I-TASSER results

I-TASSER results for job id Rv3531c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (375 residues)
MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAGCIAGCMHLAFDYERDHPFLQSG
TGPFTKMGLDNPDTLYFGTRLQANRDYVVSGRRGTTTDLSFQLLGGEYTDYNVPASQAAF
DDRELDIAADGSFEWRLRPSAPGQLVIREVYGDWSQQRGTLAIARLDTVGTAPPPLTREL
MEKRYATAGSQLVNRVKTWLQFPQWFYLNIPVNTMVAPRLTPGGLATQYSSAGHFELRPG
QALVITVPVSDAPYLGFQLGSMWYISLDYINHQTSLNASQAQADPDGKVRIVVAEQNPGV
TNWVETLGHRRGFLQFRWQRVSRELTEADGPTVELVDFDAIPAALPHYQHNKISEDDWRA
RIALRQRQIATRMLG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAGCIAGCMHLAFDYERDHPFLQSGTGPFTKMGLDNPDTLYFGTRLQANRDYVVSGRRGTTTDLSFQLLGGEYTDYNVPASQAAFDDRELDIAADGSFEWRLRPSAPGQLVIREVYGDWSQQRGTLAIARLDTVGTAPPPLTRELMEKRYATAGSQLVNRVKTWLQFPQWFYLNIPVNTMVAPRLTPGGLATQYSSAGHFELRPGQALVITVPVSDAPYLGFQLGSMWYISLDYINHQTSLNASQAQADPDGKVRIVVAEQNPGVTNWVETLGHRRGFLQFRWQRVSRELTEADGPTVELVDFDAIPAALPHYQHNKISEDDWRARIALRQRQIATRMLG
Prediction	CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCCCCEEEEEHCCCCEEEEEEHCCCCCEEEEEEHCCCCCCCCCCCEEEEEHCCCCCCCCCCCEEEEHCCCCCCEEEEEEHCCCCCCCCCEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCEEEEEEEHCCCCCCEEEEHCCCCCCCCCCCCCCEEHCCCEEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
Conf.Score	966999999999999998588999989999999999999999999999848899878857898654568997656568887799769999667997669999975888998876646776667655589987899995899987999876588788998699999589999999999999999999999999999999999999987658888778866789987766578878985899699999858999855898756555556777777566686678789985999996899998877789999965799998689999988889789998778878768988888899999999999999999998769
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAGCIAGCMHLAFDYERDHPFLQSGTGPFTKMGLDNPDTLYFGTRLQANRDYVVSGRRGTTTDLSFQLLGGEYTDYNVPASQAAFDDRELDIAADGSFEWRLRPSAPGQLVIREVYGDWSQQRGTLAIARLDTVGTAPPPLTRELMEKRYATAGSQLVNRVKTWLQFPQWFYLNIPVNTMVAPRLTPGGLATQYSSAGHFELRPGQALVITVPVSDAPYLGFQLGSMWYISLDYINHQTSLNASQAQADPDGKVRIVVAEQNPGVTNWVETLGHRRGFLQFRWQRVSRELTEADGPTVELVDFDAIPAALPHYQHNKISEDDWRARIALRQRQIATRMLG
Prediction	722440251054035104636317333210301300020012000100210331020130222211000000001012010346230102032230310000011042344424223130325504236503010101164011000000010276431401021135655424414364025103300410141032014004412452321304333341221110100101020453000002052470320000030000000013313010133203325402000000252130000000121420000000020754146452030320314403730356524403373034004401510341158
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCCCCEEEEEHCCCCEEEEEEHCCCCCEEEEEEHCCCCCCCCCCCEEEEEHCCCCCCCCCCCEEEEHCCCCCCEEEEEEHCCCCCCCCCEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCEEEEEEEHCCCCCCEEEEHCCCCCCCCCCCCCCEEHCCCEEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAGCIAGCMHLAFDYERDHPFLQSGTGPFTKMGLDNPDTLYFGTRLQANRDYVVSGRRGTTTDLSFQLLGGEYTDYNVPASQAAFDDRELDIAADGSFEWRLRPSAPGQLVIREVYGDWSQQRGTLAIARLDTVGTAPPPLTRELMEKRYATAGSQLVNRVKTWLQFPQWFYLNIPVNTMVAPRLTPGGLATQYSSAGHFELRPGQALVITVPVSDAPYLGFQLGSMWYISLDYINHQTSLNASQAQADPDGKVRIVVAEQNPGVTNWVETLGHRRGFLQFRWQRVSRELTEADGPTVELVDFDAIPAALPHYQHNKISEDDWRARIALRQRQIATRMLG

