I-TASSER results

I-TASSER results for job id Rv3481c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (229 residues)
MRGLLPVAGHWVSVLTGLVPLALVIALSPLSVIPAVLVVHSPQPRPSSLAFLGGWLLGLA
VVTAVFVAASGALGGLSTTSPAWASWLRVVLGSALIVFGVLRWLTRHRHTEMPGWMRAFA
SFTPARAGLVGAVLVVVRPEVLIICAAAGLAIGSGGHGAAGSWIYTAFFAMLAASTVAIP
ILAYVAAGDRLDDSLERLKDWMEKNHAGMVAAILVVIGLLLLYNGVHAM

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MRGLLPVAGHWVSVLTGLVPLALVIALSPLSVIPAVLVVHSPQPRPSSLAFLGGWLLGLAVVTAVFVAASGALGGLSTTSPAWASWLRVVLGSALIVFGVLRWLTRHRHTEMPGWMRAFASFTPARAGLVGAVLVVVRPEVLIICAAAGLAIGSGGHGAAGSWIYTAFFAMLAASTVAIPILAYVAAGDRLDDSLERLKDWMEKNHAGMVAAILVVIGLLLLYNGVHAM
Prediction	CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	9988777875899999999999999865678999999984998746799999999999999999999987765778888865799999999999999999999647898889868888876875679999999998487579999999999998588578999999999999999999999999986788999999999999997868999999999999999988759
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MRGLLPVAGHWVSVLTGLVPLALVIALSPLSVIPAVLVVHSPQPRPSSLAFLGGWLLGLAVVTAVFVAASGALGGLSTTSPAWASWLRVVLGSALIVFGVLRWLTRHRHTEMPGWMRAFASFTPARAGLVGAVLVVVRPEVLIICAAAGLAIGSGGHGAAGSWIYTAFFAMLAASTVAIPILAYVAAGDRLDDSLERLKDWMEKNHAGMVAAILVVIGLLLLYNGVHAM
Prediction	7551352432213101322230301011333201000000144222200000203321331321111001311344544443121001011112112200220243565553341143047143330231021011242431000010022114342431220100210101021213322001001243045205403500453422000000233122101311455
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHC
MRGLLPVAGHWVSVLTGLVPLALVIALSPLSVIPAVLVVHSPQPRPSSLAFLGGWLLGLAVVTAVFVAASGALGGLSTTSPAWASWLRVVLGSALIVFGVLRWLTRHRHTEMPGWMRAFASFTPARAGLVGAVLVVVRPEVLIICAAAGLAIGSGGHGAAGSWIYTAFFAMLAASTVAIPILAYVAAGDRLDDSLERLKDWMEKNHAGMVAAILVVIGLLLLYNGVHAM

4czbA2

0.11

0.10

0.91

MUSTER

ISLLKR-------VIKTVVRLDITFLIT-LLISGFIFNMVLNLPYTSPVGYLFGAITAATDPATLIPVFSR--VRTNPEVAITLEAESIFNDPLGIVSTSVILGLFGLFSLS-------MLENYFIPGLLVALGSI----FLARPLGVFLGLIGSKHSFKEKLYFALEGPVVPAALAVTVGIEILKNADKIPASITKYITPTDIAGTIIIGTFMTILLSVILEASWAGM

4ke2A

0.12

0.10

0.86

0.82

dPPAS

----MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAA----SVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------

2n4xA

0.12

0.09

0.78

1.27

wdPPAS

--------------QLMAFALGILSVFSPLPVVPLIFAGSR-GRALDAFLIVAGLTISMLILGYTASLFFGFFR-------VVAMLFLLIFALILLSDELDEKVS--------IFASRMTSGQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN--------PLVMLSYGLGMAVTIAAVFKMGEK---FVKA---------RKVTGAIVLLYLAYFALTEVLLL

3jd8A

0.11

0.95

1.00

wMUSTER

FTAERSIEDELNRESDSDVFTVVISYA--IMFLYISLALGHMK------SCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFL---GALSVMPAVHTFSLFAGLAVFIDFAEDGTSVQASESCLFRFFKNSYSPLKDWMRPIVIAIFVGVLSFSIAVL

2n4xA

0.13

0.10

0.78

2.20

wPPAS

------------QLM--AFALGILSVFSPLPVVPLIF--GSRGRALDAFLIVAGLTISMLILGYTASLFFGFF-------RVVAMLFLLIFALILLSDELDEKV--------SIFASRMTS-QTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN--------PLVMLSYGLGMAVTIAAVFKMGEK----------FVKANFRKVTGAIVLLYLAYFALTEVLLL

