I-TASSER results

I-TASSER results for job id Rv3658c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (266 residues)
MSGIASAALILSLALVVLPGSPRCRLTPDDTGRRVLLVGARRVAWGVGCVAVGVAALLPL
PTVVAVAVLGATLGLRYRRRRRYLRRSREGQALEAALELVVGELRAGAHPVRAFSIAADE
TGGPVAVALRAVAARARLGADVTAGLLAAARSSALPAYWERLAVCWQLGSDHGLAIASLM
RAAQRDVAERQRFSARVSAGMAGARASAAILAILPLLGVLLGQLIGARPLSFLLTGRVGG
WLLVVGLTLACAGLLWSDRITDRPVL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSGIASAALILSLALVVLPGSPRCRLTPDDTGRRVLLVGARRVAWGVGCVAVGVAALLPLPTVVAVAVLGATLGLRYRRRRRYLRRSREGQALEAALELVVGELRAGAHPVRAFSIAADETGGPVAVALRAVAARARLGADVTAGLLAAARSSALPAYWERLAVCWQLGSDHGLAIASLMRAAQRDVAERQRFSARVSAGMAGARASAAILAILPLLGVLLGQLIGARPLSFLLTGRVGGWLLVVGLTLACAGLLWSDRITDRPVL
Prediction	CCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
Conf.Score	99754566676666665575566777765677645788999999999999999999999999999999999999999999999999999999899999999999869999999999999767589999999999999899999999999998598899999999999999989989999999999999999999999998755678999999999999999998595889998689799999999999999999999999857789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSGIASAALILSLALVVLPGSPRCRLTPDDTGRRVLLVGARRVAWGVGCVAVGVAALLPLPTVVAVAVLGATLGLRYRRRRRYLRRSREGQALEAALELVVGELRAGAHPVRAFSIAADETGGPVAVALRAVAARARLGADVTAGLLAAARSSALPAYWERLAVCWQLGSDHGLAIASLMRAAQRDVAERQRFSARVSAGMAGARASAAILAILPLLGVLLGQLIGARPLSFLLTGRVGGWLLVVGLTLACAGLLWSDRITDRPVL
Prediction	56221200020110112033433341445534232323232322222323332333333333322222223322311133125422541362024003100200324230340042007414520250043004115353414400430274261640030001002103634240140043005304524524541462334431213222332333233120131300120012330210000013113213220230152647
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MSGIASAALILSLALVVLPGSPRCRLTPDDTGRRVLLVGARRVAWGVGCVAVGVAALLPLPTVVAVAVLGATLGLRYRRRRRYLRRSREGQALEAALELVVGELRAGAHPVRAFSIAADETGGPVAVALRAVAARARLGADVTAGLLAAARSSALPAYWERLAVCWQLGSDHGLAIASLMRAAQRDVAERQRFSARVSAGMAGARASAAILAILPLLGVLLGQLIGARPLSFLLTGRVGGWLLVVGLTLACAGLLWSDRITDRPVL

2vmbA

0.14

0.06

0.45

1.03

wPPAS

---------------------------------------------------------------------GFAF---------KRGIS--TPDLALITRQLATLVQSGMPLEECLRAVAEQSEKRIRTMLVAVRAKVTEGYTLSDSLGDYPHVFD-----ELFRSMVAAGEKSG-HLDSVLERLADYAENRQKMRSKLQQASENLYF------------------------------------------------------------

5cwoA

0.12

0.10

0.82

1.30

dPPAS2

-----PELEEWIRRAKEVAKEVEKVAQRAEEEGNPDLRDSAKELRRAVEEAIEEAKKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRAALELVRAVIEA---IEEAVKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRA-ALELVRAVIEAIEEAVKQGNPLVERVARLAKKAAELIKRAIRAEKENRDERREALERVREVIERIEELVRQG----------------------------------------

4yxxA

0.14

0.11

0.76

1.03

PPAS

-------------------------------------------------------VSLEQALKILKVAAELGTTVEEAVKRALKLKTKLGVSLEQALKILEVAAELGTTVEEAVKRALKLKTKSLEQALKILEVAAKLGTTVEEAVKRALKLKTLGVSLEQALKILKVAAELGTTVEEAVKRALKLKTKLVSLEQALKILEVAAELGTTVEEAVKRALKLKTKLGV--------SLEQALKILEVAAKLGTTVEEAVKRALKLKTK

