAFVMLLVALAVAVTVDTLLAASTRKLRFTRSPYTSARLGQPVDASLLLCNGGRRRFRGQVRDAWPPSARAQPHTHDVDVAAGQRQQVHTALRPVRRGDQRAAMVTARSIGPLGLAGRQSSQSVPGLVRVLPPFLSRKHLPSRLAKLREIDGLLPTLIRGQGTEFDSLREYVVGDDVRSIDWRASARRADVMVRTWRPERDRRVVIVLDTGRMAAGRVGVDPTAADPAGWPRLDWSMDAALLLAALASRAGDHVDFLAHDRISRAGVFGASRSELLAQLVDAMAPLRPALIESDWHAMIATILRRTRRRSLVVLLTDLNATALDEGLLPVLPQLSARHHVLVAAVADPRVDQLAAGRSDAAAVYDAAAAERARNDRRAIASQLRRGGVDVIDAPPAEIAPGLADRYLAMKATGRL
Prediction	CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCEEEEEEEEEEHCCCCCEEEEEEHCCCCCCCCCCCEEEEEHCCCEEEEEEEEEHCCCEEEEEHCCEEEEHCCCCCEEEEEEEHCCCCEEEEHCCCCHHHHCHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHCCCCCCHHHHHHHHHHHHHHCCC
Conf.Score	98765999999999999999999999999999999999999999857887589999868887898568999999978998589999985886656677758999879958999999985765689977599999588775899999848858999688544444445555456667754456788888878855789999864477544444798689988646689599999789876677787766667667788999999999999999998995899997797577758998889999999999977878888999999999999799986999996999985779999999999986968999995875765578898899999999999999999999999999999699889876799999999999998899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MILTGRTGLLALICVLPIALSPWPARAFVMLLVALAVAVTVDTLLAASTRKLRFTRSPYTSARLGQPVDASLLLCNGGRRRFRGQVRDAWPPSARAQPHTHDVDVAAGQRQQVHTALRPVRRGDQRAAMVTARSIGPLGLAGRQSSQSVPGLVRVLPPFLSRKHLPSRLAKLREIDGLLPTLIRGQGTEFDSLREYVVGDDVRSIDWRASARRADVMVRTWRPERDRRVVIVLDTGRMAAGRVGVDPTAADPAGWPRLDWSMDAALLLAALASRAGDHVDFLAHDRISRAGVFGASRSELLAQLVDAMAPLRPALIESDWHAMIATILRRTRRRSLVVLLTDLNATALDEGLLPVLPQLSARHHVLVAAVADPRVDQLAAGRSDAAAVYDAAAAERARNDRRAIASQLRRGGVDVIDAPPAEIAPGLADRYLAMKATGRL
Prediction	33333211110002222222233333222222222221120000002313202030323540434460403010205230201000002015405256241303033534130303030441240403302010000000010214042622010103025145022323334413142324340423304311312421431301021001232000221344231200000000110212232322233223120001000000000100143411000000144233213253144002200410251436455230340042026203540144240202236106301500430143000000000023055035456413301121004203520530152046130310203264001300320041134447
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCEEEEEEEEEEHCCCCCEEEEEEHCCCCCCCCCCCEEEEEHCCCEEEEEEEEEHCCCEEEEEHCCEEEEHCCCCCEEEEEEEHCCCCEEEEHCCCCHHHHCHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHCCCCCCHHHHHHHHHHHHHHCCC
MILTGRTGLLALICVLPIALSPWPARAFVMLLVALAVAVTVDTLLAASTRKLRFTRSPYTSARLGQPVDASLLLCNGGRRRFRGQVRDAWPPSARAQPHTHDVDVAAGQRQQVHTALRPVRRGDQRAAMVTARSIGPLGLAGRQSSQSVPGLVRVLPPFLSRKHLPSRLAKLREIDGLLPTLIRGQGTEFDSLREYVVGDDVRSIDWRASARRADVMVRTWRPERDRRVVIVLDTGRMAAGRVGVDPTAADPAGWPRLDWSMDAALLLAALASRAGDHVDFLAHDRISRAGVFGASRSELLAQLVDAMAPLRPALIESDWHAMIATILRRTRRRSLVVLLTDLNATALDEGLLPVLPQLSARHHVLVAAVADPRVDQLAAGRSDAAAVYDAAAAERARNDRRAIASQLRRGGVDVIDAPPAEIAPGLADRYLAMKATGRL

4rckA

0.12

0.05

0.43

1.04

wdPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHRDLVVDLSGSA-----EEDKTSNGDFVDRLTAVKQVVSDFIDQ---KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRT-VLNLVGQRTALGLATKTFIESNAPQRTIILLSDGANTAGVLEPLEAAQLAKDNH-IYTVGIGAGEQVRGFFGKQTVNTARD-----------EDTLTKIATTGGQYFRARNADELAEIYQTIDALEP----

4fx5A1

0.15

0.05

0.35

1.80

dPPAS2

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SENVEVIIIDCSGSDYPRTK----------------AAKEATKVAIDTLTDGAFFAVVAGTEGARVVYPTGGQYQSRAAAKEAVGRLHANGGTARWLAQAGRIFDTAPSAKHAILLTDKDESETPADLARAIQSSIGNFTADCRGIEDWEPKELRRDPATLAEDFRETAKS---------------------------------------------

