I-TASSER results

I-TASSER results for job id Rv3683

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (319 residues)
MAAVLPTLIRTGAVALGSAIAGIGYAALVERNAFVLREVTMPVLTPGSTPLRVLHISDLH
MLPNQHRKQAWLRELASWEPDLVVNTGDNLAHPKAVPAVVQTLSDLLSRPGVFVFGSNDY
FGPRLKNPMNYLTSPDHRVRGAALPWQDLRAAFTERGWLDLTHTRREFEVAGLHIAAAGV
DDPHIDRDRYDTIAGPASPAANLRLGLTHSPEPRVLDRFAADGYQLVLAGHTHGGQLCLP
LYGALVTNCGLDRSRAKGASHWGANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPM
GGRDSSSNLGRSQPTVSVR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAAVLPTLIRTGAVALGSAIAGIGYAALVERNAFVLREVTMPVLTPGSTPLRVLHISDLHMLPNQHRKQAWLRELASWEPDLVVNTGDNLAHPKAVPAVVQTLSDLLSRPGVFVFGSNDYFGPRLKNPMNYLTSPDHRVRGAALPWQDLRAAFTERGWLDLTHTRREFEVAGLHIAAAGVDDPHIDRDRYDTIAGPASPAANLRLGLTHSPEPRVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRAKGASHWGANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSSSNLGRSQPTVSVR
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHCCCCCCCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHCCCCEEEHCCCCCCCCHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEHCCCEEEEEHCCEEEEEEHCCCCCCCCCCHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHCCCEEEEHCCCCCEEEHCCCCCEHCCCCCCCCCCEEEEEEHCCEEEEEHCCCCCCCCCCEHCCCCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9867899999999999999999999999856758999999779987779968999967888998589999999999779999998798899975899999999866889869987888788887655677764666544566777799999999999988567668999789689999758877788888898756898888589998899868999988659859998658998688577786454666677644445898699899995788888899845588987999999867888887655566778887789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAAVLPTLIRTGAVALGSAIAGIGYAALVERNAFVLREVTMPVLTPGSTPLRVLHISDLHMLPNQHRKQAWLRELASWEPDLVVNTGDNLAHPKAVPAVVQTLSDLLSRPGVFVFGSNDYFGPRLKNPMNYLTSPDHRVRGAALPWQDLRAAFTERGWLDLTHTRREFEVAGLHIAAAGVDDPHIDRDRYDTIAGPASPAANLRLGLTHSPEPRVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRAKGASHWGANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSSSNLGRSQPTVSVR
Prediction	5343233222310122122222221101123330314504055037526400000000010233462033005304725010000000002446304400510460362300000000011143252224204344432444514153025004713030021431334244120000102113242441342044325743000000025123104303733010000000000001013311010114133320100123376230201020132332101010100000011234444556455544454455548
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHCCCCCCCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHCCCCEEEHCCCCCCCCHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEHCCCEEEEEHCCEEEEEEHCCCCCCCCCCHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHCCCEEEEHCCCCCEEEHCCCCCEHCCCCCCCCCCEEEEEEHCCEEEEEHCCCCCCCCCCEHCCCCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCC
MAAVLPTLIRTGAVALGSAIAGIGYAALVERNAFVLREVTMPVLTPGSTPLRVLHISDLHMLPNQHRKQAWLRELASWEPDLVVNTGDNLAHPKAVPAVVQTLSDLLSRPGVFVFGSNDYFGPRLKNPMNYLTSPDHRVRGAALPWQDLRAAFTERGWLDLTHTRREFEVAGLHIAAAGVDDPHIDRDRYDTIAGPASPAANLRLGLTHSPEPRVLDRFAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRAKGASHWGANMRLHVSAGIGTSPFAPVRFCCRPEATLLTLIATPMGGRDSSSNLGRSQPTVSVR

