I-TASSER results

I-TASSER results for job id Rv3627c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (461 residues)
MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPV
ADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILT
AAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSAAPPGQDTWYHGAARIGDLV
EQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSR
RSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMA
ECIGREVAVAINRPQSFSGAVDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDAT
MQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGPAGWLRAKTGSLTAINSLVG
VLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSAAPPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSRRSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGAVDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGPAGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT
Prediction	CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHCCCCCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCEEEEEEHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEHCCCCCEEEEEEEHCCCCHHHHHHHHHHHHHHHHHCCCC
Conf.Score	98864566899999999999999998764555677777777788888887766677777777788887689999999997587767589999988999788864899788867899999999999996999679999998687778779999857777776566556665557899999999999899847999868766787788888887777766566555444578666665566666467889999999997986774776568999879999986999999999986576899999999999998999999999999999999999998886787688999877789999999999999858866899999878889998655655788766788887999986568864688999889998999999988998569999999999999978899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSAAPPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSRRSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGAVDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGPAGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT
Prediction	85343121000000000000000000000000123334354524434343442434232135534414254035104522743401100000000633410143346322210000000000000220357120302011324324010000001000002430332222332310230052037360430202001010314220212222222222201010102221212222122221222012112101210114334233341254132002034220230033004311010000001100333445221630140025005736041740200000000360100040003003201435442033002000000320002301443435451201000001102400000000206742100000000124650140023004102703148
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHCCCCCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCEEEEEEHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEHCCCCCEEEEEEEHCCCCHHHHHHHHHHHHHHHHHCCCC
MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSAAPPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSRRSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGAVDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGPAGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT

1w5dA

0.26

0.21

0.80

1.88

MUSTER

---------------------------------------------------------------------DALSGQIDKILADHPAAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLLNGNLYLKGKGDPTLL------------PSDFDKMAEILKHSGVKVINLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGISVWEPAGYALDLFKQSLKKQGITKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD--QSWFSAYLNSLPVAGNGGTLRNRMKGT----PAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIEDGKDIEDQIAVILANQ----

1w5dA

0.25

0.21

0.81

2.29

dPPAS

---------------------------------------------------------------------DALSGQIDKILADHEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLKGGNLYLKGKGDPTLL------------PSDFDKMAEILKHSGVKVIKLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTSVWEPAGYALDLFKQSLKKQGITKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD--QSWFSAYLNSLPVAGNPDRVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIEDGKDIEDQIAVILANQ----

1w5dA

0.25

0.20

0.81

3.77

wdPPAS

---------------------------------------------------------------------DALSGQIDKILADHEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLKGGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKG----------NLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTSVWEPAGYALDLFKQSLKKQGITKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD--QSWFSAYLNSLPVAGNPGTLRNRMKGT----PAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIEDGKDIEDQIAVILANQ----

1w5dA

0.26

0.21

0.80

2.37

wMUSTER

---------------------------------------------------------------------DALSGQIDKILADHPAAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLLNGNLYLKGKGDPTLL------------PSDFDKMAEILKHSGVKVIKLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGISVWEPAGYALDLFKQSLKKQGITKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD--QSWFSAYLNSLPVAGNGGTLRNRMKGT----PAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIEDGKDIEDQIAVILANQ----

1w5dA

0.25

0.20

0.81

4.32

wPPAS

---------------------------------------------------------------------DALSGQIDKILADLEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKG----------NLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTSVWEPAGYALDLFKQSLKKQGITKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD--QSWFSAYLNSLPVAGNGGTLRNRMKGT----PAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIEDGKDIEDQIAVILANQ----

1w5dA

0.26

0.21

0.80

5.08

dPPAS2

---------------------------------------------------------------------DALSGQIDKILADHEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLKGGNLYLKGKGDPTLL------------PSDFDKMAEILKHSGVKVIKLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTSVWEPAGYALDLFKQSLKKQGITKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD--QSWFSAYLNSLPVAGNPGTLRNRMKGT----PAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIEDGKDIEDQIAVILANQ----

1w5dA

0.26

0.21

0.80

3.50

PPAS

---------------------------------------------------------------------DALSGQIDKILADLEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLLNGNLYLKGKGDPTLL------------PSDFDKMAEILKHSGVKVIKLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTSVWEPAGYALDLFKQSLKKQGITKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD--QSWFSAYLNSLPVAGNPGTLRNRMKGT----PAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIEDGKDIEDQIAVILANQ----

1w5dA

0.26

0.21

0.80

4.61

Env-PPAS

---------------------------------------------------------------------DALSGQIDKILADHPAAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLKNGNLYLKGKGDPTLL------------PSDFDKMAEILKHSGVKVIKLIGDDTWHDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVVWEPAGYALDLFKQSLKKQGITKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAEVLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQD--QSWFSAYLNSLPVAGNPGTLRNRMKGT----PAQGKVRAKTGSLSTVSSLSGYAETKSGKKLVFSILLNGLIEDGKDIEDQIAVILANQ----

2wkeA

0.29

0.24

0.81

1.83

MUSTER

-------------------------------------------------------------------RLTELREDIDAILEDPALAVSGVVVVDTATGEELYSRDGGEQLLPASNMKLFTAAAALEVLGADHSFGTEVAAESAPGRQDLYLVGRGDPTLS------------AEDLDAMAAEVAASGVRTVDLYADDTWFDSERLVDDWWPEDEPYAYSAQISALTVAHGERFDTGVTVDEPAALAGHLFEEALESNGVTKGDVGLGGVPADAEVLADHTSAELSEILVPFMKFSNNGHAEMLVKSIGQETAGAGTWDAGLVGVEEALSGLGVDTAGLVLNDGSGLSRGNLVTADTVVDLLGQAGS--APWAQTWSASLPVAGEGGTLANRMRGT----AAEGVVEAKTGTMSGVSALSGYVPGPEG-ELAFSIVNNGHGPAPLAVQDAIAVRLAEYAHQA

2wkeA

0.26

0.22

0.83

2.19

dPPAS

-------------------------------------------------------------------RLTELREDIDAILEDPEGAVSGVVVVDTATGEELYSRDGGEQLLPASNMKLFTAAAALEVLGADHSFGTEVAAESAPGRQDLYLVGRGDPTLSAEDLDAMAAEVAASGVRTV----------RGDLYADDTWFDSERLVDDWWPEDEPYAYSAQISALTVAHGERFDTGVTVDEPAALAGHLFEEALESNGVTVKGDVGLADWQDAEVLADHTSAELSEILVPFMKFSNNGHAEMLVKSIGQETAGAGTWDAGLVGVEEALSGLGVDTAGLVLNDGSGLSRGNLVTADTVVDLLGQAGS--APWAQTWSASLPVAGESDPVGGTLANRMRGTAAEGVVEAKTGTMSGVSALSGYVPGPEG-ELAFSIVNNGHSPAPLAVQDAIAVRLAEYAHQA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.93

Estimated TM-score = 0.48±0.15

Estimated RMSD = 11.7±4.5Å

Download Model 2

C-score=-2.41

Download Model 3

C-score=-2.38

Download Model 4

C-score=-2.80

Download Model 5

C-score=-3.28

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1w5dA	0.790	1.01	0.268	0.803
2	2wkeA	0.783	1.58	0.285	0.813
3	3a3iA	0.733	2.52	0.252	0.792
4	2ex8A	0.728	2.59	0.261	0.790
5	3v39A	0.605	3.78	0.161	0.705
6	5cerA	0.602	3.65	0.155	0.699
7	2j9oD	0.479	3.52	0.121	0.553
8	5tfqA	0.478	3.41	0.106	0.547
9	1e25A	0.475	3.50	0.130	0.547
10	1ci8A	0.473	4.35	0.144	0.573

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.72	126	2y55B	FP5	Rep, Mult	113,114,117,295,297,344,345,346,408,409,410,411,412
2	0.13	24	1xpbA	SO4	Rep, Mult	114,295,387,408,409,410,411,416
3	0.11	20	2xdmC	BO8	Rep, Mult	114,117,210,213,218,295,297,344,345,346,348,410,411,412,413
4	0.02	9	3d4fA	MA4	Rep, Mult	401,405,418,422,432,434,447,448,452,455,456
5	0.01	3	1w8qA	CO	Rep, Mult	128,131,132
6	0.01	2	1tdgA	MA4	Rep, Mult	409,416,418,445
7	0.01	3	1ongA	MA4	Rep, Mult	388,391,392,409,416,447,448
8	0.00	1	3zvwC	MG	Rep, Mult	234,235
9	0.00	1	1w8qA	CO	Rep, Mult	158,163,279,281

