I-TASSER results

I-TASSER results for job id Rv3600c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (272 residues)
MLLAIDVRNTHTVVGLLSGMKEHAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTG
TAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAY
DRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRS
VVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGFSVDHDVAIVATGHTAPLLLPELHT
VDHYDQHLTLQGLRLVFERNLEVQRGRLKTAR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLLAIDVRNTHTVVGLLSGMKEHAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGFSVDHDVAIVATGHTAPLLLPELHTVDHYDQHLTLQGLRLVFERNLEVQRGRLKTAR
Prediction	CEEEEEHCCCCEEEEEEHCCCCCCEEEEEEEEHCCCCCCHHHHHHHHHHHHCCCHHHCCEEEEEHCCCHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCCEEEEEEHCCCCCEEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHCCCHHHHHHHCCCCEEHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
Conf.Score	97899978996899999588878779999997589878968999999999878855578589997786889999999999979986899778887898668998556587999999999998599899998798689999959997886776788899999999988868999888887789999999999999999999999999999999867778888689997898689999789988985866899999999999998776567789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLLAIDVRNTHTVVGLLSGMKEHAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGFSVDHDVAIVATGHTAPLLLPELHTVDHYDQHLTLQGLRLVFERNLEVQRGRLKTAR
Prediction	60100422422000000125444430122020315452113100310340053425404200000002401530140046107230100022404130414163054000000000000143164100000000000000016623110000001130024003630440460517536512153023001100010000002300530274056445654010000121042016206321302522004002200520373665635658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEEEHCCCCEEEEEEHCCCCCCEEEEEEEEHCCCCCCHHHHHHHHHHHHCCCHHHCCEEEEEHCCCHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCCEEEEEEHCCCCCEEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHCCCHHHHHHHCCCCEEHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
MLLAIDVRNTHTVVGLLSGMKEHAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGFSVDHDVAIVATGHTAPLLLPELHTVDHYDQHLTLQGLRLVFERNLEVQRGRLKTAR

2h3gX

0.36

0.32

0.90

3.07

MUSTER

MIFVLDVGNTNAVLGVFEE----GELRQHWRMETDRHKTEDEYGMLVKQLLELSFEDVKGIIVSSVVPPIMFALERMCEKYFKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSI-------EITKPSSVVGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAK-----QEPKVIATGGLAKLISEESNVIDVVDPFLTLKGLYMLYERNA-----------

2h3gX

0.36

0.32

0.90

5.88

dPPAS

MIFVLDVGNTNAVLGVFEE----GELRQHWRMETDRHKTEDEYGMLVKQLLELSFEDVKGIIVSSVVPPIMFALERMCEKYFKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSI-------EITKPSSVVGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAK-----QEPKVIATGGLAKLISEESNVIDVVDPFLTLKGLYMLYERNA-----------

2h3gX

0.35

0.31

0.90

5.60

wdPPAS

MIFVLDVGNTNAVLGVFEE----GELRQHWRMETDRHKTEDEYGMLVKQLLELSFEDVKGIIVSSVVPPIMFALERMCEKYFKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSIEITKP-------SSVVGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAK-----QEPKVIATGGLAKLISEESNVIDVVDPFLTLKGLYMLYERNA-----------

3djcG

0.35

0.33

0.92

3.72

wMUSTER

LILCIDVGNSHIYGGVFDG----DEIKLRFRHTS-KVSTSDELGIFLKSVLRCSPETIRKIAICSVVPQVDYSLRSACVKYFSIDP-FLLQAGVKTGLNIKYRNPVEVGADRIANAIAATHSFPQNIIVIDFGTATTFCAISHKKAYLGGAILPGLRLSADALSKNTAKLPSVEIIKTESVVGRSTIESIQSGVYYGVLGACKELIQRIHHEAF---NGDQILILATGGFASLFDK-QGLYDHLVPDLVLQGIRLAAMMNT-----------

