I-TASSER results

I-TASSER results for job id Rv3529c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (384 residues)
MTRRPDRKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKM
NRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGL
HMWLAEYPQPRPPRETWESNPLYRQLDAQFTQHHAENPGYTGLHFMAAYELEECWQLLRQ
SLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALD
ALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERF
NAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTVHAESQSGARA
PKHSYSLADYGLTVEMVKERFAGL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTRRPDRKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDAQFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTVHAESQSGARAPKHSYSLADYGLTVEMVKERFAGL
Prediction	CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHCHCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEHCCHHHHHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHCCC
Conf.Score	998888888889999999999998987788988558889999999999965889899999999999999999999999998865566777898899959999789999999869665555556665677888865555576899999999988776667666566888876579999999755445676646778999998667669999999999999866899869987968999999999989999599997798899999999999888765678899999999999999999999999997698868987887888779999999999989999999999999999977556778887789898799999999987589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTRRPDRKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDAQFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTVHAESQSGARAPKHSYSLADYGLTVEMVKERFAGL
Prediction	656346264123033014302651406101443530140021004004634503420121013300310230020250055126147450420000000000000001200221220100210101101111333122222003304420431233133033013131420100120021001000020002012003003433114004302400320224465310000002003104201500040000000000110010002013202421234121330022003101400320151066135520001315220430251033005206140265015203511562465544441413064040437303631377
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHCHCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEHCCHHHHHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHCCC
MTRRPDRKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDAQFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTVHAESQSGARAPKHSYSLADYGLTVEMVKERFAGL

2zq5A

1.00

0.95

2.90

MUSTER

------RKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDADFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTT--------------SYSLADYGLTVEMVKERFAGL

2zq5A

0.99

0.95

3.83

dPPAS

------RKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDADFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTH-------------SYSLADYGLTVEMVKERFAGL

2zq5A

0.99

0.95

5.34

wdPPAS

------RKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDADFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTH-------------SYSLADYGLTVEMVKERFAGL

2zq5A

1.00

0.94

0.95

3.50

wMUSTER

-------KDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDADFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTT--------------SYSLADYGLTVEMVKERFAGL

2zq5A

0.99

0.95

5.64

wPPAS

------RKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDADFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTH-------------SYSLADYGLTVEMVKERFAGL

2zq5A

0.99

0.95

10.60

dPPAS2

------RKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDADFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTH-------------SYSLADYGLTVEMVKERFAGL

2zq5A

0.99

0.95

4.87

PPAS

------RKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDADFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTH-------------SYSLADYGLTVEMVKERFAGL

2zq5A

0.99

0.95

8.29

Env-PPAS

------RKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLLDAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRTGTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDADFTQHHAENPGYTGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQLIGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGWSTKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRHFGLTLSDEARQAMTTH-------------SYSLADYGLTVEMVKERFAGL

2z6vA

0.27

0.26

0.98

2.67

MUSTER

----SDFDNITTADDVFKLAAQRTGLSEID--SDSWREGLALIVDEVNTSPVFTPFGRQRVLDDATNALGRRLQVHAYIQDHPEVLDAPVERPLIVLGMPRTGTTVISYLLDQDPARRSLLHWQCVHPIPPASTETLRTDPRCLALLDEQRKILDAVAKMPLPHWEDADGPTEDMFIHNQDFKGLSWDSFLPTDRYARWLFDEDMSSTYEYQKRYLQVLQSTAP-GSWSLKMPSHSVHIEALLKVFPDARLIWAHRDPYKATGSLCNLWRLPQSLVMNTLDQTEMGRLAMWQMRYHVDRPLRARERIGDERFFHMYYHEMMRDPMDVMRRIYEWADEPLTAETEARMRNWLAHHP-QDRFALNAYRLDEYGLTVEALQPIFAEY

