I-TASSER results

I-TASSER results for job id Rv3446c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (404 residues)
MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALLDERPVAVDSLWFDAL
RSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRSWLLRQASSGVSAATVV
VEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGITAVVLIDVPSTVAGAAAL
AAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAARPATRSRVPTLARVAAAG
VALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWSTQRVVSGPGSARVQVTSPA
DPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDFNPSDIRAGRPAVTYREVRAG
HQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRSVHAVG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALLDERPVAVDSLWFDALRSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRSWLLRQASSGVSAATVVVEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGITAVVLIDVPSTVAGAAALAAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAARPATRSRVPTLARVAAAGVALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWSTQRVVSGPGSARVQVTSPADPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDFNPSDIRAGRPAVTYREVRAGHQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRSVHAVG
Prediction	CCCCCEEEEHCCCCEEEEHCCCCCCCCHHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCEEEEEHCCCCEEEHCCCCEEEEEHCCCCHHHCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHEEHCCCCCCCCCCCCCCCEEEEEEEEEEHCCCCCEEHCCCCCCCCEEEEHCCCCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCCEEEEEEEEHCCCCEEEEEEEEHCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHHCC
Conf.Score	99887578857875566646888888778999999886776687588557899999999999977888867999668988899999999987668978998743554445556667658998568866775578668986578754444445554456788876798678988877656665544566778876567568776666667788888988888888887655544456777887766543444567888888998756888768999779974555578888866999679999779999976789888899999999999977998576567877657855579998489976899999978879999875788875679999999999977639
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALLDERPVAVDSLWFDALRSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRSWLLRQASSGVSAATVVVEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGITAVVLIDVPSTVAGAAALAAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAARPATRSRVPTLARVAAAGVALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWSTQRVVSGPGSARVQVTSPADPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDFNPSDIRAGRPAVTYREVRAGHQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRSVHAVG
Prediction	86523000100131012112454424354003100310323102147322304400320022002323310000000113450141033003412430201210211333344233200002014421211324221223434534104420321331244432000012255243433233211331233634214145242441444434356433544454444442210000000000000000000123445354544423113140303223614454136554433241335731300000003234364254005203520574243112303452423624000022336623010000023611000001235555530350044004104238
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCEEEEHCCCCEEEEHCCCCCCCCHHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCEEEEEHCCCCEEEHCCCCEEEEEHCCCCHHHCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHEEHCCCCCCCCCCCCCCCEEEEEEEEEEHCCCCCEEHCCCCCCCCEEEEHCCCCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCCEEEEEEEEHCCCCEEEEEEEEHCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHHCC
MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALLDERPVAVDSLWFDALRSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRSWLLRQASSGVSAATVVVEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGITAVVLIDVPSTVAGAAALAAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAARPATRSRVPTLARVAAAGVALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWSTQRVVSGPGSARVQVTSPADPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDFNPSDIRAGRPAVTYREVRAGHQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRSVHAVG

2lnjA

0.13

0.05

0.37

0.99

wPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPLGSCGGVGIASQRYSDDGYEFLYPNGWIGVDVKGASPGVDVVFRDLIERDENLSVIISEIPSDTATDVGYRFMKTVNDASQGELINAEAR-DEDGQVYYTLEYR-VGDHDLASVTTNRGKLITFDLSTAEDRWDTVKSLFDTVASSFHVY-

5gaoE

0.20

0.14

0.72

1.63

dPPAS2

------------------------------------------------------------AAAA---------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------------------------RAAAAAAAAAAAAAAAAAAAAA

5gaoE

0.19

0.16

0.84

1.57

PPAS

----------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAA-------------AAAAAAAATTKEAYKKLSQKFHGTKSNKK