2h3gX

0.35

0.31

0.90

5.08

wPPAS

MIFVLDVGNTNAVLGVFEE----GELRQHWRMETDRHKTEDEYGMLVKQLLELSFEDVKGIIVSSVVPPIMFALERMCEKYFKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSIEITKP-------SSVVGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAK-----QEPKVIATGGLAKLISEESNVIDVVDPFLTLKGLYMLYERNA-----------

2h3gX

0.36

0.32

0.90

8.74

dPPAS2

MIFVLDVGNTNAVLGVFEE----GELRQHWRMETDRHKTEDEYGMLVKQLLELSFEDVKGIIVSSVVPPIMFALERMCEKYFKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSI-------EITKPSSVVGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAK-----QEPKVIATGGLAKLISEESNVIDVVDPFLTLKGLYMLYERNA-----------

2h3gX

0.35

0.31

0.90

4.50

PPAS

MIFVLDVGNTNAVLGVFEE----GELRQHWRMETDRHKTEDEYGMLVKQLLELSFEDVKGIIVSSVVPPIMFALERMCEKYFKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSIEITKP-------SSVVGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAK-----QEPKVIATGGLAKLISEESNVIDVVDPFLTLKGLYMLYERNA-----------

2h3gX

0.35

0.31

0.90

5.84

Env-PPAS

MIFVLDVGNTNAVLGVFEE----GELRQHWRMETDRHKTEDEYGMLVKQLLELSFEDVKGIIVSSVVPPIMFALERMCEKYFKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSIEITKP-------SSVVGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAK-----QEPKVIATGGLAKLISEESNVIDVVDPFLTLKGLYMLYERNA-----------

3djcG

0.35

0.33

0.92

3.03

MUSTER

LILCIDVGNSHIYGGVFDG----DEIKLRFRHTS-KVSTSDELGIFLKSVLRCSPETIRKIAICSVVPQVDYSLRSACVKYFSIDP-FLLQAGVKTGLNIKYRNPVEVGADRIANAIAATHSFPQNIIVIDFGTATTFCAISHKKAYLGGAILPGLRLSADALSKNTAKLPSVEIIKTESVVGRSTIESIQSGVYYGVLGACKELIQRIHHEA---FNGDQILILATGGFASLFDK-QGLYDHLVPDLVLQGIRLAAMMNT-----------

3djcG

0.35

0.33

0.92

5.66

dPPAS

LILCIDVGNSHIYGGVFDG----DEIKLRFRHT-SKVSTSDELGIFLKSVLRCSPETIRKIAICSVVPQVDYSLRSACVKYFSIDP-FLLQAGVKTGLNIKYRNPVEVGADRIANAIAATHSFPNNIIVIDFGTATTFCAISHKKAYLGGAILPGLRLSADALSKNTAKLPSVEIIKTESVVGRSTIESIQSGVYYGVLGACKELIQRIHHEA---FNGDQILILATGGFASLFDK-QGLYDHLVPDLVLQGIRLAAMMNT-----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.23

Estimated TM-score = 0.88±0.07

Estimated RMSD = 3.5±2.4Å

Download Model 2

C-score=0.06

Download Model 3

C-score=-0.14

Download Model 4

C-score=-4.20

Download Model 5

C-score=-1.74

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3djcG	0.875	1.52	0.355	0.923
2	2h3gX	0.874	1.07	0.357	0.897
3	3bf3A	0.840	1.82	0.302	0.901
4	4o5fA	0.782	2.46	0.192	0.882
5	2f9wA	0.765	2.60	0.219	0.871
6	4h0pA	0.728	3.97	0.090	0.941
7	1tuuA	0.708	3.56	0.103	0.893
8	2e1yA	0.708	3.84	0.100	0.912
9	4ijnA	0.703	3.40	0.097	0.871
10	3p4iA	0.702	3.87	0.106	0.904

