I-TASSER results

I-TASSER results for job id Rv3438

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (280 residues)
MPRIRKLVAALHRRGPHRVLRGDLAFAGLPGVVYTPEAGLHLPGVAFGHDWLTGTSRYSG
LLEHLASWGIVAAAPDSERGLAPSVLNLAFDLGVALDIVAGVRLGPGKISVHPAKLGLVG
HGFGGSAAVFAAAGLTGTHVKSVAAIFPTVTNPAAEQPAATLDVPGLILTAPGDPKTLTS
NALGLSRAWDKATLRIVSKARAGGLVEGRRLTKVLGLPGPHRRTQRSVRALLTGYLLYTL
GGDKTYRRFADPDLQLPKTDPIDPEAPPITPGEKIVTLLK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPRIRKLVAALHRRGPHRVLRGDLAFAGLPGVVYTPEAGLHLPGVAFGHDWLTGTSRYSGLLEHLASWGIVAAAPDSERGLAPSVLNLAFDLGVALDIVAGVRLGPGKISVHPAKLGLVGHGFGGSAAVFAAAGLTGTHVKSVAAIFPTVTNPAAEQPAATLDVPGLILTAPGDPKTLTSNALGLSRAWDKATLRIVSKARAGGLVEGRRLTKVLGLPGPHRRTQRSVRALLTGYLLYTLGGDKTYRRFADPDLQLPKTDPIDPEAPPITPGEKIVTLLK
Prediction	CCCHHHHHHHHCCCCCCEEHCCCCCCCCCCEEEEHCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEHCCCCEEEEHCCCHHHHHHHHHHCCCCCCCEEEEEHCCCCCCCCCCHHHHHCCCCEEEEHCCCCCCCCCCCHHHHHHHCCCCEEEEHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
Conf.Score	9868888898777788646545667788768999768999856999968999986789999999999786899858999988876667899999999998577789875666675899975865899999997899988458999678778887655566589988999758987777887788888769868999879875565677654454468888767899999999999999987986889875886556887778877776665678888759
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPRIRKLVAALHRRGPHRVLRGDLAFAGLPGVVYTPEAGLHLPGVAFGHDWLTGTSRYSGLLEHLASWGIVAAAPDSERGLAPSVLNLAFDLGVALDIVAGVRLGPGKISVHPAKLGLVGHGFGGSAAVFAAAGLTGTHVKSVAAIFPTVTNPAAEQPAATLDVPGLILTAPGDPKTLTSNALGLSRAWDKATLRIVSKARAGGLVEGRRLTKVLGLPGPHRRTQRSVRALLTGYLLYTLGGDKTYRRFADPDLQLPKTDPIDPEAPPITPGEKIVTLLK
Prediction	6742451055044522140233503232110100002564500000000000133620230021001200000000053233153441041033004103415234651402252000000121010001001635644020000000142314235215403000000003424322433134026524421012045142300033433231123433454224201000000012104617504511435272562431436536553373035118
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHCCCCCCEEHCCCCCCCCCCEEEEHCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEHCCCCEEEEHCCCHHHHHHHHHHCCCCCCCEEEEEHCCCCCCCCCCHHHHHCCCCEEEEHCCCCCCCCCCCHHHHHHHCCCCEEEEHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
MPRIRKLVAALHRRGPHRVLRGDLAFAGLPGVVYTPEAGLHLPGVAFGHDWLTGTSRYSGLLEHLASWGIVAAAPDSERGLAPSVLNLAFDLGVALDIVAGVRLGPGKISVHPAKLGLVGHGFGGSAAVFAAAGLTGTHVKSVAAIFPTVTNPAAEQPAATLDVPGLILTAPGDPKTLTSNALGLSRAWDKATLRIVSKARAGGLVEGRRLTKVLGLPGPHRRTQRSVRALLTGYLLYTLGGDKTYRRFADPDLQLPKTDPIDPEAPPITPGEKIVTLLK

4eb0A

0.18

0.16

0.88

1.97

MUSTER

QRGPNPTRSALTADGPFSVATYTVSRGFGGGVIYYPTTSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTN-SRFDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQ--NPSLKAAVPLTPWHTDKTFN-----TSVPVLIVGAEADTVAPVQHAIPFYQNLPPKVYVELDNASHFAPNSNN----------------AAISVYTISWMKLWVDNDTRYRQFLCN-VNDPALSDFRTNNRHCQ----------