4rckA

0.12

0.05

0.43

1.06

Env-PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHRDLVVDLSGSA-----EEDKTSNGDFVDRLTAVKQVVSDFIDQR--KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRT-VLNLVGQRTALGLATKTFIESNAPQRTIILLSDGANTAGVLEPLEAAQLAKDNHKIYTVGIGAGEQVRGFFGKQTVNTARDL---------DEDTLTKIATTGGQYFRARN----ADELAEIYQTIDA--L

4rckA

0.12

0.05

0.40

1.75

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHRDLVVDLSGSA-----EEDKTSNGDFVDRLTAVKQVVSDFIDQR--KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRT-VLNLVGQRTALGLATKTFIESNAPQRTIILLSDGANTAGVLEPLEAAQLAKDNHKIYTVGIGAGEQVRGFFGARDLDEDTLTKIATRNADELAEIYQTIDAL-----------------------------

3ibsA

0.12

0.05

0.44

1.63

dPPAS2

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGVEVIIALDISNSL----------AQDVQPSRLEKAKRLISRLVDEL--DNDKVGIVFAG-DAFTQLPITSDYISAKFLESISPSLISKQG-TAIGEAINLATRSFTPQRAIIVITDGENHEGG--AVEAAKAAAEKGQVSVLGVGPE--GAPIPVEGTNDYRRDREGNVIVTRLNEGCQEIAKDGKGIYVRVDNSNSAQKAISQEISKAKS---

4rckA1

0.09

0.02

0.22

1.55

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHRDLVVDLSGSA-----EEDKTSNGDFVDRLTAVKQVVSDFIDQR--KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRT-VLNLVGQRTAIGEGLGLATKTF-------------------------------------------------------------------------------------------------------------

1shuX

0.13

0.05

0.37

1.41

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCRRAFDLYFVLDKSGSVA---------------NNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGE-TYIHEGLKLANEQIKTSSIIIALTDKLDGLVPSYAEKEAKISRSLGSVYCVGVLDFEQAQLVKGGFQALKGIINSILAQSC------------------------------------------

4fxgB1

0.12

0.11

0.93

0.81

MUSTER

DSLTT-------WEIHGLSLSKTKG------------LCVATPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEGLCLAGGAQQVLVPAGSARPVAFSVVPTAAAA---VSLKVVARGSFEAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIPGNSDPMIPDGDFNSYVRVTASDPLDTLGSEG--ALSPGGVASLLRLPRGCGEQTMIYL-APTLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQRKADGSYAAWLSRDSSTWL----TAFVLKVLSLAQEQVGGSPE-KLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVALTAFVTIALHHGLAVFQ-DEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAAPVDLLGVAHNNLMAMAQETGD

4rckA

0.11

0.05

0.44

0.92

dPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHRDLVVDLSGSA-----EEDKTSNGDFVDRLTAVKQVVSDFIDQR--KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLVGQRTAILGLATKTFIESNAPQRTIILLSDGANTAGVLEPLEAAQLAKDNHKIYTVGIGAGEQVRGFFGKQTVNTARDLD---------EDTLTKIATTGGQYFRARNADELAEIYQTIDALEP----

3ibsA

0.13

0.06

0.44

1.00

wdPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGVEVIIALDISNSL----------AQDVQPSRLEKAKRLISRLVDEL--DNDKVGIVFAGD-AFTQLPITSDYISAKFLESISPSLISK-QGTAIGEAINLATRSFTPQRAIIVITD--GENHEGGAVEAAKAAAEKG-VSVLGVGPEGAPIPVEGTNDYRR--DREGNVIVTRLNEGCQEIAKDGKGIYVRVDNSNSAQKAISQEISKAKS---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.80

Estimated TM-score = 0.30±0.10

Estimated RMSD = 16.7±2.9Å

Download Model 2

C-score=-3.03

Download Model 3

C-score=-4.98

Download Model 4

C-score=-5.00

Download Model 5

C-score=-3.50

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3zmrA	0.787	2.29	0.089	0.846
2	4nf7A	0.563	3.07	0.075	0.636
3	4x0vA	0.560	2.94	0.064	0.627
4	3ayrA	0.558	3.23	0.084	0.634
5	1edgA	0.556	2.97	0.060	0.625
6	4yheA	0.555	2.92	0.086	0.623
7	4w8aA	0.553	3.21	0.105	0.629
8	2jepA	0.552	2.73	0.081	0.614
9	3icgA1	0.551	2.82	0.084	0.614
10	4im4A	0.547	2.70	0.075	0.607