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.436	2vgkD	0.784	1.53	0.285	0.813	3.4.16.4	128,158,282
2	0.312	3a3iA	0.733	2.52	0.252	0.792	3.4.16.4	114,208,295,346,411,437
3	0.293	2j9pA	0.788	1.08	0.268	0.803	3.4.16.4	114,387,409,411
4	0.198	3c4pA	0.465	3.36	0.143	0.529	3.5.2.6	342
5	0.156	1iysA	0.462	3.47	0.146	0.534	3.5.2.6	411
6	0.119	3lezA	0.452	3.38	0.129	0.518	3.5.2.6	295,297
7	0.074	2wafA	0.471	4.14	0.097	0.568	3.4.-.-	114
8	0.067	1g68A	0.472	3.18	0.118	0.534	3.5.2.6	390
9	0.067	2v1zA	0.463	3.35	0.123	0.527	3.5.2.6	390
10	0.067	1dy6A	0.460	3.56	0.130	0.536	3.5.2.6	114,117,295
11	0.067	1yljA	0.461	3.44	0.159	0.531	3.5.2.6	318
12	0.067	1bsgA	0.461	3.65	0.185	0.536	3.5.2.6	114,117,289
13	0.067	1hzoA	0.464	3.40	0.126	0.534	3.5.2.6	117,295
14	0.067	1djaA	0.454	3.35	0.133	0.523	3.5.2.6	135
15	0.067	1bueA	0.454	3.59	0.122	0.529	3.5.2.6	114,117
16	0.060	1rp5A	0.451	4.59	0.107	0.557	3.4.-.-	114
17	0.060	2rcxB	0.442	4.86	0.098	0.568	3.5.2.6	362
18	0.060	3bydA	0.458	3.44	0.136	0.527	3.5.2.6	135
19	0.060	2e8iA	0.448	4.61	0.075	0.560	3.5.1.46	336,355
20	0.060	1iyqA	0.461	3.45	0.147	0.531	3.5.2.6	NA
21	0.060	3bfdA	0.465	3.33	0.139	0.531	3.5.2.6	NA
22	0.060	1c3bA	0.441	4.71	0.092	0.560	3.5.2.6	114,117,408
23	0.060	1fr1A	0.450	4.78	0.110	0.566	3.5.2.6	114,117,408
24	0.060	1n4oB	0.458	3.51	0.152	0.529	3.5.2.6	NA
25	0.060	2zc7A	0.446	4.67	0.099	0.562	3.5.2.6	114,117,408
26	0.060	3a3jA	0.448	3.73	0.114	0.527	3.4.16.4	126
27	0.060	3cg5A	0.461	3.48	0.167	0.531	3.5.2.6	135
28	0.060	1alqA	0.403	3.61	0.130	0.471	3.5.2.6	135
29	0.060	2ex2A	0.727	2.61	0.261	0.790	3.4.16.4	110,114,296,346,384,409,411
30	0.060	1mfoA	0.451	3.52	0.154	0.523	3.5.2.6	135
31	0.060	2j9oD	0.479	3.52	0.121	0.553	3.4.16.4	320,377
32	0.060	1skfA	0.448	3.55	0.154	0.521	3.4.16.4	343
33	0.060	2blmA	0.451	3.36	0.148	0.518	3.5.2.6	295

