I-TASSER results

I-TASSER results for job id Rv3512

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (1079 residues)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Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| PQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGDAGKAGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGGTGGSGGAGGTGGDGGAANGGTAGAGGAGGNGGKGGDGGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGDGGDGAAGAVGISGATGAGDGGHGGTGAAGGNGGTGGAGGSGIDGVGGGTGGTGGNGGNGAIGGAGGDAGGSGNSGGNGGIGGKGGNAGAGGAAGSNGGTVGANGTGGDGGNGGAAGAATAGSNGGAGTGSAGGNGGTGGRGGSGGAGGDGIGGVGGGKGGNGADGEVGGAGGAGGSGPNTSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGAGGTGGAGAASSATNGGSGGAGGTGGDGGSGGAGGTGGAGGTGGAAGDGGQGGQGGAGGGAGGQGGAGGAGGTGGNGGNITGGTAGTAGAAGNGGAAGKGGAGGQGGTGGGTGGQGGAGGDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGGDGGDAGTGGNGGNGGNRNSGNGTGGAGGNGGGGANGGAGGAGGSGGGTGGNGGAGGDAGDAGNGGNGNGTGNGGNGGNGGIAGMGGNGGAGTGSGNGGNGGSGGNGGNAGMGGNSGTGSGDGGAGGNGGAAGTGGTGGDGGLTGTGGTGGSGGTGGDGGNGGNGADNTANMTAQAGGDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQGGAGGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTGGTGGAGIGSLGGGTGGDGGNGGNGGTGGEGGEVGGAGGTGGAAGNGGDGGTGGTGGGDGGAGGTGGTGGTGGLGDPRVGGSGGDGGTGGSGGAAGNGGNGGNAGAGGNGNGGTGGAGGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTGGDGGTGGGGGNGGTGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGGAGGKGGSGGV
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	99999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999899999999999999999999999999999999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| PQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGDAGKAGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGGTGGSGGAGGTGGDGGAANGGTAGAGGAGGNGGKGGDGGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGDGGDGAAGAVGISGATGAGDGGHGGTGAAGGNGGTGGAGGSGIDGVGGGTGGTGGNGGNGAIGGAGGDAGGSGNSGGNGGIGGKGGNAGAGGAAGSNGGTVGANGTGGDGGNGGAAGAATAGSNGGAGTGSAGGNGGTGGRGGSGGAGGDGIGGVGGGKGGNGADGEVGGAGGAGGSGPNTSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGAGGTGGAGAASSATNGGSGGAGGTGGDGGSGGAGGTGGAGGTGGAAGDGGQGGQGGAGGGAGGQGGAGGAGGTGGNGGNITGGTAGTAGAAGNGGAAGKGGAGGQGGTGGGTGGQGGAGGDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGGDGGDAGTGGNGGNGGNRNSGNGTGGAGGNGGGGANGGAGGAGGSGGGTGGNGGAGGDAGDAGNGGNGNGTGNGGNGGNGGIAGMGGNGGAGTGSGNGGNGGSGGNGGNAGMGGNSGTGSGDGGAGGNGGAAGTGGTGGDGGLTGTGGTGGSGGTGGDGGNGGNGADNTANMTAQAGGDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQGGAGGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTGGTGGAGIGSLGGGTGGDGGNGGNGGTGGEGGEVGGAGGTGGAAGNGGDGGTGGTGGGDGGAGGTGGTGGTGGLGDPRVGGSGGDGGTGGSGGAAGNGGNGGNAGAGGNGNGGTGGAGGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTGGDGGTGGGGGNGGTGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGGAGGKGGSGGV
Prediction	85346354345146145266156255256145255145245244245245264246145146165165164245265255264245245254345224425426525614414616516526346354245245146164264264363453453462452552441441451552541451441362451441542354255255246156144145246165154262242442242541425244144144146154144144145145155244244145164424624514424424624332542442341141451414246244155154144144142452441421423524514515414413411414414434524615424423414514514233442542552552452452451462544254253264243252442341442452442452461451451461451462451451551451651461452451452451442551461551462451451551452561451551462442452444364246245244145144124145145165146145154145244325425424424424414424523414412514515614515415514246254145144244234145134246144145145145165245145265146145144154134154244425524516514514614516614515515626614615515514424524514424525524514523434514434524514615616514616516424424424624413524544526514524424424442452552652651441642614246246145165155245144245154145244246244144145145144244435235245145144145162542542632442432634624524425524514614514515524515514524514514414422424413604524424512424516325246244246245346456667
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060