4eb0A

0.18

0.16

0.88

2.57

dPPAS

QRGPNPTRSALTADGPFSVATYTVSRLSVSGVIYYPTGSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTN-SRFDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQ--NPSLKAAVPLTPWHTDKTFN-----TSVPVLIVGAEADTVAPVSQHAIPFYQNTPKVYVELDNASHFAPNSNN----------------AAISVYTISWMKLWVDNDTRYRQFLCNVNDPALSDFRTNNRHCQ-----------

4eb0A

0.18

0.16

0.88

2.88

wdPPAS

QRGPNPTRSALTADGPFSVATYTVSSGFGGGVIYYPTGSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTN-SRFDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQ--NPSLKAAVPLTPWHTDKTFN-----TSVPVLIVGAEADTVAPVSQHAIPFYQNTPKVYVELDNASHFAPNSNN----------------AAISVYTISWMKLWVDNDTRYRQFLCNVND-PALSDFRTNNRHCQ----------

4eb0A

0.18

0.16

0.88

2.48

wMUSTER

QRGPNPTRSALTADGPFSVATYTVSRGFGGGVIYYPTTSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTN-SRFDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQ--NPSLKAAVPLTPWHTDKTFN-----TSVPVLIVGAEADTVAPVQHAIPFYQNLPPKVYVELDNASHFAPNSNN----------------AAISVYTISWMKLWVDNDTRYRQFLCN-VNDPALSDFRTNNRHCQ----------

4eb0A

0.19

0.16

0.87

3.17

wPPAS

-SNPNPTRSALTADGPFSVATYTVSRLSVSGVIYYPTGSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTNSR-FDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQ--NPSLKAAVPLTPWHTDKTF-----NTSVPVLIVGAEADTVAPVSHAIPFYQNTTPKVYVELDNASHFAPNSNN----------------AAISVYTISWMKLWVDNDTRYRQFLCNVND-PALSDFRTNNRHCQ----------

4eb0A

0.18

0.16

0.88

4.39

dPPAS2

QRGPNPTRSALTADGPFSVATYTVSRLSVSGVIYYPTGSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTN-SRFDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQ--NPSLKAAVPLTPWHTDKTFN-----TSVPVLIVGAEADTVAPVQHAIPFYQNLPPKVYVELDNASHFAPNSNN----------------AAISVYTISWMKLWVDNDTRYRQFLCN-VNDPALSDFRTNNRHCQ----------

4eb0A

0.19

0.16

0.88

2.83

PPAS

QRGPNPTRSALTADGPFSVATYTVSRLSVSGVIYYPTTSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTNSR-FDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAEQ--NPSLKAAVPLTPWHTDKTFN-----TSVPVLIVGAEADTVAPVSHAIPFYQNLPPKVYVELDNASHFAPNSNN----------------AAISVYTISWMKLWVDNDTRYRQFLCNVND-PALSDFRTNNRHCQ----------

4eb0A

0.19

0.16

0.88

3.52

Env-PPAS

QRGPNPTRSALTADGPFSVATYTVSRLSVSGVIYYPTTSLTFGGIAMSPGYTADASSLAWLGRRLASHGFVVLVINTNS-RFDYPDSRASQLSAALNYLRTSSPSAVRARLDANRLAVAGHSMGGGGTLRIAE--QNPSLKAAVPLTPWHTDKTFN-----TSVPVLIVGAEADTVAPVSHAIPFYQNLPPKVYVELDNASHFAPNSNN----------------AAISVYTISWMKLWVDNDTRYRQFLCNVND-PALSDFRTNNRHCQ----------

3visA

0.19

0.16

0.88

1.93

MUSTER

ERGPNPTESMLERSGPFSVSEERASRFGAGGTIYYPRENNTYGAIAISPGYTGTQSSIAWLGERIASHGFVVIAIDTN-TTLDQPDSRARQLNAALDYMLTDASSAVRNRIDASRLAVMGHSMGGGGTLRLASQ--RPDLKAAIPLTPWHLNKS----WRDITVPTLIIGAEYDTIASVLHSKPFYNSIPDKAYLELDGASHFAPNITN----------------KTIGMYSVAWLKRFVDEDTRYTQFLCPGPRTLSDVEEYRSTCPF-----------

