I-TASSER results

I-TASSER results for job id Rv3629c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (365 residues)
MSTFRIFGFSLLMTVVALVTGYLHGGPTALFLLAVLALLEVSLSFDNAIINAAILQRMSP
FWQRMFLTIGILIAVFGMRLVFPLAIIWTTAGLDPVRAMELALRPPAHGALEFADGSPSY
EKLITAAHPQIAAFGGMFLLMLFLDFVVHDRDIKWLKWIEVPFARIGRLGQVPVIVASVG
LVLAGALLTHSSDQRGTVLIAGLLGMVTYLVVNGISRAFRPAGLGEATPGVQARQAAGKA
GCALFLYLEVLDAAFSFDGVTGAFAITTDPIIIALGLGVVGAMFVRSITIYLVRQDTLDR
YVYLEHGAHWAIGALAIILLLSIDHRFAVPEWVTASVGVVFIGAAFTESVRRNRLTVRSP
TKFGS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTFRIFGFSLLMTVVALVTGYLHGGPTALFLLAVLALLEVSLSFDNAIINAAILQRMSPFWQRMFLTIGILIAVFGMRLVFPLAIIWTTAGLDPVRAMELALRPPAHGALEFADGSPSYEKLITAAHPQIAAFGGMFLLMLFLDFVVHDRDIKWLKWIEVPFARIGRLGQVPVIVASVGLVLAGALLTHSSDQRGTVLIAGLLGMVTYLVVNGISRAFRPAGLGEATPGVQARQAAGKAGCALFLYLEVLDAAFSFDGVTGAFAITTDPIIIALGLGVVGAMFVRSITIYLVRQDTLDRYVYLEHGAHWAIGALAIILLLSIDHRFAVPEWVTASVGVVFIGAAFTESVRRNRLTVRSPTKFGS
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHCHHHHHHHHHHHHHHHHHHCCHHHHEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
Conf.Score	97577778999999999999999999999999999999999875454556688987758899999999999999999999999999876579999999999985887766667788878999999987898888899999999999865864565367899999985756567889999999999998656655457899999999999999999998677665567776544344444467788999999999986665555543589355556777999999999999999998999867888999999999999999997557678778999999999999999999998655555667789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTFRIFGFSLLMTVVALVTGYLHGGPTALFLLAVLALLEVSLSFDNAIINAAILQRMSPFWQRMFLTIGILIAVFGMRLVFPLAIIWTTAGLDPVRAMELALRPPAHGALEFADGSPSYEKLITAAHPQIAAFGGMFLLMLFLDFVVHDRDIKWLKWIEVPFARIGRLGQVPVIVASVGLVLAGALLTHSSDQRGTVLIAGLLGMVTYLVVNGISRAFRPAGLGEATPGVQARQAAGKAGCALFLYLEVLDAAFSFDGVTGAFAITTDPIIIALGLGVVGAMFVRSITIYLVRQDTLDRYVYLEHGAHWAIGALAIILLLSIDHRFAVPEWVTASVGVVFIGAAFTESVRRNRLTVRSPTKFGS
Prediction	43203324111000020122013213321110000001000000011000005105503530211000000221233222120100001005020220020002104433444464453024103602110001112002201010004434220032014103312504301000001112300100123464311000002101200000200341064654555554443443232000000021031013003111100000042000001132111000010000000232006403203100010012000000010245040111011221313233121100032254565666778
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHCHHHHHHHHHHHHHHHHHHCCHHHHEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MSTFRIFGFSLLMTVVALVTGYLHGGPTALFLLAVLALLEVSLSFDNAIINAAILQRMSPFWQRMFLTIGILIAVFGMRLVFPLAIIWTTAGLDPVRAMELALRPPAHGALEFADGSPSYEKLITAAHPQIAAFGGMFLLMLFLDFVVHDRDIKWLKWIEVPFARIGRLGQVPVIVASVGLVLAGALLTHSSDQRGTVLIAGLLGMVTYLVVNGISRAFRPAGLGEATPGVQARQAAGKAGCALFLYLEVLDAAFSFDGVTGAFAITTDPIIIALGLGVVGAMFVRSITIYLVRQDTLDRYVYLEHGAHWAIGALAIILLLSIDHRFAVPEWVTASVGVVFIGAAFTESVRRNRLTVRSPTKFGS

