I-TASSER results

I-TASSER results for job id Rv3659c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (352 residues)
MLGDTEVLANLRVLQTELTGAGILEPLLSADGTTDVLVTAPDSVWVDDGNGLRRSQIRFA
DESAVRRLAQRLALAAGRRLDDAQPWVDGQLTGIGVGGFAVRLHAVLPPVATQGTCLSLR
VLRPATQDLAALAAAGAIDPAAAALVADIVTARLAFLVCGGTGAGKTTLLAAMLGAVSPD
ERIVCVEDAAELAPRHPHLVKLVARRANVEGIGEVTVRQLVRQALRMRPDRIVVGEVRGA
EVVDLLAALNTGHEGGAGTVHANNPGEVPARMEALGALGGLDRAALHSQLAAAVQVLLHV
ARDRAGRRRLAEIAVLRQAEGRVQAVTVWHADRGMSDDAAALHDLLRSRASA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLGDTEVLANLRVLQTELTGAGILEPLLSADGTTDVLVTAPDSVWVDDGNGLRRSQIRFADESAVRRLAQRLALAAGRRLDDAQPWVDGQLTGIGVGGFAVRLHAVLPPVATQGTCLSLRVLRPATQDLAALAAAGAIDPAAAALVADIVTARLAFLVCGGTGAGKTTLLAAMLGAVSPDERIVCVEDAAELAPRHPHLVKLVARRANVEGIGEVTVRQLVRQALRMRPDRIVVGEVRGAEVVDLLAALNTGHEGGAGTVHANNPGEVPARMEALGALGGLDRAALHSQLAAAVQVLLHVARDRAGRRRLAEIAVLRQAEGRVQAVTVWHADRGMSDDAAALHDLLRSRASA
Prediction	CCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEHCCCCEEEEHCCEEEEHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCCCCCCCCCEEEEEEHCCCCCCCCEEEEEHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHCCCCCEEEHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEEHCCCCCEEEEEEEEEHCCCCCEEEEEEEEHCCCCCCCCCHHHHHHHHHCCC
Conf.Score	9889999999999999998778667887599987899868997899989968996677899999999999999998998888898567997688888898589999487779997899986789999999999989999999999999999899599987899888999999999799998599986885447889987999985788888777899999999985799989998678989999999999799986577658999999999999998769999999999999877899997569995899999999788995999987887478777775589999987789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLGDTEVLANLRVLQTELTGAGILEPLLSADGTTDVLVTAPDSVWVDDGNGLRRSQIRFADESAVRRLAQRLALAAGRRLDDAQPWVDGQLTGIGVGGFAVRLHAVLPPVATQGTCLSLRVLRPATQDLAALAAAGAIDPAAAALVADIVTARLAFLVCGGTGAGKTTLLAAMLGAVSPDERIVCVEDAAELAPRHPHLVKLVARRANVEGIGEVTVRQLVRQALRMRPDRIVVGEVRGAEVVDLLAALNTGHEGGAGTVHANNPGEVPARMEALGALGGLDRAALHSQLAAAVQVLLHVARDRAGRRRLAEIAVLRQAEGRVQAVTVWHADRGMSDDAAALHDLLRSRASA
Prediction	7244631340042014101200202410615701311002433000134541241614023362023004200431734035630201030224635420000000002003511000001136531305302631203520040021004340000001212222220020004103672000000113104052521000102456454434020330032001130100000001151013002001011300000000420430041013004437143620251013001000001337624010000010344624123231032355345444203501464578
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEHCCCCEEEEHCCEEEEHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCCCCCCCCCEEEEEEHCCCCCCCCEEEEEHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHCCCCCEEEHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEEHCCCCCEEEEEEEEEHCCCCCEEEEEEEEHCCCCCCCCCHHHHHHHHHCCC
MLGDTEVLANLRVLQTELTGAGILEPLLSADGTTDVLVTAPDSVWVDDGNGLRRSQIRFADESAVRRLAQRLALAAGRRLDDAQPWVDGQLTGIGVGGFAVRLHAVLPPVATQGTCLSLRVLRPATQDLAALAAAGAIDPAAAALVADIVTARLAFLVCGGTGAGKTTLLAAMLGAVSPDERIVCVEDAAELAPRHPHLVKLVARRANVEGIGEVTVRQLVRQALRMRPDRIVVGEVRGAEVVDLLAALNTGHEGGAGTVHANNPGEVPARMEALGALGGLDRAALHSQLAAAVQVLLHVARDRAGRRRLAEIAVLRQAEGRVQAVTVWHADRGMSDDAAALHDLLRSRASA