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.62	30	3bf1C	PAU	Rep, Mult	66,107,108,109,111,112,137,152
2	0.22	9	3bf1F	ADP	Rep, Mult	10,11,31,133,134,157,229,230
3	0.06	4	3bf1A	PAU	Rep, Mult	167,169,170,186
4	0.04	3	5b8hA	2PN	Rep, Mult	8,9,10,11,13,132,133,134
5	0.04	4	4k42A	CA	Rep, Mult	6,249
6	0.01	1	2gtd0	III	Rep, Mult	9,66,101,102,103,109,112,140,148,149,150,151,152,154,158,159,162,163,165,166,167,168,169,189,190,193,197,200,201,204,208,209,212
7	0.01	1	4a7lA	CA	Rep, Mult	112,131,133,249
8	0.01	1	2h3g0	III	Rep, Mult	102,103,104,107,149,150,151,152,153,154,159,163,180,181,185,186,189,192,193,196,197,199,200,201,205,208,209,212

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.500	3djcG	0.875	1.52	0.355	0.923	2.7.1.33	6,65,67,108,110,112,131,150,152,154,228
2	0.489	3bf3A	0.840	1.82	0.302	0.901	2.7.1.33	6,11,65,67,108,110,112,131,151,228,249
3	0.486	2h3gX	0.874	1.07	0.357	0.897	2.7.1.33	6,13,65,108,110,112,132,150,228,249
4	0.362	2f9wA	0.765	2.60	0.219	0.871	2.7.1.33	6,131,155,228
5	0.067	2aa4A	0.598	4.07	0.150	0.809	2.7.1.60	111
6	0.067	2aa4B	0.595	4.08	0.147	0.801	2.7.1.60	66,111,228
7	0.067	1woqA	0.577	3.66	0.149	0.739	2.7.1.63	111
8	0.067	2e2oA	0.607	3.88	0.080	0.794	2.7.1.1	111
9	0.067	1zc6B	0.574	4.40	0.118	0.812	2.7.1.59	6,162
10	0.067	1xc3A	0.607	3.78	0.098	0.787	2.7.1.4	111
11	0.066	3eo3A	0.580	4.45	0.136	0.805	5.1.3.14,2.7.1.60	111
12	0.060	2i7nA	0.608	3.27	0.078	0.754	2.7.1.33	134
13	0.060	3f9mA	0.688	3.76	0.090	0.897	2.7.1.2	111
14	0.060	3cjcA	0.632	4.60	0.078	0.871	3.1.21.1	134
15	0.060	3enoA	0.668	3.88	0.092	0.868	3.4.24.57	NA
16	0.060	1q18A	0.601	4.48	0.116	0.838	2.7.1.2	111
17	0.060	2ewsA	0.650	2.88	0.082	0.765	2.7.1.33	6
18	0.060	3enhA	0.670	3.57	0.092	0.846	3.4.24.57	227
19	0.060	2nztA	0.674	3.86	0.091	0.890	2.7.1.1	NA
20	0.060	2e20A	0.713	3.75	0.097	0.908	2.7.2.15	NA
21	0.060	2uytA	0.677	3.76	0.106	0.857	2.7.1.5	111
22	0.060	1bdgA	0.674	3.67	0.122	0.871	2.7.1.1	NA
23	0.060	2nrhB	0.618	2.90	0.179	0.721	2.7.1.33	6,113,131,134,150,228
24	0.060	1tuuA	0.708	3.56	0.103	0.893	2.7.2.1	8,133
25	0.060	2ivpA	0.679	3.47	0.108	0.853	3.4.24.57	12
26	0.060	3flcX	0.696	3.37	0.103	0.857	2.7.1.30	111
27	0.060	2iirJ	0.698	3.97	0.117	0.908	2.7.2.1	NA
28	0.060	2i7pB	0.631	3.69	0.078	0.801	2.7.1.33	134
29	0.060	2zf5Y	0.680	3.50	0.079	0.846	2.7.1.30	111,152
30	0.060	1qhaA	0.708	3.74	0.087	0.930	2.7.1.1	111

