I-TASSER results

I-TASSER results for job id Rv3661

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (287 residues)
MTVSDSPAQRQTPPQTPGGTAPRARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLLNRRAV
LKSSYAQFIFLLSGADHDQMDRMRTHLTNMCAGWDVAQVRSIVNETLHDIVTPLVFAEAA
DLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMIVEDGKYTGEVAFYCYGEG
KAQAIRELAASEGYPLEHCYAYSDSITDLPMLEAVGHASVVNPDRGLRKEASVRGWPVLS
FSRPVSLRDRIPAPSAAAIATTAAVGISALAAGAVTYALLRRFAFQP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVSDSPAQRQTPPQTPGGTAPRARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLLNRRAVLKSSYAQFIFLLSGADHDQMDRMRTHLTNMCAGWDVAQVRSIVNETLHDIVTPLVFAEAADLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMIVEDGKYTGEVAFYCYGEGKAQAIRELAASEGYPLEHCYAYSDSITDLPMLEAVGHASVVNPDRGLRKEASVRGWPVLSFSRPVSLRDRIPAPSAAAIATTAAVGISALAAGAVTYALLRRFAFQP
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEHCCCHHHHHHHHHHHCCCEEEHCEEEEHCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCCHHHEEEEHCCCHHHHHHHHCCCCEEHCCCHHHHHHHHHHCCCEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
Conf.Score	98788877766788888888888878999879988678767999999999989988888889999999999996988789999999999987999999999999999999876589899999999999999899996896899999999989978986568998999986874766789999999999999899976768875896589999987996898899999999999899588758887766776777656678888999999999998887654667899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVSDSPAQRQTPPQTPGGTAPRARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLLNRRAVLKSSYAQFIFLLSGADHDQMDRMRTHLTNMCAGWDVAQVRSIVNETLHDIVTPLVFAEAADLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMIVEDGKYTGEVAFYCYGEGKAQAIRELAASEGYPLEHCYAYSDSITDLPMLEAVGHASVVNPDRGLRKEASVRGWPVLSFSRPVSLRDRIPAPSAAAIATTAAVGISALAAGAVTYALLRRFAFQP
Prediction	75375445545444644654456421010002541303110000003201544204332103320330232044242421430141013104414263035005300452035202520240043037340300000001230042005404022010030115412000400410236300510350076370414201000313220410430520100103640262067470312304433433543423333121102022201210111121334425468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEHCCCHHHHHHHHHHHCCCEEEHCEEEEHCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCCHHHEEEEHCCCHHHHHHHHCCCCEEHCCCHHHHHHHHHHCCCEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MTVSDSPAQRQTPPQTPGGTAPRARTAAFFDLDKTIIAKSSTLAFSKPFFAQGLLNRRAVLKSSYAQFIFLLSGADHDQMDRMRTHLTNMCAGWDVAQVRSIVNETLHDIVTPLVFAEAADLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATRMIVEDGKYTGEVAFYCYGEGKAQAIRELAASEGYPLEHCYAYSDSITDLPMLEAVGHASVVNPDRGLRKEASVRGWPVLSFSRPVSLRDRIPAPSAAAIATTAAVGISALAAGAVTYALLRRFAFQP

3fvvA

0.27

0.21

0.76

2.48

MUSTER

----------------------TTRRLALFDLDHTLLPLDSDYQWADFLARTGRAGDPAEARRRNDDLMERYNRGELTAEQAAEFMLGLLA-AHSPVELAAWHEEFMRDVIRPSLTVQAVDVVRGHLAAGDLCALVTATNSFVTAPIARAFGVQHLIATDPEYRDGRYTGRIETPSFREGKVVRVNQWLAGMGLAFAESYFYSDSVNDVPLLEAVTRPIAANPSPGLREIAQARGWQVIDLF---------------------------------------------

3fvvA

0.28

0.21

0.76

3.94

dPPAS

----------------------TTRRLALFDLDHTLLPLDSDYQWADFLARTGRAGDPAEARRRNDDLMERYNRGELTAEQAAEFMLGLLA-AHSPVELAAWHEEFMRDVIRPSLTVQAVDVVRGHLAAGDLCALVTATNSFVTAPIARAFGVQHLIATDPEYRDGRYTGRIETPSFREGKVVRVNQWLAGMGLALGDSYFYSDSVNDVPLLEAVTRPIAANPSPGLREIAQARGWQVIDLF---------------------------------------------

