I-TASSER results

I-TASSER results for job id Rv3463

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (285 residues)
MTNCAAGKPSSGPNLGRFGSFGRGVTPQQATEIEALGYGAVWVGGSPPAALSWVEPILQA
TTTLCVATGIVNIWSAPAQRVAESFHRIEAAYPGRFLLGIGVGHAEMISEYRKPYNALVE
YLDRLDDYGVPANRRVVAALGPRVLGLSARRSAGAHPYLTTPEHTARARELIGPSAFLAP
EHKVVLTTDSARARTVGRQALDMYFNLANYRNNWKRLGFTDDEVSRPGSDRLVDAVVAYG
TPDAIAARLNEHLLAGADHVPIQVLTEDDNLVSALTELAKPLRLT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTNCAAGKPSSGPNLGRFGSFGRGVTPQQATEIEALGYGAVWVGGSPPAALSWVEPILQATTTLCVATGIVNIWSAPAQRVAESFHRIEAAYPGRFLLGIGVGHAEMISEYRKPYNALVEYLDRLDDYGVPANRRVVAALGPRVLGLSARRSAGAHPYLTTPEHTARARELIGPSAFLAPEHKVVLTTDSARARTVGRQALDMYFNLANYRNNWKRLGFTDDEVSRPGSDRLVDAVVAYGTPDAIAARLNEHLLAGADHVPIQVLTEDDNLVSALTELAKPLRLT
Prediction	CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHHHHCCCEEEHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEHCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCCHHHHHHEEEHCCHHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHCCC
Conf.Score	998888888777777656778875669999999998999899689998679999999997897687655557778999999999999999859969996688988766666558999999999874689888977899858688998877657754456898999999999789985877778886899999999999999998747768899998799978876579988864355568999999999999998999999985899868999999999998999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTNCAAGKPSSGPNLGRFGSFGRGVTPQQATEIEALGYGAVWVGGSPPAALSWVEPILQATTTLCVATGIVNIWSAPAQRVAESFHRIEAAYPGRFLLGIGVGHAEMISEYRKPYNALVEYLDRLDDYGVPANRRVVAALGPRVLGLSARRSAGAHPYLTTPEHTARARELIGPSAFLAPEHKVVLTTDSARARTVGRQALDMYFNLANYRNNWKRLGFTDDEVSRPGSDRLVDAVVAYGTPDAIAARLNEHLLAGADHVPIQVLTEDDNLVSALTELAKPLRLT
Prediction	754564552545240120110236212520230171302100011234110100020042044030000000033120110030022014115100000000022431541430141023003203534143231100001130121003101000011111520340153135312000000001031142014201410230130221141045240435322632222001000010206301510441261200000000134565114003300530738
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHHHHCCCEEEHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEHCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCCHHHHHHEEEHCCHHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHCCC
MTNCAAGKPSSGPNLGRFGSFGRGVTPQQATEIEALGYGAVWVGGSPPAALSWVEPILQATTTLCVATGIVNIWSAPAQRVAESFHRIEAAYPGRFLLGIGVGHAEMISEYRKPYNALVEYLDRLDDYGVPANRRVVAALGPRVLGLSARRSAGAHPYLTTPEHTARARELIGPSAFLAPEHKVVLTTDSARARTVGRQALDMYFNLANYRNNWKRLGFTDDEVSRPGSDRLVDAVVAYGTPDAIAARLNEHLLAGADHVPIQVLTEDDNLVSALTELAKPLRLT

1f07A

0.17

0.16

0.95

1.84

MUSTER

----------MKFGIEFVPNEPIEKIVKLVKLAEDVGFEYAWITDHNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKALGIEWVKPVSTIRDAIAMMRTAVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAAGSP-PPVFERHGLPFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSIGPDEKSIKLLGEVIASF---

1f07A

0.17

0.16

0.95

2.52

dPPAS

----------MKFGIEFVPNEPIEKIVKLVKLAEDVGFEYAWITDHNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKALGIEWVKPVSTIRDAIAMMRKAVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAAGSP-PPVFERHGLPFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSPIGPEKSIKLLGEVIASF---

1f07A

0.18

0.17

0.94

3.04

wdPPAS

------------MKFG-VPNEPIEKIVKLVKLAEDVGFEYAWITDHNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKATGIEWVKPVSTIRDAIAMMRTLVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAAGSP-PPVFERHGLDFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSIGPDEKSIKLLGEVIASF---

1f07A

0.18

0.17

0.94

2.28

wMUSTER

-------------KFGFVPNEPIEKIVKLVKLAEDVGFEYAWITDHNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKALGIEWVKPVSTIRDAIAMMRTLVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAAGSP-PPVFERHGLPFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSIGPDEKSIKLLGEVIASF---

1f07A

0.18

0.17

0.94

3.24

wPPAS

M------------KFG-VPNEPIEKIVKLVKLAEDVGFEYAWITDHNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKALGIEWVKPVSTIRDAIAMMRTLVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAA-GSPPPVFERHGLDFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSIGPDEKSIKLLGEVIASF---

1f07A

0.17

0.16

0.95

5.90

dPPAS2

----------MKFGIEFVPNEPIEKIVKLVKLAEDVGFEYAWITDHNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKALGIEWVKPVSTIRDAIAMMRTAVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAAGSP-PPVFERHGLPFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSPIGPEKSIKLLGEVIASF---

1f07A

0.17

0.16

0.94

2.70

PPAS

------------MKFG-VPNEPIEKIVKLVKLAEDVGFEYAWITDHNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKALGIEWVKPVSTIRDAIAMMRTAVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAAGS-PPPVFERHGLPFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSPIGP-DKEKSIKLLGEVI-F-

1f07A

0.17

0.16

0.96

4.06

Env-PPAS

MK----------FGIEFVPNEPIEKIVKLVKLAEDVGFEYAWITDHNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKALGIEWVKPVSTIRDAIAMMRTAVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAAGS-PPPVFERHGLPFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSPIGP-DKEKSIKLLGEVIASF

1z69A

0.18

0.17

0.95

1.78

MUSTER

MK----------FGIEFVPSDPALKIAYYAKLSEQQGFDHVWITDHYNDVYSTLTVLALNTNSIKIGPGVTNSYTRNPAITASSIASIAEISGGRAVLGLGPGDKATFDAWKKPLATTKEAIQAIRDFKAGNIPIYMGAQGPKMLELAGEIADGVLINASHPKDFEVAVEQIKSEVDVTAYACFSIDKDPVKAVNAAKVVVAFIVAGSP-DLVLERHGIPVEAKSQLVTPQMIEAFSICGTPDDCMKRIKDLEAIGVTQIVAGSPIGP-AKEKAIKLIGKEI-IA

1z69A

0.16

0.96

2.46

dPPAS

----------MKFGIEFVPSDPALKIAYYAKLSEQQGFDHVWITDHNRDVYSTLTVLALNTNSIKIGPGVTNSYTRNPAITASSIASIAEISGGRAVLGLGPGDKAMGIAWKKPLATTKEAIQAIRAFKAGNIPIYMGAQGPKMLELAGEIADGVLINASHPKDFEVAVEQIKSEVDVTAYACFSIDKDPVKAVNAAKVVVAFIVAGSPQIGAAIAKGDFGALMGGLVTPQMIEAFSICGTPDDCMKRIKDLEAIGVTQIVAGSPIGP-AKEKAIKLIGKEIIAK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 4 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.89

Estimated TM-score = 0.83±0.08

Estimated RMSD = 4.3±2.8Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1ezwA	0.907	1.60	0.153	0.961
2	1f07A	0.905	1.65	0.172	0.958
3	1z69A	0.902	1.67	0.179	0.958
4	1rhcA	0.825	2.43	0.157	0.919
5	2wgkA	0.815	2.81	0.139	0.958
6	3b9nB	0.812	3.10	0.123	0.954
7	2i7gB	0.806	2.59	0.111	0.916
8	5dqpA	0.799	2.80	0.120	0.919
9	3fgcD	0.792	2.83	0.144	0.926
10	3c8nA	0.790	2.68	0.178	0.902

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.51	13	1z69A	F42	Rep, Mult	44,45,46,69,70,102,103,104,111,113,114,115,116,138,139,140,141,142,143,144,156,158,181
2	0.04	1	1ezwA	MG	Rep, Mult	58,61,62
3	0.03	1	3b4yA	FLC	Rep, Mult	104,158,161,183,203,211,212,235
4	0.03	1	1zrqB	NAD	Rep, Mult	45,104,158,159,204