3visA

0.18

0.16

0.88

2.54

dPPAS

RGPNPTESMLEARSGPFSVSERFGADGFGGGTIYYPRENNTYGAIAISPGYTGTQSSIAWLGERIASHGFVVIAIDTN-TTLDQPDSRARQLNAALDYMLTDASSAVRNRIDASRLAVMGHSMGGGGTLRLASQ--RPDLKAAIPLTPWHLNKSWR----DITVPTLIIGAEYDTIASVTLHSKPFYNSTDKAYLELDGASHFAPNITN----------------KTIGMYSVAWLKRFVDEDTRYTQFLCPGPRTLSDVEEYRSTCPF-----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.01

Estimated TM-score = 0.71±0.11

Estimated RMSD = 6.1±3.7Å

Download Model 2

C-score=-0.50

Download Model 3

C-score=-0.86

Download Model 4

C-score=-3.68

Download Model 5

C-score=-1.86

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4eb0A	0.832	1.48	0.188	0.875
2	3visA	0.825	1.61	0.184	0.875
3	1jfrA	0.822	1.68	0.184	0.875
4	4wfiA	0.808	2.08	0.167	0.875
5	3f98A	0.756	3.14	0.153	0.882
6	2fx5A	0.751	2.49	0.204	0.839
7	1qo9A	0.706	3.64	0.120	0.871
8	2fj0A	0.706	3.62	0.117	0.871
9	1aknA	0.705	3.71	0.117	0.875
10	3i6mA	0.705	3.65	0.077	0.875

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.46	16	3f97A	GD7	Rep, Mult	50,51,53,58,121,122,123,202,203
2	0.05	2	3fnbA	MG	Rep, Mult	195,196,197,198,201
3	0.03	1	1eb9A	HBA	Rep, Mult	189,192,215,269