3rl3A

0.16

0.13

0.78

1.02

MUSTER

VDEYSSN------PTQAFTHYNINQSRFQPPHVHMVDPIP-YDTPKPAGHTRFVCISDTHSRTDG---------IQMPYGDILLHTGDFTELPSEVKKFNDWLGNLPYEYKIVIAGNHELTF--DKEFMADLVRFPSVSKLKPEDFDNVQSLLT--NSIYLQDSEVTVK--GFRIYGAPWNGWGFNLPRGQSLLDKWNLPEGTDILMTHGPCVELLNTVQRRRPKLHVFGGIHEG---------------------YGTMTDGYT--TYINASTCTVSFQP---TNPP--IIFDLPNP---------------------

1s8eA1

0.14

0.09

0.69

1.26

dPPAS

--------------------------------------------------MKFAHLADIHLGYEQEAFKNALEIAVQENVDFILIAGDLFHSSGTLKKAIALLQIPHSIPVFAIEGNLVRTQRGPSVLNLLEDFGLVYVIGMRKEKVENEYLT----SERLGNGEYLVKGVYKDLEIHGMKYMSSAWEANKEILKRLFRPTDNAILMLHQGVREVSEALGDEGYLYYALGHIHKRYETSYSGSPVVYPGSLERWVNKGFYIVEDFKPRFVEIKV---------------------------------------------

3rl3A

0.16

0.12

0.76

1.61

wdPPAS

--------VTITVPTQAFTHYNINQSRFQPPHVHMVDPIP-YDTPKPAGHTRFVCISDTHSRTDG---------IQMPYGDILLHTGDFTELPSEVKKFNDWLGNLPYEYKIVIAGNHELT--FDKEFMADLVRFPSVSKLKPEDFDNVQSLLT--NSIYLQDSEVTVK----GFRIYGAPGFNLPRGQSLLDKWNLIPEGT-DILMTHGPCVELLNTVQRRRPKLHVFGGIHEG---------------------YGTMTDGYT--TYINASTCTVSFQP---TNPP--IIFDLPNP---------------------

3rl3A

0.17

0.13

0.77

1.28

wMUSTER

VDEYSSN------PTQAFTHYNINQSRFQPPHVHMVDPIP-YDTPKPAGHTRFVCISDTHSRTDG---------IQMPYGDILLHTGDFTELPSEVKKFNDWLGNLPYEYKIVIAGNHELTF--DKEFMADLVRFPSVSKLKPEDFDNVQSLLT--NSIYLQDSEVTVK--GFRIYGAPWWGFNLPRGQSLLDKWNLIPEG-TDILMTHGPCVELLNTVQRRRPKLHVFGGIHEG---------------------YGTMTDGYT--TYINASTCTVSFQP---TNPP--IIFDLPNP---------------------

3d03A

0.17

0.12

0.68

1.69

wPPAS

--------------------------------------------------MLLAHISDTHFRSRGAANADVVSQLNALRPDAVVVSGDIVNCPEEYQVARQILGSLNYP-LYLIPGNHDD---------------------KALFLEYLQPLCPQLGSDA-NNMRCAVDDFA--TRLLFIDSSRAGTSKWLEAQLFEGGDKPATIFMHHPPGHRLLALVERFSLTRIFCGHNH-----------------------SLTMTQYRQALISTLPGTVH-DTDPYDLS-PASCLMHRQVGESLAHYAG--DENISCPTEE-R

1s8eA1

0.14

0.09

0.68

2.44

dPPAS2

--------------------------------------------------MKFAHLADIHLGYEQEAFKNALEIAVQENVDFILIAGDLFHSSGTLKKAIALLQIPHSIPVFAIEGNLVRTQRGPSVLNLLEDFGLVYVIGMRKEKVENEYLT----SERLGNGEYLVKGVYKDLEIHGMKYMSSAWEANKEILKRLFRPTDNAILMLHQGVREVSEALGDEGYLYYALGHIHKRYETSYSGSPVVYPGSLERWVNKGFYIVEDFKPRFVE------------------------------------------------

