I-TASSER results

I-TASSER results for job id Rv3435c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (284 residues)
MGRILRVVVGLVLVIAAYVTVIALYHSTGLGRPHEVAHGRPTADGTTVTLHVEQLQTIKG
VLVANLAVSPGTELLDSQTQGLKDDLTVTVTSVVTPTKRTWSSGSLPGVFPVPLTISGDP
ANWPFDHYRSGPITVQLYRGAAHAPERVSVTFVDRLPGWNVDISGVGDANVPAPYRVGLH
RSPSSVAFGTVIVGVLIALAGVGLFVAVQTARGRRQFQPPMTTWYAAMLFAVIPLRNALP
DAPPIGFWIDVTVVLWVVVALVTSMVLYILCWWWHLKPDVDETM

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGRILRVVVGLVLVIAAYVTVIALYHSTGLGRPHEVAHGRPTADGTTVTLHVEQLQTIKGVLVANLAVSPGTELLDSQTQGLKDDLTVTVTSVVTPTKRTWSSGSLPGVFPVPLTISGDPANWPFDHYRSGPITVQLYRGAAHAPERVSVTFVDRLPGWNVDISGVGDANVPAPYRVGLHRSPSSVAFGTVIVGVLIALAGVGLFVAVQTARGRRQFQPPMTTWYAAMLFAVIPLRNALPDAPPIGFWIDVTVVLWVVVALVTSMVLYILCWWWHLKPDVDETM
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEEHCCCCEEEEEEEEHCCCCCCCCCCCCCCCCEEEEEEHCCCCCEEEHCCCCCCCCEEEEEEEHCCCCCCCCCEEEEEEEEEEEEHCCCCCCEEEEEEEHCEHCCEEEEEHCCCCCCCCCEEEEEEEHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
Conf.Score	97367899999999999999999987568888877777888898579999999975677689999999667644688888777876999996898757986888777765689998667777998678986799999978999857899999854666789985578888875689999977973457789999999999999999999998467888668999999999999988768999998645679999999999999999999998874587755689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGRILRVVVGLVLVIAAYVTVIALYHSTGLGRPHEVAHGRPTADGTTVTLHVEQLQTIKGVLVANLAVSPGTELLDSQTQGLKDDLTVTVTSVVTPTKRTWSSGSLPGVFPVPLTISGDPANWPFDHYRSGPITVQLYRGAAHAPERVSVTFVDRLPGWNVDISGVGDANVPAPYRVGLHRSPSSVAFGTVIVGVLIALAGVGLFVAVQTARGRRQFQPPMTTWYAAMLFAVIPLRNALPDAPPIGFWIDVTVVLWVVVALVTSMVLYILCWWWHLKPDVDETM
Prediction	74210000000102111310010000224454535245644444202020305404324440303010224541237635314430001012344434231444541453503020314363000122314302010132675432302020223143130324525546433303010313421100001112102310310131011102444502110000100301022213312263120001202311311000000000000000123344526658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEEHCCCCEEEEEEEEHCCCCCCCCCCCCCCCCEEEEEEHCCCCCEEEHCCCCCCCCEEEEEEEHCCCCCCCCCEEEEEEEEEEEEHCCCCCCEEEEEEEHCEHCCEEEEEHCCCCCCCCCEEEEEEEHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MGRILRVVVGLVLVIAAYVTVIALYHSTGLGRPHEVAHGRPTADGTTVTLHVEQLQTIKGVLVANLAVSPGTELLDSQTQGLKDDLTVTVTSVVTPTKRTWSSGSLPGVFPVPLTISGDPANWPFDHYRSGPITVQLYRGAAHAPERVSVTFVDRLPGWNVDISGVGDANVPAPYRVGLHRSPSSVAFGTVIVGVLIALAGVGLFVAVQTARGRRQFQPPMTTWYAAMLFAVIPLRNALPDAPPIGFWIDVTVVLWVVVALVTSMVLYILCWWWHLKPDVDETM

3jadA

0.13

0.12

0.92

0.78

MUSTER

----------------APSEFLDKLMGKVSGYDARIRNFKGPPVNVTCNIFINSFGSITMDYRVNIFLR---QWNDPRSEYPDDSLDLDPSMLDSI-DLFFANEVTTDNKLLRISKNGDLKNFPMDQLESFGYTMLIFEWDEKGAVQVAFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMG-LIQMYIPSLLIVILSWVSFWINMDAAPAR---VGLGITTVLTMTTQSSGSRASLPYVKAIDIWMAVCLLFVFSALLEYAAVNFIARKLFISRAKRIDTV