3fvvA

0.28

0.21

0.76

4.16

wdPPAS

----------------------TTRRLALFDLDHTLLPLDSDYQWADFLARTGRAGDPAEARRRNDDLMERYNRGELTAEQAAEFMLGLLA-AHSPVELAAWHEEFMRDVIRPSLTVQAVDVVRGHLAAGDLCALVTATNSFVTAPIARAFGVQHLIATDPEYRDGRYTGRI-TPSFREGKVVRVNQWLAGMGLALGDSYFYSDSVNDVPLLEAVTRPIAANPSPGLREIAQARGWQVIDLF---------------------------------------------

3fvvA

0.28

0.21

0.76

3.07

wMUSTER

-----------------------TRRLALFDLDHTLLPLDSDYQWADFLARTGRAGDPAEARRRNDDLMERYNRGELTAEQAAEFMLGLLA-AHSPVELAAWHEEFMRDVIRPSLTVQAVDVVRGHLAAGDLCALVTATNSFVTAPIARAFGVQHLIATDPEYRDGRYTGRI-TPSFREGKVVRVNQWLAGMGLAFAESYFYSDSVNDVPLLEAVTRPIAANPSPGLREIAQARGWQVIDLF---------------------------------------------

3fvvA

0.28

0.21

0.76

4.08

wPPAS

----------------------TTRRLALFDLDHTLLPLDSDYQWADFLARTGRAGDPAEARRRNDDLMERYNRGELTAEQAAEFMLGLLA-AHSPVELAAWHEEFMRDVIRPSLTVQAVDVVRGHLAAGDLCALVTATNSFVTAPIARAFGVQHLIATDPEYRDGRYTGRIETPSFREGKVVRVNQWLAGMGLALGDSYFYSDSVNDVPLLEAVTRPIAANPSPGLREIAQARGWQVIDLF---------------------------------------------

3fvvA

0.28

0.21

0.76

7.18

dPPAS2

----------------------TTRRLALFDLDHTLLPLDSDYQWADFLARTGRAGDPAEARRRNDDLMERYNRGELTAEQAAEFMLGLLA-AHSPVELAAWHEEFMRDVIRPSLTVQAVDVVRGHLAAGDLCALVTATNSFVTAPIARAFGVQHLIATDPEYRDGRYTGRIETPSFREGKVVRVNQWLAGMGLALGDSYFYSDSVNDVPLLEAVTRPIAANPSPGLREIAQARGWQVIDLF---------------------------------------------

3fvvA

0.28

0.21

0.76

3.53

PPAS

----------------------TTRRLALFDLDHTLLPLDSDYQWADFLARTGRAGDPAEARRRNDDLMERYNRGELTAEQAAEFMLGLLA-AHSPVELAAWHEEFMRDVIRPSLTVQAVDVVRGHLAAGDLCALVTATNSFVTAPIARAFGVQHLIATDPEYRDGRYTGRIETPSFREGKVVRVNQWLAGMGLALGDSYFYSDSVNDVPLLEAVTRPIAANPSPGLREIAQARGWQVIDLF---------------------------------------------

3fvvA

0.28

0.21

0.76

4.75

Env-PPAS

----------------------TTRRLALFDLDHTLLPLDSDYQWADFLARTGRAGDPAEARRRNDDLMERYNRGELTAEQAAEFMLGLLA-AHSPVELAAWHEEFMRDVIRPSLTVQAVDVVRGHLAAGDLCALVTATNSFVTAPIARAFGVQHLIATDPEYRDGRYTGRIETPSFREGKVVRVNQWLAGMGLALGDSYFYSDSVNDVPLLEAVTRPIAANPSPGLREIAQARGWQVIDLF---------------------------------------------

1l7nB

0.21

0.15

0.70

1.86

MUSTER

---------------------EKKKKLILFDFDSTLVNNETIDEIAREA-----------VEEEVKKITKEAE-GKLNFEQSLRKRVSLL-KDLPIEKVEKAIKRI-------TPTEGAEETIKELKNRGYVVAVVSGGFDIAVNKIKEKLGLDYAFANRLIVKDGKLTGDVEEVLKENAKGEILEKIAKIEGINLEDTVAVGDGANDISF-KKAGLKIAFCAKPILKEKADIC-REILKYIK--------------------------------------------

3p96A3

0.21

0.16

0.76

2.71

dPPAS

------------------------KRLIVFDVDSTLVQGEVIEMLAAKAG----------AEGQVAAITDAAMRGELDFAQSLQQRVATL-AGLPATVIDEVAGQL-------ELMPGARTTLRTLRRLGYACGVVSGGFRRIIEPLAEELMLDYVAANELEIVDGTLTGRVGPIIDRAGKATALREFAQRAGVPMAQTVAVGDGANDIDMLAAAGLGIAFNAKPALREVA----------------DASLSHPYLDTVLFLLGVTRGEIEAADAID----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.71