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Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGDAGKAGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGGTGGSGGAGGTGGDGGAANGGTAGAGGAGGNGGKGGDGGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGDGGDGAAGAVGISGATGAGDGGHGGTGAAGGNGGTGGAGGSGIDGVGGGTGGTGGNGGNGAIGGAGGDAGGSGNSGGNGGIGGKGGNAGAGGAAGSNGGTVGANGTGGDGGNGGAAGAATAGSNGGAGTGSAGGNGGTGGRGGSGGAGGDGIGGVGGGKGGNGADGEVGGAGGAGGSGPNTSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGAGGTGGAGAASSATNGGSGGAGGTGGDGGSGGAGGTGGAGGTGGAAGDGGQGGQGGAGGGAGGQGGAGGAGGTGGNGGNITGGTAGTAGAAGNGGAAGKGGAGGQGGTGGGTGGQGGAGGDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGGDGGDAGTGGNGGNGGNRNSGNGTGGAGGNGGGGANGGAGGAGGSGGGTGGNGGAGGDAGDAGNGGNGNGTGNGGNGGNGGIAGMGGNGGAGTGSGNGGNGGSGGNGGNAGMGGNSGTGSGDGGAGGNGGAAGTGGTGGDGGLTGTGGTGGSGGTGGDGGNGGNGADNTANMTAQAGGDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQGGAGGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTGGTGGAGIGSLGGGTGGDGGNGGNGGTGGEGGEVGGAGGTGGAAGNGGDGGTGGTGGGDGGAGGTGGTGGTGGLGDPRVGGSGGDGGTGGSGGAAGNGGNGGNAGAGGNGNGGTGGAGGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTGGDGGTGGGGGNGGTGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGGAGGKGGSGGV

2pffB

0.55

0.54

1.00

8.07

MUSTER

P-GGASGLGVLTHRNKDGTGVKQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGQGSQEQG

3hr2A

0.29

0.25

0.87

13.95

dPPAS

-------------------------------------------QMSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGPQGFQGPGEGEGGSGPMGPPGPGPGKNGDDGEAGKPGRGE----RGPGPQGARGLGTAGLGMGH--RGFSGLDGAKGDTGPAGPKGEGSGENGTGQMGPRGLGERGRGPGTAGARGNDGAVGAAG-PGPTGPTGPGFGAAGAKGEAGPQGARGSEGPQGVRGEGPGPAGAAGPAGNGADG-QGAKGANGAGIAGAGFGARGPSGPQGPSGAGP-----------------KGTSGEGAGNKGDTGAKGEGPAGVQGPGPAGEEGKRGARGEGP-SGLGPGERGGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGP-DGKTGPGPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPAGKDGEAGAQG-AGPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGMGERGAAGLGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPGPAGAGDKGEAGPSGPAGPTGARGAGDRGE--------------AGPGPAGFAGPGADGQGAKGEGDTGVKGDAGPGPAGPAGPGPIGNVGAGPGSRGAAGPGATGFGAAGRVGPGPSGNAGPGPGPVGKEGGKGPRGETGPAGRGEVGPGPGPAGEKGSGADGPAGSGTPGPQGIAGQRGVVGLGQRGKRGFGLGPSGEGKQGPSGASGERGPGPMGPGLAGPGESGREGSGAEGSGRDGAGAKGDRGETGPAG-PGAGAGAPGPVGPAGKNG-DRGETGPAGPAGPIGPAGARGPAGPQGPRGD-GETGEQGDRG-IGHRGFSGLQGPGSGSGEQGPSGASGPAGPRGPGSAGSGKDGLNGLGPIGGPRGRTGDSGPAGPGPGPGPGPPSGGYDFSFLPQPPQEKSQDGGRYY---------------------------------------------------

