I-TASSER results

I-TASSER results for job id Rv3528c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (237 residues)
MMLDRLRQGGYWLVRGKINLIDRAFTSCRIESFADLGAVWGVEGAYTFRALDKYPVKEAV
LVDGRITPTVAARANSYPQLRVIEGNFGDQEIADKVGNVDALFLFDVLLHQVSPDWDTIL
DMYAKNVRCLLIYNQQWIGSTTTVRLLDLGEKHYFRNVPHSKLNKAYRDLFQKLDKKHPD
HDKPWRDIPDIWQWGITDADLESKASELGFKLLYKEDCRGFGWLPNIQNRAFLFARQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MMLDRLRQGGYWLVRGKINLIDRAFTSCRIESFADLGAVWGVEGAYTFRALDKYPVKEAVLVDGRITPTVAARANSYPQLRVIEGNFGDQEIADKVGNVDALFLFDVLLHQVSPDWDTILDMYAKNVRCLLIYNQQWIGSTTTVRLLDLGEKHYFRNVPHSKLNKAYRDLFQKLDKKHPDHDKPWRDIPDIWQWGITDADLESKASELGFKLLYKEDCRGFGWLPNIQNRAFLFARQ
Prediction	CCCCCCCCCCEEEEHCHHHHHHHHHHCCCCCCCCCCCEEHCCCCEEEEEHCCCCCCCCEEEHCCCCCHHHHHHHHCCCCCEEHCCCCCCHHHHHHHCCCCEHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEEEHCCCCEEEEEHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEHCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCEEEEEHCC
Conf.Score	986545777568763468899998866785444444546656765676643457644347655888768999876584445444778998888875787445677778875689899999999875748999855664788779987567466665589987885676899999985855678765578744456885899999999898567763346655445444446777669
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MMLDRLRQGGYWLVRGKINLIDRAFTSCRIESFADLGAVWGVEGAYTFRALDKYPVKEAVLVDGRITPTVAARANSYPQLRVIEGNFGDQEIADKVGNVDALFLFDVLLHQVSPDWDTILDMYAKNVRCLLIYNQQWIGSTTTVRLLDLGEKHYFRNVPHSKLNKAYRDLFQKLDKKHPDHDKPWRDIPDIWQWGITDADLESKASELGFKLLYKEDCRGFGWLPNIQNRAFLFARQ
Prediction	641342352020103432410330043231430130111141424100411563604400102240344025406632303114551335502642251300000100023134404300510154030000023413446320201310464104513456436504410540474347364414403300410033640342056122402136404424405504530121258
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCEEEEHCHHHHHHHHHHCCCCCCCCCCCEEHCCCCEEEEEHCCCCCCCCEEEHCCCCCHHHHHHHHCCCCCEEHCCCCCCHHHHHHHCCCCEHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEEEHCCCCEEEEEHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEHCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCEEEEEHCC
MMLDRLRQGGYWLVRGKINLIDRAFTSCRIESFADLGAVWGVEGAYTFRALDKYPVKEAVLVDGRITPTVAARANSYPQLRVIEGNFGDQEIADKVGNVDALFLFDVLLHQVSPDWDTILDMYAKNVRCLLIYNQQWIGSTTTVRLLDLGEKHYFRNVPHSKLNKAYRDLFQKLDKKHPDHDKPWRDIPDIWQWGITDADLESKASELGFKLLYKEDCRGFGWLPNIQNRAFLFARQ

3d2lC

0.12

0.11

0.93

0.78

MUSTER

--AYEQFAYVYDELVPYPEWVAWVLEQVEPKRIADIGC----TGTATLLLADHYEV--TGVDLSEELEIAQEKAETNRHVDFWVQELELPE------PVDAITILCDSLNYLQADVKQTFDSAARLLTLFDVHSPYKETLFNGKTYATHAEQSSYIWFADPGEEPLSVVHELTFFIEGED--GRYDRVDETHHQTYPPEQYITWLREAGFRVCAVTGDFKSDAPTETAERIFFVAEK

3hnrA

0.11

0.09

0.79

0.70

dPPAS

-------DIQYKEVFAHYEDILEDVVNKSFGNVLEFGV---GTGNLTNKLLLAG--RTVYGIEPSREMRMIAKEKLPKEFSITEGDFLSFEVP---TSIDTIVSTYAFHHLTDDEKNVAIAKYSQLLN-----------KGGKIVFADTADQDAYDKTVEAAKQRGFHQLANDLQTEYY----------------TRIPVMQTIFENNGFHVTFTR-------LNHFVWVMEATKQL

