I-TASSER results

I-TASSER results for job id Rv3626c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (350 residues)
MTGASELTLGNTVDWEFAASVGERLARPAPPSTEYTRRQVIDELTVAAEKAEPPVRDVTG
LIADGVVPPARVVDRPAWIRSAAESMRAMTHGSAKPRGFLTGRITGAQTGAVLAFVASGI
LGQYDPFGAAGEGCLLLVYPNVIAVERQLRVEPSDFRLWVCLHEVTHRVQFTANPWLSGY
MSQALNLLTFEPVDDIGRVVSRLADFIRSRGHGTDDSEVNPSGILGLVRAVQSEPQRKAL
DQLLVLGTLLEGHAEHVMDAVGPMVVPSVATIRRRFDDRRHHKQPPLQRLVRALLGFDAK
LSQYTRGKAFVDHVVDRAGMKLFNTIWSGPETLPLPAEIENPQRWIDRVL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGASELTLGNTVDWEFAASVGERLARPAPPSTEYTRRQVIDELTVAAEKAEPPVRDVTGLIADGVVPPARVVDRPAWIRSAAESMRAMTHGSAKPRGFLTGRITGAQTGAVLAFVASGILGQYDPFGAAGEGCLLLVYPNVIAVERQLRVEPSDFRLWVCLHEVTHRVQFTANPWLSGYMSQALNLLTFEPVDDIGRVVSRLADFIRSRGHGTDDSEVNPSGILGLVRAVQSEPQRKALDQLLVLGTLLEGHAEHVMDAVGPMVVPSVATIRRRFDDRRHHKQPPLQRLVRALLGFDAKLSQYTRGKAFVDHVVDRAGMKLFNTIWSGPETLPLPAEIENPQRWIDRVL
Prediction	CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHC
Conf.Score	99988988889989999999999984889999979999999999999999999899985889898888579985889999999999999977888877665678899999999999877557667777899985998547799999998999799999999999999999985857999999999999987568899999999999997668999788888755677556899999999999999999999888999987655679969999999999998799999999999978655789999999999999999777777787658656999888866999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGASELTLGNTVDWEFAASVGERLARPAPPSTEYTRRQVIDELTVAAEKAEPPVRDVTGLIADGVVPPARVVDRPAWIRSAAESMRAMTHGSAKPRGFLTGRITGAQTGAVLAFVASGILGQYDPFGAAGEGCLLLVYPNVIAVERQLRVEPSDFRLWVCLHEVTHRVQFTANPWLSGYMSQALNLLTFEPVDDIGRVVSRLADFIRSRGHGTDDSEVNPSGILGLVRAVQSEPQRKALDQLLVLGTLLEGHAEHVMDAVGPMVVPSVATIRRRFDDRRHHKQPPLQRLVRALLGFDAKLSQYTRGKAFVDHVVDRAGMKLFNTIWSGPETLPLPAEIENPQRWIDRVL
Prediction	74446645442100040035004421555454355424400440250053034103510303454434302102243014201510440043145225413231101100100030043000011011236521000003103400661714351000000000001210021011015202510350054142325402520452155345344474345424412042352661340043031000000010000013003630230530251044017652310230032001010125205403400420165222620430061043023461063044005217
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHC
MTGASELTLGNTVDWEFAASVGERLARPAPPSTEYTRRQVIDELTVAAEKAEPPVRDVTGLIADGVVPPARVVDRPAWIRSAAESMRAMTHGSAKPRGFLTGRITGAQTGAVLAFVASGILGQYDPFGAAGEGCLLLVYPNVIAVERQLRVEPSDFRLWVCLHEVTHRVQFTANPWLSGYMSQALNLLTFEPVDDIGRVVSRLADFIRSRGHGTDDSEVNPSGILGLVRAVQSEPQRKALDQLLVLGTLLEGHAEHVMDAVGPMVVPSVATIRRRFDDRRHHKQPPLQRLVRALLGFDAKLSQYTRGKAFVDHVVDRAGMKLFNTIWSGPETLPLPAEIENPQRWIDRVL

3cmnA

0.31

0.26

0.84

2.45

MUSTER

-----------LIDWEQARQAALRLSQWEQAPVDN-RAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLGVQIGGLLGYLAQ-RVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL-----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRT-MLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD

3cmnA

0.31

0.26

0.84

3.26

dPPAS

-----------LIDWEQARQAALRLSQWEQAPV-DNRAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLGVQIGGLLGYLAQ-RVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL-----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRT-MLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD

3cmnA

0.31

0.26

0.84

4.52

wdPPAS

-----------LIDWEQARQAALRLSQWEQAPVDN-RAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLGVQIGGLLGYLAQ-RVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL-----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRT-MLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD

3cmnA

0.33

0.27

0.84

2.98

wMUSTER

------------IDWEQARQAALRLSQWEQAPVDN-RAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEE-MYEKSSKLLGVQIGGLLGYLAQRVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL-----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRT-MLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD

3cmnA

0.33

0.27

0.84

4.53

wPPAS

-----------LIDWEQARQAALRLSQWEQAPVD-NRAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMY-EKSSKLLGVQIGGLLGYLAQRVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL-----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRT-MLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD

3cmnA

0.31

0.26

0.84

8.93

dPPAS2

-----------LIDWEQARQAALRLSQWEQAPV-DNRAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLGVQIGGLLGYLAQ-RVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL-----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRT-MLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD

3cmnA

0.31

0.26

0.84

3.66

PPAS

-----------LIDWEQARQAALRLSQWEQAPVD-NRAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLGVQIGGLLGYLAQ-RVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFA------------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRT-MLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD

3cmnA

0.31

0.26

0.84

8.34

Env-PPAS

-----------LIDWEQARQAALRLSQWEQAPV-DNRAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLGVQIGGLLGYLAQ-RVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL-----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRT-MLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMD

3cmnA1

0.27

0.12

0.46

1.02

MUSTER

-----------LIDWEQARQAALRLSQWEQAPV-DNRAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLGVQIGGLLGYLAQ-RVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3cmnA1

0.27

0.12

0.46

1.63

dPPAS

-----------LIDWEQARQAALRLSQWEQAPV-DNRAFRREQYARMVALSEPLIADYLGVRLPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLGVQIGGLLGYLAQ-RVLGQYDLSLLSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.39

Estimated TM-score = 0.66±0.13

Estimated RMSD = 7.4±4.2Å

Download Model 2

C-score=-1.05

Download Model 3

C-score=-1.84

Download Model 4

C-score=-4.86

Download Model 5

C-score=-4.85

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3cmnA	0.817	1.40	0.312	0.843
2	3o0yA	0.499	4.83	0.103	0.666
3	5l43A	0.481	5.02	0.069	0.663
4	4ka7A	0.478	5.14	0.048	0.674
5	3ebgA	0.477	4.90	0.106	0.634
6	1y791	0.476	5.20	0.065	0.674
7	2c6fA	0.474	4.88	0.064	0.640
8	1r4lA	0.474	5.00	0.072	0.646
9	2dqmA	0.472	5.27	0.089	0.643
10	2xdtA	0.471	4.91	0.081	0.629

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	7	1zkxB	ZN	Rep, Mult	163,167,251
2	0.08	4	2p9xD	ZN	Rep, Mult	251,255
3	0.02	1	1xvbB	BBX	Rep, Mult	173,176,266
4	0.02	1	5ezmA	MPG	Rep, Mult	249,252
5	0.02	1	2bkoA	CA	Rep, Mult	257,260
6	0.02	1	1w5cB	CLA	Rep, Mult	239,246
7	0.02	1	3fuhA	5H1	Rep, Mult	78,81,116,122,125,126
8	0.02	1	2ofwA	ADX	Rep, Mult	141,142
9	0.02	1	2yptE	III	Rep, Mult	120,121,160,163,167,251,304
10	0.02	1	1jgtB	MG	Rep, Mult	14,125
11	0.02	1	1rrvA	BGC	Rep, Mult	14,131,132
12	0.02	1	3kziX	CLA	Rep, Mult	244,247
13	0.02	1	3fu3A	IMD	Rep, Mult	306,307,310,339
14	0.02	1	1y66B	DIO	Rep, Mult	250,253,257
15	0.02	1	3dsuA	FPP	Rep, Mult	124,156
16	0.02	1	2dysN	DCW	Rep, Mult	249,334