4ihqA

0.24

0.23

0.97

2.71

MUSTER

MRLSVPKEYVIYHFIRDKLYTGSLEPLIRDPYIEDISIPGLGHVYIVHVFGPMRTSIKFENYEELDNLIVSLSEKSYRPVSHNRPVVDASLPD------GSRVNFVYGVISRRGSNLTVRKFSRVPTSITQLIMFGTLSSMMAAYIWTMLDEGMNLFVCGETASGKTTTLNAITAFIPPNLKIVTIEDTPELTVPHSNWVAEVTRETG--GEGTIKLFDLLKAALRQRPNYILVGAIRDKEGNVAFQAMQTGH-SVMATFHAANITTLIQRLTGYP--IEVPKSYINNLNIALFQTALYD-KKGNLIRRVVEVDEIIDIDNDVVYIPAFTYDSVQDKGSSYLNKIAVKRGID

2gzaC

0.25

0.22

0.87

4.81

dPPAS

------DEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPM------GERIQIVRPPACEHGTSVTIRKPSFTRRTLEDYAQQGFFKGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPHPNHVHLFYPP--------VTAATLLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRLPYEIIRRLLYLVVDVVVHVHNGHDGTGRHISEVWYDPNTKRALSLQ-------------------------

2gzaC

0.25

0.22

0.87

4.69

wdPPAS

------DEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPM------GERIQIVRPPACEHGTSVTIRKPSFTRRTLEDYAQQGFFKGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDPNHVHLFY--------PPVTAATLLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRLPYEIIRRLLYLVVDVVVHVHNGHDGTRHISEVWY--PNTKRALSLQ-------------------------

4ihqA

0.24

0.23

0.96

3.52

wMUSTER

RLS-VPKEYVIYHFIRDKLYTGSLEPLIRDPYIEDISIPGLGHVYIVHVFGPMRTSIKFENYEELDNLIVSLSEKSYRPVSHNRPVVDASLPD------GSRVNFVYGVISRRGSNLTVRKFSRVPTSITQLIMFGTLSSMMAAYIWTMLDEGMNLFVCGETASGKTTTLNAITAFIPPNLKIVTIEDTPELTVPHSNWVAEVTRETG--GEGTIKLFDLLKAALRQRPNYILVGAIRDKEGNVAFQAMQTGH-SVMATFHAANITTLIQRLTGYP--IEVPKSYINNLNIALFQTALYDKK-GNLIRRVVEVDEIIDIDNDVVYIPAFTYDSVQDKGSSYLNKIAVKRGID

2gzaC

0.25

0.22

0.86

4.17

wPPAS

------DEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPM------GERIQIVRPPACEHGTSVTIRKPSFTRRTLEDYAQQGFFKGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPHPNHVHLFYPP--------VTAATLLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNQLPYEIIRRLLYLVVDVVVHVHNGHDGTRHISEVWY--PNTKRLSLQ--------------------------

2gzaC

0.26

0.22

0.84

8.43

dPPAS2

------DEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPM------GERIQIVRPPACEHGTSVTIRKPSFTRRTLEDYAQQGFFKGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPHPNHVHLFYPP--------VTAATLLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRLPYEIIRRLLYLVVDVVVHVHNGHDGTRHISEVWY-------------------------------------

2gzaC

0.25

0.22

0.87

4.04

PPAS

------DEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPM------GERIQIVRPPACEHGTSVTIRKPSFTRRTLEDYAQQGFFKGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPHPNHVHLFYPP--------VTAATLLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRLPYEIIRRLLYLVVDVVVHVHNGHDGTRHISEVWY--PNTKRALSLQ-------------------------

2gzaC

0.25

0.22

0.87

6.86

Env-PPAS

------DEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPM------GERIQIVRPPACEHGTSVTIRKPSFTRRTLEDYAQQGFFKGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPHPNHVHLFYPP--------VTAATLLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRLPYEIIRRLLYLVVDVVVHVHNGHDGTRHISEVWYDPNTKRALSLQ--------------------------