3d03A

0.15

0.10

0.69

1.46

PPAS

--------------------------------------------------MLLAHISDTHFRSRGAANADVVSQLNALRPDAVVVSGDIVNCPEEYQVARQILGSLNYP-LYLIPGNHDD---------------------KALFLEYLQPLCPQLGSDA-NNMRCAVDDFA--TRLLFIDSSRAGTSKWLEAQLFEGGDKPATIFMHHPPLHRLLALVERFPLTRIFCGHNHSL-----------------------TMTQYRQALISTLPGTVHADTDPYYDLSPASCLMHRQVGESLAHYAGPWLYDENISCPTEE

3auzA1

0.16

0.11

0.69

1.51

Env-PPAS

----------------------------------------------RGSHMMFVHIADNHLGYIYDSFKLCIKKILEIKPDVVLHSGDLFNDLKALRIAMQAFKKLHENKVYIVAGNHEMP----------------RRLGEESPLALLK------DYVKILDGKDVINVNGEEIFICGTYYHKKSKRDKLKNFESEAKNYKKKILMLHQPLDYELEHFDLPKFSYYALGHIHKRILERFNDGILAYSGSTEIIYRYEDYKKEGKGFYLVDFSGNDLDISDIEK-IDIE------------------------------

1s8eA1

0.15

0.10

0.69

0.98

MUSTER

--------------------------------------------------MKFAHLADIHLGYEQEAFKNALEIAVQENVDFILIAGDLFHSSGTLKKAIALLQIPKEIPVFAIEGNLVRTQRG-PSVLNLLEDFGLVYVIGMRKEKVENEYLT---SERLGNGEYLVKGVYKDLEIHGMKYMSSAWEANKEILKRLFRPTDNAILMLHQGVREVSEAGLGDGYLYYALGHIHKRYETSYSGSPVVYPGSLERWVNKGFYIVEDFKPRFVE--------IKV-------------------------------------

1s8eA

0.12

0.10

0.83

1.05

dPPAS

--------------------------------------------------MKFAHLADIHLGYEQEAFKNALEIAVQENVDFILIAGDLFHSSGTLKKAIALLQIPHSIPVFAIEGNLVRTQRGPSVLNLLEDFGLVYVIGMRKEKVENEYLT----SERLGNGEYLVKGVYKDLEIHGMKYMSSAWEANKEILKRLFRPTDNAILMLHQGVREVSEALGDEGYLYYALGHIHKRYETSYSGSPVVYLERWDFGDYEVRYEWDGIKFKERYGVNKDFKPRFVEIKVRP-FIDVKIKGSEEEIRKAIKRLIPLIPKNAYV

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.67

Estimated TM-score = 0.51±0.15

Estimated RMSD = 10.2±4.6Å

Download Model 2

C-score=-3.27

Download Model 3

C-score=-3.23

Download Model 4

C-score=-4.74

Download Model 5

C-score=-2.04

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3rl3A	0.669	2.72	0.123	0.765
2	4fbkA	0.559	3.99	0.125	0.699
3	2xmoA	0.557	4.38	0.112	0.712
4	5fi9A	0.556	4.75	0.104	0.737
5	5ebbA	0.552	4.40	0.107	0.709
6	4ykeA1	0.551	3.72	0.144	0.674
7	1warA	0.549	3.84	0.137	0.683
8	5karA	0.548	4.12	0.126	0.690
9	2yeqA2	0.547	4.42	0.112	0.709
10	3auzA	0.545	3.63	0.128	0.655

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.42	68	3ivdA	FE	Rep, Mult	58,88,117,118,209,231
2	0.39	69	4m0vA	MN	Rep, Mult	58,60,88,231,233
3	0.00	1	2z06B	CO	Rep, Mult	58,230,231,232,233,248,250