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2np0A	0.377	6.41	0.053	0.606	3.4.24.69	23
2	0.060	1nekA	0.390	7.17	0.048	0.697	1.3.99.1,	NA
3	0.060	1dmtA	0.439	5.58	0.017	0.646	3.4.24.11	164
4	0.060	3b8eC	0.383	6.23	0.041	0.614	3.6.3.9	117,166,247
5	0.060	3dwcB	0.438	5.15	0.095	0.609	3.4.17.19	252
6	0.060	1bqbA	0.427	4.45	0.066	0.554	3.4.21.19,3.4.24.29	164
7	0.060	1r1jA	0.430	5.74	0.041	0.643	3.4.24.11	167,249,251
8	0.060	2o36A	0.436	5.53	0.066	0.620	3.4.24.15	167,296,298
9	0.060	1h19A	0.463	5.06	0.080	0.631	3.3.2.6	NA
10	0.060	1i1iP	0.446	5.42	0.057	0.631	3.4.24.16	NA
11	0.060	1gw6A	0.463	5.24	0.079	0.637	3.3.2.6	164
12	0.060	3ebgA	0.477	4.90	0.106	0.634	3.4.11.-	164
13	0.060	1s4bP	0.438	5.32	0.046	0.611	3.4.24.15	NA
14	0.060	2rnpC	0.309	7.78	0.017	0.611	2.7.7.6	NA
15	0.060	1jqoA	0.399	6.11	0.051	0.634	4.1.1.31	275
16	0.060	1espA	0.417	4.77	0.039	0.557	3.4.24.28	NA
17	0.060	1aroP	0.384	6.64	0.061	0.640	2.7.7.6	NA
18	0.060	3b8eA	0.411	6.62	0.031	0.680	3.6.3.9	NA
19	0.060	3bkkA	0.467	5.21	0.059	0.657	3.4.15.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.473	5.06	0.10	0.64	4qpeA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787 GO:0046872
1	0.07	0.467	5.10	0.07	0.64	3ciaA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787 GO:0046872
2	0.07	0.470	4.93	0.06	0.65	3ahmA	GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0046872
3	0.07	0.478	5.14	0.05	0.67	4ka7A	GO:0004222 GO:0005739 GO:0005759 GO:0005829 GO:0006508 GO:0006518 GO:0008233 GO:0008237 GO:0009507 GO:0009536 GO:0009570 GO:0016787 GO:0046872
4	0.07	0.471	5.17	0.08	0.65	4wz9B	GO:0005737 GO:0005886 GO:0006508 GO:0008237 GO:0008270 GO:0042277 GO:0043171 GO:0070006
5	0.07	0.461	5.20	0.07	0.64	4fkeA	GO:0001525 GO:0001618 GO:0004177 GO:0005737 GO:0005886 GO:0006508 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0030154 GO:0042277 GO:0043171 GO:0046718 GO:0046872 GO:0070006
6	0.07	0.463	5.19	0.09	0.64	5c97A	GO:0000209 GO:0002480 GO:0004177 GO:0005576 GO:0005622 GO:0005765 GO:0005829 GO:0005886 GO:0005887 GO:0006508 GO:0007165 GO:0007267 GO:0007565 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0030163 GO:0030659 GO:0031905 GO:0042277 GO:0043171 GO:0046872 GO:0048471 GO:0060395 GO:0061024 GO:0070006
7	0.07	0.464	5.00	0.10	0.63	3q7jA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872
8	0.07	0.472	5.23	0.08	0.64	5ab0C	GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005783 GO:0005788 GO:0005789 GO:0005886 GO:0006508 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0046872 GO:0070006
9	0.07	0.471	4.99	0.08	0.63	5ab0A	GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005783 GO:0005788 GO:0005789 GO:0005886 GO:0006508 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0046872 GO:0070006
10	0.07	0.467	5.02	0.07	0.63	4kx7A	GO:0001525 GO:0002003 GO:0002005 GO:0003081 GO:0004177 GO:0005765 GO:0005886 GO:0005887 GO:0005903 GO:0006508 GO:0007267 GO:0008233 GO:0008237 GO:0008270 GO:0008283 GO:0009897 GO:0016020 GO:0016021 GO:0016324 GO:0016477 GO:0016787 GO:0031410 GO:0032835 GO:0042277 GO:0043171 GO:0045177 GO:0046872 GO:0070006 GO:0070062
11	0.07	0.470	5.10	0.09	0.64	4fyrA	GO:0001525 GO:0001618 GO:0004177 GO:0004872 GO:0005615 GO:0005737 GO:0005765 GO:0005793 GO:0005829 GO:0005886 GO:0005887 GO:0006508 GO:0006725 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0009897 GO:0012506 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0030154 GO:0031983 GO:0035814 GO:0042277 GO:0043171 GO:0046718 GO:0046872 GO:0070006 GO:0070062
12	0.07	0.470	5.20	0.07	0.65	4xo4A	GO:0004177 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016787 GO:0042277 GO:0042802 GO:0043171 GO:0046872 GO:0070006
13	0.07	0.477	4.90	0.11	0.63	3ebgA	GO:0004177 GO:0005737 GO:0005829 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872
14	0.07	0.460	4.99	0.10	0.63	3u24A	GO:0046872
15	0.07	0.471	4.91	0.08	0.63	2yd0A	GO:0001525 GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005138 GO:0005151 GO:0005164 GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005829 GO:0005886 GO:0006508 GO:0006509 GO:0008217 GO:0008233 GO:0008235 GO:0008237 GO:0008270 GO:0009617 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0043231 GO:0045088 GO:0045444 GO:0045766 GO:0046872 GO:0070006 GO:0070062
16	0.07	0.463	5.24	0.08	0.64	3b7rL	GO:0004177 GO:0004301 GO:0004463 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006508 GO:0006691 GO:0008233 GO:0008237 GO:0008270 GO:0010043 GO:0016787 GO:0019370 GO:0042277 GO:0043171 GO:0043434 GO:0044822 GO:0046872 GO:0060509 GO:0070006 GO:0070062
17	0.07	0.462	5.23	0.11	0.63	5dllA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787
18	0.07	0.446	5.42	0.06	0.63	1i1iP	GO:0004222 GO:0005737 GO:0005739 GO:0005758 GO:0005829 GO:0006508 GO:0006518 GO:0008233 GO:0008237 GO:0016787 GO:0046872 GO:0070012

Consensus prediction of GO terms

Molecular Function	GO:0070011	GO:0046914
GO-Score	0.57	0.37
Biological Processes	GO:0019538
GO-Score	0.57
Cellular Component	GO:0009570	GO:0005759	GO:0005886	GO:0005829
GO-Score	0.07	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.