4nuyA2

0.12

0.09

0.79

0.80

dPPAS

EKTMMVNLAEGATVIGGSADPVNARKVFDGQLGSETDNISLGWDS----KQSIIFKLKEDGLIKHWRFFNDSARNPETTNKPIQEASLQIFNIKDYNLDNLLENPNKFDDE------------------KYWITVDTYSAQGERATAFSNTLNNITSKWRVVFDTKGDRYSVPELQILGYPLPN------------ADTIMKTVTTAKELSQQKDKFSQKMLDELKIKEMALETSLNSK--------IFDVTAINANAGVLKDCIEK-----------------

3jadA

0.11

0.10

0.90

1.20

wdPPAS

----------------APSEFLDKLMGKVSGYDARIRPNFKGPP-NIFINSFGSIAETTMDYRVNIFLR---QWNDPRSEYPDDSLDLDPSMLDSI-DLFFANEVTTDNKLLRISKNGDLKNFPMDVQTCIMQLESFGYTMNDLIFEWDVQVADTLPQFILKEE-NTGKFTCIEARFHLERQMG-LIQMYIPSLLIVILSWVSFWINMDAAPAR---VGLGITTVLTMTTQSSGSRASLPKVSYV--AIDIWMAVCLLFVFSALLEYAAVNFIARKLFISRAKR

3jadA

0.14

0.13

0.92

0.97

wMUSTER

----------------APSEFLDKLMGKVSGYDARIRPNFKGPPNVTCNIFINSFGSITMDYRVNIFLR---QWNDPRSEYPDDSLDLDPSMLDSI-DLFFANEVTTDNKLLRISKNGDLKNFPMDQLESFGYTMLIFEWDEKGAVQVALTLPQILKEKDLRYCTKHYNTGKIEARFHLERQMG-LIQMYIPSLLIVILSWVSFWINMDAAPAR---VGLGITTVLTMTTQSSGSRASLPKVKAIDIWMAVCLLFVFSALLEYAAVNFIARKLFISRAKRIDTV

3jadA

0.15

0.12

0.83

1.21

wPPAS

IR-------------------------NFKGPP-----------NVTCNIFINSFGSTTMDYRVNIFLR---QWNDPRSEYPDDSLDLDPSMLDSI-DLFFANEVTTDNKLLRISKNGDLKNFPMDVQTCIMQLESFGYTMNDLIFEWDVQVADTLPQFILKEE-NTGKFTCIEARFHLERQMG-LIQMYIPSLLIVILSWVSFWINMDAAPAR----GLGITTVLTMTTQSSGSRASLP-VKAIDIWMAVCLLFVFSALLEYAAVNFIARKLFISRAKRIDTV

3jadA

0.13

0.12

0.92

1.28

dPPAS2

------------------APSEFLDKLMGKVSGYDARIRPNFKGPNIFINSFGSIAETTMDYRVNIFLR--QQWNDPRSEYPDDSLDLDPSMLDSIWDLFFANEVTTDNKLLRISKNGDLKNFPMDVQTCIMQLESFGYTMNDLIFEWDVQVADGLTLKDLRYCTKHYNTGKIEARFHLERQMGYLIQMYIPSLLIVILSWVSFWINMDAAPAR---VGLGITTVLTMTTQSSGSRASLPYVKAIDIWMAVCLLFVFSALLEYAAVNFIARKLFISRAKRIDTV

3jadA

0.14

0.13

0.90

1.16

PPAS

------------------APSEFLDKLMGKVSGYDARNFKGPPVNVTCNIFINSFGSTTMDYRVNIFLR---QWNDPRSEYPDDSLDLDPSMLDSI-DLFFANEVTTDNKLLRISKNGDLKNFPMDQLESFGYTMNDLIFEWDEKGAVQVADGLTLPQFILKEE-NTGKFTCIEARFHLERQMG-LIQMYIPSLLIVILSWVSFWINMDAAPAR----GLGITTVLTMTTQSSGSRASLPYVKAIDIWMAVCLLFVFSALLEYAAVNFIARKLFISRAKRIDTV