4ke2A

0.12

0.10

0.86

1.26

dPPAS2

----MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAA----SVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------

2n4xA

0.12

0.10

0.82

1.46

PPAS

------------QLM--AFALGILSVFSPLPVVPLIF--GSRGRALDAFLIVAGLTISMLILGYTASLFFGFFR-------VVAMLFLLIFALILLSDELDEKVSIFASR---MTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN--------PLVMLSYGLGMAVTIAAVFKMGEKF------VKANFQLI-RKVTGAIVLLYLAYFALTEVLLL

2n4xA

0.11

0.09

0.83

0.90

Env-PPAS

------------QLM--AFALGILSVFSPLPVVPLIFAGSR-GRALDAFLIVAGLTISMLILGYTASLFFGFFR-------VVAMLFLLIFALILLSDELDEKVSIFASR---MTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN--------PLVMLSYGLGMAVTIAAVFKMGEKF------VKANFQLI-RKVTGAIVLLYLAYFALTEVLLL

2n4xA

0.12

0.10

0.80

0.90

MUSTER

------------QLM--AFALGILSVFSPLPVVPLIF--GSRGRALDAFLIVAGLTISMLILGYT-------ASLFFGFFRVVAMLFLLIFALILLSDELDEKVS--------IFASRMTSGLSWKSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN--------PLVMLSYGLGMAVTIAAVFKMGEKF------VKANFQLI-RKVTGAIVLLYLAYFALTEVLLL

4bwzA2

0.12

0.11

0.88

0.77

dPPAS

------RLKDILAVGKEAFLVAVLGVALPFLGGYLYGLEIG--FETLPALFLGTALVATSVGITARVLQELGVLSRPYSRIILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAEEEYAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE-------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.20

Estimated TM-score = 0.45±0.15

Estimated RMSD = 10.6±4.6Å

Download Model 2

C-score=-3.22

Download Model 3

C-score=-3.32

Download Model 4

C-score=-3.95

Download Model 5

C-score=-4.04

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2n4xA	0.695	2.70	0.102	0.817
2	4dvqA	0.476	5.20	0.054	0.734
3	2vn0A	0.468	5.35	0.069	0.734
4	3b98A	0.467	5.50	0.040	0.747
5	2iagA	0.461	5.26	0.066	0.734
6	1zo4B	0.461	5.27	0.066	0.729
7	3na0A	0.459	5.48	0.055	0.734
8	3qz1A	0.458	5.40	0.079	0.725
9	4a01A	0.457	5.80	0.050	0.777
10	3k9vA	0.457	5.14	0.055	0.712

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	3	2w72A	XE	Rep, Mult	21,22,25,49
2	0.05	2	4xk8l	CLA	Rep, Mult	22,52,56
3	0.02	1	1bjyB	CTC	Rep, Mult	191,195,198
4	0.02	1	3bwxA	CA	Rep, Mult	124,127
5	0.02	1	2b2jA	XE	Rep, Mult	111,115,207,210,211
6	0.02	1	3d9sB	PS6	Rep, Mult	15,156
7	0.02	1	2wse1	CLA	Rep, Mult	50,54
8	0.02	1	4o6nB	MPG	Rep, Mult	141,210,214
9	0.02	1	1q0kE	THJ	Rep, Mult	88,91
10	0.02	1	2axtM	UNK	Rep, Mult	181,185,194
11	0.02	1	4fe1B	CLA	Rep, Mult	18,35
12	0.02	1	3wmn2	BCL	Rep, Mult	97,101
13	0.02	1	1swiC	BNZ	Rep, Mult	18,22
14	0.02	1	2r9rB	PGW	Rep, Mult	198,213
15	0.02	1	3oibA	IOD	Rep, Mult	32,35,202
16	0.02	1	5egiB	DMU	Rep, Mult	144,213
17	0.02	1	3bz1F	PL9	Rep, Mult	173,176
18	0.02	1	3b99A	U51	Rep, Mult	95,96,98,99,103,104,139