1kyzE2

0.23

0.15

0.68

0.72

wdPPAS

------------------------YTGFGLKSLVDVGG----TGAVINTIVSKYPTIKGINFDL---PHVIEDAPSYPGVEHVGGDM------VSIPKADAVFMKWI-CHD----WDEHCLKFLKNCYEAL-------PDNGKVIVAEC--------LPVAPDSSLATKGVVHIDVI--NPGGKER----------TQKEFEDLAKGAGFQGFKVHCNAFN--------YIMEFLKK

3hnrA

0.12

0.09

0.76

0.72

wMUSTER

IQ-YKEVFA------HYEDILEDVVNKSF-GNVLEFGV----TGNLTNKLLLAG--RTVYGIE--PSREMRMIAKELPKFSITEGDFLSFEV----TSIDTIVSTYAFHHLTDDEKNVAIAKYSQLLN----------GG--KIVFADTADQDAYDKTVEAAKQRGFHQLANDLQTEY----------------YTRIPVMQTIFENNGFHVTFTR-------LNHF-VWVMEATKQ

3jwhA

0.17

0.12

0.73

0.69

wPPAS

ISLNQQ----------RMNGVVAALKQSNARRVIDLGG----QGNLLKILLKDSFFEQITGVD--VSYRSLEIAQERERLQLIQGALTYQDKRF--HGYDAATVIEVIEHLDLSRLGAFERVLFEFAQ----------K----IVIVTTPNIEYNVKFAHRFERSQFQNWANKITERFA------YNVQ--FQ-PIGEAD-----PEVGS-------P----------TQMAVFIHR

3jwhA

0.17

0.12

0.74

0.85

dPPAS2

ISLNQQ----------RMNGVVAALKQSNARRVIDLGG----QGNLLKILLKDSFFEQITGVD--VSYRSLEIAQERERLQLIQGALTYQD--KRFHGYDAATVIEVIEHLDLSRLGAFERVLFEFAQ------------PKIVIVTTP-NIEYNVKFAHRFERSQFQNWANKITERFA------YNVQFQ---PIGEAD-----PEVGS-----------------PTQMAVFIHR

2p35A

0.16

0.14

0.89

0.79

PPAS

--AQQYLKFEDERTRPARDLLAQV--LERVLNGYDLG-----PGNSTELLTDRYGVNVITGID--SDDDLEKAADRLPNTNFGKADLATWKPA---QKADLLYANAV-FQWV-PDHLAVLSQLDQ---VLAVQPDNLQEPTHIAHADGGPWKDAFKPLPPPS---DYFNALSPK-DVWHTVYNHPKDADSIVEWAAGEENREAFLADYTRRIAYPPADGRL--LLRFPRLFVVAVKK

5fcdA

0.12

0.10

0.86

1.12

Env-PPAS

----DNTPPG------AEYTIDYWIKHGCINKKSDLAC--ST-GFSSRECFKKEGAS-AEGID--ISEVANEKAKKNNLLKYYVADACDLPFED--NTFTHVLGGCNFAF-I-QNRLIALNETHRCLNCISNFYYRRKISDKLINDV---YNAINFRPNPLWTLEYWHQFFSETLV-------SEEN----HEESQSEDELKADIYDYIFNERFLKIRRPLNIQRDYQGVTLQIWRK

3ceqB

0.11

0.10

0.91

0.72

MUSTER

ATMLNILALVYRDQNKYKEAAHLLNDALAIRE------TLGKDHPAVAATL--NNLAVLYGKRGKYKEAEPLCKRALEIREKVLGK-FHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLG----DDPNVAKTKNNLASCYLKQGKYQDAETL--YKEILTRAHEKEFSVNGDNKPIWMHAEEREECKVDSPTVNTTLRSLG--ALYRRQ-GKLEAAHTLEDCAS--NR-

2r3sA1

0.15

0.12

0.81

0.68

dPPAS

SEGTLSPEHPVWVQANPAQLIAQLVNEIEPLKVLDISA---SHGLFGIAVAQHNPNAEIFGVDWSVLEVAKENARIQGVYHTIAGSAFEVDY---GNDYDLVLLPNFLHHFDVATCEQLLRKIKTA-----------LAVEGKVIVFD--------FIPNSDRITPPDAAAFSLVLATTPNGDAYT------------FAEYESFSNAGFSHSQLHS------LPTTQQQVIVAYK-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.07