2oap2

0.23

0.21

0.93

2.45

MUSTER

VSFTDNFYSRLYYLFRDFFGYGLIDP-LEDTNVEDISCDGYNIPIFIYHQKYGNVETNIVLDQEKLDRVLRLTQRSGKHISIANPIVDATLPD------GSRLQATFGTVTPRGSSFTIRKFTIEPLTPIDLIEKGTVPSGVLAYLWLAIEHKFSAIVVGETASGKTTTLNAIF--IPPDAKVVSIEDTREIKLYHENWIAEVTRTGEID-------YDLLRAALRQRPDYIIVGEVRGREAQTLFQAS-TGH-ASYSTLHAGDI-NQVYRLESE------PLKVPRSLQFLDIALVQTWVRGNTRLRRTKEVNEILGVDKNLLVNQFVKWDPKEDKVSPKKLEKADFLGVS

1g6oA

0.23

0.19

0.84

4.31

dPPAS

-LSAEDKKFLEVERALKEAALNPLRHATEEENITEICYNGNKVVWVLKNGEWQPFDVRDRKAFSLSHFARCCASFKKKTIDYENPILSSNLAN------GERVQIVLSPVTVNDESISIRIPSKTTYPHSFFEEQGFYNEQAISAIKDGIAIGKNVIVCGGTGSGKTTYIKSIE-FIPKEERIISIEDTEEIVFKHKNYTQLFFG-------GNITSADCLKSCLR-RPDRIILGELRSSEAYDFYNVLCSGHKGTLTTLHAGSSEEAFIRLANSSAARNIKFESLIEGFKDLIDIVHINH-----HKQCDEFYIK------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.52

Estimated TM-score = 0.78±0.09

Estimated RMSD = 5.4±3.5Å

Download Model 2

C-score=-1.05

Download Model 3

C-score=-3.40

Download Model 4

C-score=-4.44

Download Model 5

C-score=-1.03

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4ihqA	0.871	2.48	0.229	0.955
2	2oap2	0.739	3.54	0.215	0.898
3	3jvvA	0.707	3.23	0.200	0.824
4	2gszA	0.705	3.34	0.190	0.835
5	1g6oA	0.661	3.41	0.193	0.787
6	5fl3A	0.651	4.11	0.183	0.810
7	1p9wA	0.643	4.07	0.178	0.810
8	4ksrA	0.641	4.06	0.179	0.801
9	5e7pA	0.469	5.50	0.089	0.673
10	2gzaC	0.466	2.74	0.155	0.508

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.45	17	1nlyB	AGS	Rep, Mult	126,132,161,162,165,166,167,168,236,261,308
2	0.17	8	1opxA	SO4	Rep, Mult	161,162,163,165,166,167
3	0.10	5	2oap2	ANP	Rep, Mult	120,122,132,135,162,165,166,167,168,236,308
4	0.05	3	4ihqA	ADP	Rep, Mult	132,135,137,165,166,167,168,308
5	0.05	2	2oaq2	PO4	Rep, Mult	167,191,236,259
6	0.04	3	2agvA	PTY	Rep, Mult	21,24,68,72,75,76
7	0.01	1	2voyK	III	Rep, Mult	165,168,169,176