3hr2A

0.27

0.24

0.87

16.17

wdPPAS

----QMSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGPQGFQGPGEGEGGSGPMGPPGPGP--GKNGDDGEAGKPGRGE--RGPGPQGARGLGTAGLGM------------------------GHRGFSGLDGAKGDTGP--AGPKGEGSGENGTGQMGPRGLGERGRGPGTAGARGNDGAVGAAGPGPTGPTGPGFGAA-GAKGEAGPQGARGSEGPQGVRGEGPGPAGAAGPAG-NGADGQGAKGANGAGIAGAGFGARGPSGPQGPSGAGPKGTSGEGAGNKGDTGAKGEGPAGVQGP-----------------------GPAGEEGKRGARGEGPSGLGPGE----RGGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGPDGKTGP-GPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPAGKDGEAGAQGA-GPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGMGERGAAGLGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPGPAGAGDKGEAGPSGPAGPTGARGAGDRGEAGPPAGFAGPGADGQGAKGEGDTGVKGDAGPGPAGPAGPGPIGNVGAGPGSRGAAGPGATGFGAAGRV--GPGPSGNAGPGPGPVGKEGGKG-PRGETGPAGRGEVGPGPGPAGEKGSGADGPAGSGTPGPQGIAGQRGVVGLGQRGKRGFGLGPSGEGKQGPSGASGERGPGPMGPGLAGPGESGREGSGAEGSGRDGAGAKGDRGETGPAGPGAGAGAPGPVGPAGKNG--------------------DRGETGPAGPAGPIGPAGARGPAGPQGPRGD-GETGEQGDRG-IGHRGFSGLQGPGSGSGEQGPSGASGPAGPRGPGSAGSGKDGLNGLGPIGGPRGRTGDSGPAGPGPGPGPGPPSGGYDFSFLPQPPQEKSQDGGRYY---------------------------------------------------

2pffB

0.54

1.00

10.40

wMUSTER

P-GGASGLGVLTHRNKDGT-GVRVIVAGTLDINPDDDYGFKQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGQGSQEQG

3hr2A

0.28

0.24

0.87

13.76

wPPAS

-QMSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGPQGFQGPGEGEGGSGPMGPPGPGP--GKNGDDGEAGKPGRGE--RGPGPQGARGLGTAGLGMG---------------------------HRGFSGLDGAKGDTGP--AGPKGEGSGENGTGQMGPRGLGERGRGPGTAGARGNDGAVGAAGPGPTGPTGPGFGAA-GAKGEAGPQGARGSEGPQGVRGEGPGPAGAAGPAGNGADGQ-GAKGANGAGIAGAGFGARGPSGPQGPSGAGPKGTSGEGAGNKGDTGAKGEGPAGVQGPGPAGE--------------------EGKRGARGEGPSGLGPGERG----GGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGPDGKTGP-------GPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPAGKDGEAGAQG-AGPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGMGERGAAGLGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPGP------------AGAGDKGEAGPSGPAGPTGARGAGDRGEAGP-------GPAGFAGPGADGQGAKGEGDTGVKGDAG-PGPAGPAGPGPIGNVGAGPGSRGAAGPGATGFGAAGRVGPGPSGNAGPGPGPVGKEGGKGPRGETGPAGRGEVGPGPGPAGEKGSGADGPAGSGTPGPQGIAGQRGVVGLGQRGKRGFGLGPSGEGKQGPSGASGERGPGPMGPGLAGPGESGREGSGAEGSGRDGAGAKG--------------------------------DRGETGPAGPGAGAGAPGPVGPAGKNGDRGETGPAGPAGPIGPAGARGPAGPQGPRG-DGETGEQGDRG--------------IGHRGFSGLQGPGSGSGEQGPSGASGPAGPRGPGS--AGSGKDGLNGLGPIGGPRGRTGDSGPAGPGPGPGPGPPSGG--YDFSFLPQPPQEKSQDGGRYY-