2vmbA

0.13

0.06

0.45

1.23

Env-PPAS

------------------------------------------------------------------------------GFAFKRGIS--TPDLALITRQLATLVQSGMPLEECLRAVAEQSEPRIRTMLVAVRAKVTEGYTLSDSLGDY-----PHVFDELFRSMVAAGEKSG-HLDSVLERLADYAENRQKMRSKLQQASENLYF------------------------------------------------------------

4ke2A

0.14

0.10

0.74

1.26

dPPAS2

----------------------------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETI---------------------NVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------

4yxzA

0.13

0.99

1.01

PPAS

-ISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKVEELLKLAKAAYYSGTTVEEAYKLALKLGIS-VEELLKLAEAAYYSGTTVEEAYKLALKLGISKAAYYSVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKL-

4yxxA

0.15

0.12

0.76

1.23

dPPAS2

--VSLEQALKILKVAAELGTTVEEAVKRA-----LKLKTKLGVSLEQALKILEVAAELGTTVEEAVKRALKLKTKLGVS-------------LEQALKILEVAAKLGTTVEEAVKRALKLKGVSLEQALKILKVAAELGTTVEEAVKRALKLKTKLGVLEQALKILEVAAELGTTVEEAVKRALKLKTKLVSLEQALKILEVAAKLGTTVEEAVKRALKLKTK-------------------------------------------

5cwiA

0.09

0.08

0.85

1.20

dPPAS2

----DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEDIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEA---VKLACELAQEHPNADIAKLCIKAASEAAE---AASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHQKARDEIKEASQKAEEVKERCER------------------------------

5cwqA

0.08

0.07

0.88

1.18

dPPAS2

-----EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAV---LALAEVACCRGN----SEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH---------------------

4yxzA

0.12

0.98

0.91

MUSTER

-ISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSTTVEEAYKLALKSVEELLKLAKAAYYSGTTVEEAYKLALKLGIS-VEELLKLAEAAYYSGTTVEEAYKLALKLISVEELLKLAKAAYYSVEEA-ISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLALKL-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.54

Estimated TM-score = 0.33±0.11

Estimated RMSD = 14.5±3.7Å

Download Model 2

C-score=-3.83

Download Model 3

C-score=-4.19

Download Model 4

C-score=-4.43

Download Model 5

C-score=-4.63

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4yxzA	0.862	2.50	0.118	0.985
2	3wsxA	0.554	5.42	0.059	0.891
3	4wjlA	0.535	5.81	0.077	0.883
4	1xfdA	0.529	5.84	0.077	0.880
5	1z68A	0.524	5.61	0.051	0.846
6	4ffvA	0.520	5.77	0.058	0.857
7	4noxA	0.519	5.94	0.053	0.872
8	3wj9A	0.518	6.15	0.073	0.902
9	3f6kA	0.517	5.68	0.054	0.850
10	5a5uB	0.515	5.88	0.041	0.857

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1dy7B	HEC	Rep, Mult	105,140,142,150,158,159,162,163,167
2	0.04	2	4pe1A	DCD	Rep, Mult	210,213
3	0.04	2	2axtH	CLA	Rep, Mult	15,18
4	0.02	1	1s5lk	CLA	Rep, Mult	215,219
5	0.02	1	1iw7P	MG	Rep, Mult	142,146
6	0.02	1	4xgcC	III	Rep, Mult	207,208
7	0.02	1	1lphD	IPH	Rep, Mult	109,113
8	0.02	1	1n0wA	MG	Rep, Mult	91,104,107
9	0.02	1	1z68B	NDG	Rep, Mult	229,231,236,237
10	0.02	1	3ak3D	EDO	Rep, Mult	13,16
11	0.02	1	2a68P	MG	Rep, Mult	197,200,201
12	0.02	1	4po7A	III	Rep, Mult	6,10,11,13,244,245,258,265
13	0.02	1	3b29A	LSM	Rep, Mult	212,239,243
14	0.02	1	1jb0M	CLA	Rep, Mult	208,212
15	0.02	1	2d0vA	CA	Rep, Mult	157,158,161,175,177
16	0.02	1	2wycA	3LA	Rep, Mult	72,75
17	0.02	1	2p9xD	ZN	Rep, Mult	94,98
18	0.02	1	3kziX	CLA	Rep, Mult	104,107
19	0.02	1	1aofA	HEM	Rep, Mult	88,89,92,93,97,108,113,118,123,124,125
20	0.02	1	2dysO	CDL	Rep, Mult	7,11,14,15,18