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.18	9	3azrA	CBK	Rep, Mult	158,182,236,237,285,286,371,378,420
2	0.08	4	1w25A	MG	Rep, Mult	200,201,234,238
3	0.04	2	2yj0E	FMN	Rep, Mult	196,206,207
4	0.04	2	3ufnB	ROC	Rep, Mult	199,200
5	0.02	1	1h4pA	UUU	Rep, Mult	264,267,268,271
6	0.02	1	3l55A	NA	Rep, Mult	218,262,265,266
7	0.02	1	4w8bA	BGC	Rep, Mult	158,182
8	0.02	1	1h4pA	UUU	Rep, Mult	256,258,259,261,263,307
9	0.02	1	3n9kA	BGC	Rep, Mult	364,365,412,413,414
10	0.02	1	2oswA	NA	Rep, Mult	276,277,279,336
11	0.02	1	3d6aA	MG	Rep, Mult	341,356
12	0.02	1	3talA	MN	Rep, Mult	234,285

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2oykB	0.490	3.69	0.084	0.584	3.2.1.123	NA
2	0.060	2osxA	0.495	3.68	0.087	0.589	3.2.1.123	412,415
3	0.060	2jieA	0.459	4.81	0.051	0.584	3.2.1.21	NA
4	0.060	2jf6B	0.463	4.98	0.040	0.609	3.2.1.105	NA
5	0.060	1od0B	0.453	4.82	0.040	0.580	3.2.1.21	NA
6	0.060	2fhcA	0.460	6.60	0.059	0.723	3.2.1.41	214
7	0.060	3cmjA	0.459	4.81	0.072	0.591	3.2.1.21	NA
8	0.060	2jepA	0.552	2.73	0.081	0.614	3.2.1.151	NA
9	0.060	1gnxA	0.463	4.70	0.075	0.593	3.2.1.21	NA
10	0.060	2z1sA	0.453	5.10	0.036	0.600	3.2.1.21	224
11	0.060	1h1nA	0.461	3.66	0.091	0.548	3.2.1.4	NA
12	0.060	2e3zA	0.462	4.92	0.029	0.602	3.2.1.21	NA
13	0.060	1cenA	0.487	3.46	0.104	0.566	3.2.1.4	NA
14	0.060	1edgA	0.556	2.97	0.060	0.625	3.2.1.4	NA
15	0.060	3l4uA	0.457	5.88	0.065	0.657	3.2.1.20,3.2.1.3	281
16	0.060	1dwaM	0.473	4.71	0.065	0.607	3.2.1.147	NA
17	0.060	2zoxA	0.455	5.07	0.050	0.598	3.2.1.21	NA
18	0.060	1eceB	0.467	4.30	0.081	0.580	3.2.1.4	237
19	0.060	1ceoA	0.486	3.38	0.105	0.561	3.2.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.15	0.787	2.29	0.09	0.85	3zmrA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0009279 GO:0016020 GO:0016787 GO:0016798 GO:0033946 GO:0085030 GO:2000899
1	0.07	0.551	2.83	0.08	0.61	3ndyA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030247
2	0.07	0.558	3.23	0.08	0.63	3ayrA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
3	0.07	0.556	2.97	0.06	0.62	1edgA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245
4	0.07	0.563	3.07	0.07	0.64	4nf7A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030247
5	0.07	0.511	2.83	0.08	0.57	3amdB	GO:0004553 GO:0005576 GO:0005975 GO:0006073 GO:0008152 GO:0008422 GO:0009251 GO:0009986 GO:0016787 GO:0016798
6	0.07	0.555	2.92	0.09	0.62	4yheA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
7	0.07	0.552	2.73	0.08	0.61	2jepA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0033946
8	0.07	0.476	3.64	0.12	0.56	4ee9A	GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798
9	0.07	0.476	3.66	0.08	0.56	4lx4B	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
10	0.07	0.550	3.06	0.08	0.62	5d9nA	GO:0004553 GO:0005975 GO:0006080 GO:0016985
11	0.07	0.559	2.88	0.06	0.62	4x0vC	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
12	0.07	0.553	3.21	0.10	0.63	4w8aA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
13	0.07	0.547	2.70	0.07	0.61	4im4A	GO:0000272 GO:0003824 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030248 GO:0045493 GO:0046555 GO:0046872 GO:2000884
14	0.07	0.543	3.20	0.12	0.62	4w84A	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0033946
15	0.07	0.537	3.00	0.08	0.61	4v2xA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
16	0.07	0.510	2.77	0.10	0.57	5bywE	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245
17	0.07	0.508	2.87	0.08	0.57	3ncoA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
18	0.07	0.487	3.46	0.10	0.57	1cenA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245
19	0.07	0.466	3.73	0.09	0.56	3w0kA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
20	0.07	0.476	3.82	0.08	0.57	3qr3A	GO:0000272 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030248
21	0.07	0.471	3.14	0.09	0.53	3amgB	GO:0004553 GO:0005576 GO:0005975 GO:0006073 GO:0008152 GO:0008422 GO:0009251 GO:0009986 GO:0016787 GO:0016798

Consensus prediction of GO terms

Molecular Function	GO:0052736
GO-Score	0.31
Biological Processes	GO:0030243	GO:0051275	GO:0044403	GO:2000895	GO:0010411
GO-Score	0.39	0.39	0.31	0.31	0.31
Cellular Component	GO:0019867	GO:0030313	GO:0044462
GO-Score	0.31	0.31	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.