3hr2A

0.26

0.23

0.87

14.74

dPPAS2

-------------------------QMSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGPQGFQGPGEGEGGSGPMGPPGPGP--GKNGDDGEAGKPGRGERGPGPQGARGLGTAGLGMGH-----RGFSGLDGAKGDTGP-----AGPKGEGSGENGTGQMGPRGLGERGRGPGTAGARGNDGAVGAAGPGPTGPTGPGFG-AAGAKGEAGPQGARGSEGPQGVRGEGPGPAGAAGPAGNGADGQ-GAKGANGAGIAGAGFGARGPSGPQGPSGAGPKGTSGEGAGNK-----------------------GDTGAKGEGPAGVQGPGPAGEEGKRGARGEGPSGLG----PGERGGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGPDGK-TGPGPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPAGKDGEAGAQG-AGPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGMGERGAAGLGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPGPAGAGDKGEAGPSGPAGPTGARGAGDRGEAGPPAGFAGPGADGQGAKGEGDTGVKGDAGPGPAGPAGPGPIGNVGAGPGSRGAAGPGATGGAAGRVGPGPSGNAGPGPGPVGKEGGKG-PRGETGPAGRGEVGPGPGPAGEKGSGADGPAGSGTPGPQGIAGQRGVVGLGQRGKRGFGLGPSGEGKQGPSGASGERGPGPMGPGLAGPGESGREGSGAEGSGRDGAGAKGDRGETGPAGPGAGAGAPGPVGPAGKNG--------------------DRGETGPAGPAGPIGPAGARGPAGPQGPRGD-GETGEQGDRG-IGHRGFSGLQGPGSGSGEQGPSGASGPAGPRGPGSAGSGKDGLNGLGPIGGPRGRTGDSGPAGPGPGPGPGPPSGGYDFSFLPQPPQEKSQDGGRYY---------------------------------------------------

3hr2B

0.31

0.27

0.87

14.01

PPAS

DKGVSAGPGPMGLMGPRGPGAVGA--GPQGFQGPAG--EGEGQTGPAGSRGPAGPGKAGEDGHGKPGRGERGVVGPQGARGFGTGLG-FGIRGHNGLD------------------------------GLKGQGAQGVGEGAGENGTGQAGARGLGERGRVGAGPAGARGSDGSVGPVGPAGPIGSAGPGFGAGPGELGPVGNGPAGPAGPRGEAG-LGLSGPVGPGNPGANGLTGAGATGLGVAGAGLGPRGIGPVGAAGATGPRGLVGEGPAGSGETGNKGEGSAG--------------------------------------------------------------AQGPGPSGEEGKRGSPGEPGSAGPAGPGLRGSGSRGLGADGRAGVMGPPGNRG-------------STGPAGVRGPNGDAGRGEGLMGPR-GLGSGNVGPAGKEGPVG--LGIDGRGPIGPAGPRGEAGNIGFGPKGPSGDGKGEKGHPGLAGARG-AGPDGNNGAQG-PGPQGVQGGKGEQGPAGPGFQGLGPSGTAGEVGKGERGLPGEFGLGPAGPRGERGPGESGAAGPSGPIGIRGPSG-AGPDGNKGEAGAVGAPGS-------AGASGPGGLGERGA--AGIGGKGEKGETGLRGEIGN-----PGRDGARGAGAIGA--GPAGASGDRGEAGAAGPSGPAGPRGSPGERGEVGPAGPNGFAGPAGSAGQGAGEKGTKGPKGENGIVGPTGPVGAAGPSGPNGPPGPAGSRGDGGPPGMTG-FGAAGRTGPGPSGITGPGPGAAGKEGIRGPRGDQGPVGRTGEIGASGPPGFAGEKGPSGEGTTGP--GTAGPQGLLGAGILGLGSRGERGQGIAGALGEGPLGIAGPG-ARGPGAVGSGVNGAGEAGRDGNGSDGPGRDGQGHKGERG-YGNIGPTGAAGAPGPHGSVGPAGKHGNRGEPGPAGSV-GPVGAVGPRGPSGPQGIRGDKGEPG-DGARGLPGLKGHNGLQGLPGLAGLHGDQGAPGPVGPAGPRGPAGPSGPIGKDGRSGHPGPVGPGVRGSQGSQGPAGPGPGPGPPGVS