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1sllA	0.427	6.52	0.089	0.782	4.2.2.15	105,106
2	0.060	1qksB	0.467	5.86	0.051	0.778	1.7.2.1	96,120
3	0.060	3g0bB	0.439	5.52	0.055	0.714	3.4.14.5	185
4	0.060	1z68A	0.524	5.61	0.051	0.846	3.4.21.-	NA
5	0.060	2bixA	0.429	6.38	0.079	0.756	1.14.99.-	188
6	0.060	1w6sC	0.428	6.41	0.043	0.767	1.1.99.8	NA
7	0.060	1cruB	0.434	6.15	0.076	0.748	1.1.5.2	131
8	0.060	2w68C	0.237	6.25	0.057	0.410	3.2.1.18	98
9	0.060	2jkbA	0.412	6.46	0.038	0.737	3.2.1.18,4.2.2.15	NA
10	0.060	2d0vA	0.465	6.41	0.058	0.835	1.1.99.8	NA
11	0.060	1lrwA	0.460	5.97	0.067	0.782	1.1.99.8	NA
12	0.060	1kv9A	0.464	6.24	0.079	0.804	1.1.99.-	NA
13	0.060	1k3iA	0.402	6.39	0.067	0.718	1.1.3.9	NA
14	0.060	1xc6A	0.425	6.34	0.032	0.759	3.2.1.23	NA
15	0.060	1e5tA	0.432	5.96	0.068	0.733	3.4.21.26	NA
16	0.060	2ebsB	0.424	6.26	0.089	0.756	3.2.1.150	NA
17	0.060	3h71B	0.418	6.39	0.031	0.733	3.2.1.18	NA
18	0.060	2gbcA	0.521	5.87	0.070	0.876	3.4.14.5,3.4.15.5	NA
19	0.060	1oygA	0.413	6.35	0.042	0.726	2.4.1.10	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.398	6.10	0.06	0.68	2ecfA	GO:0006508 GO:0008236
1	0.07	0.554	5.42	0.06	0.89	3wsxA	GO:0000042 GO:0001540 GO:0004888 GO:0005576 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005783 GO:0005794 GO:0005802 GO:0005887 GO:0006605 GO:0006622 GO:0006629 GO:0006810 GO:0006869 GO:0006892 GO:0006897 GO:0006898 GO:0007165 GO:0008202 GO:0008203 GO:0014910 GO:0016020 GO:0016021 GO:0030169 GO:0030306 GO:0031985 GO:0032091 GO:0032460 GO:0034362 GO:0043407 GO:0045053 GO:0045732 GO:0050768 GO:0051604 GO:0055037 GO:0070062 GO:0070863 GO:1901215 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:2001137
2	0.07	0.505	5.93	0.04	0.85	4wjlB	GO:0005886 GO:0006508 GO:0008236 GO:0008239 GO:0015459 GO:0016020 GO:0016021 GO:0072659 GO:0090004 GO:1901379
3	0.07	0.566	5.37	0.05	0.89	3wsyA	GO:0000042 GO:0001540 GO:0004888 GO:0005576 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005783 GO:0005794 GO:0005802 GO:0005887 GO:0006605 GO:0006622 GO:0006629 GO:0006810 GO:0006869 GO:0006892 GO:0006897 GO:0006898 GO:0007165 GO:0008202 GO:0008203 GO:0014910 GO:0016020 GO:0016021 GO:0030169 GO:0030306 GO:0031985 GO:0032091 GO:0032460 GO:0034362 GO:0043407 GO:0045053 GO:0045732 GO:0050768 GO:0051604 GO:0055037 GO:0070062 GO:0070863 GO:1901215 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:2001137
4	0.07	0.524	5.61	0.05	0.85	1z68A	GO:0001525 GO:0002020 GO:0004175 GO:0004222 GO:0004252 GO:0005178 GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0005925 GO:0006508 GO:0006915 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0009986 GO:0010710 GO:0010716 GO:0016020 GO:0016021 GO:0016787 GO:0030027 GO:0030054 GO:0031258 GO:0032587 GO:0042803 GO:0042995 GO:0043542 GO:0045177 GO:0045178 GO:0046983 GO:0051603 GO:0051917 GO:0060244 GO:0071158 GO:0071438 GO:0071850 GO:0097325 GO:1900119 GO:1902362 GO:1903054