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3dsiA	0.427	5.52	0.042	0.699	4.2.1.92	180
2	0.060	1tqnA	0.434	5.63	0.054	0.738	1.14.13.67,1.14.13.32,1.14.13.97	NA
3	0.060	3juvA	0.433	5.65	0.070	0.725	1.14.13.70	30
4	0.060	3dbmA	0.423	5.39	0.042	0.686	4.2.1.92	54,59,81
5	0.060	1mx9D	0.422	5.67	0.084	0.690	3.1.1.1	NA
6	0.060	1oxaA	0.425	5.35	0.059	0.659	3.4.23.23	NA
7	0.060	3eqmA	0.450	5.63	0.064	0.751	1.14.14.1	NA
8	0.060	2wm4A	0.421	5.53	0.074	0.686	1.14.-.-	NA
9	0.060	2vn0A	0.468	5.35	0.069	0.734	1.14.14.1	NA
10	0.060	3e6iA	0.447	5.72	0.072	0.738	1.14.13.-	NA
11	0.060	1n6bA	0.444	5.68	0.062	0.734	1.14.14.1	NA
12	0.060	2hi4A	0.449	5.38	0.074	0.712	1.14.14.1	NA
13	0.060	3k9vA	0.457	5.14	0.055	0.712	1.14.13.-	NA
14	0.060	2wuzA	0.441	5.64	0.064	0.721	1.14.13.70	175
15	0.060	2f9qA	0.443	5.40	0.064	0.707	1.14.14.1	NA
16	0.060	3daxA	0.453	5.31	0.045	0.738	1.14.13.17	176
17	0.060	1w0eA	0.408	5.44	0.083	0.672	1.14.13.67,1.14.14.1	NA
18	0.060	2ve3A	0.427	5.44	0.063	0.686	1.14.-.-	NA
19	0.060	1egyA	0.424	5.30	0.065	0.659	1.14.-.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.26	0.695	2.70	0.10	0.82	2n4xA	GO:0016020 GO:0016021
1	0.17	0.452	5.63	0.08	0.72	3kw4A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0016020 GO:0016491 GO:0016705 GO:0016712 GO:0020037 GO:0031090 GO:0043231 GO:0046872 GO:0055114 GO:0070330
2	0.08	0.456	5.72	0.05	0.75	3c6gB	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006766 GO:0008395 GO:0010038 GO:0010164 GO:0010212 GO:0016020 GO:0016491 GO:0016705 GO:0020037 GO:0030343 GO:0031090 GO:0036378 GO:0042359 GO:0043231 GO:0046872 GO:0055114
3	0.07	0.465	5.05	0.06	0.72	3v8dA	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006629 GO:0006699 GO:0006707 GO:0008123 GO:0008202 GO:0008203 GO:0016020 GO:0016125 GO:0016491 GO:0016705 GO:0020037 GO:0031090 GO:0042632 GO:0043231 GO:0046872 GO:0055114 GO:0070857 GO:0071333 GO:0071397
4	0.07	0.474	5.21	0.06	0.73	4dvqE	GO:0002017 GO:0003091 GO:0004497 GO:0004507 GO:0005506 GO:0005739 GO:0005743 GO:0006629 GO:0006694 GO:0006700 GO:0006705 GO:0008202 GO:0008203 GO:0008395 GO:0016020 GO:0016125 GO:0016491 GO:0016705 GO:0016709 GO:0020037 GO:0031966 GO:0032342 GO:0032870 GO:0034651 GO:0035865 GO:0044550 GO:0046872 GO:0047783 GO:0055075 GO:0055078 GO:0055114 GO:0071375
5	0.07	0.455	5.46	0.07	0.74	4j14A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006629 GO:0006699 GO:0006707 GO:0006805 GO:0007399 GO:0008202 GO:0008203 GO:0008395 GO:0016020 GO:0016021 GO:0016125 GO:0016491 GO:0016705 GO:0020037 GO:0031090 GO:0033781 GO:0043231 GO:0046872 GO:0055114
6	0.07	0.448	5.80	0.07	0.76	3tbgA	GO:0004497 GO:0005506 GO:0005739 GO:0005783 GO:0005789 GO:0006629 GO:0006805 GO:0008144 GO:0008202 GO:0008392 GO:0008395 GO:0009804 GO:0009820 GO:0009822 GO:0016020 GO:0016098 GO:0016491 GO:0016705 GO:0016712 GO:0017144 GO:0019369 GO:0019825 GO:0020037 GO:0031090 GO:0033076 GO:0042737 GO:0043231 GO:0046483 GO:0046872 GO:0051100 GO:0055114 GO:0070330 GO:0070989 GO:0090350
7	0.07	0.479	5.17	0.06	0.73	4kpaA	GO:0003824 GO:0003958 GO:0004497 GO:0005506 GO:0005737 GO:0008152 GO:0010181 GO:0016491 GO:0016705 GO:0016712 GO:0020037 GO:0042802 GO:0046872 GO:0055114 GO:0070330