3wpaA

0.08

0.07

0.80

1.03

dPPAS2

------------------NVAQGNQTN---VGDALTALD------------NAINTAATTSKSTVSNGQNIVVSK----------------SKNADGSDNYEVSTAKDLTVDSVKAGDTVLNNANNAVVLNNTGLTISGGPSVTLAGIDAGNKTIQNVANAVNATDAVNKGQLDSAINNVNNNVNELANNAVKY--DDASKDKITLGGGATGTTITNVKDGTVAQGSKDAVNGGQLWNVQQQVDQNTTDISNIKNDINNGTVGLVQQAGKDAPVTVAKDTGGTTVNVAGTDGNRVVTGVKEGA----VNATSKDAVNGSQLNTTNQAVVNYLGGGAGYDNITGSFTAP------------------SYTVGDSKYN-------NVGGAIDALNQADQALNSKID

4w4iA

0.12

0.08

0.63

1.02

dPPAS2

-----------------------------------------------NAVELTVDNAWFIAETIGAGTFPWVLAITMPYSAQRGAFVDRQRDELTPQGVINP-AVADWIKVVCFPDRWLDLRYVGPASADGACELLRGIVALRTGTGKKTGNGVVALRNAQLVTFTAMDIDDPRALVPILGVGLAHRPPARFDEFSLPTRVGARADERLRSGVPLGEVVDYLGIP-----------ASARPVVESVF---------------SGPRSYVEIVAGCNRDG--RHTTTEVGSAGRVLVSPAFDGEWVSTFSP-----GTPFAIAVAIQTLTACLPD----------------------------------------------------------------------

4lgnA1

0.10

0.09

0.94

0.71

MUSTER

VAIGGDGIVFAPGILYVRTDIGGLLDWVGWNNWGYNGVV--SIAADPINTNK--VWAAVGMYTNSWDPNDGAILR-ATWQITPLPFKLGGNMPGRGMGERLAV-------DPNNDNILYFGAPSGKGLWRSTDSGATWSQMTNFPDVGTYIANPTDGYQSDIQGVVWVAFDKSSSSLGQASKTIFVGVADPNNPVFWSRDGGATWQAVPGAPTGFIPHKGVFDPVNHVLYIATSNTGGPYDGSSGDVWKFSVTSGTSPVPSTDTANDYFGYSGLTID--------RQHPNTIMVATQISWWPDTIIFRSTD--GGATWTRIWDWTSYPNRSLRYVLDISAEPWLTFGVQPNPPVPSPKLGWMDE-AMAIDNSDRMLYGTGAATNDLTKWDSGGQIHIAPM-VKG

5gaoE

0.19

0.16

0.84

0.92

dPPAS

---------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------AAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----AAAAA------------------AAATTKEAYKKLSQKFHGTKSNKK

2lnjA

0.12

0.04

0.37

0.87

wdPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPLGSCGGVGIASLQRYSDGYEFLYPNGWIGVDVKGASPGVDVVFRDLIERDENLSVIISEIPSDTATDVGYRFMKTVNDASQGELINAE-ARDEDGQVYYTLEYRVLVGHDLASVTTNRGKLITFDLSTAEDRWDTVKSLFDTVASSFHVY-

1ddoA

0.11

0.08

0.78

0.67

wMUSTER

---RVVVIGAG-STALCIHERYHSV-----------LQPLDVKVYADRFTP---------TTDVAAG-----LWQPSEPSNPQEANWNQQTFNY--------LSHIGSPNAANMGTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWF---NTSLILEGR-------KYLQWLTERLTERGVKFFLRKVESFEEVARGGAD-------------------VIINCTGVWAGVLQ--------------PDPLLQPGRGQIIKVDAPWNFIITHDLERGIYNSPYIIPGLQ-AVTLGGTFQVGNEINNIQDHNTIWEGCCR----LEPTLKDAKIV--GEYTGFRPVRPQVRLEREQLRFGSVIHNYG-HGGYGHWGCALEVAKLFGKVLEERN

2xb3A

0.11

0.04

0.34

0.84

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQAYVDDGYEFLYPRGWVQVQVEDPV---DVVFHDIIETTENVSVVVNTVASTSPEEVGDRLLRNIIAPSESGLIAATSQ-KADDKTYYILEYAVTLPHNLSSIAVSRGKVYTLSVSAPEERWPKVEDQFKTIVSSFTVY-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.26