Estimated TM-score = 0.62±0.14

Estimated RMSD = 7.7±4.3Å

Download Model 2

C-score=-2.13

Download Model 3

C-score=-2.60

Download Model 4

C-score=-2.15

Download Model 5

C-score=-3.34

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3fvvA	0.723	1.54	0.283	0.763
2	4ezeA	0.643	2.66	0.142	0.735
3	4nv0A	0.641	3.42	0.143	0.787
4	4gxtA	0.636	3.52	0.154	0.777
5	4as2A	0.632	3.17	0.168	0.749
6	3p96A	0.630	3.33	0.189	0.767
7	2bduA	0.628	3.40	0.103	0.770
8	3n28A	0.623	3.26	0.136	0.746
9	1l8oA	0.618	2.94	0.136	0.718
10	1y8aA	0.609	3.57	0.140	0.749

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.70	111	4knvA	MG	Rep, Mult	31,33,204
2	0.28	42	1f5sA	PO4	Rep, Mult	31,32,33,137,138,181,207
3	0.00	1	1f5sB	PO4	Rep, Mult	228,234
4	0.00	1	1j97B	PO4	Rep, Mult	145,148,149
5	0.00	1	1rku0	III	Rep, Mult	127,128,132,133,134,141,145,155,156,157,158,159,160,172,174,175,183,184,195
6	0.00	1	2voyK	III	Rep, Mult	177,181,184,185,192
7	0.00	1	1l7pA	SEP	Rep, Mult	31,32,33,40,69,73,79,86,137,138,181,207
8	0.00	1	3ar2A	NA	Rep, Mult	212,214,215,236
9	0.00	1	1rkvB	MG	Rep, Mult	204,222
10	0.00	1	1l8l0	III	Rep, Mult	96,99,104,142,160,161,162,163,164,165,167,169,173

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.419	1lvhA	0.516	4.11	0.099	0.679	5.4.2.6	31,137,181
2	0.386	1f5sA	0.601	3.14	0.199	0.718	3.1.3.3	31,33,181,208
3	0.325	1l8lA	0.623	2.78	0.136	0.718	3.1.3.3	137
4	0.211	1l8oB	0.603	2.96	0.133	0.707	3.1.3.3	33,222
5	0.209	1judA	0.495	4.43	0.092	0.662	3.8.1.2	31,35,137,203,208
6	0.192	2w11A	0.474	4.45	0.074	0.620	3.8.1.2	31,35,137,203,208
7	0.154	2r8zP	0.472	2.92	0.137	0.550	3.1.3.45	33,238
8	0.145	2feaA	0.557	3.41	0.111	0.686	3.1.3.-	204,208
9	0.139	1qh9A	0.498	4.54	0.092	0.669	3.8.1.2	152
10	0.078	2vkqA	0.641	3.27	0.105	0.780	3.1.3.5	33,138,204
11	0.066	2gmwB	0.457	3.26	0.161	0.544	3.1.3.-	NA
12	0.060	1cqzB	0.499	4.61	0.123	0.672	3.3.2.10,3.3.2.3	NA
13	0.060	1rdfA	0.519	4.18	0.112	0.683	3.11.1.1	31
14	0.060	1k1eK	0.478	3.38	0.189	0.571	3.1.3.45	33,209,238
15	0.060	2hszA	0.526	4.44	0.120	0.697	3.1.3.18	32
16	0.060	3b8cA	0.520	4.80	0.092	0.728	3.6.3.6	31
17	0.060	2no4B	0.497	4.55	0.094	0.665	3.8.1.2	31,35,137,203,208
18	0.060	2jc9A	0.482	4.74	0.092	0.672	3.1.3.5	89
19	0.060	2qltA	0.514	4.61	0.106	0.700	3.1.3.-	NA
20	0.060	1q17C	0.494	5.02	0.072	0.718	3.5.1.-	NA
21	0.060	2hi0A	0.538	4.07	0.161	0.693	3.1.3.18	NA
22	0.060	2hdoA	0.499	3.85	0.082	0.631	3.1.3.18	NA
23	0.060	2nyvA	0.525	4.12	0.141	0.672	3.1.3.18	33,137,208
24	0.060	3glrA	0.511	5.11	0.083	0.753	3.5.1.-	NA
25	0.060	2b0cA	0.479	4.11	0.134	0.624	3.1.3.-	31,137
26	0.060	1zd3A	0.510	4.47	0.093	0.679	3.3.2.10	259
27	0.060	2g80A	0.500	3.68	0.122	0.631	3.1.3.77	139,204
28	0.060	1ynsA	0.522	3.65	0.135	0.655	3.1.3.77	137,159
29	0.060	1qq5A	0.503	4.64	0.086	0.690	3.8.1.2	148,203
30	0.060	3b8cB	0.520	4.79	0.092	0.728	3.6.3.6	122