3hr2A

0.28

0.25

0.87

7.59

Env-PPAS

-QMSYGYDEKSAGVSVPGPMGPSGPRGLGPGAGPQGFQGPGEGEGGSGPMGPPGPGP--GKNGDDGEAGKPGRGE--RGPGPQGARGLGTAGLGMG---------------------------HRGFSGLDGAKGDTGP--AGPKGEGSGENGTGQMGPRGLGERGRGPGTAGARGNDGAVGAAGPGPTGPTGPGFGAAG-AKGEAGPQGARGSEGPQGVRGEGPGPAGAAGPAGNGADGQ----GAKGANGAGIAGAGFGARGPSGPQGPSGAGPKGTSGEGAG-------NKGDTGAKGEGPAGVQGPGPAGEEGKRGA----------RGEGPSGLGPG----------ERGGGSRGFGADGVAGPKGPSGERGSGPAGPKGSGEAGRGEAGLGAKGLTGSGSGP----DGKTGPGPAGQDGRGPAGPGARGQAGVMGFGPKGTAGEGKAGERGVGPGAVGPAGKDGEAGAQG-AGPAGPAGERGEQGPAGSGFQGLGPAGPGEAGKGEQGVGDLGAGPSGARGERGFGERGVQGPGPAGPRGNNGAGNDGAKGDTGAGAGSQGAGLQGMGERGAAGLGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPGPAGAGDKGEAGPSGPAGPTGARGAGDRGEAGP----------------GPAGFAGPGADGQGAKGEGDTGVKGDAG-PGPAGPAGPGPIGNVGAGPGSRGAAGPGATGFGAAGRVGPGPSGNAGPGPGPVGKEGGKGPRGETGPAGRGEVGPGPGPAGEKGSGADGPAGSGTPGPQGIAGQRGVVGLGQRGKRGFGLGPSGEGKQGPSGASGERGPGPMGPGLAGPGESGREGSGAEGSGRDGAGAKGDR-----------------------------GETGPAGPGAGAGAPGPVGPAGKNGDRGETGPAGPAGPIGPAGARGPAGPQGPRG-DGETGEQGDRG-----------------IGHRGFSGLQGPGSGSGEQGPSGASGPAGPRGPGS--AGSGKDGLNGLGPIGGPRGRTGDSGPAGPGPGPGPGPPSGG--YDFSFLPQPPQEKSQDGGRYY-

3hr2B

0.32

0.28

0.87

7.03

MUSTER

-----SDKGVSAGPGPMGLMGPRGPGAVGA--GPQGFQGPAG--EGEGQTGPAGSRGPAGPGKAGEDGHGKPGRGERGVVGPQGARGFGTGLG----------------------------FGIRGHNGLDGLKGQGAQGVGEGAGENGTGQAGARGLGERGRVGAGPAGARGSDGSVGPVGPAGPIGSAGPGFGAGPGELGPVGNGPAGPAGPRGEAG-LGLSGPVGPGNPGANGLTGAGATGLGVAGAGLGPRGIGPVGAAGATGPRGLVGEGPAGSGETGNKG------------------------------------------EGSAGAQG-----------------PGPSGEEGKRGSPGEPGSAGPAGPGLRGSGSRGLGADGRAGVMGPPGNRGSTG----------PAGVRGPNGDAGRGEGLMGPR-GLGSGNVGPAGKEGPVG--LGIDGRGPIGPAGPRGEAGNIGFGPKGPSGDGKGEKGHPGLAGARG----AGPDGNNGAQG-PGPQGVQGGKGEQGPAGPGFQGLGPSGTAGEVGKGERGLPGEFGLGPAGPRGERGPGESGAAGPSGPIGIRGPSG-AGPDGNKGEAGAVGAPG----SAGASGPGGLGE--RGAAGIGGKGEKGETGLRGE-----------IGNPGRDGARGAGAIGA--GPAGASGDRGEAGAAGPSGPAGPRGSPGERGEVGPAGPNGFAGPAGSAGQGAGEKGTKGPKGENGIVGPTGPVGAAGPSGPNGPPGPAGSRGDGGPPGMTG-FGAAGRTGPGPSGITGPGPGAAGKEGIRGPRGDQGPVGRTGEIGASGPPGFAGEKGPSGEGT--TGPGTAGPQGLLGAGILGLGSRGERGQGIAGALGEGPLGIAG-PGARGPGAVGSGVNGAGEAGRDGNGSDGPGRDGQGHKGERGNIGPTGAAGAPGPHGSVGPAGKHGNRGEPGPAGS-VGPVGAVGPRGPSGPQGIRGDKGEPGARGLPGLKGHNGLQGLPGLAGLHGDQGAPGPVGPAGPRGPAGPSGPIGKDGRSGHPGPVGPAGV--RGSQGSQGPAGPGPGPGPPGVS