3u07A

0.13

0.10

0.79

1.46

wdPPAS

-----------------------TNVDLAEDAYIYGYSIDEAYKFFYHTAENNYPLNEFQPTI-------NNDTLH--GWLDAAEPVIVSVPDDEGRYWILHTDGHYTNARGTKGGQFFAAQDWQGEVPAS-VDEVVRVDSNLVKLGRIAVND-ALNYDQWNIRTLGKNGPKGSGNADKQWLDKYQSIPEQLKLAKVGEKKGEHLVELAPKTDLLGTRDTLGWGLPPISYRKSDFKLDGSKHDYVRFKAPNVSFWSVTIYGNDNRLAKNDLNRHSRGDR-TKADKDGYYTIYSANEKGRDPNFLPVP--EKPFYAIRFYGADDA-GEYQPEIKVVK---------------------------------------

3u07A

0.14

0.11

0.77

0.93

wPPAS

-----------------------TNVDLAEDAYIYGYSIDEAYKFFYHTAENNYPEFQ--PTI-------NNDTLH--GWLDAAEPVIVSVPDDEGRYWILHTDGHYTNTRGTKGGQFFAAQGEV---PAS-VDEVVRVDSNLVKLGRIAVNDEDAKVDQWNIRTLGKNGPKGSGNADKQWLDKYQSIPEQLKLAKVGEKKGEHLVELAPKTLGTRDTLGDAWGLPPISYRKSDFKLDGSKHDYVRFKAPNVSFWSVTIYGNDNRLAKNDLNRHSRGD-RTKADKDGYYTIYSANEKGRDPNFLPVEK---PFYAIRFYG----ADDA-QPEIKVVK--------------------------------------

2p3yA

0.12

0.10

0.81

1.32

wdPPAS

------------QETVVPSRPTQETFQRATQAYLWGIPASSIEWLNVSRNDFKFEGFFNTLKQKQGIITANFTTPYVIGTWNLEKT-------GP---LIINL--SLLGPDKGKGGKYLI-KDLN---PKG-YYVIRPKTNVVYGGIRILEPD-KQVVPNITTQPYADGKLGRPVEERDRFVAQLKFLGEEQKKILLEASKVGRAAQSNDYTKRFTQPYWKGSTIPGFRYLVTYQWLSGEHTYKLHVPVPASNFWSTTVYDE-RLIINDAGSPDISSRKNLKVNSDGSIDVYYGPKPVKENNWVQTNPGEGWFTYFRFYGPTEKFDKSWTGDIELV---------------------------------------

3u07A

0.13

0.11

0.80

0.78

MUSTER

-----------------------TNVDLAEDAYIYGYSIDEAYKFFYHTAENNYPLNEFQPTI-------NNDTLHL-GWLDAAEPVIVSVPDDEGRYWILHTDGHYTNARGTKGGQFFAAQDWQGEVPASVDEVVRVD--SNLVKLGRIAVNDEDAKVQWNIRTLGKNGPKPVQRADKQWLDKYQSIGPEQLKLAKVGEKKGEHLVELAPKTDARTLLGTRWGLPPIEASKSDFKLDGSKHDYVRFKAPNVEFWSVTIYGNDNRLAKNDLNRHSRGDR-TKADKDGYYTIYSANEKGRDPNFLPVP--EKPFYAIRFYGADDAIQSGEYPEIKVVK--------------------------------------