2z6vA

0.27

0.26

0.98

3.49

dPPAS

----SDFDNITTADDVFKLAAQRTGLSEID--SDSWREGLALIVDEVNTSPVFTPFGRQRVLDDATNALGRRLQVHAYIQDHPEVLDAPVERPLIVLGMPRTGTTVISYLLDQDPARRSLLHWQCVHPIPPASTETLRTDPRCLALLDEQRKILDTRAKMPLPHWEDADGPTEDMFIHNQDFKGLSWDSFLPTDRYARWLFDEDMSSTYEYQKRYLQVLQSTAPG-SWSLKMPSHSVHIEALLKVFPDARLIWAHRDPYKATGSLCNLWRLPQSLVMNLLDQTEMGRLAMWQMRYHVDRPLRARERIGDERFFHMYYHEMMRDPMDVMRRIYEWADEPLTAETEARMRNWLAHHP-QDRFALNAYRLDEYGLTVEALQPIFAEY

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.73

Estimated TM-score = 0.96±0.05

Estimated RMSD = 3.2±2.3Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2zq5A	0.931	1.20	0.995	0.948
2	2z6vA	0.890	2.49	0.263	0.979
3	3ap1A	0.480	4.06	0.173	0.583
4	4gbmA	0.479	3.65	0.115	0.565
5	1q44A	0.473	5.25	0.127	0.654
6	4goxA	0.472	3.83	0.163	0.565
7	1nstA	0.471	4.29	0.134	0.586
8	1fmjA	0.471	5.23	0.107	0.648
9	1q20A	0.459	4.86	0.112	0.604
10	3cklB	0.457	4.82	0.096	0.599

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.28	16	4goxA	A3P	Rep, Mult	100,101,103,104,105,106,256,264,267,317,321,351,356,357,358
2	0.05	3	3ap2A	A3P	Rep, Mult	101,102,103,104,105,106,256,264,268,317,321,357,358,360,361,362,363,366,369
3	0.04	2	3ap1B	III	Rep, Mult	100,170,172,175,176,178,179,182,233,234,237,238,270,271,272,273
4	0.02	1	1cjmA	SO4	Rep, Mult	101,102,103,104,105,232
5	0.02	1	1j99A	HGI	Rep, Mult	332,333,336,337,338,339
6	0.02	1	3ap2A	III	Rep, Mult	110,111,114,117,227
7	0.02	1	3ug6A	MG	Rep, Mult	105,114
8	0.02	1	1vkjA	SO4	Rep, Mult	105,231
9	0.02	1	1r3nF	BIB	Rep, Mult	256,371
10	0.02	1	2ovbA	SO4	Rep, Mult	256,264,267

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2e9bA	0.399	6.10	0.048	0.615	3.2.1.41	96
2	0.060	1l1lA	0.396	6.84	0.047	0.664	1.17.4.2	NA
3	0.060	1bifA	0.403	4.42	0.066	0.529	3.1.3.46,2.7.1.105	101,104,261,263
4	0.060	2veoB	0.412	6.35	0.053	0.641	3.1.1.3	320
5	0.060	1q20A	0.459	4.86	0.112	0.604	2.8.2.2	NA
6	0.060	3cklB	0.457	4.82	0.096	0.599	2.8.2.-	NA
7	0.060	2e8yA	0.404	5.95	0.048	0.612	3.2.1.41	NA
8	0.060	1j99A	0.451	4.68	0.103	0.586	2.8.2.14,2.8.2.2	NA
9	0.060	2fahA	0.420	6.87	0.041	0.706	4.1.1.32	NA
10	0.060	2wanA	0.406	5.94	0.035	0.615	3.2.1.41	NA
11	0.060	1t8uB	0.448	3.87	0.119	0.542	2.8.2.30	103,233,260,321
12	0.060	1yq2A	0.411	6.56	0.060	0.664	3.2.1.23	NA
13	0.060	1cjmA	0.410	4.17	0.102	0.505	2.8.2.1	NA
14	0.060	2ad1A	0.419	4.61	0.105	0.544	2.8.2.-	235
15	0.060	1k6mA	0.402	4.53	0.052	0.529	2.7.1.105,3.1.3.46	99,103,105,358
16	0.060	1w78A	0.396	5.91	0.083	0.568	6.3.2.17,6.3.2.12	NA
17	0.060	2wtzB	0.420	5.19	0.083	0.576	6.3.2.13	97
18	0.060	1ytmA	0.413	6.72	0.075	0.674	4.1.1.49	NA
19	0.060	3crrA	0.400	3.64	0.088	0.477	2.5.1.8	243,250

