I-TASSER results

I-TASSER results for job id Rv3467

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (317 residues)
MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTERARKRGITLSNQQYDG
MSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHD
GLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGKGFTGGGTLLPMADVIRMTSH
AHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFANDRGCTKPGCDAPAYHSQA
HHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGHTEWLPPPHLDHGQPRTNTF
HHPERFLHNQDDDDKPD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTERARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGKGFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGHTEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDKPD
Prediction	CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEHCCCCCEEEEEEHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHCHHHHHCCCCCCHCCCCCCCCHHHHHHHHHHCHHHEHCCCCCEEEHCCCCCEEHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHCCHHCHHHCCCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	85899999999999775999999999999999988888887578876557799766899779999986999999999999998655667888777777888765556788887455554689999987557888888788775899987688865467875557888889788888887554433445665688779996665577677889999999998589899999999845555555776567899998885455656557778897688789996799689999999999999999644688999999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTERARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGKGFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGHTEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDKPD
Prediction	77314401430053047131630250043005213464445465514321112143322000202020204001203410442234222444433334434444443554411332210100020021104344234444230100020314304322432222221302133222001203302110322211124622202222434213420110010224101101042013201101033135313010400120033014436543223434733020111341444422323212034114667666668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEHCCCCCEEEEEEHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHCHHHHHCCCCCCHCCCCCCCCHHHHHHHHHHCHHHEHCCCCCEEEHCCCCCEEHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHCCHHCHHHCCCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTERARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGKGFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFANDRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGHTEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDKPD

4ogcA3

0.12

0.05

0.41

1.25

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------DG--FTSERADERDKANRRRYNDNQEAKKIQRDYGK-----EGYISRGDIVRLDALELQGCCLY--CGTGYHTCQLDHIVPQAGPGSNNRGNLVAVCERCNRSKSN--------------TPFVWAQKCGIPHVGRKQTPNTSSEDRTQEDPE

4ke2A

0.15

0.09

0.61

1.15

dPPAS2

IDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAA---SIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP------------------------------------------------------------------------------------------------------------------------

5gaoE

0.12

0.98

1.36

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------RAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATT

4z0vA2

0.10

0.09

0.95

0.69

MUSTER

FDHRHLYTKKVTEDAL-LADTYAQEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNAD-VICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLARKSKFSLLSQHDISFYEALESDPLHKELLEKLVLYPSAQEKVLQRSSVLQVSVLQSTKDSSKRICVANTHLYWHGGYIRLIQMAVALAHIRHVSCDLYPGIPVIFCGDFNSTPSTGMYHFVING--------------SIPEDHWASNGEEERCNMSLTHFFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSD

5gaoE

0.12

0.11

0.98

0.78

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATT

4ogcA3

0.11

0.04

0.41

0.84

wdPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------DGFTSERADERDKANRRRYNDNQEAKKIQRDYGK-----EGYISRGDIVRLDALELQGCCLY--CGTGYHTCQLDHIVPQAGPGSNNRGNLVAVCERCNRSKSN--------------TPFACGIPHVGVKEAIGRVRGWRKQTPNTSSED

4at7B

0.11

0.10

0.92

0.65

wMUSTER

--IFVNDDRHVMAKHSSVYLEAVQNMVSHTERALK--AVSDWIDEQEKRTLRGVMRKGDLDLELVLLCKTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNTKEPPLS-HLTSPVVREEMEKVLAGETLSVNDPPDVL-KCLAALASLRHAQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELL---EKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHK-------------GMDPLPDYTVQI-PPSTTYAITPMKRPM-

2qgpB

0.12

0.03

0.21

0.80

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NY-KREK---RRSQWWKNRIARICHY--CGEIFPPEETDHLVPVVRGGKSTRGNVVPACKECNNRKKY------ESE--------------------------------------

5cwiA

0.09

0.06

0.70

0.99

dPPAS2

AESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRQAARDAIKLASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER------------------------------------------------------------------------------------------------

4fsxA3

0.09

0.97

0.93

PPAS

VDNSFACQSLKYNHPQTEVRNELPGDVDVICG---PCQGKDEKNKQVTFDIVAYLKPKYVLENVVDILKFADGYLGKYALSCLVAKYQARLGVALPQFRRVFLWGALSSVLPKYPLPTYDVVVRGGAPNAFSQCVAYDETQKPSLKKALLLGDAISDLPKVQNHQPNDVEYGGSPKTEFQRYIRLSRKDLDWSFGEGAGPGKLLDHQPLRLNNDDYERVQQIPVKKGANFRDLKGVRVGANNIVEWDPEIER-----VKLSSGKPLVPDYASFIKGKSLKPFGRLWWDETVPTVVTRAEPHNQVIIHPTQARVLTIR