3hr2B

0.29

0.25

0.87

13.68

dPPAS

--------SDKGVSAGPGPMGLMGPRGPGAVGAGPQGF-QGPAGEGEGQTGPAGSRGPAGPGKAGEDGHGKPGRGERGVVGPQGARGFGTGLGF--GIRGHNGLDGLKGQGAQGVGEGAGENGTGQAGARGL--GERGRVGAGPAGARGSDGSVGPVGPAGPIGSAGPGFGAGPGELGVGNGPAGPAGPRGEAGLGLSPVGPGNPGANGLTGAGATGLGVAGAGLGPRGIGPVGAAGATGPRGLVGEGPAGSGETGNKGEGSAGAPGPSGEEGKRGSPGEPGSAGPAG-PGLRGSGSRGLGADGRA-GVMGPPGNRGSTGPAG-VRGPNGDAGRGEGLMGPRGLGSGNVGPAG-KEGPVGLGIDGRGPIGPAGPRGEAGNIGFGPKGPSGDGKGEKGHPGLAGARGAGPDGNNGAQGPGPQGVQGGKGEQGPAGPGFQGLGPSGTAGEVGKGERGLPGEFGLPAGPRGERGPGESGAAGPSGPIGIRGPSG-AGPDGNKGEAGAVGAPGSAGASGPGGLGER--GAAGIGGKGEKGETGLRGEIGNPGRDGARGAGAIGAGPAGASGDRGEAGAAGPSGPAGPRGSPGERGEVGPAGPNGFAGPAGSAGQGAGEKGTKGPKGENGIVGPTGPVGAAGPSGPNGPPGPAGSRGDGGPPGMTGFGAAGRTGPGPSGITGPGPGAAGKEGIRGPRGDQGPVGRTGEIGASGPPGFAGEKGPSGEGTTGPGTAGPQGLLGAGILGL--GSRGERGQGIAGALGEGPLGIAGPGARGPGAVGSGVNGAGEAGRDGNGSDGPGRDGQGHKGERG-YGNIGPTGAAGAPGPHGSVGPAGKHGNRGEPGPAGSVGPVGAVGPRGPSGPQGIRGDKGEPG--DGARGLPGLKGHNGLQ-GLPGLAGLHGDQGAPGPVGPAGPRGPAGPSGPIGKDGRSGHPGPVGPAGVRGSQGSQGPAGPGPGPGPPGVSGGG------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=2.00

Estimated TM-score = 0.99±0.04

Estimated RMSD = 4.7±3.1Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2pffB	0.975	1.67	0.541	0.996
2	3hmjG	0.944	2.10	0.062	0.978
3	2uvcG	0.934	2.73	0.068	0.988
4	5anbK	0.299	9.10	0.046	0.465
5	4z9rA	0.290	3.52	0.084	0.316
6	3j38z	0.287	8.17	0.045	0.417
7	1kekA	0.287	9.35	0.053	0.452
8	4iglA	0.286	9.59	0.055	0.463
9	4z38A	0.284	3.57	0.081	0.310
10	5a22A	0.282	9.84	0.035	0.463