3u07A

0.11

0.09

0.81

0.90

dPPAS

-----------------------TNVDLAEDAYIYGYSIDEAYKFFYHTAVEN------NYPLNEFQPTINNDTLHLGWLDVAAEPVIVSVPDDEGRYWILHTDGHYTNARGTKGGQFFAAQDWQGEVPASVDEVVRVDSN--LVKLGRIAVNYLGKNGPKPVQRTYPDPKKGSGNADKQWLDKYQSIPEQLKLAKVGEKKGEHLVELAPKTDARTLLGTRQWGLPPIEASYRKSDFDSIKHDYVRFKAPNVSFWSVTIYGNDNRLAKNDLNRHSRGDR-TKADKDGYYTIYSANEKGRDPNFLPVP--EKPFYAIRFYGADDAQSGEYQPEIKVVK--------------------------------------

2p3yA2

0.14

0.05

0.38

1.02

wdPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQSNDYTKRFLDERAAWFYE------------ITVSRGKSTIPGFGQRYLVTYQWLSGEHTYKLHVPVPASNFWSTTVYDE-RLIINDAGSPDISSRKNLKVNSDGSIDVYYGPKPVKENNWVQTNPGEGWFTYFRFYGPTEKFDKSWTGDIELV---------------------------------------

3u07A

0.14

0.11

0.80

0.88

wMUSTER

-----------------TN------VDLAEDAYIYGYSIDEAYKFFYHTAENNYPLNEFQPTI-------NNDTLHL-GWLDAAEPVIVSVPDDEGRYWILHTDGHYTNARGTKGGQFFAAQDQGEVPASVD---VVRVDSNLVKLGRIAVNDEDAKVALWNIRTLGKNGPKPVQRADKQWLDKYQSIGPEQLKLAKVGEKKGEHLVELAPKTDARTLLGTRWGLPPISYRKSDFKLDGSKHDYVRFKAPNVSFWSVTIYGNDNRLAKNDLNRHSRGDR-TKADKDGYYTIYSANEKGRDPNFLPVP--EKPFYAIRFYGADDAIQSGEYPEIKVVK--------------------------------------

2p3yA

0.12

0.10

0.80

wPPAS

L---KFESDFETKNLNE-------DFQRATQAYLWGIPASSIEWLNVSRNDFKFEGFFNTLKQKQGIITANFTTPYVIGTWNAKAGLDVLSLLGPDK--GKYLIVPPGEK-----------KDLN---PKGYYVI--PKTNVVYGGIRILEPD--VDRVNITTQPYADGKLGRKPVEERDFVAQLKFLGEEQKKILLEASKVGRAAQSNDYTKRFTQPSVSLDQRSENYDSRGKSTIPGFGQRYLVTYQGEHTYWSTTVYDERLIIND-AGSPDISSRKNLKVNSDGSIDVYYGPKPVG-NNWVQTNPGEGWFTYFRFYG----PTEK-TGDIELV---------------------------------------

4hb1A

0.25

0.03

0.12

0.95

dPPAS2

--EELLKQALQQAQQLLQQAQELAKEELLKQALQQAQQLLQQAQEL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3u07A

0.14

0.11

0.80

0.89

PPAS

-----------------------TNVDLAEDAYIYGYSIDEAYKFFYHTAENNYP-------LNEFQPTINNDTLHL-GWLDAAEPVIVSVPDDEGRYWILHTDGHYTNARGTKGGQFFAAQDWQGEVPASVDEVVR-VDSNLVKLGRIAVNDYLGKNGPKPVQRTYPDPKKGSGNADKQWLDKYQSIPEQLKLAKVGEKKGEHLVELAPKTDTLLGTRDTLGDAPRDIFALGQWGLPPIEASYRKSDFGSKHDWSVTIYGNDNRLAKNDLNRHSRGD-RTKADKDGYYTIYSANEKGRDPNFLPVP--EKPFYAIRFYGADDA-SGEYQPEIKVVK--------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.24