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.36

Estimated TM-score = 0.34±0.12

Estimated RMSD = 14.5±3.7Å

Download Model 2

C-score=-4.12

Download Model 3

C-score=-3.77

Download Model 4

C-score=-4.99

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5gaoE	0.712	4.26	0.119	0.905
2	3s4wB	0.410	6.06	0.045	0.656
3	5t8vA	0.408	6.59	0.067	0.694
4	5cskA	0.401	6.44	0.046	0.681
5	3p8cB	0.388	6.28	0.028	0.628
6	2cseW	0.375	6.01	0.040	0.596
7	5ganA	0.374	6.52	0.031	0.631
8	4r04A	0.373	6.78	0.042	0.647
9	3jb9A	0.367	6.51	0.026	0.625
10	3p8cA	0.363	6.36	0.045	0.603

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	9	2entA	ZN	Rep, Mult	226,231,241,242
2	0.06	4	3ph3B	RB5	Rep, Mult	241,242
3	0.03	2	3ho8B	COA	Rep, Mult	242,243,244,245,246,248
4	0.03	2	1hloB	NUC	Rep, Mult	206,208,209
5	0.02	1	3cv1A	CA	Rep, Mult	212,215
6	0.02	1	2gagA	FMN	Rep, Mult	11,12,16,20,27
7	0.02	1	1z8qA	OXY	Rep, Mult	203,207
8	0.02	1	2gagA	FOA	Rep, Mult	246,250,251,252
9	0.02	1	3ho8D	COA	Rep, Mult	13,14,15
10	0.02	1	3cmvB	MG	Rep, Mult	75,84,143
11	0.02	1	3gl6A	ZN	Rep, Mult	226,231
12	0.02	1	3rrpA	LMR	Rep, Mult	85,88,90
13	0.02	1	2xt6A	TPP	Rep, Mult	58,60,116,120
14	0.02	1	3sucA	ATP	Rep, Mult	30,31,32,59,61
15	0.02	1	3cmvE	ANP	Rep, Mult	64,66,67,68,69
16	0.02	1	2xqsA	CVM	Rep, Mult	215,219
17	0.02	1	3cmvC	ANP	Rep, Mult	22,23,24,25,26,27,103
18	0.02	1	3a9qR	CA	Rep, Mult	208,212