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.23	14	2uv8G	FMN	Rep, Mult	66,67,68,69,70,117,119,132,156,182,185,186,208,209,238,239,242,479,484
2	0.03	2	2ckjD	FES	Rep, Mult	562,563,564,566,567,569,570,572
3	0.03	2	2ak3B	SO4	Rep, Mult	1068,1071,1073,1074
4	0.03	2	2uvcI	NAP	Rep, Mult	94,119,186,187,188,284,366,435,437,438,456,457,459,479
5	0.03	2	1af0A	CA	Rep, Mult	994,995,996,997,999,1023
6	0.02	1	3fcsC	IMD	Rep, Mult	1002,1046
7	0.02	1	2ckjB	FES	Rep, Mult	570,572,575,576,578,588
8	0.02	1	3p4gA	CA	Rep, Mult	1019,1020,1021,1023,1033,1034,1035,1038
9	0.02	1	3eubS	FES	Rep, Mult	118,119,121,123,124,129,131
10	0.02	1	1d4m1	MYR	Rep, Mult	1051,1052
11	0.02	1	1a34A	U	Rep, Mult	1061,1062
12	0.02	1	3as1A	CTI	Rep, Mult	926,947,948,949
13	0.02	1	2v46M	NUC	Rep, Mult	8,9

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1itzA	0.251	8.27	0.064	0.369	2.2.1.1	735
2	0.060	2vz8B	0.251	9.83	0.041	0.418	2.3.1.85	NA
3	0.060	1fo4A	0.272	9.79	0.045	0.447	1.17.1.4	NA
4	0.060	3btaA	0.263	9.66	0.032	0.425	3.4.24.69	NA
5	0.060	1ay0A	0.249	8.54	0.068	0.373	2.2.1.1	486
6	0.060	1r9jB	0.246	8.33	0.063	0.364	2.2.1.1	995
7	0.060	2jfdA	0.133	7.52	0.047	0.185	2.3.1.85	NA
8	0.060	1b0pA	0.299	9.41	0.050	0.478	1.2.7.1	NA
9	0.060	2gjlA	0.248	3.07	0.096	0.265	1.13.12.16	132,239,284,286
10	0.060	1qssA	0.137	7.47	0.045	0.189	2.7.7.7	62
11	0.060	3dy5A	0.246	10.03	0.040	0.410	1.13.11.40,4.2.1.92	NA
12	0.060	2g25A	0.275	8.94	0.051	0.422	1.2.4.1	NA
13	0.060	2vuaA	0.143	7.33	0.037	0.195	3.4.24.69	NA
14	0.060	3b9jJ	0.121	7.12	0.047	0.164	1.17.1.4,1.17.3.2	266,267
15	0.060	3b9jI	0.068	5.21	0.071	0.081	1.17.1.4,1.17.3.2	353,364,439
16	0.060	2r8oB	0.251	8.43	0.060	0.373	2.2.1.1	NA
17	0.060	2pdaA	0.304	9.43	0.051	0.487	1.2.7.1	NA
18	0.060	2e1qA	0.274	9.71	0.048	0.447	1.17.3.2,1.17.1.4	NA
19	0.060	3hmjA	0.254	9.53	0.043	0.404	2.3.1.86	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.251	2.99	0.12	0.27	2z6iB	GO:0000166 GO:0003824 GO:0004318 GO:0016491 GO:0018580 GO:0051213 GO:0055114
1	0.06	0.244	9.97	0.05	0.40	5iy6A	GO:0000398 GO:0000974 GO:0001055 GO:0001172 GO:0003677 GO:0003899 GO:0003968 GO:0005634 GO:0005654 GO:0005665 GO:0005730 GO:0006283 GO:0006351 GO:0006353 GO:0006355 GO:0006366 GO:0006367 GO:0006368 GO:0006370 GO:0008543 GO:0010467 GO:0016740 GO:0016779 GO:0031047 GO:0031625 GO:0033120 GO:0035019 GO:0042795 GO:0044822 GO:0046872 GO:0050434
2	0.06	0.247	9.70	0.04	0.40	5flmA	GO:0001047 GO:0001055 GO:0003677 GO:0003899 GO:0005665 GO:0005719 GO:0006351 GO:0006366 GO:0016740 GO:0016779
3	0.06	0.224	3.81	0.11	0.25	3khpA
4	0.06	0.227	3.43	0.08	0.24	1s9cG	GO:0000038 GO:0001649 GO:0003857 GO:0005102 GO:0005739 GO:0005777 GO:0005778 GO:0005782 GO:0006629 GO:0006631 GO:0006635 GO:0006699 GO:0008209 GO:0008210 GO:0016020 GO:0016491 GO:0016508 GO:0016616 GO:0016829 GO:0016853 GO:0033540 GO:0033989 GO:0036109 GO:0036111 GO:0036112 GO:0042803 GO:0043231 GO:0044594 GO:0055114 GO:0060009