Estimated TM-score = 0.47±0.15

Estimated RMSD = 10.4±4.6Å

Download Model 2

C-score=-3.98

Download Model 3

C-score=-2.62

Download Model 4

C-score=-4.69

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5f8cA	0.657	3.55	0.093	0.831
2	2zwaB	0.650	3.71	0.087	0.844
3	5cvuB	0.642	3.34	0.137	0.802
4	5thyA	0.640	3.81	0.085	0.835
5	2p7iB	0.637	3.67	0.130	0.802
6	4qvgA2	0.637	3.73	0.127	0.823
7	1tw2B	0.637	3.71	0.154	0.819
8	5iccA	0.636	3.47	0.141	0.797
9	4a6dA	0.635	3.37	0.151	0.797
10	1rjeC	0.633	4.24	0.073	0.869

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.17	6	3gxoD	SAH	Rep, Mult	37,38,39,63,85,86,87,104,110,111
2	0.06	2	1mioB	CA	Rep, Mult	117,121
3	0.03	1	3k6sA	MG	Rep, Mult	22,24,27,106
4	0.03	1	1zbuD	MG	Rep, Mult	22,106,116,117
5	0.03	1	2anuA	ZN	Rep, Mult	180,217
6	0.03	1	3shyA	MG	Rep, Mult	160,180
7	0.03	1	2g9zA	PO4	Rep, Mult	100,106,136
8	0.03	1	3thrB	C2F	Rep, Mult	12,14,18
9	0.03	1	5eehC	P9P	Rep, Mult	11,18,106,174
10	0.03	1	2g9zA	MG	Rep, Mult	100,106
11	0.03	1	1ig3A	VIB	Rep, Mult	136,148,160