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.229	2ocgA	0.593	2.23	0.158	0.657	3.1.-.-	118,124,128,167,174,182,194
2	0.202	1auoA	0.585	2.39	0.120	0.657	3.1.1.1	174
3	0.188	1i6wB	0.530	2.74	0.158	0.611	3.1.1.3	174
4	0.180	2h1iA	0.549	3.02	0.124	0.657	3.1.1.1	61,148,205
5	0.180	3cn7A	0.571	2.46	0.116	0.643	3.1.1.1	174
6	0.143	1fj2A	0.584	2.88	0.130	0.675	3.1.4.39	NA
7	0.140	1jjfA	0.632	3.22	0.126	0.750	3.2.1.8	60
8	0.119	3gbsA	0.465	3.45	0.095	0.568	3.1.1.74	174
9	0.109	3esbA	0.477	3.94	0.083	0.604	3.1.1.74	174
10	0.089	1dinA	0.611	2.68	0.155	0.704	3.1.1.45	174
11	0.066	3dcnA	0.470	3.79	0.075	0.586	3.1.1.74	174
12	0.060	1jjiA	0.636	2.71	0.157	0.729	3.1.1.1	NA
13	0.060	1crlA	0.682	3.40	0.098	0.829	3.1.1.3	NA
14	0.060	1lnsA	0.672	3.92	0.102	0.861	3.4.14.11	174
15	0.060	2c7bA	0.659	2.62	0.181	0.746	3.1.1.1	178
16	0.060	1z68A	0.632	3.09	0.156	0.746	3.4.21.-	174
17	0.060	1r9mB	0.637	3.46	0.114	0.771	3.4.14.5	174
18	0.060	2gbcA	0.638	3.40	0.120	0.768	3.4.14.5,3.4.15.5	174
19	0.060	3g0bB	0.638	3.07	0.115	0.754	3.4.14.5	NA
20	0.060	1cleA	0.682	3.41	0.083	0.832	3.1.1.3	NA
21	0.060	2ecfA	0.637	3.01	0.171	0.750	3.4.14.5	174
22	0.060	1c7jA	0.692	3.76	0.115	0.868	3.1.1.-	72
23	0.060	1qz3A	0.645	2.90	0.167	0.750	3.1.1.1	NA
24	0.060	3f98A	0.756	3.14	0.153	0.882	3.1.1.47	43,115,165
25	0.060	1eveA	0.706	3.65	0.077	0.875	3.1.1.7	NA
26	0.060	1k4yA	0.697	3.55	0.119	0.857	3.1.1.1	NA
27	0.060	1aknA	0.705	3.71	0.117	0.875	3.1.1.13,3.1.1.3	NA
28	0.060	1mx9D	0.703	3.61	0.122	0.868	3.1.1.1	NA
29	0.060	1gz7C	0.683	3.31	0.106	0.825	3.1.1.3	236
30	0.060	3k2iA	0.653	2.88	0.133	0.754	3.1.2.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.832	1.48	0.19	0.88	4eb0A	GO:0003847 GO:0016042 GO:0016787 GO:0050525
1	0.34	0.822	1.68	0.18	0.88	1jfrA
2	0.33	0.825	1.61	0.18	0.88	3visA	GO:0003847 GO:0015996 GO:0016042 GO:0046872 GO:0047746
3	0.32	0.808	2.08	0.17	0.88	4wfiA	GO:0003847 GO:0016042 GO:0046872
4	0.31	0.756	3.14	0.15	0.88	3f98A	GO:0003847 GO:0005543 GO:0005576 GO:0005615 GO:0005737 GO:0006629 GO:0016042 GO:0016787 GO:0016788 GO:0034362 GO:0034374 GO:0034440 GO:0034441 GO:0047499 GO:0050729 GO:0090026
5	0.29	0.829	1.69	0.18	0.88	4cg3A	GO:0003847 GO:0015996 GO:0016042 GO:0016787 GO:0047746 GO:0050525
6	0.26	0.576	2.48	0.18	0.65	1hkhA	GO:0003824 GO:0004601 GO:0098869
7	0.26	0.573	2.52	0.11	0.64	4ke6E	GO:0016787 GO:0047372 GO:0052689
8	0.25	0.587	2.62	0.13	0.67	1q0rA	GO:0016787 GO:0017000 GO:0052689
9	0.22	0.622	2.81	0.15	0.71	3fcxB	GO:0005737 GO:0005788 GO:0016023 GO:0016787 GO:0016788 GO:0018738 GO:0031410 GO:0046294 GO:0047374 GO:0052689 GO:0070062 GO:1901687
10	0.21	0.631	2.40	0.19	0.70	2o2gA	GO:0016787
11	0.15	0.619	2.60	0.18	0.70	3pf8A	GO:0016787
12	0.10	0.602	2.94	0.15	0.69	3fnbA	GO:0004252 GO:0006508
13	0.07	0.638	2.45	0.18	0.72	3f67A	GO:0016787
14	0.07	0.626	3.09	0.11	0.74	3fakA	GO:0008152 GO:0016787
15	0.07	0.625	2.74	0.17	0.72	3e4dA	GO:0016787 GO:0018738 GO:0046294 GO:0046872 GO:0052689
16	0.07	0.628	2.71	0.17	0.72	3i6yA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
17	0.07	0.606	2.72	0.17	0.70	4opmA	GO:0004806 GO:0016787
18	0.07	0.614	3.29	0.14	0.74	4b6gA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
19	0.07	0.624	2.72	0.15	0.71	3ls2A	GO:0016787 GO:0018738 GO:0046294 GO:0052689
20	0.07	0.590	2.72	0.12	0.68	3wmrA	GO:0006508 GO:0008233 GO:0016787
21	0.07	0.601	2.84	0.11	0.70	4i3fA	GO:0016787
22	0.07	0.575	2.73	0.12	0.65	4lheA	GO:0016787 GO:0047372 GO:0052689
23	0.07	0.578	2.50	0.18	0.65	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
24	0.07	0.588	3.09	0.14	0.70	3fcyA

Consensus prediction of GO terms

Molecular Function	GO:0003847	GO:0046872	GO:0050525	GO:0047746	GO:0047499	GO:0005543
GO-Score	0.80	0.54	0.37	0.33	0.30	0.30
Biological Processes	GO:0016042	GO:0015996	GO:0034440	GO:0034374	GO:0034441	GO:0090026	GO:0050729
GO-Score	0.80	0.33	0.30	0.30	0.30	0.30	0.30
Cellular Component	GO:0005737	GO:0034362
GO-Score	0.30	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.