I-TASSER results

I-TASSER results for job id Rv3587c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (264 residues)
MLDLEPRGPLPTEIYWRRRGLALGIAVVVVGIAVAIVIAFVDSSAGAKPVSADKPASAQS
HPGSPAPQAPQPAGQTEGNAAAAPPQGQNPETPTPTAAVQPPPVLKEGDDCPDSTLAVKG
LTNAPQYYVGDQPKFTMVVTNIGLVSCKRDVGAAVLAAYVYSLDNKRLWSNLDCAPSNET
LVKTFSPGEQVTTAVTWTGMGSAPRCPLPRPAIGPGTYNLVVQLGNLRSLPVPFILNQPP
PPPGPVPAPGPAQAPPPESPAQGG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLDLEPRGPLPTEIYWRRRGLALGIAVVVVGIAVAIVIAFVDSSAGAKPVSADKPASAQSHPGSPAPQAPQPAGQTEGNAAAAPPQGQNPETPTPTAAVQPPPVLKEGDDCPDSTLAVKGLTNAPQYYVGDQPKFTMVVTNIGLVSCKRDVGAAVLAAYVYSLDNKRLWSNLDCAPSNETLVKTFSPGEQVTTAVTWTGMGSAPRCPLPRPAIGPGTYNLVVQLGNLRSLPVPFILNQPPPPPGPVPAPGPAQAPPPESPAQGG
Prediction	CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCEEEEEEEEHCCCCCEEEHCCCCCEEEEEEHCCCCEEEHCCCCCCCCCCCEEEHCCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	999899999998999999999999999999999999998636888888887778888888888989999999998889999999999999888999999998888889999944389999858877789976589999998899986898799858999997899778757898888886579978995799999987887888888888889996799999989955677689985888889999999888888888888789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLDLEPRGPLPTEIYWRRRGLALGIAVVVVGIAVAIVIAFVDSSAGAKPVSADKPASAQSHPGSPAPQAPQPAGQTEGNAAAAPPQGQNPETPTPTAAVQPPPVLKEGDDCPDSTLAVKGLTNAPQYYVGDQPKFTMVVTNIGLVSCKRDVGAAVLAAYVYSLDNKRLWSNLDCAPSNETLVKTFSPGEQVTTAVTWTGMGSAPRCPLPRPAIGPGTYNLVVQLGNLRSLPVPFILNQPPPPPGPVPAPGPAQAPPPESPAQGG
Prediction	745355632334400200000000001222023212110013244456555565444455556545455555555655455555465545555565555544545566651545304030436565144544040202031336340313146631302031356430022440446555333404474534240404344347514575550421202020314745244140305524564654657555556447544668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCEEEEEEEEHCCCCCEEEHCCCCCEEEEEEHCCCCEEEHCCCCCCCCCCCEEEHCCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MLDLEPRGPLPTEIYWRRRGLALGIAVVVVGIAVAIVIAFVDSSAGAKPVSADKPASAQSHPGSPAPQAPQPAGQTEGNAAAAPPQGQNPETPTPTAAVQPPPVLKEGDDCPDSTLAVKGLTNAPQYYVGDQPKFTMVVTNIGLVSCKRDVGAAVLAAYVYSLDNKRLWSNLDCAPSNETLVKTFSPGEQVTTAVTWTGMGSAPRCPLPRPAIGPGTYNLVVQLGNLRSLPVPFILNQPPPPPGPVPAPGPAQAPPPESPAQGG

3isyA

0.13

0.05

0.40

0.96

wPPAS

----------------------------------------------------------------------------------------------------------------NQEVVLSIDAIQE----PE-QIKFNSLKNQSERAIEFQFSTGQFELVVYDSEHKERYRSKE---TQAFQNLTLESGETYDFSDVWKEV------------PEPGTYEVKVTFKGRAENVQQFEVK---------------------------

5gaoE

0.16

0.12

0.76

1.81

dPPAS2

-------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------AAAAA------AAAAAAAAAAAAAA--------AAAAAAA-------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAA

5gaoE

0.13

0.12

0.98

1.34

PPAS

----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

4ufqA

0.12

0.08

0.69

1.38

dPPAS2

---------------------------------------ATTTFDGPVAAERFSADTTLEAAFLKTTSETNHAATIYQAGTSGDGAALNVISDNPGTSAYLSGTETARGT-----LKITHRGYADGSDKDAA---ALSLDLRVA-------GTAAQGIYVTATNG----------PTKGNLIALRNNTGLDDFVVK-----------------GTGRIGVGIDRAATPRAQVHIVQRGDALAEGSVRIGNAATVPTSVDSSGGG