4kjsA

0.10

0.09

0.87

0.97

MUSTER

----IFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM--GRATESLSIRIGGLLNATFGN--AVELIISMFALKETGIVLASL-TGSVLGNLLLVAGLSFFVGGLKYARQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMG-----------NASKLNLSIGISIIMILLYVAALYFKSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFG-------------WSELFIGVIIVAIVGNAAEHASAIIMAF--NKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPLVTLPELVAMVSAVLLMIAISNDGDSNWFEGATLLAAYVIMAIGFFLL--------------

5aymA

0.10

0.09

0.92

1.05

dPPAS

GRLLTRSGDQAWDFVVPFALLVIFPGKLQVAAFYYLIVKIGTFLL--TPSSGKWIDTHPRIQVVKWGVWLQFFAILAGMVFFGMLDGLVRAG----------------------GRESWLLSVLFIALALSGVMASLGSQITDISVGND-----LAPSLVAP-EKLTHFNSWLRRIDLATEVGAPILAGALFPLAGLFLIGLWNLVSFVPEYFLLRNVIQRSGLKIKVLGSFSDPIFWLILSYALLWLSVLSPHGVLLAAYLKDEMRLPETEIGLFRGLGAVFGLISTVSFPYLVRRLGLISSSRWHLGFQGVTLGIAVTAFAMGSTASVYVFLGCILLSRVGLYGFSNGEFELRQRLIPEGRRG

4n7wA

0.13

0.10

0.78

1.11

wdPPAS

--MLVKITRLFPVWALLLSVAAYFRPTTFTGIGPYVGPLLMLIMF--VTLRLDDFKR----------PAPVAAATFLHYLIMPLTAWILA-RMPPDLSAGMVL--ASGTASYLAKGDVALSVTISAVSTLVGVFATPLLTRLYVD------------------------ATISV--VVGMLKSILQIVV------IPITAGLVIHHTFTKTVKRIEPYL--------------------PAMSMVCILAIISAVVAG-SQSHIASVGFVVIIAVILHNGIGLLSGYWGGKLFGFDESTCRTLAIEVGM----SGLAATLGKIYFSP-LAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE----

3wajA

0.14

0.95

1.00

wMUSTER

V-LVIAALISVKLRILNPWNSVFLGGNDPWYYYRLIENTIHNIWFDPGSIAGIIFSTSGESLRAVLAFIPAIGGVLAILPVYLLTREVFDKRAAVIAAFLIAIVPGQFSILGFND------------HHIWEAFWQVSALGTFLLAYLTARQMAYPVIAGITIGLYVLSWGAGFIIAPIILAFMFFAFVLAGFVNADRKNLSLVAVVTFAVSALIYLPFAFNYPGFSTIFYSPFQLLVLLGSAVIAAAFYQIEKWND-GMPLAVIVLT-ALIMGLFFVLTNAVLHFGALFFFGMAGILYSAYRFRSFPEMALLIWAIAMFIALWGQNR--FAYYFAAVSAVYSALALSVVFDKLHFRVAFALLIA

4n7wA

0.13

0.10

0.79

1.17

wPPAS

M-LVKITRLFPVWALLLSVAAYFRPTTTGIGPYVGPLLMLIMFAM--VTLR---LDDFKRVLSR---PAPVAAATFLHYLIMPLTAWILA-RMPPDLSAGMVL--ASGTA-YLAKGDVALSVTISAVSTLVGVFATPLLTRLYVDATIS-------------VDVVG----MLKSILQIVVIPITAGLV------IHHTFTKTVKRIE---------YL--------------------PAMSMVCILAIISAVVAG-SQSHIASVGFVVIIAVILHNGIGLLSGYWGGKLFGFDESTCRTLAIEVGM----SGLAATLGKIYFS--LAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE----