5	0.06	0.229	3.53	0.07	0.25	3kh8A
6	0.06	0.215	3.78	0.04	0.24	3omlA	GO:0003824 GO:0004300 GO:0005777 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0016491 GO:0016616 GO:0016829 GO:0033540 GO:0042803 GO:0055114 GO:0080023
7	0.06	0.223	3.31	0.04	0.24	1pn4D	GO:0003824 GO:0005777 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0016491 GO:0016616 GO:0016829 GO:0016853 GO:0055114
8	0.06	0.206	9.12	0.04	0.32	4mz0A	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
9	0.06	0.200	8.81	0.04	0.31	4mz0B	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
10	0.06	0.206	3.57	0.09	0.22	3khpC
11	0.06	0.209	3.31	0.06	0.23	1s9cD	GO:0000038 GO:0001649 GO:0003857 GO:0005102 GO:0005739 GO:0005777 GO:0005778 GO:0005782 GO:0006629 GO:0006631 GO:0006635 GO:0006699 GO:0008209 GO:0008210 GO:0016020 GO:0016491 GO:0016508 GO:0016616 GO:0016829 GO:0016853 GO:0033540 GO:0033989 GO:0036109 GO:0036111 GO:0036112 GO:0042803 GO:0043231 GO:0044594 GO:0055114 GO:0060009
12	0.06	0.201	3.31	0.05	0.22	1pn4C	GO:0003824 GO:0005777 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0016491 GO:0016616 GO:0016829 GO:0016853 GO:0055114
13	0.06	0.195	2.69	0.08	0.21	4oobA	GO:0004312 GO:0005835 GO:0005886 GO:0006631 GO:0006633 GO:0018812 GO:0019171 GO:0055114
14	0.06	0.173	9.11	0.04	0.27	1ng9A	GO:0000018 GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0005829 GO:0006281 GO:0006298 GO:0006974 GO:0008301 GO:0016887 GO:0030983 GO:0032136 GO:0032300 GO:0042802 GO:0043531
15	0.06	0.175	7.35	0.05	0.24	1pxyB	GO:0003779 GO:0005737 GO:0005856 GO:0007623 GO:0046872
16	0.06	0.171	8.58	0.04	0.26	2pffB	GO:0003824 GO:0004312 GO:0004313 GO:0004314 GO:0004318 GO:0004319 GO:0004320 GO:0004321 GO:0005811 GO:0005829 GO:0005835 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016295 GO:0016296 GO:0016297 GO:0016409 GO:0016491 GO:0016740 GO:0016787 GO:0016829 GO:0019171 GO:0042759 GO:0047451 GO:0055114
17	0.06	0.160	7.67	0.06	0.22	3etcB	GO:0003824 GO:0008152
18	0.06	0.190	8.63	0.04	0.28	4hnxA	GO:0004596 GO:0005737 GO:0006474 GO:0017196 GO:0022626 GO:0031415 GO:0031416

Consensus prediction of GO terms

Molecular Function	GO:0001055	GO:0051213	GO:0018580	GO:0031625	GO:0004318	GO:0003968	GO:0000166	GO:0046872	GO:0001047	GO:0044822	GO:0005102	GO:0016853	GO:0044594	GO:0033989	GO:0042803	GO:0003857	GO:0016508
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0006355	GO:0008543	GO:0042795	GO:0035019	GO:0006353	GO:0006283	GO:0000398	GO:0033120	GO:0050434	GO:0001172	GO:0006368	GO:0006367	GO:0006370	GO:0031047	GO:0036112	GO:0006699	GO:0033540	GO:0060009	GO:0008209	GO:0001649	GO:0036111	GO:0036109	GO:0000038	GO:0008210
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0005665	GO:0000974	GO:0005730	GO:0005719	GO:0005782	GO:0005778	GO:0005739
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.