Estimated TM-score = 0.27±0.08

Estimated RMSD = 17.7±2.5Å

Download Model 2

C-score=-4.29

Download Model 3

C-score=-3.91

Download Model 4

C-score=-3.06

Download Model 5

C-score=-4.92

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wpaA	0.624	4.31	0.071	0.777
2	1xi5A	0.412	6.44	0.036	0.656
3	1e07A	0.384	7.05	0.041	0.646
4	1sjjA	0.384	6.90	0.027	0.629
5	5dzvA	0.340	6.86	0.058	0.572
6	3k8pD	0.326	7.03	0.035	0.547
7	4oj5A	0.324	5.81	0.051	0.483
8	3gqnA	0.323	6.45	0.054	0.502
9	2qzvA	0.319	7.10	0.056	0.542
10	2dfsA	0.316	7.02	0.052	0.525

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	6	2xmwA	CU1	Rep, Mult	379,393
2	0.06	3	4il4B	LSM	Rep, Mult	245,249,252
3	0.04	2	4us4A	78M	Rep, Mult	245,249,257
4	0.04	2	3kviA	FAH	Rep, Mult	237,238
5	0.04	2	2jstB	HLT	Rep, Mult	365,368,396
6	0.02	1	3sucA	ATP	Rep, Mult	326,327,332,335,336,337,338,343
7	0.02	1	1w5cB	CLA	Rep, Mult	238,245
8	0.02	1	4fnnA	STE	Rep, Mult	181,184
9	0.02	1	1w7j2	III	Rep, Mult	306,323,330,331
10	0.02	1	2hodB	CA	Rep, Mult	299,301,305,306
11	0.02	1	4qi3A	HEM	Rep, Mult	363,380
12	0.02	1	2xzhA	VH2	Rep, Mult	350,365,367,378
13	0.02	1	1ag9A	CA	Rep, Mult	354,356
14	0.02	1	1yklG	DHB	Rep, Mult	270,277
15	0.02	1	1w7j3	III	Rep, Mult	389,390,392,393,394,395,396,397,398,399,400,401,402,403