Estimated TM-score = 0.45±0.14

Estimated RMSD = 12.0±4.4Å

Download Model 2

C-score=-3.33

Download Model 3

C-score=-3.28

Download Model 4

C-score=-3.63

Download Model 5

C-score=-3.78

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3u07A	0.734	2.43	0.119	0.805
2	2p3yA	0.579	5.54	0.073	0.824
3	1szqA	0.406	5.90	0.038	0.605
4	1tg7A	0.402	5.80	0.055	0.597
5	3og2A	0.401	5.87	0.073	0.597
6	5ikyA	0.398	7.05	0.050	0.685
7	2hp0A	0.391	6.11	0.043	0.595
8	5a22A	0.388	7.17	0.036	0.675
9	1vw1A	0.386	6.76	0.040	0.635
10	4lglA	0.382	7.15	0.048	0.664

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	3	3vb9D	MG	Rep, Mult	71,76,149,318
2	0.05	2	3vb9D	MG	Rep, Mult	71,76,148,244,317,319
3	0.05	2	1fbmD	RTL	Rep, Mult	33,40
4	0.05	2	2ia5C	MG	Rep, Mult	284,286
5	0.02	1	1nd4A	MG	Rep, Mult	302,329
6	0.02	1	1su4A	CA	Rep, Mult	277,280,301,302
7	0.02	1	5apwB	CA	Rep, Mult	28,31
8	0.02	1	3e4qA	CA	Rep, Mult	301,302,303
9	0.02	1	3ar5A	PTY	Rep, Mult	73,276,279
10	0.02	1	3dc7B	MG	Rep, Mult	3,4
11	0.02	1	3i6bA	KDO	Rep, Mult	268,317
12	0.02	1	2wpnB	SBY	Rep, Mult	64,87
13	0.02	1	1rwtB	CHL	Rep, Mult	303,306
14	0.02	1	1pmhX	BMA	Rep, Mult	229,258,315
15	0.02	1	4y2nB	MG	Rep, Mult	88,161
16	0.02	1	1l6mB	DBH	Rep, Mult	87,165
17	0.02	1	4bcxA	PDO	Rep, Mult	100,148