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.295	1f07A	0.905	1.65	0.172	0.958	1.5.99.11	72,171
2	0.275	1tqxA	0.580	2.90	0.067	0.681	5.1.3.1	NA
3	0.234	1ezwA	0.907	1.60	0.153	0.961	1.5.99.11	70,145
4	0.211	3exrA	0.588	2.78	0.077	0.688	4.1.1.85	76,81
5	0.138	1rhcA	0.825	2.43	0.157	0.919	1.1.99.5	NA
6	0.112	2v81A	0.570	2.94	0.104	0.677	4.1.2.21	NA
7	0.104	1j2wA	0.558	3.06	0.119	0.663	4.1.2.4	NA
8	0.101	1vlwB	0.568	3.11	0.092	0.681	4.1.3.16	NA
9	0.099	2czfA	0.491	3.73	0.076	0.618	4.1.1.23	180
10	0.096	3f4wA	0.580	2.73	0.083	0.677	4.1.2.-	266
11	0.096	2cz5A	0.577	2.71	0.095	0.667	4.1.1.23	NA
12	0.093	2yw3E	0.548	3.14	0.120	0.663	4.1.2.14	NA
13	0.087	1v5xA	0.540	2.81	0.101	0.628	5.3.1.24	NA
14	0.083	1eixC	0.602	3.09	0.097	0.723	4.1.1.23	NA
15	0.082	1xbzB	0.584	2.84	0.066	0.688	4.1.1.85	76
16	0.081	2fliC	0.577	2.95	0.103	0.681	5.1.3.1	NA
17	0.075	2h6rB	0.558	2.99	0.107	0.656	5.3.1.1	NA
18	0.072	1tqjC	0.568	3.10	0.109	0.677	5.1.3.1	NA
19	0.070	1vqtA	0.515	3.18	0.112	0.628	4.1.1.23	NA
20	0.067	1h1yB	0.566	2.95	0.105	0.670	5.1.3.1	NA
21	0.067	1h1yA	0.565	2.98	0.105	0.670	5.1.3.1	NA
22	0.060	2fvlA	0.648	4.09	0.077	0.846	1.1.1.225,1.1.1.50	NA
23	0.060	1g5aA	0.663	4.29	0.077	0.902	2.4.1.4	NA
24	0.060	1qbaA	0.665	4.11	0.085	0.863	3.2.1.52	52
25	0.060	1pyfA	0.665	4.38	0.082	0.881	1.1.1.-	134
26	0.060	3fgcA	0.784	2.75	0.149	0.898	1.14.14.3	NA
27	0.060	1kfwA	0.674	4.06	0.082	0.874	3.2.1.14	NA
28	0.060	1xkjA	0.784	2.84	0.156	0.923	1.14.14.3	58,94,258
29	0.060	1afsA	0.649	4.10	0.095	0.842	1.1.1.213,1.1.1.50	NA
30	0.060	3burA	0.656	4.15	0.122	0.856	1.3.1.3	NA
31	0.060	2gftB	0.677	4.04	0.092	0.874	3.2.1.89	NA
32	0.060	1kwgA	0.655	3.36	0.115	0.796	3.2.1.23	NA
33	0.060	1gveA	0.655	4.15	0.068	0.856	1.-.-.-	245,277
34	0.060	1fhlA	0.662	3.84	0.071	0.839	3.2.1.89	NA
35	0.060	1lucA	0.781	2.77	0.158	0.895	1.14.14.3	NA
36	0.060	1z69C	0.902	1.68	0.179	0.958	1.5.99.11	142,145,147
37	0.060	1v93A	0.675	4.11	0.123	0.881	1.5.1.20	NA
38	0.060	1hjuC	0.659	3.80	0.097	0.832	3.2.1.89	NA
39	0.060	3dopB	0.653	4.20	0.127	0.856	1.3.1.3	NA
40	0.060	1xjbA	0.647	4.14	0.073	0.849	1.3.1.20,1.1.1.213	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.902	1.67	0.18	0.96	1z69A	GO:0005737 GO:0006730 GO:0015948 GO:0016491 GO:0016705 GO:0018537 GO:0019386 GO:0055114
1	0.33	0.905	1.65	0.17	0.96	1f07A	GO:0005737 GO:0006730 GO:0015948 GO:0016491 GO:0016705 GO:0018537 GO:0019386 GO:0055114
2	0.32	0.789	2.94	0.19	0.91	4us5C	GO:0004497 GO:0016705 GO:0055114
3	0.31	0.773	3.04	0.14	0.90	3raoB	GO:0016705 GO:0055114
4	0.29	0.812	2.56	0.18	0.92	3c8nA	GO:0004497 GO:0005618 GO:0005829 GO:0005886 GO:0005975 GO:0016491 GO:0016614 GO:0016705 GO:0045454 GO:0052749 GO:0055114 GO:0070967
5	0.29	0.781	2.77	0.16	0.89	1lucA	GO:0004497 GO:0008218 GO:0016491 GO:0016705 GO:0047646 GO:0055114
6	0.27	0.820	2.50	0.12	0.93	2i7gB	GO:0004497 GO:0016705 GO:0055114
7	0.27	0.815	2.80	0.14	0.96	5aecA	GO:0004497 GO:0016491 GO:0016705 GO:0055114