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1vjiA	0.482	5.72	0.053	0.752	1.3.1.42	NA
2	0.060	3gh4A	0.489	5.43	0.075	0.709	3.2.1.52	NA
3	0.060	1q45B	0.436	5.74	0.055	0.668	1.3.1.42	NA
4	0.060	1iwpA	0.492	5.85	0.083	0.771	4.2.1.30	60
5	0.060	2epoA	0.473	5.56	0.050	0.709	3.2.1.52	NA
6	0.060	2vkzG	0.475	5.74	0.053	0.730	2.3.1.38,3.1.2.14	87
7	0.060	1kxhA	0.499	5.39	0.062	0.727	3.2.1.1	83,104
8	0.060	2z1aA	0.476	4.41	0.092	0.630	3.1.3.5	253
9	0.060	1kbpA	0.531	4.19	0.080	0.671	3.1.3.2	NA
10	0.060	1bwlA	0.489	5.67	0.067	0.749	1.6.99.1	NA
11	0.060	2g3mF	0.489	5.82	0.080	0.765	3.2.1.20	NA
12	0.060	2zxqA	0.486	5.68	0.043	0.746	3.2.1.97	101,103,120
13	0.060	4kbpA	0.532	4.17	0.080	0.671	3.1.3.2	190
14	0.060	1warA	0.549	3.84	0.137	0.683	3.1.3.2	213,233
15	0.060	2q3rA	0.487	5.68	0.049	0.743	1.3.1.42	99,157
16	0.060	2j63A	0.486	5.71	0.082	0.721	4.2.99.18	NA
17	0.060	1aqhA	0.499	5.35	0.071	0.724	3.2.1.1	88
18	0.060	2uv8G	0.474	5.77	0.052	0.724	2.3.1.86	NA
19	0.060	2nxfA	0.525	3.52	0.139	0.630	3.6.1.16,3.6.1.53,3.6.1.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.42	0.670	2.82	0.11	0.77	3rl5A	GO:0016787 GO:0046872
1	0.39	0.539	3.74	0.13	0.66	3d03A	GO:0000166 GO:0004115 GO:0016787 GO:0046872
2	0.38	0.544	3.98	0.15	0.67	3ib7A	GO:0000166 GO:0004115 GO:0005506 GO:0005576 GO:0005618 GO:0005737 GO:0005886 GO:0006198 GO:0008199 GO:0008663 GO:0009405 GO:0016020 GO:0016311 GO:0016787 GO:0016791 GO:0030145 GO:0042301 GO:0042545 GO:0046872
3	0.36	0.542	3.76	0.14	0.66	3av0A	GO:0004518 GO:0004519 GO:0004527 GO:0006281 GO:0006302 GO:0006974 GO:0016787 GO:0030145 GO:0042802 GO:0046872 GO:0090305
4	0.30	0.557	4.38	0.11	0.71	2xmoA	GO:0004115 GO:0016787 GO:0046872
5	0.07	0.516	3.19	0.14	0.61	1uf3A	GO:0046872
6	0.07	0.545	3.49	0.13	0.65	4ltyA	GO:0004518 GO:0004519 GO:0004527 GO:0006259 GO:0006260 GO:0006310 GO:0008408 GO:0016787 GO:0046872 GO:0090305
7	0.07	0.559	3.99	0.12	0.70	4fbkA	GO:0000014 GO:0000723 GO:0000724 GO:0000729 GO:0000784 GO:0004518 GO:0004519 GO:0004527 GO:0005634 GO:0006281 GO:0006302 GO:0006303 GO:0006974 GO:0007131 GO:0008310 GO:0008311 GO:0008408 GO:0016787 GO:0030145 GO:0030870 GO:0031573 GO:0034613 GO:0035861 GO:0042138 GO:0051321 GO:1990421 GO:1990918
8	0.07	0.552	3.67	0.14	0.67	4ykeB	GO:0004518 GO:0004519 GO:0004527 GO:0005634 GO:0006281 GO:0006302 GO:0006974 GO:0008408 GO:0016787 GO:0030145 GO:0030870 GO:0046872 GO:0051321 GO:0090305
9	0.07	0.531	3.65	0.15	0.64	3qg5D	GO:0003677 GO:0004518 GO:0004519 GO:0004527 GO:0006259 GO:0006260 GO:0006310 GO:0008408 GO:0016787 GO:0046872 GO:0090305