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1h54B	0.353	7.22	0.038	0.619	2.4.1.8	NA
2	0.060	2w41B	0.346	6.93	0.063	0.587	2.7.1.30	76
3	0.060	2eabA	0.354	7.24	0.021	0.624	3.2.1.63	NA
4	0.060	2owoA	0.338	6.77	0.041	0.560	6.5.1.2	73
5	0.060	1vbgA	0.339	7.11	0.039	0.576	2.7.9.1	NA
6	0.060	1ti6A	0.369	6.50	0.016	0.600	1.97.1.2	74
7	0.060	2w00B	0.347	6.61	0.052	0.573	3.1.21.3	315
8	0.060	1fp4B	0.369	6.86	0.057	0.608	1.18.6.1	39
9	0.060	1kfxL	0.332	6.66	0.050	0.549	3.4.22.53	318
10	0.060	2vuaA	0.282	7.25	0.039	0.496	3.4.24.69	NA
11	0.060	1szqA	0.406	5.90	0.038	0.605	4.2.1.79	259
12	0.060	3b8cA	0.378	6.59	0.046	0.627	3.6.3.6	70
13	0.060	1y2mB	0.367	6.78	0.065	0.603	4.3.1.24	100
14	0.060	2nqaB	0.287	6.37	0.052	0.459	3.4.22.53,3.4.22.52	NA
15	0.060	1q16A	0.369	7.16	0.039	0.643	1.7.99.4	NA
16	0.060	2b3xA	0.358	6.59	0.067	0.587	4.2.1.3	NA
17	0.060	1eulA	0.342	7.23	0.032	0.603	3.6.3.8	70
18	0.060	2e20A	0.336	6.17	0.057	0.512	2.7.2.15	NA
19	0.060	2ipyA	0.323	6.61	0.060	0.531	4.2.1.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.409	5.94	0.04	0.61	1szqA	GO:0003994 GO:0006099 GO:0016829 GO:0019629 GO:0019679 GO:0047547 GO:0051537
1	0.06	0.401	5.87	0.07	0.60	3og2A	GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0016787 GO:0016798
2	0.06	0.402	5.80	0.06	0.60	1tg7A	GO:0000272 GO:0004553 GO:0004565 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798
3	0.06	0.325	7.32	0.07	0.58	4aybA	GO:0003677 GO:0003899 GO:0006351 GO:0008270 GO:0016740 GO:0016779 GO:0046872
4	0.06	0.254	6.69	0.06	0.42	4r27A	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
5	0.06	0.287	6.74	0.03	0.47	2uu7A	GO:0000166 GO:0003824 GO:0004351 GO:0004356 GO:0005524 GO:0005737 GO:0005739 GO:0006542 GO:0006807 GO:0016829 GO:0016874
6	0.06	0.399	5.94	0.06	0.60	4iugA	GO:0000272 GO:0004553 GO:0004565 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798
7	0.06	0.288	6.13	0.04	0.45	3thcA	GO:0004308 GO:0004553 GO:0004565 GO:0005737 GO:0005764 GO:0005773 GO:0005794 GO:0005975 GO:0006027 GO:0006687 GO:0008152 GO:0016787 GO:0016798 GO:0016936 GO:0019388 GO:0042340 GO:0043202 GO:0043231 GO:0044262 GO:0048471 GO:0070062
8	0.06	0.356	5.74	0.05	0.53	3w5gA	GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0016787 GO:0016798
9	0.06	0.284	6.86	0.03	0.48	4e8cA	GO:0004553 GO:0004565 GO:0005975 GO:0016787
10	0.06	0.248	7.26	0.04	0.43	3c8zB	GO:0000166 GO:0005524 GO:0008270 GO:0010125 GO:0016874 GO:0035446 GO:0046872
11	0.06	0.248	6.88	0.02	0.42	3dwkC	GO:0008658 GO:0016020 GO:0016021
12	0.06	0.293	6.72	0.05	0.47	4madB	GO:0004553 GO:0004565 GO:0005975
13	0.06	0.250	6.96	0.03	0.43	2yq4C	GO:0000166 GO:0008152 GO:0016491 GO:0016616 GO:0051287 GO:0055114
14	0.06	0.303	7.49	0.06	0.55	3hkzA	GO:0000428 GO:0003677 GO:0003899 GO:0006351 GO:0008270 GO:0016740 GO:0016779 GO:0046872
15	0.06	0.241	7.41	0.04	0.42	4yjyA	GO:0003824 GO:0008152 GO:0009058 GO:0009813 GO:0016210 GO:0016740 GO:0016746 GO:0016747
16	0.06	0.231	7.10	0.03	0.40	4jz7C	GO:0000166 GO:0005829 GO:0006525 GO:0008804 GO:0016301 GO:0016310 GO:0016740 GO:0019546
17	0.06	0.258	7.20	0.06	0.46	2eggA	GO:0004764 GO:0008652 GO:0009073 GO:0009423 GO:0016491 GO:0019632 GO:0050661 GO:0055114
18	0.06	0.266	6.58	0.05	0.43	1vffA	GO:0004553 GO:0005975

Consensus prediction of GO terms

Molecular Function	GO:0016787
GO-Score	0.36
Biological Processes	GO:0044238
GO-Score	0.31
Cellular Component	GO:0005576
GO-Score	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.