8	0.07	0.466	5.43	0.05	0.74	3na1A	GO:0004497 GO:0005506 GO:0005739 GO:0005743 GO:0005759 GO:0006629 GO:0006694 GO:0006700 GO:0006704 GO:0008202 GO:0008203 GO:0008207 GO:0008386 GO:0016020 GO:0016125 GO:0016491 GO:0016705 GO:0016709 GO:0020037 GO:0031966 GO:0034650 GO:0042359 GO:0044550 GO:0046872 GO:0055114 GO:0071375
9	0.07	0.455	5.31	0.06	0.73	3mzsA	GO:0004497 GO:0005506 GO:0005739 GO:0005743 GO:0006629 GO:0006694 GO:0006700 GO:0006704 GO:0008202 GO:0008203 GO:0008207 GO:0008386 GO:0016020 GO:0016491 GO:0016705 GO:0016709 GO:0020037 GO:0031966 GO:0034650 GO:0042359 GO:0044550 GO:0046872 GO:0055114 GO:0071375
10	0.07	0.468	5.35	0.07	0.73	2vn0A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006082 GO:0006805 GO:0008392 GO:0008395 GO:0016020 GO:0016491 GO:0016705 GO:0017144 GO:0019373 GO:0019825 GO:0020037 GO:0031090 GO:0034875 GO:0042738 GO:0043231 GO:0046872 GO:0055114 GO:0070330 GO:0070989 GO:0097267
11	0.07	0.463	5.44	0.07	0.73	4y8wC	GO:0004497 GO:0004509 GO:0005496 GO:0005506 GO:0005783 GO:0005789 GO:0006694 GO:0006704 GO:0006705 GO:0008202 GO:0008289 GO:0008395 GO:0016020 GO:0016125 GO:0016491 GO:0016705 GO:0020037 GO:0031090 GO:0043231 GO:0046872 GO:0055114
12	0.07	0.444	5.68	0.06	0.73	1n6bA	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0016020 GO:0016491 GO:0016705 GO:0020037 GO:0031090 GO:0043231 GO:0046872 GO:0055114 GO:0070330
13	0.07	0.458	5.40	0.08	0.72	3qz1A	GO:0004497 GO:0005496 GO:0005506 GO:0005783 GO:0005789 GO:0006694 GO:0008202 GO:0008289 GO:0008395 GO:0016020 GO:0016491 GO:0016705 GO:0020037 GO:0031090 GO:0043231 GO:0046872 GO:0055114
14	0.07	0.461	5.26	0.07	0.73	2iagA	GO:0001516 GO:0004497 GO:0005506 GO:0005615 GO:0005634 GO:0005737 GO:0005783 GO:0005789 GO:0005901 GO:0006629 GO:0006631 GO:0006633 GO:0006690 GO:0006693 GO:0006769 GO:0007566 GO:0008116 GO:0016020 GO:0016021 GO:0016705 GO:0016853 GO:0019371 GO:0020037 GO:0032088 GO:0035360 GO:0045019 GO:0045766 GO:0046697 GO:0046872 GO:0050728 GO:0055114 GO:0071347 GO:0071354 GO:0071456 GO:0097190 GO:1900119
15	0.07	0.438	5.53	0.07	0.72	5eqbA	GO:0004497 GO:0005506 GO:0005783 GO:0005886 GO:0006629 GO:0006694 GO:0006696 GO:0008202 GO:0008398 GO:0016020 GO:0016021 GO:0016126 GO:0016491 GO:0016705 GO:0020037 GO:0046872 GO:0055114 GO:0070988
16	0.07	0.441	5.72	0.05	0.73	1z11A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0005881 GO:0008202 GO:0008389 GO:0008392 GO:0008395 GO:0009804 GO:0016020 GO:0016491 GO:0016705 GO:0016712 GO:0017144 GO:0019373 GO:0019899 GO:0020037 GO:0031090 GO:0042738 GO:0043231 GO:0046226 GO:0046872 GO:0055114
17	0.07	0.462	5.50	0.05	0.73	4gqsA	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006805 GO:0008202 GO:0008392 GO:0008395 GO:0016020 GO:0016098 GO:0016491 GO:0016705 GO:0017144 GO:0018675 GO:0018676 GO:0019373 GO:0019825 GO:0019899 GO:0020037 GO:0031090 GO:0042738 GO:0043231 GO:0046483 GO:0046872 GO:0052741 GO:0055114 GO:0097267
18	0.07	0.441	5.45	0.07	0.72	4r21B	GO:0004497 GO:0004508 GO:0005506 GO:0016491 GO:0016705 GO:0020037 GO:0042448 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0016712	GO:0005506	GO:0020037
GO-Score	0.34	0.33	0.33
Biological Processes	GO:0055114
GO-Score	0.33
Cellular Component	GO:0044432	GO:0042175	GO:0031224
GO-Score	0.57	0.57	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.