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.067	3hnrA	0.592	3.53	0.101	0.743	2.1.1.-	NA
2	0.067	3e05D	0.539	3.51	0.073	0.692	2.1.1.132	38,84,87
3	0.067	3grzB	0.527	3.63	0.093	0.683	2.1.1.-	NA
4	0.067	3gdhA	0.547	3.49	0.142	0.683	2.1.1.-	NA
5	0.067	3cbgA	0.560	4.05	0.079	0.751	2.1.1.-	NA
6	0.067	1suiA	0.568	4.29	0.059	0.789	2.1.1.104	NA
7	0.066	1susD	0.567	4.29	0.075	0.785	2.1.1.104	106
8	0.066	1f38A	0.524	3.74	0.055	0.692	2.1.1.-	NA
9	0.066	2pxxA	0.552	3.28	0.101	0.679	3.4.24.71	NA
10	0.066	1nt2A	0.535	3.92	0.085	0.709	2.1.1.-	NA
11	0.066	1xcjA	0.573	4.17	0.118	0.772	2.1.1.2	106
12	0.066	3bwmA	0.549	3.62	0.076	0.717	2.1.1.6	NA
13	0.066	3e05B	0.540	3.47	0.073	0.692	2.1.1.132	NA
14	0.066	2cl5A	0.550	3.65	0.082	0.722	2.1.1.6	NA
15	0.060	1uirB	0.561	3.80	0.091	0.738	2.5.1.16	11,63,104,106
16	0.060	1bhjA	0.617	4.18	0.095	0.819	2.1.1.20	207
17	0.060	1kpiA	0.604	4.15	0.106	0.797	2.1.1.79	NA
18	0.060	1ri1A	0.610	4.21	0.075	0.831	2.1.1.56	37,63
19	0.060	3bgdA	0.575	3.36	0.112	0.726	2.1.1.67	89
20	0.060	2aovA	0.569	4.55	0.108	0.802	2.1.1.8	NA
21	0.060	2ip2A	0.620	3.53	0.142	0.789	2.1.1.-	NA
22	0.060	2a14A	0.579	3.77	0.070	0.772	2.1.1.49	11,37,82,104
23	0.060	1fp1D	0.626	3.54	0.151	0.797	2.1.1.-	110
24	0.060	2ytzA	0.579	3.74	0.100	0.755	2.1.1.32	63,106
25	0.060	1kywC	0.626	3.62	0.149	0.806	2.1.1.68	110
26	0.060	2i62C	0.574	3.83	0.080	0.772	2.1.1.1	11,37,41
27	0.060	1ej6A	0.577	4.01	0.082	0.764	2.7.7.50	35,37,41,43,66,68,71
28	0.060	3lccA	0.598	3.51	0.106	0.755	2.1.1.-	66,82,84
29	0.060	3i58A	0.615	3.38	0.130	0.776	2.1.1.-	110
30	0.060	1tpyA	0.609	4.01	0.152	0.797	2.1.1.79	NA
31	0.060	1wznA	0.595	4.14	0.141	0.793	2.1.1.-	NA
32	0.060	1fp2A	0.627	3.35	0.119	0.781	2.1.1.150	110
33	0.060	2ex4A	0.593	3.29	0.154	0.743	2.1.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.09	0.637	3.71	0.15	0.82	1tw2B	GO:0008168 GO:0008171 GO:0016740 GO:0017000 GO:0032259 GO:1901771
1	0.09	0.636	3.47	0.14	0.80	5iccA	GO:0008168 GO:0008171 GO:0016740 GO:0030786 GO:0032259 GO:0046983
2	0.08	0.627	3.35	0.12	0.78	1fp2A	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0033800 GO:0046983
3	0.08	0.650	3.71	0.09	0.84	2zwaB	GO:0005737 GO:0005739 GO:0005829 GO:0006400 GO:0008033 GO:0008168 GO:0008175 GO:0008757 GO:0016740 GO:0030488 GO:0031591 GO:0032259
4	0.08	0.637	3.52	0.12	0.81	3gwzA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:1901663
5	0.08	0.629	3.59	0.11	0.80	4pggA	GO:0005829 GO:0008168 GO:0008171 GO:0008757 GO:0016740 GO:0019438 GO:0032259 GO:0046872 GO:0046983 GO:0047763 GO:0051536 GO:0051539
6	0.08	0.634	4.21	0.07	0.87	1rjdC	GO:0005829 GO:0006481 GO:0008168 GO:0010506 GO:0016740 GO:0018423 GO:0032259 GO:0043623
7	0.08	0.640	3.35	0.14	0.80	5cvjA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983 GO:0050630
8	0.08	0.634	3.52	0.14	0.81	3p9iA	GO:0008168 GO:0008171 GO:0016206 GO:0016740 GO:0032259 GO:0046983
9	0.08	0.638	3.52	0.11	0.82	4qvgC	GO:0008168 GO:0008171 GO:0032259
10	0.07	0.626	3.54	0.15	0.80	1fp1D	GO:0008168 GO:0008171 GO:0016740 GO:0030751 GO:0032259 GO:0033802 GO:0046983
11	0.07	0.622	3.49	0.10	0.79	1x19A	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
12	0.07	0.635	3.37	0.15	0.80	4a6dA	GO:0005829 GO:0006412 GO:0008168 GO:0008171 GO:0008172 GO:0008757 GO:0016740 GO:0017096 GO:0030187 GO:0032259 GO:0042802 GO:0042803 GO:0046219
13	0.07	0.626	3.62	0.15	0.81	1kywC	GO:0008168 GO:0008171 GO:0009699 GO:0009809 GO:0016740 GO:0032259 GO:0046983 GO:0047763
14	0.07	0.630	3.58	0.13	0.80	4eviA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983
15	0.07	0.615	3.38	0.13	0.78	3i58A	GO:0008168 GO:0008171 GO:0016740 GO:0017000 GO:0032259
16	0.07	0.633	3.49	0.12	0.81	3mczA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
17	0.07	0.625	4.08	0.09	0.85	3p71T	GO:0003880 GO:0005829 GO:0006464 GO:0006479 GO:0006481 GO:0008168 GO:0008276 GO:0008757 GO:0010906 GO:0016740 GO:0018423 GO:0031333 GO:0032259 GO:0042981 GO:0090266
18	0.07	0.618	3.82	0.10	0.82	4kifB	GO:0008168 GO:0016740 GO:0017000 GO:0032259
19	0.07	0.606	3.63	0.14	0.78	2qyoA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983
20	0.07	0.582	4.31	0.12	0.79	3dtnA	GO:0046872
21	0.07	0.592	3.32	0.17	0.74	5cvdA	GO:0005634 GO:0005654 GO:0005737 GO:0006480 GO:0007051 GO:0007059 GO:0008168 GO:0008276 GO:0016740 GO:0018011 GO:0018012 GO:0018016 GO:0032259 GO:0035572 GO:0035573 GO:0071885
22	0.07	0.597	3.20	0.09	0.73	1xtpA	GO:0005737 GO:0006480 GO:0008168
23	0.07	0.498	3.17	0.13	0.62	3hm2A	GO:0006479 GO:0008152 GO:0008168 GO:0008276 GO:0009236 GO:0016740 GO:0032259
24	0.07	0.598	3.82	0.16	0.78	4z2yA	GO:0008168 GO:0008171 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0008168	GO:0005515
GO-Score	0.36	0.32
Biological Processes	GO:0032259
GO-Score	0.36
Cellular Component	GO:0005739	GO:0005829
GO-Score	0.08	0.08

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
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