3jadA

0.12

0.93

1.14

Env-PPAS

---------APSEFLDKLMGKVSGY------DARIRPNFKGPPVNVTCNIFINSFGSTTMDYRVNIFLR--QQWNDPRSEYPDDSLDLDPSMLDSIWDLFFANEVTTDNKLLRISKNGDLKNFPMDQLESFGYTMLIFEWDEKGAVQVAFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYLIQMYIPSLLIVILSWVSFWINMDAAPAR---VGLGITTVLTMTTQSSGSRASLPYVKAIDIWMAVCLLFVFSALLEYAAVNFIARKLFISRAKRIDTV

4cofA

0.14

0.13

0.92

0.72

MUSTER

PGN------------MSFVKETVDKLLKGYDIRLRPDFGGPP--CVGMNIDIASIDMVNMDYTLTMYFQ---YWRDKRLAGIPLNLTLDNRVADQLDKKSFVHGVTVKNRMIRLHPDGDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRVTGVESIVEHRLVSRNVVFATGALSLSFRLKRNIG-ILQTYMPSILITILSWVSFWINYDASAAR---VALGITTVLTMTTINTHLRETLPKIPYV-KAIDMYLMGCFVFVFLALLEYAFVNYIFFSQPARAAAI

3jadA

0.11

0.10

0.92

0.80

dPPAS

------------------APSEFLDKLMGKVSGYDARIRPNFKGPNIFINSFGSIAETTMDYRVNIFLRQDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEVTTDNKLLRISKNGDLKNFPMDVQTCIMQLESFGYTMNKGAVQVAFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQ------MGYYLIQMYIPSLLIVILSWVSFWINMDAAPLGITTVLTMTTQSSGSRASLPYVKAIDIWMAVCLLFVFSALLEYAAVNFIARKLFISRAKRIDTV

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.67

Estimated TM-score = 0.51±0.15

Estimated RMSD = 9.9±4.6Å

Download Model 2

C-score=-3.94

Download Model 3

C-score=-4.70

Download Model 4

C-score=-3.75

Download Model 5

C-score=-4.54

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3jadA	0.728	3.69	0.125	0.915
2	3rhwA	0.709	3.68	0.100	0.894
3	4cofA	0.700	3.81	0.092	0.912
4	4pirA	0.697	3.88	0.088	0.894
5	2bg9A	0.694	4.17	0.086	0.922
6	2bg9E	0.693	4.04	0.053	0.912
7	5kxiB	0.692	3.98	0.110	0.912
8	2bg9C	0.688	4.07	0.086	0.912
9	5kxiA	0.683	3.97	0.107	0.905
10	2bg9B	0.679	4.22	0.064	0.915

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	7	4f8hD	LMD	Rep, Mult	59,226,229,230,234,235,238,239
2	0.08	5	3rifD	IVM	Rep, Mult	229,232,237,246,249,250,253,254,257
3	0.06	4	2xjmH	CO	Rep, Mult	236,250
4	0.05	3	3p4wD	DSF	Rep, Mult	124,191,236,245,248,249
5	0.05	3	3ri5E	IVM	Rep, Mult	264,265,266,269,271,272
6	0.05	3	1ocoB	HEA	Rep, Mult	254,255
7	0.02	1	3lw5K	CLA	Rep, Mult	227,231
8	0.02	1	1gzmB	C8E	Rep, Mult	225,261
9	0.02	1	4bntD	36E	Rep, Mult	192,196
10	0.02	1	3ri5A	RI5	Rep, Mult	219,223
11	0.02	1	2y6pC	MG	Rep, Mult	119,250
12	0.02	1	2o013	CLA	Rep, Mult	262,265
13	0.02	1	2wsf4	CLA	Rep, Mult	220,224,225