10	0.07	0.541	3.49	0.13	0.65	4fcxB	GO:0000014 GO:0000723 GO:0000724 GO:0000729 GO:0000784 GO:0004518 GO:0004519 GO:0004527 GO:0005634 GO:0006281 GO:0006302 GO:0006303 GO:0006974 GO:0007131 GO:0008310 GO:0008311 GO:0008408 GO:0016787 GO:0030145 GO:0030870 GO:0031573 GO:0034613 GO:0035861 GO:0042138 GO:0051321 GO:1990421 GO:1990918
11	0.07	0.532	3.64	0.11	0.64	3dscA	GO:0004518 GO:0004519 GO:0004527 GO:0006281 GO:0006302 GO:0006974 GO:0016787 GO:0030145 GO:0042802 GO:0046872 GO:0090305
12	0.07	0.539	3.79	0.16	0.66	3t1iD	GO:0000014 GO:0000019 GO:0000724 GO:0000729 GO:0000731 GO:0000732 GO:0000781 GO:0000784 GO:0000790 GO:0000794 GO:0003677 GO:0003690 GO:0004003 GO:0004518 GO:0004519 GO:0004520 GO:0004527 GO:0005634 GO:0005654 GO:0005694 GO:0005737 GO:0005829 GO:0005913 GO:0006260 GO:0006281 GO:0006302 GO:0006303 GO:0006310 GO:0006974 GO:0007004 GO:0007062 GO:0007095 GO:0007129 GO:0007131 GO:0007507 GO:0008022 GO:0008283 GO:0008408 GO:0016032 GO:0016605 GO:0016787 GO:0030145 GO:0030870 GO:0031573 GO:0031860 GO:0031954 GO:0032206 GO:0032481 GO:0032508 GO:0032876 GO:0033674 GO:0035861 GO:0043066 GO:0046597 GO:0048471 GO:0051276 GO:0051321 GO:0090305 GO:0098609 GO:0098641 GO:1901796
13	0.07	0.464	5.79	0.08	0.72	3u7vA	GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0009341 GO:0016787 GO:0016798
14	0.06	0.407	5.92	0.06	0.64	3bxwA	GO:0002376 GO:0004553 GO:0004568 GO:0005576 GO:0005615 GO:0005634 GO:0005764 GO:0005770 GO:0005802 GO:0005975 GO:0006032 GO:0008061 GO:0016020 GO:0045087 GO:0070062 GO:0070492 GO:1900016
15	0.06	0.319	6.73	0.06	0.56	1pguB	GO:0003779 GO:0005737 GO:0005856 GO:0005884 GO:0006970 GO:0030042 GO:0030479 GO:0032466 GO:0051016
16	0.06	0.361	5.75	0.11	0.57	2a0mA	GO:0046872
17	0.06	0.289	6.50	0.05	0.48	2qmiA
18	0.06	0.284	5.82	0.06	0.44	3iwaA	GO:0005623 GO:0016491 GO:0045454 GO:0050660 GO:0055114
19	0.06	0.282	5.58	0.11	0.45	4pooA	GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539

Consensus prediction of GO terms

Molecular Function	GO:0004115	GO:0000166	GO:0030145	GO:0042301	GO:0016791	GO:0008663	GO:0008199	GO:0042802	GO:0004519	GO:0004527
GO-Score	0.73	0.62	0.60	0.38	0.38	0.38	0.38	0.36	0.36	0.36
Biological Processes	GO:0009405	GO:0006198	GO:0042545	GO:0016311	GO:0006302	GO:0090305
GO-Score	0.38	0.38	0.38	0.38	0.36	0.36
Cellular Component	GO:0005576	GO:0005737	GO:0005618	GO:0005886
GO-Score	0.38	0.38	0.38	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.