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1y2mB	0.316	5.72	0.070	0.479	4.3.1.24	176
2	0.060	1ej6A	0.301	6.81	0.044	0.543	2.7.7.50	111
3	0.060	1t3qB	0.309	6.63	0.074	0.539	1.3.99.17	NA
4	0.060	3gtdA	0.308	5.81	0.059	0.470	4.2.1.2	NA
5	0.060	1j3uA	0.308	5.55	0.056	0.461	4.3.1.1	NA
6	0.060	2a4zA	0.295	6.19	0.034	0.464	2.7.1.153	NA
7	0.060	1yfmA	0.310	5.76	0.083	0.467	4.2.1.2	NA
8	0.060	2je8B	0.300	6.21	0.047	0.498	3.2.1.25	NA
9	0.060	2qf7B	0.340	6.60	0.039	0.584	6.4.1.1	NA
10	0.060	3b8eC	0.304	5.01	0.047	0.429	3.6.3.9	NA
11	0.060	2fknB	0.298	6.34	0.046	0.505	4.2.1.49	108
12	0.060	1mc0A	0.249	5.72	0.006	0.363	3.1.4.17	152
13	0.060	3no9A	0.318	5.69	0.047	0.476	4.2.1.2	104
14	0.060	3e04D	0.300	6.20	0.052	0.476	4.2.1.2	NA
15	0.060	2nztA	0.338	5.99	0.056	0.539	2.7.1.1	NA
16	0.060	1qhaA	0.338	6.07	0.054	0.536	2.7.1.1	NA
17	0.060	3ihyC	0.305	6.16	0.074	0.495	2.7.1.137	21,123
18	0.060	2x38A	0.300	6.17	0.046	0.486	2.7.1.153	21
19	0.060	2cseW	0.375	6.01	0.040	0.596	3.6.4.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.15	0.712	4.26	0.12	0.91	5gaoE	GO:0000387 GO:0000398 GO:0000481 GO:0005634 GO:0005681 GO:0006397 GO:0008380 GO:0030529 GO:0045292 GO:0046540
1	0.06	0.340	6.60	0.04	0.58	2qf7B	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
2	0.06	0.335	6.33	0.03	0.55	4qslG	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
3	0.06	0.300	6.56	0.04	0.52	2qf7A	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
4	0.06	0.325	6.52	0.03	0.55	3bg5A	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
5	0.06	0.329	6.65	0.03	0.57	4qslD	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
6	0.06	0.334	6.00	0.03	0.54	4qslA	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
7	0.06	0.284	6.68	0.03	0.50	5douD	GO:0000050 GO:0000166 GO:0001889 GO:0003824 GO:0004070 GO:0004087 GO:0004088 GO:0004151 GO:0004175 GO:0005509 GO:0005524 GO:0005543 GO:0005634 GO:0005730 GO:0005737 GO:0005739 GO:0005743 GO:0005759 GO:0005980 GO:0006207 GO:0006508 GO:0006526 GO:0006541 GO:0006807 GO:0007494 GO:0008152 GO:0009636 GO:0010043 GO:0014075 GO:0016595 GO:0016874 GO:0019240 GO:0019433 GO:0032094 GO:0032403 GO:0032496 GO:0033762 GO:0034201 GO:0042493 GO:0042594 GO:0042645 GO:0043200 GO:0043234 GO:0044344 GO:0045909 GO:0046209 GO:0046872 GO:0048545 GO:0050667 GO:0051384 GO:0051591 GO:0055081 GO:0060416 GO:0070365 GO:0070409 GO:0071320 GO:0071377 GO:0071400 GO:0071548 GO:0072341
8	0.06	0.316	6.32	0.04	0.52	4hnvB	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872
9	0.06	0.297	6.15	0.02	0.48	3ff6A	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0005634 GO:0005739 GO:0005741 GO:0005829 GO:0006084 GO:0006629 GO:0006631 GO:0006633 GO:0006768 GO:0006853 GO:0008152 GO:0010629 GO:0010884 GO:0010906 GO:0012505 GO:0016020 GO:0016874 GO:0031325 GO:0031667 GO:0031999 GO:0043086 GO:0046322 GO:0046872 GO:0050995 GO:0051289 GO:0060421 GO:0097009 GO:2001295
10	0.06	0.281	6.89	0.03	0.50	3va7A	GO:0000166 GO:0003824 GO:0004039 GO:0004075 GO:0004847 GO:0005524 GO:0005737 GO:0016874 GO:0043419 GO:0046872
11	0.06	0.274	6.72	0.03	0.48	5csaA	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0005737 GO:0005783 GO:0005789 GO:0006606 GO:0006629 GO:0006631 GO:0006633 GO:0006998 GO:0008152 GO:0016020 GO:0016874 GO:0042759 GO:0046872 GO:2001295
12	0.06	0.296	5.83	0.04	0.47	1uyrA	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0005737 GO:0005783 GO:0005789 GO:0006606 GO:0006629 GO:0006631 GO:0006633 GO:0006998 GO:0008152 GO:0016020 GO:0016874 GO:0042759 GO:0046872 GO:2001295
13	0.06	0.410	6.06	0.04	0.66	3s4wB	GO:0000793 GO:0005634 GO:0005730 GO:0005737 GO:0006281 GO:0006974 GO:0007049 GO:0007129 GO:0007275 GO:0007276 GO:0010332 GO:0034599 GO:0045589 GO:0048854 GO:0050727 GO:0051090 GO:0070182 GO:0097150 GO:2000348
14	0.06	0.301	6.14	0.04	0.49	4wyoB	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0005737 GO:0005783 GO:0005789 GO:0006606 GO:0006629 GO:0006631 GO:0006633 GO:0006998 GO:0008152 GO:0016020 GO:0016874 GO:0042759 GO:0046872 GO:2001295
15	0.06	0.285	6.95	0.05	0.52	3u9sA	GO:0003824 GO:0004075 GO:0004485 GO:0005524 GO:0008300 GO:0046872 GO:1905202
16	0.06	0.249	6.32	0.03	0.40	4rcnA	GO:0003824 GO:0004075 GO:0005524 GO:0016874 GO:0046872
17	0.06	0.345	6.59	0.06	0.59	5i6hB	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0006633 GO:0016874 GO:0046872
18	0.06	0.323	6.42	0.03	0.54	4qshC	GO:0000166 GO:0003677 GO:0003824 GO:0004075 GO:0004736 GO:0005524 GO:0006090 GO:0006094 GO:0009374 GO:0016874 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0016885	GO:0003676	GO:0032550	GO:0019842	GO:0032559	GO:0035639	GO:0033293	GO:0043169	GO:0016879
GO-Score	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46
Biological Processes	GO:0032787	GO:0006006	GO:0019319
GO-Score	0.46	0.46	0.46
Cellular Component	GO:0005681	GO:0046540
GO-Score	0.15	0.15

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.