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.46	0.623	2.78	0.14	0.72	1l8lA	GO:0000287 GO:0004647 GO:0005509 GO:0005737 GO:0005829 GO:0006563 GO:0006564 GO:0008152 GO:0008652 GO:0009612 GO:0016311 GO:0016787 GO:0016791 GO:0031667 GO:0033574 GO:0042803 GO:0043005 GO:0046872
1	0.46	0.601	3.14	0.20	0.72	1f5sA	GO:0000287 GO:0004647 GO:0005737 GO:0006564 GO:0008152 GO:0008652 GO:0016311 GO:0016787 GO:0016791 GO:0046872
2	0.45	0.603	2.76	0.17	0.70	3kd3A	GO:0004647 GO:0006564 GO:0008152 GO:0016311 GO:0016787 GO:0016791 GO:0046872
3	0.42	0.622	2.66	0.14	0.72	3m1yC	GO:0004647 GO:0006564 GO:0008152 GO:0016311 GO:0016791 GO:0046872
4	0.41	0.531	3.96	0.10	0.68	2hcfA	GO:0016787 GO:0046872
5	0.38	0.723	1.54	0.28	0.76	3fvvA	GO:0008152 GO:0016311 GO:0016791
6	0.36	0.603	2.97	0.15	0.71	1rkuA	GO:0000287 GO:0004413 GO:0004647 GO:0006564 GO:0008652 GO:0009088 GO:0016311 GO:0016787 GO:0043899 GO:0046654 GO:0046820 GO:0046872
7	0.34	0.457	3.29	0.14	0.54	2rarA	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872
8	0.29	0.447	3.48	0.13	0.54	3fzqA	GO:0016787
9	0.29	0.474	2.88	0.13	0.55	2r8xH	GO:0009103 GO:0016311 GO:0016787 GO:0019143 GO:0046872
10	0.26	0.443	4.01	0.18	0.55	1nf2A	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872
11	0.26	0.495	4.43	0.09	0.66	1judA	GO:0008152 GO:0016787 GO:0018784 GO:0019120
12	0.25	0.471	2.95	0.16	0.55	3e81A	GO:0005829 GO:0008781 GO:0016311 GO:0016740 GO:0016779 GO:0016787 GO:0019143 GO:0046872
13	0.23	0.643	2.66	0.14	0.74	4ezeA	GO:0004647 GO:0006564 GO:0008152 GO:0016311 GO:0016787 GO:0016791
14	0.23	0.623	3.26	0.14	0.75	3n28A	GO:0000287 GO:0004647 GO:0005737 GO:0006545 GO:0006564 GO:0008152 GO:0008652 GO:0016311 GO:0016787 GO:0016791 GO:0046872
15	0.21	0.464	3.38	0.17	0.55	2qyhB	GO:0016787
16	0.17	0.630	3.31	0.19	0.77	5it0A	GO:0000287 GO:0004647 GO:0006564 GO:0008152 GO:0008652 GO:0016311 GO:0016597 GO:0016787 GO:0016791 GO:0046872
17	0.16	0.490	4.50	0.14	0.66	4eekA	GO:0008152 GO:0016787 GO:0046872
18	0.15	0.528	4.11	0.14	0.68	2nyvA	GO:0005975 GO:0008152 GO:0008967 GO:0016311 GO:0016787 GO:0046295 GO:0046872
19	0.14	0.565	4.01	0.10	0.72	2om6A	GO:0008152 GO:0016787
20	0.14	0.555	3.40	0.18	0.69	4ap9A	GO:0004647 GO:0006564 GO:0008152 GO:0016311 GO:0016791
21	0.13	0.460	3.47	0.15	0.55	3dnpA	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283
22	0.10	0.490	3.51	0.15	0.60	1j8dA	GO:0005829 GO:0008781 GO:0009103 GO:0016311 GO:0016787 GO:0019143 GO:0046872
23	0.09	0.528	4.30	0.12	0.69	2hszA	GO:0005975 GO:0008152 GO:0008967 GO:0016311 GO:0016787 GO:0046295 GO:0046872
24	0.07	0.497	4.55	0.09	0.67	2no4B	GO:0008152 GO:0016787 GO:0018784 GO:0019120

Consensus prediction of GO terms

Molecular Function	GO:0004647	GO:0000287	GO:0005509	GO:0042803
GO-Score	0.91	0.71	0.46	0.46
Biological Processes	GO:0016311	GO:0006564	GO:0033574	GO:0031667	GO:0009612
GO-Score	0.91	0.91	0.46	0.46	0.46
Cellular Component	GO:0005829	GO:0043005
GO-Score	0.46	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.