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.50	0.838	1.85	0.30	0.90	3bexA	GO:0000166 GO:0004594 GO:0005524 GO:0005737 GO:0015937 GO:0016301 GO:0016310 GO:0016740 GO:0043169 GO:0046872
1	0.48	0.874	1.07	0.36	0.90	2h3gX	GO:0000166 GO:0004594 GO:0005524 GO:0005737 GO:0015937 GO:0016301 GO:0016310 GO:0016740 GO:0043169 GO:0046872
2	0.48	0.879	1.44	0.35	0.92	3djcB	GO:0000166 GO:0004594 GO:0005524 GO:0005737 GO:0015937 GO:0016301 GO:0016310 GO:0016740 GO:0043169 GO:0046872
3	0.37	0.782	2.46	0.19	0.88	4o5fA	GO:0000166 GO:0004594 GO:0005524 GO:0005737 GO:0015937 GO:0016301 GO:0016310 GO:0016740
4	0.37	0.783	2.57	0.22	0.89	2f9wA	GO:0000166 GO:0004594 GO:0005524 GO:0005737 GO:0015937 GO:0016301 GO:0016310 GO:0016740 GO:0043169 GO:0046677 GO:0046872
5	0.33	0.789	2.60	0.20	0.89	5b8hA	GO:0000166 GO:0004594 GO:0005524 GO:0005737 GO:0015937 GO:0016301 GO:0016310 GO:0016740
6	0.20	0.618	2.90	0.18	0.72	2nrhB	GO:0000166 GO:0004594 GO:0005524 GO:0005737 GO:0015937 GO:0016301 GO:0016310 GO:0016740 GO:0043169 GO:0046872
7	0.14	0.592	4.61	0.11	0.83	2qm1B	GO:0004340 GO:0005737 GO:0006096 GO:0016301 GO:0016310 GO:0046872 GO:0051156
8	0.07	0.577	4.39	0.12	0.81	1zc6B	GO:0016301 GO:0016310 GO:0016740 GO:0045127 GO:0046835
9	0.06	0.379	5.52	0.04	0.60	1yqdA	GO:0000166 GO:0008270 GO:0016491 GO:0046872 GO:0055114
10	0.06	0.359	5.65	0.06	0.54	2ebdA	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
11	0.06	0.364	5.37	0.06	0.57	1zjjB	GO:0046872
12	0.06	0.325	5.93	0.05	0.53	3frkA	GO:0003824
13	0.06	0.299	5.89	0.05	0.49	1o60A	GO:0003824 GO:0005737 GO:0008152 GO:0008676 GO:0009058 GO:0009103 GO:0016740 GO:0019294
14	0.06	0.275	5.33	0.05	0.41	3l8eA	GO:0000287 GO:0005737 GO:0005829 GO:0005975 GO:0008270 GO:0009103 GO:0009244 GO:0016311 GO:0016787 GO:0016791 GO:0034200 GO:0046872 GO:0097171
15	0.06	0.239	5.00	0.05	0.35	3vn5A	GO:0000287 GO:0003676 GO:0003723 GO:0004518 GO:0004519 GO:0004523 GO:0005737 GO:0006298 GO:0006401 GO:0016070 GO:0016787 GO:0032299 GO:0043137 GO:0046872 GO:0090305 GO:0090502
16	0.06	0.269	6.25	0.03	0.47	2f4nB	GO:0016740
17	0.06	0.237	5.13	0.08	0.36	1kn1B	GO:0009507 GO:0009535 GO:0009536 GO:0009579 GO:0015979 GO:0016020 GO:0018298 GO:0030089 GO:0055114
18	0.06	0.239	4.98	0.07	0.35	2vjtB	GO:0015979 GO:0018298 GO:0030089 GO:0055114
19	0.06	0.226	5.56	0.05	0.36	3dbjB	GO:0015979 GO:0018298 GO:0030089 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0004594	GO:0046872
GO-Score	0.95	0.95	0.92
Biological Processes	GO:0015937	GO:0016310	GO:0046677
GO-Score	0.95	0.95	0.37
Cellular Component	GO:0005737
GO-Score	0.95

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.