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ileA	0.367	5.79	0.039	0.570	6.1.1.5	189
2	0.060	1ea0A	0.338	6.58	0.050	0.588	1.4.1.13	NA
3	0.060	3c2wC	0.362	5.60	0.063	0.560	2.7.13.3	198,200
4	0.060	2vdcA	0.362	5.52	0.072	0.560	1.4.1.13	NA
5	0.060	2veaA	0.369	5.46	0.061	0.563	2.7.13.3	200
6	0.060	1ug9A	0.349	6.36	0.048	0.602	3.2.1.70	NA
7	0.060	2x1lA	0.350	5.04	0.057	0.503	6.1.1.10	224
8	0.060	3eqlM	0.363	5.99	0.070	0.595	2.7.7.6	NA
9	0.060	2vz9B	0.346	6.49	0.061	0.606	2.3.1.85	NA
10	0.060	2zxqA	0.365	6.55	0.064	0.623	3.2.1.97	NA
11	0.060	3ixzA	0.381	6.14	0.034	0.648	3.6.3.10	NA
12	0.060	3b8eA	0.353	6.36	0.054	0.613	3.6.3.9	NA
13	0.060	2rgrA	0.359	6.32	0.021	0.623	5.99.1.3	NA
14	0.060	1bgwA	0.310	6.47	0.043	0.539	5.99.1.3	NA
15	0.060	2vz8A	0.344	6.61	0.061	0.602	2.3.1.85	NA
16	0.060	1f13A	0.354	6.11	0.021	0.595	2.3.2.13	NA
17	0.060	3b8eC	0.359	6.52	0.044	0.637	3.6.3.9	NA
18	0.060	1mhsA	0.372	6.50	0.043	0.641	3.6.3.6	NA
19	0.060	2vkzG	0.380	6.26	0.050	0.644	2.3.1.38,3.1.2.14	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.696	3.83	0.09	0.89	4pirC	GO:0004889 GO:0004993 GO:0005230 GO:0005232 GO:0005886 GO:0005892 GO:0006810 GO:0006811 GO:0007210 GO:0007271 GO:0015276 GO:0015464 GO:0016020 GO:0016021 GO:0022850 GO:0030054 GO:0034220 GO:0042166 GO:0045202 GO:0045211 GO:0051378 GO:0098655 GO:1904602
1	0.21	0.693	4.13	0.08	0.92	4aq5C	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
2	0.17	0.633	3.84	0.11	0.82	4z90A	GO:0005230 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0034220
3	0.11	0.711	3.80	0.11	0.91	3jafA	GO:0005230 GO:0005254 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006821 GO:0007218 GO:0007417 GO:0008270 GO:0016020 GO:0016021 GO:0016594 GO:0016934 GO:0022824 GO:0030054 GO:0030425 GO:0034220 GO:0034707 GO:0042995 GO:0043200 GO:0043204 GO:0045202 GO:0045211 GO:0045664 GO:0046872 GO:0051260 GO:0060012 GO:0071230 GO:0071294 GO:0071361 GO:0099565 GO:1902476
4	0.11	0.700	3.81	0.09	0.91	4cofA	GO:0004890 GO:0005216 GO:0005230 GO:0005254 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006821 GO:0007165 GO:0007605 GO:0016020 GO:0016021 GO:0022851 GO:0030054 GO:0034220 GO:0034707 GO:0043523 GO:0043524 GO:0045202 GO:0045211 GO:0048666 GO:0060021 GO:0060080 GO:0060119 GO:0060384 GO:0071420 GO:0090102 GO:1901215 GO:1902476 GO:1902711
5	0.10	0.693	4.13	0.10	0.92	4aq5A	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
6	0.10	0.697	3.98	0.07	0.92	4aq5B	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
7	0.10	0.692	4.05	0.05	0.91	4aq5E	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
8	0.09	0.699	3.71	0.11	0.89	4tnwA	GO:0005230 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0008068 GO:0016020 GO:0016021 GO:0016595 GO:0030054 GO:0031987 GO:0045202 GO:0045211 GO:0051259 GO:1902476
9	0.09	0.655	3.84	0.07	0.85	4ireB	GO:0005230 GO:0005267 GO:0005272 GO:0005886 GO:0006810 GO:0006811 GO:0006813 GO:0006814 GO:0016020 GO:0016021 GO:0035725 GO:0071805