5	0.07	0.492	6.28	0.09	0.88	4po7A	GO:0001503 GO:0005634 GO:0005764 GO:0005765 GO:0005768 GO:0005769 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0005886 GO:0005905 GO:0006810 GO:0006895 GO:0006897 GO:0007186 GO:0007218 GO:0007275 GO:0008333 GO:0008625 GO:0009986 GO:0010008 GO:0010465 GO:0010468 GO:0014902 GO:0016020 GO:0016021 GO:0016023 GO:0016050 GO:0019899 GO:0030136 GO:0030140 GO:0030154 GO:0030379 GO:0030425 GO:0031965 GO:0032509 GO:0032580 GO:0032868 GO:0038180 GO:0043025 GO:0043231 GO:0045599 GO:0046323 GO:0048011 GO:0048227 GO:0048406 GO:0048471 GO:0051005 GO:1904037
6	0.07	0.529	5.66	0.05	0.86	2aj8A	GO:0001618 GO:0001662 GO:0001666 GO:0002020 GO:0004177 GO:0004252 GO:0005102 GO:0005576 GO:0005765 GO:0005886 GO:0005925 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0033632 GO:0035641 GO:0036343 GO:0042110 GO:0042802 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0046581 GO:0046718 GO:0070062 GO:0071438
7	0.07	0.457	6.38	0.04	0.81	4q1vA	GO:0006508 GO:0008236 GO:0016787 GO:0046872
8	0.07	0.485	5.56	0.08	0.77	2bklB	GO:0004252 GO:0006508 GO:0008236 GO:0070008
9	0.07	0.449	6.08	0.08	0.77	3azoA	GO:0004177 GO:0006508 GO:0008236
10	0.07	0.398	6.34	0.04	0.71	2d5lA	GO:0004177 GO:0006508 GO:0008233 GO:0008236 GO:0016787
11	0.07	0.443	6.01	0.08	0.74	5fkqA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0030247 GO:0030248
12	0.07	0.432	6.27	0.07	0.75	3o4jC	GO:0005737 GO:0006508 GO:0008236 GO:0016787
13	0.07	0.391	6.60	0.07	0.72	4hxgF	GO:0006508 GO:0008236 GO:0046872
14	0.07	0.521	5.87	0.07	0.88	2gbcA	GO:0002020 GO:0002709 GO:0004177 GO:0004252 GO:0005102 GO:0005518 GO:0005576 GO:0005783 GO:0005794 GO:0005886 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0042277 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0051234 GO:0071438
15	0.06	0.442	6.40	0.05	0.79	4amyA	GO:0004252 GO:0005737 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0070008
16	0.06	0.527	5.94	0.09	0.89	4n8eB	GO:0001618 GO:0001662 GO:0001666 GO:0002020 GO:0004177 GO:0004252 GO:0005102 GO:0005576 GO:0005765 GO:0005886 GO:0005925 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0033632 GO:0035641 GO:0036343 GO:0042110 GO:0042802 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0046581 GO:0046718 GO:0070062 GO:0071438
17	0.06	0.529	5.84	0.08	0.88	1xfdA	GO:0005886 GO:0006508 GO:0008076 GO:0008236 GO:0008239 GO:0009986 GO:0015459 GO:0016020 GO:0016021 GO:0043025 GO:0043268 GO:0070062 GO:0072659 GO:1901379
18	0.06	0.455	6.20	0.06	0.78	2xe4A	GO:0004252 GO:0005737 GO:0005829 GO:0006508 GO:0008236 GO:0016787 GO:0070008 GO:0070012

Consensus prediction of GO terms

Molecular Function	GO:0070011	GO:0017171
GO-Score	0.37	0.37
Biological Processes	GO:0019538
GO-Score	0.37
Cellular Component	GO:0031224	GO:0044421
GO-Score	0.38	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.