5aymA

0.11

0.10

0.91

1.91

dPPAS2

GRLLTRSGDQAWDFVVPFALLVIFPGKLQVAAFYYLIVKIGTFLL--TPSSGKWIDTHPRIQVVKWGVWLQFFAILAGMVFFGMLDGLVRAG----------------------GRESWLLSVLFIALALSGVMASLGSQITDISVGND-----LAPSLVAP-EKLTHFNSWLRRIDLATEVGAPILAGALFPLAGLFLIGLWNLVSFVPEYFLLRNVIQRSGLKIKVLGSFSDPIFWLILSYALLWL----SVLSPHGVLLAAYLKDPETEIGLFRGLGAVFGLISTVSFPYLVRRLGLISSSRWHLGFQGVTLGIAVTAFAMGSTASVYVFLGCILLSRVGLYGFSNGEFELRQRLIPEGRRG

4n7wA

0.13

0.11

0.80

1.17

PPAS

M-LVKITRLFPVWALLLSVAAYFRPTTTGIGPYVGPLLMLIMFAM--VTLR---LDDFKRVLSR---PAPVAAATFLHYLIMPLTAWILAMRMPPDLSAGMVL--ASGTA-YLAKGDVALSVTISAVSTLVGVFATPLLTRLYVD---------------------ATISVDVVGMLKSILQIVVIPIT------AGLVIHHTFTKTVKRIEPYLPAMS-------------------MVCILAIISAVVAGSQSHIASVGFV------VIIAVILHNGIGLLSGYWGGKLFGFDESTCRTLAIEVGM----SGLAATLGKIYFSP-LAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE----

4mieA

0.10

0.08

0.83

0.78

Env-PPAS

MV-VK----------VGVIGTGAMGRAHIDRLTNVLTGAEVV-----AVIDHEAAEAAVRDFHKVYPDDTSLLQVFFGGAHEATVLKALDTDKFP-----LATT------------LEGAKRIVDKELTK----SKK-VIQVGFMRRYDQG----IRALKEKLDTIGAP-----------LVVRASHINPNVASN--YSNEMAITDTLIHEIDEMHWLLDDEYTSIQITYPRQSAEVRNEGLPQLATLT-----TK-KGTVIQVLVHYEVKLEVIGTGELQLPNYGLGPILRSNANQQTAVEMSWINRFIQAYNTEVQEFIDEVAKSEPPVGAWDGYIAAITAAAANRSQKDQETVLINVAGTPT

4k1cA

0.11

0.10

0.89

0.95

MUSTER

QYILKALNFLLVFVPLGLIWGHFQLSHTLTFLFNFLAIIPLAAILANTEELADKAGN-NATFGNAVELIVSIIALKKVRIVQASMLGSLLSNLLLVLGLCFIFGGYNRVQQTFNQT------AAQTMSSLLAIACASLLIPAAFRATLPF--------------IDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTIS----------NPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVESTGLSK-TFIGLIVIPIVGNAAEHVTSVLVAMKMDLALGVAIGSSLQVALFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGE--------N

4kjsA

0.10

0.09

0.87

1.03

dPPAS

------IFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALAS-YMGRATESLSIRIGGLLNATFGNAVELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGLKYARQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMG-----------NASKLNLSIGISIIMILLYVAALYFKSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFGWS--------------ELFIGVIIVAIVGNAAEH--ASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSITSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEGATLLAAYVIMAIGFFLL--------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.83

Estimated TM-score = 0.39±0.13

Estimated RMSD = 13.5±4.0Å

Download Model 2

C-score=-2.49

Download Model 3

C-score=-2.86

Download Model 4

C-score=-3.62

Download Model 5

C-score=-3.64

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4n7wA	0.730	2.65	0.117	0.816
2	3zuxA	0.702	2.91	0.085	0.797
3	4czbA	0.622	4.72	0.078	0.833
4	4cz8A	0.606	4.57	0.094	0.811
5	1zcdA	0.601	4.50	0.107	0.792
6	4bwzA	0.600	4.73	0.072	0.814
7	3kbcA	0.478	5.84	0.073	0.704
8	5a1sA	0.464	5.33	0.079	0.657
9	5l4kZ	0.390	6.66	0.045	0.638
10	4adyA	0.380	6.55	0.053	0.616