10	0.07	0.637	3.93	0.11	0.83	4x5tA	GO:0001508 GO:0001964 GO:0002087 GO:0005230 GO:0005254 GO:0005267 GO:0005272 GO:0005622 GO:0005783 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006813 GO:0006814 GO:0006820 GO:0006821 GO:0006936 GO:0007218 GO:0007268 GO:0007340 GO:0007601 GO:0007628 GO:0008270 GO:0009897 GO:0016020 GO:0016021 GO:0016594 GO:0016933 GO:0016934 GO:0022824 GO:0030054 GO:0030425 GO:0030977 GO:0034220 GO:0034707 GO:0035725 GO:0042391 GO:0042995 GO:0043005 GO:0043025 GO:0043204 GO:0043231 GO:0043576 GO:0045202 GO:0045211 GO:0046872 GO:0050884 GO:0050905 GO:0051260 GO:0051291 GO:0051970 GO:0060012 GO:0060013 GO:0060077 GO:0060080 GO:0071230 GO:0071294 GO:0071361 GO:0071805 GO:0097305 GO:1902476 GO:2000344
11	0.07	0.620	3.86	0.07	0.80	4yeuA	GO:0005230 GO:0005267 GO:0005272 GO:0005886 GO:0006810 GO:0006811 GO:0006813 GO:0006814 GO:0016020 GO:0016021 GO:0034220 GO:0035725 GO:0071805
12	0.07	0.444	4.27	0.07	0.59	4zk1B	GO:0005230 GO:0005576 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202
13	0.07	0.440	3.86	0.07	0.56	4aoeA	GO:0005230 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0034220
14	0.06	0.443	3.70	0.07	0.56	2qc1B	GO:0003009 GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0005892 GO:0006810 GO:0006811 GO:0006812 GO:0007165 GO:0007271 GO:0007274 GO:0007528 GO:0009986 GO:0015464 GO:0016020 GO:0016021 GO:0019228 GO:0030054 GO:0031594 GO:0035094 GO:0042166 GO:0042391 GO:0045202 GO:0045211 GO:0046716 GO:0048630 GO:0050881 GO:0050905 GO:0070050 GO:0098655 GO:0099565
15	0.06	0.439	4.07	0.04	0.57	5afmB	GO:0000187 GO:0001540 GO:0001666 GO:0004889 GO:0005216 GO:0005230 GO:0005576 GO:0005886 GO:0005892 GO:0006810 GO:0006811 GO:0006816 GO:0006874 GO:0007165 GO:0007271 GO:0007613 GO:0008284 GO:0015276 GO:0015464 GO:0015643 GO:0016020 GO:0016021 GO:0017081 GO:0022848 GO:0030054 GO:0032720 GO:0034220 GO:0035094 GO:0042166 GO:0042803 GO:0045202 GO:0045211 GO:0045766 GO:0050890 GO:0098655 GO:0099565
16	0.06	0.440	3.87	0.06	0.56	4aodA	GO:0005230 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0034220
17	0.06	0.440	3.89	0.09	0.56	4d01A	GO:0004889 GO:0005216 GO:0005230 GO:0005262 GO:0005886 GO:0005887 GO:0005892 GO:0006810 GO:0006811 GO:0006812 GO:0006816 GO:0007165 GO:0007204 GO:0007271 GO:0007605 GO:0015276 GO:0016020 GO:0016021 GO:0022848 GO:0030054 GO:0042166 GO:0042472 GO:0045202 GO:0045211 GO:0050910 GO:0070588 GO:0098655 GO:0099565
18	0.06	0.428	3.95	0.07	0.55	4zjsA	GO:0003009 GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0005892 GO:0006810 GO:0006811 GO:0006812 GO:0007165 GO:0007271 GO:0007274 GO:0007528 GO:0009986 GO:0015276 GO:0015464 GO:0016020 GO:0016021 GO:0019228 GO:0030054 GO:0031594 GO:0034220 GO:0035094 GO:0042166 GO:0042391 GO:0045202 GO:0045211 GO:0046716 GO:0046872 GO:0048630 GO:0050881 GO:0050905 GO:0070050 GO:0098655 GO:0099565

Consensus prediction of GO terms

Molecular Function	GO:0070405	GO:0022824	GO:0042165	GO:0099589	GO:0008227	GO:0043176	GO:1901363	GO:0097159	GO:0005253	GO:0015108	GO:0004889
GO-Score	0.45	0.45	0.45	0.45	0.45	0.45	0.43	0.42	0.42	0.42	0.39
Biological Processes	GO:0007268	GO:0007186	GO:0006821	GO:0098661	GO:0098655
GO-Score	0.45	0.45	0.42	0.42	0.39
Cellular Component	GO:0030054	GO:0045211	GO:0005887	GO:0034703	GO:0098802
GO-Score	0.51	0.51	0.45	0.45	0.45

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.