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.67	0.931	1.20	0.99	0.95	2zq5A
1	0.43	0.890	2.49	0.26	0.98	2z6vA
2	0.21	0.472	3.83	0.16	0.57	4goxA	GO:0003824 GO:0008152 GO:0016740 GO:0031177
3	0.20	0.417	4.40	0.12	0.53	3mgcA	GO:0008146
4	0.17	0.451	4.68	0.10	0.59	1j99A	GO:0004062 GO:0004304 GO:0005737 GO:0005829 GO:0006629 GO:0007586 GO:0008146 GO:0008202 GO:0016042 GO:0016740 GO:0030573 GO:0047704 GO:0050294 GO:0050427 GO:0051923
5	0.14	0.454	4.63	0.10	0.59	1efhB	GO:0004062 GO:0004304 GO:0005737 GO:0005829 GO:0006629 GO:0007586 GO:0008146 GO:0008202 GO:0016042 GO:0016740 GO:0030573 GO:0047704 GO:0050294 GO:0050427 GO:0051923
6	0.10	0.413	4.25	0.13	0.52	3nibA	GO:0008146
7	0.10	0.459	4.86	0.11	0.60	1q20A	GO:0000103 GO:0004027 GO:0005634 GO:0005737 GO:0005783 GO:0005829 GO:0006629 GO:0008146 GO:0008202 GO:0016740 GO:0043231 GO:0050294 GO:0050427 GO:0070062
8	0.07	0.474	5.57	0.11	0.67	1x8kA	GO:0008146 GO:0046872
9	0.07	0.479	3.65	0.12	0.57	4gbmA	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
10	0.07	0.481	4.05	0.18	0.58	3ap2A	GO:0000139 GO:0005783 GO:0005794 GO:0006478 GO:0008476 GO:0016020 GO:0016021 GO:0016740 GO:0070062
11	0.07	0.471	5.34	0.12	0.66	2q3mA	GO:0005737 GO:0005794 GO:0006952 GO:0008146 GO:0009651 GO:0009751 GO:0016131 GO:0016740 GO:0080118 GO:1990135
12	0.07	0.457	4.82	0.10	0.60	3cklB	GO:0004062 GO:0005737 GO:0005829 GO:0006576 GO:0006629 GO:0006805 GO:0008146 GO:0008202 GO:0009812 GO:0016740 GO:0018958 GO:0030855 GO:0042403 GO:0050427 GO:0051923
13	0.07	0.445	4.50	0.10	0.57	1aqyA	GO:0004304 GO:0005496 GO:0005737 GO:0007565 GO:0008146 GO:0008210 GO:0008289 GO:0016740 GO:0045600 GO:0047894 GO:0050294 GO:0051923
14	0.07	0.454	4.69	0.08	0.60	2zytX	GO:0000103 GO:0004062 GO:0005737 GO:0006584 GO:0006629 GO:0008146 GO:0016740 GO:0051923
15	0.06	0.452	3.94	0.12	0.55	3rnlA	GO:0016740 GO:0046872
16	0.06	0.450	4.87	0.10	0.60	4jvlA	GO:0004062 GO:0004304 GO:0005496 GO:0005737 GO:0005829 GO:0008146 GO:0008202 GO:0008210 GO:0008289 GO:0016740 GO:0045600 GO:0047894 GO:0050294 GO:0050427 GO:0051923
17	0.06	0.427	4.41	0.13	0.54	3mgbA	GO:0008146
18	0.06	0.437	4.58	0.09	0.57	3bfxA	GO:0004062 GO:0005737 GO:0005829 GO:0008146 GO:0009308 GO:0016740 GO:0050427 GO:0051923 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0019842	GO:0072341	GO:0033218	GO:0008146
GO-Score	0.43	0.43	0.43	0.34
Biological Processes	GO:0006790	GO:0008206	GO:0006706	GO:0034035	GO:0044707	GO:0046128	GO:0009150	GO:0072329
GO-Score	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34
Cellular Component	GO:0044444
GO-Score	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.