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	3	2nwxA	NA	Rep, Mult	275,336,337,338,339
2	0.05	2	2y3nD	CA	Rep, Mult	258,260,269
3	0.05	2	2qeiA	CXX	Rep, Mult	277,281,307,309,313,334
4	0.05	2	2ie7A	CA	Rep, Mult	262,267
5	0.05	2	2ewgB	MG	Rep, Mult	252,256,258
6	0.03	1	3opxA	MG	Rep, Mult	46,258
7	0.03	1	3usgA	UND	Rep, Mult	68,71
8	0.03	1	4n7wB	MPG	Rep, Mult	276,279,280,282,283,286,296,351
9	0.03	1	1siwA	SF4	Rep, Mult	280,285,286,303,304,307
10	0.03	1	3f3aA	TRP	Rep, Mult	316,317,320,330
11	0.03	1	1ro6A	MN	Rep, Mult	108,145
12	0.03	1	3zuyA	PTY	Rep, Mult	279,283,286,296,303,347,350,351,354
13	0.03	1	1h0hA	UNX	Rep, Mult	73,74,299,302

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2i7tA	0.327	6.21	0.053	0.526	3.1.27.-	30
2	0.060	1t3tA	0.360	5.95	0.064	0.542	6.3.5.3	122
3	0.060	1ti6A	0.347	7.24	0.055	0.614	1.97.1.2	257,337
4	0.060	1e1cA	0.374	6.67	0.058	0.608	5.4.99.2	NA
5	0.060	3bicA	0.335	6.85	0.043	0.567	5.4.99.2	NA
6	0.060	3g4dA	0.345	5.98	0.044	0.520	4.2.3.13	NA
7	0.060	1n1hA	0.337	7.40	0.032	0.608	2.7.7.48	307
8	0.060	1mroB	0.335	6.59	0.096	0.545	2.8.4.1	281,287,309
9	0.060	1no3A	0.347	6.49	0.050	0.553	1.13.11.12	NA
10	0.060	2i7vA	0.347	6.64	0.042	0.570	3.1.27.-	NA
11	0.060	2cvpA	0.335	6.77	0.060	0.559	5.3.1.9	NA
12	0.060	3iayA	0.339	6.23	0.033	0.540	2.7.7.7	NA
13	0.060	2iukB	0.315	7.02	0.037	0.545	1.13.11.12	317
14	0.060	1biqB	0.339	6.43	0.052	0.537	1.17.4.1	NA
15	0.060	2iukA	0.339	6.38	0.053	0.540	1.13.11.12	NA
16	0.060	1ygeA	0.345	6.45	0.046	0.545	1.13.11.12	NA
17	0.060	3f93A	0.349	6.96	0.058	0.597	3.2.1.-	269,331
18	0.060	2je8B	0.343	6.48	0.038	0.559	3.2.1.25	305
19	0.060	1bqgA	0.317	6.41	0.070	0.510	4.2.1.40	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.730	2.65	0.12	0.82	4n7wA	GO:0016020 GO:0016021
1	0.11	0.702	2.91	0.09	0.80	3zuxA	GO:0016020 GO:0016021
2	0.08	0.630	4.58	0.07	0.83	4czbB	GO:0005886 GO:0006810 GO:0006811 GO:0006812 GO:0006814 GO:0015297 GO:0015299 GO:0016020 GO:0016021 GO:0042802 GO:0055085 GO:1902600
3	0.07	0.608	4.44	0.09	0.80	4atvA	GO:0005886 GO:0006810 GO:0006811 GO:0006814 GO:0006885 GO:0015081 GO:0015297 GO:0015491 GO:0015992 GO:0016020 GO:0016021 GO:0035725 GO:0055085 GO:0098655
4	0.07	0.614	4.62	0.11	0.82	4cz8A	GO:0006810 GO:0006812 GO:0015299 GO:0016020 GO:0016021 GO:0055085 GO:1902600
5	0.07	0.600	4.73	0.07	0.81	4bwzA	GO:0006810 GO:0006812 GO:0015299 GO:0016020 GO:0016021 GO:0046872 GO:0055085 GO:1902600
6	0.07	0.483	5.50	0.07	0.70	4x2sC	GO:0015293 GO:0016020 GO:0016021 GO:0055085
7	0.07	0.429	6.41	0.08	0.68	4ky0C	GO:0015293 GO:0016020 GO:0016021 GO:0055085
8	0.06	0.454	5.51	0.07	0.65	5a1sD	GO:0005886 GO:0006101 GO:0006810 GO:0008514 GO:0015293 GO:0015711 GO:0016020 GO:0016021 GO:0055085