8	0.25	0.825	2.43	0.16	0.92	1rhcA	GO:0016705 GO:0055114
9	0.24	0.749	3.04	0.13	0.86	2b81C	GO:0004497 GO:0005886 GO:0016491 GO:0016705 GO:0055114
10	0.23	0.784	2.95	0.15	0.90	1nqkA	GO:0004497 GO:0008726 GO:0009408 GO:0016491 GO:0016705 GO:0042802 GO:0046306 GO:0055114
11	0.22	0.784	2.75	0.15	0.90	3fgcA	GO:0004497 GO:0008218 GO:0016491 GO:0016705 GO:0047646 GO:0055114
12	0.21	0.593	2.92	0.11	0.70	1dvjA	GO:0003824 GO:0004590 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
13	0.20	0.907	1.60	0.15	0.96	1ezwA	GO:0005737 GO:0006730 GO:0015948 GO:0016491 GO:0016705 GO:0018537 GO:0019386 GO:0055114
14	0.17	0.812	3.10	0.12	0.95	3b9nB	GO:0000166 GO:0004497 GO:0016705 GO:0055114
15	0.16	0.787	3.30	0.12	0.92	3sdoA	GO:0004497 GO:0016491 GO:0016705 GO:0055114
16	0.15	0.783	3.15	0.10	0.91	1yw1A	GO:0004497 GO:0016491 GO:0016705 GO:0055114
17	0.15	0.778	2.99	0.12	0.90	3sdoB	GO:0004497 GO:0016491 GO:0016705 GO:0055114
18	0.14	0.575	2.63	0.10	0.66	3ajxA	GO:0003824 GO:0004590 GO:0005975 GO:0006207 GO:0006730 GO:0008152 GO:0016829 GO:0019647 GO:0043801
19	0.13	0.588	2.78	0.08	0.69	3exrA	GO:0003824 GO:0004590 GO:0006207 GO:0008152
20	0.11	0.584	2.84	0.07	0.69	1xbzB	GO:0000287 GO:0003824 GO:0004590 GO:0005975 GO:0006207 GO:0008152 GO:0016829 GO:0016831 GO:0019854 GO:0033982 GO:0046872
21	0.11	0.575	3.09	0.08	0.69	3ru6B	GO:0003824 GO:0004590 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
22	0.10	0.580	2.73	0.08	0.68	3f4wA	GO:0003824 GO:0004590 GO:0005975 GO:0006207 GO:0008152 GO:0016829 GO:0043801
23	0.10	0.577	2.71	0.10	0.67	2cz5A	GO:0003824 GO:0004590 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
24	0.09	0.576	3.07	0.10	0.69	4muzA	GO:0003824 GO:0004590 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
25	0.08	0.574	2.98	0.05	0.68	3iebB	GO:0003824 GO:0004590 GO:0005975 GO:0006207 GO:0008152 GO:0016832
26	0.08	0.577	2.98	0.10	0.68	4luiB	GO:0003824 GO:0004590 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
27	0.07	0.593	3.00	0.09	0.69	3tc6A	GO:0000162 GO:0003824 GO:0004425 GO:0004640 GO:0006568 GO:0008152 GO:0008652 GO:0009073 GO:0016829 GO:0016831
28	0.07	0.552	3.36	0.07	0.66	1yxyA	GO:0003824 GO:0005975 GO:0006051 GO:0008152 GO:0016853 GO:0016857 GO:0019262 GO:0047465
29	0.07	0.568	3.99	0.09	0.73	3t4cA	GO:0003824 GO:0005737 GO:0008152 GO:0008676 GO:0009058 GO:0009103 GO:0016740 GO:0019294
30	0.06	0.391	6.53	0.05	0.69	2d7uA	GO:0000166 GO:0000287 GO:0004019 GO:0005525 GO:0005737 GO:0006164 GO:0016874 GO:0044208 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0016705	GO:0018537	GO:0050662	GO:0097367	GO:1901363	GO:0097159	GO:0004497
GO-Score	0.86	0.58	0.58	0.58	0.55	0.55	0.52
Biological Processes	GO:0019386	GO:0006730	GO:0050794	GO:0019725	GO:0044238
GO-Score	0.58	0.58	0.58	0.58	0.50
Cellular Component	GO:0044444	GO:0030312	GO:0016020
GO-Score	0.58	0.58	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.