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1p4rA	0.221	6.50	0.040	0.351	2.1.2.3,3.5.4.10	NA
2	0.060	1itzB	0.243	5.98	0.044	0.366	2.2.1.1	325
3	0.060	3hz3A	0.222	7.05	0.043	0.371	2.4.1.5	352
4	0.060	2hldK	0.233	6.29	0.078	0.366	3.6.3.14	NA
5	0.060	1l9mB	0.240	6.66	0.022	0.386	2.3.2.13	307
6	0.060	1g8mA	0.182	6.92	0.031	0.302	3.5.4.10,2.1.2.3	NA
7	0.060	3b8eA	0.235	6.26	0.062	0.366	3.6.3.9	NA
8	0.060	2q2eB	0.224	6.14	0.072	0.344	5.99.1.3	NA
9	0.060	1ug9A	0.231	6.43	0.025	0.359	3.2.1.70	NA
10	0.060	1jkyA	0.223	6.41	0.043	0.342	3.4.24.83	NA
11	0.060	3komA	0.236	6.06	0.045	0.356	2.2.1.1	353
12	0.060	2r8oB	0.223	6.05	0.023	0.337	2.2.1.1	NA
13	0.060	3b43A	0.290	7.31	0.038	0.497	2.7.11.1	NA
14	0.060	3ixzA	0.243	6.36	0.029	0.374	3.6.3.10	NA
15	0.060	3c8xA	0.117	5.61	0.010	0.171	2.7.10.1	NA
16	0.060	2np0A	0.229	6.55	0.012	0.356	3.4.24.69	NA
17	0.060	3b8eC	0.242	6.20	0.063	0.366	3.6.3.9	NA
18	0.060	2c9aA	0.150	5.94	0.024	0.223	3.1.3.48	NA
19	0.060	1mc0A	0.186	6.13	0.035	0.280	3.1.4.17	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.624	4.31	0.07	0.78	3wpaA	GO:0009405 GO:0019867
1	0.06	0.374	6.49	0.05	0.59	3lvhA	GO:0005198 GO:0005739 GO:0005905 GO:0006886 GO:0016020 GO:0016192 GO:0030117 GO:0030130 GO:0030132 GO:0030659 GO:0031410 GO:0042470 GO:1900126
2	0.06	0.365	4.20	0.06	0.45	3wqaA	GO:0009405 GO:0019867
3	0.06	0.305	3.90	0.08	0.37	3wprA	GO:0009405 GO:0019867
4	0.06	0.248	4.62	0.06	0.32	2yo2A	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0009405 GO:0010691 GO:0019867 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
5	0.06	0.212	5.39	0.07	0.29	4usxC	GO:0009405 GO:0019867
6	0.06	0.225	7.13	0.04	0.38	4pa0A	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006091 GO:0006936 GO:0006941 GO:0007512 GO:0008218 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0018298 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0055010 GO:0060048
7	0.06	0.199	6.85	0.08	0.32	4pa0B	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006091 GO:0006936 GO:0006941 GO:0007512 GO:0008218 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0018298 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0055010 GO:0060048
8	0.06	0.211	3.63	0.07	0.25	3zmfA	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0009405 GO:0010691 GO:0019867 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
9	0.06	0.227	7.26	0.04	0.39	4p7hB	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006091 GO:0006936 GO:0006941 GO:0007512 GO:0008218 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0018298 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0055010 GO:0060048
10	0.06	0.199	6.12	0.03	0.30	3pr7A	GO:0009405 GO:0019867
11	0.06	0.189	5.15	0.06	0.26	3ntnB	GO:0009405 GO:0019867
12	0.06	0.170	7.04	0.01	0.28	1bpoB	GO:0005198 GO:0005819 GO:0005905 GO:0006886 GO:0006898 GO:0007030 GO:0007067 GO:0008022 GO:0016020 GO:0016192 GO:0030118 GO:0030130 GO:0030132 GO:0030315 GO:0030506 GO:0030659 GO:0030669 GO:0031072 GO:0031410 GO:0042277 GO:0042383 GO:0042470 GO:0043195 GO:1900126
13	0.06	0.199	4.31	0.05	0.25	2ynzA	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0009405 GO:0010691 GO:0019867 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
14	0.06	0.180	6.58	0.04	0.29	4w5tA	GO:0000340 GO:0000932 GO:0000993 GO:0001047 GO:0003676 GO:0003723 GO:0003725 GO:0003727 GO:0003729 GO:0003743 GO:0004518 GO:0004519 GO:0004521 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005844 GO:0005845 GO:0006351 GO:0006355 GO:0006412 GO:0006413 GO:0006417 GO:0007223 GO:0008022 GO:0009791 GO:0010501 GO:0010586 GO:0010628 GO:0016020 GO:0016442 GO:0016787 GO:0016891 GO:0030425 GO:0030529 GO:0031047 GO:0031054 GO:0035068 GO:0035087 GO:0035194 GO:0035196 GO:0035197 GO:0035198 GO:0035278 GO:0035279 GO:0035280 GO:0044822 GO:0045944 GO:0045947 GO:0046872 GO:0048015 GO:0060213 GO:0070551 GO:0070578 GO:0090502 GO:0090624 GO:0090625 GO:1900153
15	0.06	0.157	5.04	0.06	0.21	3laaA	GO:0009405 GO:0019867
16	0.06	0.180	3.65	0.07	0.22	3d9xA	GO:0009405 GO:0019867
17	0.06	0.165	4.42	0.09	0.21	2ynyA	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0009405 GO:0010691 GO:0019867 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
18	0.06	0.205	6.30	0.06	0.32	1kfdA	GO:0003676 GO:0003677 GO:0003824 GO:0003887 GO:0004518 GO:0004527 GO:0005737 GO:0005829 GO:0006139 GO:0006260 GO:0006261 GO:0006281 GO:0006284 GO:0006974 GO:0008408 GO:0008409 GO:0016740 GO:0016779 GO:0016787 GO:0071897 GO:0090305

Consensus prediction of GO terms

Molecular Function	GO:0005198	GO:0001190	GO:0001135	GO:0001084	GO:0000978	GO:0000981	GO:0042802	GO:0003682
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0051704
GO-Score	0.55
Cellular Component	GO:0016020
GO-Score	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.