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1bf2A	0.437	6.76	0.067	0.753	3.2.1.68	NA
2	0.060	1ultA	0.395	6.45	0.063	0.633	6.2.1.3	45
3	0.060	2zrpA	0.379	4.30	0.063	0.483	3.4.99.37	165,167,187,189
4	0.060	2vz9B	0.313	5.40	0.058	0.452	2.3.1.85	NA
5	0.060	2dkfA	0.399	5.90	0.072	0.602	3.1.-.-	NA
6	0.060	1ea0A	0.399	6.43	0.053	0.642	1.4.1.13	NA
7	0.060	3gm8A	0.393	6.59	0.033	0.656	3.2.1.-	NA
8	0.060	3bq5A	0.376	6.39	0.041	0.608	2.1.1.14	NA
9	0.060	3crvA	0.398	6.02	0.059	0.617	3.6.4.12	220,225
10	0.060	2ebsB	0.393	6.22	0.053	0.631	3.2.1.150	47
11	0.060	2okcB	0.414	5.90	0.072	0.625	2.1.1.72	NA
12	0.060	2vdcF	0.384	6.40	0.045	0.631	1.4.1.13	NA
13	0.060	2jfdA	0.260	6.45	0.041	0.432	2.3.1.85	NA
14	0.060	2o1xB	0.396	6.17	0.060	0.622	2.2.1.7	NA
15	0.060	1bhgA	0.404	7.03	0.058	0.716	3.2.1.31	NA
16	0.060	1kwgA	0.394	6.78	0.070	0.665	3.2.1.23	17
17	0.060	1t34A	0.428	5.74	0.090	0.633	4.6.1.2	239,249
18	0.060	2o1xC	0.376	6.33	0.059	0.597	2.2.1.7	234
19	0.060	1sqfA	0.395	6.07	0.074	0.614	2.1.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.48	0.871	2.48	0.23	0.95	4ihqA	GO:0000166 GO:0005524 GO:0006810
1	0.43	0.764	3.43	0.21	0.92	2oap2	GO:0000166 GO:0005524 GO:0006810
2	0.42	0.716	3.16	0.20	0.83	3jvuA	GO:0000166 GO:0005524 GO:0005737 GO:0006810 GO:0043107 GO:0043108 GO:0044096
3	0.39	0.681	3.70	0.18	0.83	2ewvA	GO:0000166 GO:0005524 GO:0006810
4	0.10	0.704	4.35	0.17	0.89	3jc8Ba	GO:0005524 GO:0006810 GO:0008565 GO:0009297 GO:0015031
5	0.08	0.674	3.34	0.19	0.80	1g6oA	GO:0000166 GO:0005524 GO:0005737 GO:0006810 GO:0009405
6	0.08	0.641	4.06	0.18	0.80	4ksrA	GO:0000166 GO:0005524 GO:0005737 GO:0006810 GO:0008565 GO:0015031 GO:0015627 GO:0015628
7	0.08	0.651	4.11	0.18	0.81	5fl3A	GO:0005524 GO:0006810
8	0.07	0.625	3.35	0.20	0.74	1nlzC	GO:0000166 GO:0005524 GO:0005737 GO:0006810 GO:0009405
9	0.07	0.525	4.22	0.15	0.66	4phtB	GO:0005524 GO:0006810 GO:0008565 GO:0015627 GO:0015628
10	0.07	0.466	2.74	0.15	0.51	2gzaC	GO:0000166 GO:0005524 GO:0005737 GO:0006810 GO:0009405
11	0.06	0.346	4.04	0.07	0.43	1nlfA	GO:0000166 GO:0005524 GO:0006276
12	0.06	0.334	4.46	0.10	0.43	2yz2A	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0016020 GO:0016787 GO:0016887 GO:0032217 GO:0032218
13	0.06	0.331	4.32	0.11	0.42	3vx4D	GO:0000166 GO:0005524 GO:0006508 GO:0006810 GO:0008233 GO:0008234 GO:0016020 GO:0016021 GO:0016887 GO:0022885 GO:0042626 GO:0043213 GO:0055085
14	0.06	0.315	3.89	0.08	0.40	3iuyA	GO:0000166 GO:0003676 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0010501 GO:0016787
15	0.06	0.365	4.95	0.14	0.49	4fwiB	GO:0000166 GO:0005524 GO:0006810 GO:0015833 GO:0016887 GO:0046872 GO:0051536 GO:0051539
16	0.06	0.301	5.73	0.06	0.45	4bejB	GO:0000166 GO:0000266 GO:0001836 GO:0003374 GO:0003924 GO:0005525 GO:0005737 GO:0005739 GO:0005741 GO:0005777 GO:0005794 GO:0005829 GO:0005874 GO:0005903 GO:0005905 GO:0006897 GO:0006921 GO:0008289 GO:0010821 GO:0012501 GO:0012505 GO:0015630 GO:0016020 GO:0016559 GO:0016787 GO:0030054 GO:0030672 GO:0031410 GO:0031625 GO:0032459 GO:0042802 GO:0042803 GO:0043065 GO:0043231 GO:0043234 GO:0043653 GO:0045202 GO:0048471 GO:0050714 GO:0051289 GO:0060047 GO:0061025 GO:0070266 GO:0070584 GO:0070585 GO:0090141 GO:0090149 GO:0090200 GO:1900063 GO:1903146 GO:1903578 GO:2001244
17	0.06	0.288	6.63	0.07	0.47	3i4kA	GO:0003824 GO:0008152 GO:0016853 GO:0018849 GO:0018850 GO:0030145 GO:0046872
18	0.06	0.339	3.74	0.15	0.41	1vplA	GO:0005524 GO:0016887

Consensus prediction of GO terms

Molecular Function	GO:0005524
GO-Score	0.90
Biological Processes	GO:0006810	GO:0043107	GO:0043108
GO-Score	0.90	0.42	0.42
Cellular Component	GO:0044096	GO:0005737
GO-Score	0.42	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.