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.57	0.727	2.61	0.26	0.79	2ex2A	GO:0000270 GO:0004175 GO:0004180 GO:0004185 GO:0006508 GO:0007049 GO:0008360 GO:0008658 GO:0009002 GO:0009252 GO:0009253 GO:0009254 GO:0016787 GO:0016998 GO:0030288 GO:0042597 GO:0043093 GO:0046677 GO:0051301 GO:0071555
1	0.56	0.691	2.62	0.24	0.75	3a3eB	GO:0004185 GO:0006508
2	0.50	0.735	2.49	0.25	0.79	3a3dA	GO:0004185 GO:0006508 GO:0007049 GO:0008360 GO:0009002 GO:0009252 GO:0016787 GO:0042597 GO:0046677 GO:0051301 GO:0071555
3	0.31	0.451	3.36	0.15	0.52	2blmA	GO:0005886 GO:0008800 GO:0016020 GO:0016787 GO:0030655 GO:0046677
4	0.30	0.788	1.08	0.27	0.80	2j9pA	GO:0004185 GO:0005576 GO:0006508 GO:0007049 GO:0008360 GO:0009002 GO:0009252 GO:0016787 GO:0051301 GO:0071555
5	0.28	0.595	3.22	0.17	0.67	5cedA	GO:0004180 GO:0004185 GO:0006508 GO:0009002 GO:0016787
6	0.27	0.784	1.56	0.28	0.81	4b4xA	GO:0004180 GO:0004185 GO:0005576 GO:0006508 GO:0008233 GO:0008360 GO:0009002 GO:0009252 GO:0016787 GO:0046677 GO:0071555
7	0.26	0.605	3.78	0.16	0.70	3v39A	GO:0004180 GO:0004185 GO:0006508 GO:0009002 GO:0016787
8	0.26	0.463	3.35	0.12	0.53	2v1zA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
9	0.24	0.468	3.38	0.14	0.54	3w4oA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
10	0.20	0.454	3.35	0.13	0.52	1djaA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
11	0.20	0.602	3.65	0.15	0.70	5cerA	GO:0004180 GO:0004185 GO:0006508 GO:0009002 GO:0016787
12	0.19	0.460	3.35	0.14	0.53	4yfmA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
13	0.19	0.466	3.24	0.12	0.53	4id4A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
14	0.17	0.457	3.77	0.17	0.54	2wuqB	GO:0006351 GO:0006355
15	0.08	0.468	3.22	0.13	0.53	3cjmA	GO:0016020 GO:0016021
16	0.07	0.475	3.50	0.13	0.55	1e25A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
17	0.07	0.456	3.43	0.12	0.52	3qhyA	GO:0008800 GO:0016787 GO:0017001 GO:0030655 GO:0046677
18	0.06	0.433	3.20	0.17	0.49	3mfdA	GO:0004175 GO:0004180 GO:0005887 GO:0006508 GO:0008233 GO:0008360 GO:0009002 GO:0009252 GO:0016020 GO:0016787 GO:0030435 GO:0071555
19	0.06	0.260	7.25	0.06	0.43	2hb6A	GO:0004177 GO:0005622 GO:0005737 GO:0006508 GO:0008233 GO:0008235 GO:0016787 GO:0019538 GO:0030145 GO:0040009 GO:0042802 GO:0046662 GO:0046872
20	0.06	0.249	7.21	0.04	0.41	2bvfA	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0018530 GO:0050660 GO:0055114
21	0.06	0.234	7.65	0.02	0.40	1wleB	GO:0000166 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0005739 GO:0005759 GO:0006412 GO:0006418 GO:0006434 GO:0016874 GO:0097056
22	0.06	0.240	6.11	0.07	0.35	4wepB	GO:0005215 GO:0005886 GO:0006810 GO:0006865 GO:0030288 GO:0031460 GO:0042597 GO:0055052 GO:0071474
23	0.06	0.227	6.75	0.05	0.36	1osnA	GO:0000166 GO:0004797 GO:0005524 GO:0006230 GO:0016301 GO:0016310 GO:0016740 GO:0071897
24	0.06	0.238	6.85	0.05	0.38	1d2fB	GO:0003824 GO:0004121 GO:0006351 GO:0006355 GO:0008652 GO:0009058 GO:0009086 GO:0016829 GO:0030170 GO:0043433 GO:0080146
25	0.06	0.219	7.32	0.03	0.36	4k6nA	GO:0003824 GO:0004084 GO:0005737 GO:0006532 GO:0008152 GO:0008696 GO:0009098 GO:0009099 GO:0016829 GO:0030170 GO:0046654 GO:0046656
26	0.06	0.228	6.74	0.03	0.36	1s70A	GO:0000781 GO:0004721 GO:0004722 GO:0005634 GO:0005737 GO:0005925 GO:0005975 GO:0005977 GO:0006470 GO:0007049 GO:0016787 GO:0016791 GO:0017018 GO:0019901 GO:0030155 GO:0032922 GO:0042752 GO:0043153 GO:0046872 GO:0050115 GO:0051301 GO:0070062 GO:0070688 GO:0072357
27	0.06	0.213	6.18	0.06	0.31	4fosA	GO:0004764 GO:0008652 GO:0009073 GO:0009423 GO:0016491 GO:0019632 GO:0050661 GO:0055114
28	0.06	0.183	5.97	0.06	0.27	1bs9A	GO:0000272 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0030245 GO:0045493 GO:0046555 GO:0052689

Consensus prediction of GO terms

Molecular Function	GO:0009002	GO:0004175	GO:0008658	GO:0008800
GO-Score	0.85	0.57	0.57	0.31
Biological Processes	GO:0006508	GO:0046677	GO:0008360	GO:0009252	GO:0071555	GO:0009253	GO:0009254	GO:0016998	GO:0043093	GO:0030655
GO-Score	0.93	0.85	0.85	0.85	0.85	0.57	0.57	0.57	0.57	0.31
Cellular Component	GO:0030288	GO:0005886	GO:0005576
GO-Score	0.57	0.31	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.