5cdcB

0.13

0.11

0.91

1.01

PPAS

QQQVCPLQNVPAWGY-----------------------SLYKGIDMSVPLAYDPNNELGDLKDVFPSAVDEMA-KTTDAIQKPIANGDDWGGVIPVGMPCYSKSIRTIKISETENRETEVIDAAPSYWRAT-MCYRITVVKTAFHTGRLEIGVIPVKPTVNNIGPDQDQLTGAVAPSDNNYKYILDLTNEVTIRVPFVSNKMFLKTAGIYGANSENNWNFHESFSGFLCIRPVTKLMAPDTVSDNPLTSGPTQVYRPPPTASAA

3isyA

0.13

0.05

0.41

1.30

dPPAS2

----------------------------------------------------------------------------------------------------------------NQEVVLSIDAIQE-----PEQIKFNSLKNQSERAIEFQFSTGKFELVVYDSEHKERYRYSKEKFTQAFQNLTLESGETYDFSDVWKEV------------PEPGTYEVKVTFKGRAENLQQFEVK---------------------------

2kfuA

0.15

0.09

0.59

1.30

dPPAS2

-------------------------------------------------------VTDMNPDIEKDQTSDEVTVETSVFRADFLSELDAPAQAGTESAVSGVEGLPPGSA-------------------------LLVVKRGPNAGSRFLLDQA--ITSAGRHPDSDIFLDDV-TVSRRHAEFRLENNEFNVVDV-----GSLNREPVDSAVLANG---DEVQIGK-----FRLVFLTGPKQGEDDGSTGGP------------

4ut1A2

0.08

0.03

0.43

1.30

dPPAS2

---------------------------------------LAAGVATNSGTGVISQGSVSAGYQLPSGTTTLAYNAASKTLSGFPVGTTVTIAGTPPTSINITSATTPVPYDPSKGASMTISSTTQPAPSGVMNGVSVSLSGTPADGDQFTIG----------------------------------------------------------------------------------------------------------------

5f44A

0.12

0.11

0.85

0.81

MUSTER

IWTGDGAKPLQ-----------VDFTIYNVTANYWASPKDYKGSFDSAPVAATGTTNDKGQLTQALPIQSKDASGKTRAAV------HETNPRAGYNTSADFWLTLPAKAAADGNVYVYPKNVQKT-----TYERTFVKKDAETKE-----VLEGAGFKISNSDGKFLKLTDKDGQSVSIGEGFIDV-LANNYRLTWVAESDATVFTSDKSADNTTTYTAVETNGYDAAANTDFKADNSSSDILDAPSGILP------------

5gaoE

0.13

0.12

0.96

0.97

dPPAS

-----------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.45

Estimated TM-score = 0.25±0.07

Estimated RMSD = 17.0±2.8Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cdcB	0.757	3.40	0.096	0.894
2	1b35C	0.613	4.41	0.077	0.814
3	3napC	0.611	4.56	0.076	0.818
4	5j96C	0.588	4.60	0.096	0.807
5	4qpgC	0.560	4.67	0.087	0.773
6	1b35A	0.525	5.10	0.074	0.776
7	3vbfC	0.519	4.63	0.101	0.720
8	3cjiB	0.519	4.55	0.097	0.724
9	1bev3	0.519	4.83	0.100	0.739
10	5j96A	0.515	4.66	0.059	0.716

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	1vbc1	J77	Rep, Mult	94,100,135,152,193,195,198,204,205,226,229
2	0.07	4	1fpn3	III	Rep, Mult	221,226,227,228
3	0.06	3	3etdB	B1T	Rep, Mult	17,18,21
4	0.04	2	4w5oA	MG	Rep, Mult	150,151
5	0.02	1	2qifB	CU1	Rep, Mult	206,218
6	0.02	1	1tmf3	III	Rep, Mult	15,202
7	0.02	1	2buqA	CAQ	Rep, Mult	9,15
8	0.02	1	4pe4A	REV	Rep, Mult	28,30
9	0.02	1	2wff3	III	Rep, Mult	88,89,93,230,231,232,233,235,236,239
10	0.02	1	2a9cA	MO	Rep, Mult	174,175
11	0.02	1	1h3vB	NAG	Rep, Mult	135,193,195
12	0.02	1	3tiqB	MG	Rep, Mult	112,141
13	0.02	1	3s6lA	IOD	Rep, Mult	216,217,231
14	0.02	1	2pe7A	PDC	Rep, Mult	210,211
15	0.02	1	2civA	MAN	Rep, Mult	64,66
16	0.02	1	3s6pB	CA	Rep, Mult	226,232
17	0.02	1	3rl3A	MN	Rep, Mult	178,197