9	0.06	0.266	6.87	0.04	0.45	1u0uA	GO:0003824 GO:0005737 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747 GO:0050198
10	0.06	0.232	6.98	0.05	0.40	4pe5C	GO:0004872 GO:0004970 GO:0004972 GO:0005102 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007611 GO:0010942 GO:0014069 GO:0014070 GO:0014075 GO:0016020 GO:0016021 GO:0016594 GO:0016595 GO:0017146 GO:0019899 GO:0022843 GO:0030054 GO:0032590 GO:0034220 GO:0034765 GO:0035235 GO:0035254 GO:0042165 GO:0043025 GO:0043083 GO:0043195 GO:0043197 GO:0044307 GO:0045202 GO:0045211 GO:0046982 GO:0046983 GO:0048511 GO:0051262 GO:0051592 GO:0060076 GO:0060992 GO:0071287 GO:2000463
11	0.06	0.251	6.65	0.06	0.41	5ipqC	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0035235 GO:0045202 GO:0045211
12	0.06	0.273	7.11	0.04	0.46	3ug4C	GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046373 GO:0046556
13	0.06	0.236	6.66	0.05	0.39	5ipqA	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0035235 GO:0045202 GO:0045211
14	0.06	0.231	7.29	0.02	0.41	5fxkA	GO:0004872 GO:0004970 GO:0004972 GO:0005102 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007611 GO:0010942 GO:0014069 GO:0014070 GO:0014075 GO:0016020 GO:0016021 GO:0016594 GO:0016595 GO:0017146 GO:0019899 GO:0022843 GO:0030054 GO:0032590 GO:0034220 GO:0034765 GO:0035235 GO:0035254 GO:0042165 GO:0043025 GO:0043083 GO:0043195 GO:0043197 GO:0044307 GO:0045202 GO:0045211 GO:0046982 GO:0046983 GO:0048511 GO:0051262 GO:0051592 GO:0060076 GO:0060992 GO:0071287 GO:2000463
15	0.06	0.274	6.55	0.06	0.44	4rzyA	GO:0016787
16	0.06	0.242	7.00	0.04	0.42	5fxgA	GO:0004872 GO:0004970 GO:0004972 GO:0005102 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0007611 GO:0010942 GO:0014069 GO:0014070 GO:0014075 GO:0016020 GO:0016021 GO:0016594 GO:0016595 GO:0017146 GO:0019899 GO:0022843 GO:0030054 GO:0032590 GO:0034220 GO:0034765 GO:0035235 GO:0035254 GO:0042165 GO:0043025 GO:0043083 GO:0043195 GO:0043197 GO:0044307 GO:0045202 GO:0045211 GO:0046982 GO:0046983 GO:0048511 GO:0051262 GO:0051592 GO:0060076 GO:0060992 GO:0071287 GO:2000463
17	0.06	0.246	6.14	0.04	0.39	4rpfA	GO:0000166 GO:0004413 GO:0005524 GO:0005737 GO:0006566 GO:0008652 GO:0009088 GO:0016301 GO:0016310 GO:0016740
18	0.06	0.251	6.49	0.06	0.40	4tlmC	GO:0004872 GO:0004970 GO:0005216 GO:0005234 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0035235 GO:0045202 GO:0045211

Consensus prediction of GO terms

Molecular Function	GO:0015299	GO:0042802	GO:0015491	GO:0015081
GO-Score	0.14	0.08	0.07	0.07
Biological Processes	GO:0044763	GO:0044765
GO-Score	0.40	0.40
Cellular Component	GO:0016021
GO-Score	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.