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1fmd2	0.368	4.95	0.053	0.534	3.4.22.46	187
2	0.060	1qqp1	0.381	5.42	0.051	0.595	3.4.22.46	226
3	0.060	1gthA	0.321	6.57	0.050	0.595	1.3.1.2	NA
4	0.060	1bev1	0.444	5.49	0.077	0.682	2.7.7.48	242
5	0.060	1zba1	0.382	5.36	0.063	0.595	3.6.1.15	NA
6	0.060	1qgc1	0.368	5.20	0.053	0.561	3.4.22.28	150,194
7	0.060	1n63B	0.364	6.59	0.044	0.663	1.2.99.2	NA
8	0.060	2mev1	0.458	5.53	0.049	0.724	3.6.1.15	NA
9	0.060	1jrpB	0.370	6.62	0.037	0.682	1.17.1.4	NA
10	0.060	1oopA	0.442	5.65	0.087	0.697	2.7.7.48	138,195
11	0.060	1js4A	0.380	6.14	0.079	0.663	3.2.1.4	NA
12	0.060	1piv1	0.443	5.61	0.102	0.697	3.4.22.29	NA
13	0.060	2fh7A	0.365	6.58	0.065	0.674	3.1.3.48	217
14	0.060	1jroB	0.368	6.54	0.033	0.674	1.1.1.204	NA
15	0.060	1h0hA	0.389	6.54	0.080	0.708	1.2.1.2	NA
16	0.060	1f8vA	0.397	5.35	0.071	0.614	3.4.23.44	162
17	0.060	1d4m1	0.445	5.53	0.067	0.693	3.6.1.15	NA
18	0.060	2bbvA	0.392	5.24	0.062	0.595	3.4.23.44	NA
19	0.060	2weiA	0.246	6.39	0.043	0.447	2.7.1.17	150,172

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.611	4.56	0.08	0.82	3napC	GO:0005198 GO:0019012 GO:0019028
1	0.07	0.613	4.41	0.08	0.81	1b35C	GO:0005198 GO:0019012 GO:0019028 GO:0030430
2	0.07	0.586	4.65	0.09	0.80	5j98C	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005524 GO:0006351 GO:0006508 GO:0008233 GO:0008234 GO:0016020 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019028 GO:0033644 GO:0039694
3	0.07	0.560	4.67	0.09	0.77	4qpgC	GO:0005198 GO:0019012 GO:0019028
4	0.07	0.505	4.59	0.12	0.70	5aooC	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0033644 GO:0034220 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0046718 GO:0051259
5	0.07	0.506	4.61	0.08	0.70	2wff3	GO:0005198 GO:0019012 GO:0019028 GO:0019030
6	0.07	0.521	4.66	0.11	0.73	4aedC	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0033644 GO:0034220 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0046718 GO:0046872 GO:0051259
7	0.07	0.520	4.70	0.11	0.73	5abjC	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0033644 GO:0034220 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0046718 GO:0051259
8	0.07	0.508	4.75	0.07	0.71	1aym3	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0051259 GO:0075509
9	0.07	0.509	4.88	0.07	0.72	1cov3	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0046872 GO:0051259 GO:0075509
10	0.07	0.506	4.87	0.06	0.72	1ev13	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0051259 GO:0075509 GO:0075513
11	0.07	0.510	4.91	0.10	0.72	1rhi3	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0051259 GO:0075509
12	0.07	0.506	4.84	0.07	0.72	3iypB	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0033644 GO:0034220 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0046718 GO:0051259
13	0.07	0.512	4.71	0.09	0.72	5bnnC	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0033644 GO:0034220 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0046718 GO:0051259
14	0.07	0.507	4.91	0.09	0.72	1d4m3	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0046872 GO:0051259 GO:0075509
15	0.07	0.507	4.90	0.10	0.72	1d3i3	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039664 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0051259 GO:0075509
16	0.07	0.505	4.79	0.08	0.72	2hwd3	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0051259 GO:0075509
17	0.07	0.508	4.87	0.08	0.72	2c8iC	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0051259 GO:0075509
18	0.07	0.507	4.72	0.12	0.71	3epd3	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0033644 GO:0034220 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0046718 GO:0051259

Consensus prediction of GO terms

Molecular Function	GO:0005198	GO:0003968	GO:0003724	GO:0005524	GO:0003723	GO:0004197	GO:0005216
GO-Score	0.29	0.13	0.13	0.13	0.13	0.13	0.07
Biological Processes	GO:0039694	GO:0006508	GO:0001172	GO:0006351	GO:0034220	GO:0019062	GO:0039707	GO:0046718	GO:0051259
GO-Score	0.13	0.13	0.13	0.13	0.07	0.07	0.07	0.07	0.07
Cellular Component	GO:0044423
GO-Score	0.58

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.