I-TASSER results

I-TASSER results for job id Rv3415c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (275 residues)
MNETPHAPVVEQVLVAAAFGNQPGSWPLPTAITPHHLWLRAVAAGGQGRYAHAYGDLSVL
RRLVPAGPLASLAHSTQGSLLRQLGWHTLARGWDGRALALAGADREAGADALIGLAADAL
GVGRFAAAGALLDRADPLVVSPLVADRLAVRRRWVAAELAMATGDGATAVRHAEEAVELT
QAMAVASARHRVKSDVVLAAALCSAGAVARARAVGEEALDATARFGLLPLRWALACLLID
IGTVTFSAQQLRELTKIRNICAGQVRRAGGCWRTA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MNETPHAPVVEQVLVAAAFGNQPGSWPLPTAITPHHLWLRAVAAGGQGRYAHAYGDLSVLRRLVPAGPLASLAHSTQGSLLRQLGWHTLARGWDGRALALAGADREAGADALIGLAADALGVGRFAAAGALLDRADPLVVSPLVADRLAVRRRWVAAELAMATGDGATAVRHAEEAVELTQAMAVASARHRVKSDVVLAAALCSAGAVARARAVGEEALDATARFGLLPLRWALACLLIDIGTVTFSAQQLRELTKIRNICAGQVRRAGGCWRTA
Prediction	CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEHCC
Conf.Score	99888887568999998658898888889998899999999999766758889999899857888769999999999999999888789999769999986898578999999999998688878999999999999866788875699999999999999879989999999999999987589987645678999999987668868999999999999999898675999999987578988658899999999999999999978755579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MNETPHAPVVEQVLVAAAFGNQPGSWPLPTAITPHHLWLRAVAAGGQGRYAHAYGDLSVLRRLVPAGPLASLAHSTQGSLLRQLGWHTLARGWDGRALALAGADREAGADALIGLAADALGVGRFAAAGALLDRADPLVVSPLVADRLAVRRRWVAAELAMATGDGATAVRHAEEAVELTQAMAVASARHRVKSDVVLAAALCSAGAVARARAVGEEALDATARFGLLPLRWALACLLIDIGTVTFSAQQLRELTKIRNICAGQVRRAGGCWRTA
Prediction	63745434314520331013253433403445402410230012112131030243044045644312010001013000222221133024022300330354441101000000010002030420330043036206767522103012100300010143337402520540341255373523212020300000010124446303400440152056230100210010001213455444432541440353015203434441458
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEHCC
MNETPHAPVVEQVLVAAAFGNQPGSWPLPTAITPHHLWLRAVAAGGQGRYAHAYGDLSVLRRLVPAGPLASLAHSTQGSLLRQLGWHTLARGWDGRALALAGADREAGADALIGLAADALGVGRFAAAGALLDRADPLVVSPLVADRLAVRRRWVAAELAMATGDGATAVRHAEEAVELTQAMAVASARHRVKSDVVLAAALCSAGAVARARAVGEEALDATARFGLLPLRWALACLLIDIGTVTFSAQQLRELTKIRNICAGQVRRAGGCWRTA

3ceqB

0.16

0.13

0.83

1.05

MUSTER

----------------------------------------------LVPRGSAVPLCKQALESGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFKPIWMHAEEREESKDKRRDSWYKAPTVNTTLRSLGALYRRQ-GKLEAA

2vq2A

0.12

0.10

0.80

0.82

dPPAS

-----------------------------ANQVSNIKTQLAMEYMRGQDYRQATASIEDALKSDPK---NELAWLVRAEIYQYLKVNDKAQESFRQALSIKPDSAEINNNYGWFLCGR---LNRPAESMAYFDKALADPTYPT-----PYIANLNKGICSAKQGQFGLAEAYLKRSLAAQP--------QFPPAFKELARTKMLAGQLGDADYYFKKYQSRVEVL-QADDLLLGWKIAKALGNAQAAYEYEAQLQANFPYSEELQTVLT------

3ceqB

0.13

0.12

0.92

1.70

wdPPAS

RGSAVPLCKQALEDLEKTSGHD-------HPDVATMLNILALVYRDQNKYKEAAHLLNDALALGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIR-KFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLK-KYQDAETLYKEILTRAHEKEGSVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKA----KVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNR----------

3ceqB

0.14

0.13

0.91

1.52

wMUSTER

RGSA--VPLCKQALEDLE-GHD-------HPDVATMLNILALVYRDQNKYKEAAHLLNDALALGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIR-KFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLK-KYQDAETLYKEILTRAHEKEGSVNGDNKPIWMHAEEREESKDKRRDSAPYGEY--GSWYKA-CKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRN-----------

3ceqB

0.15

0.13

0.83

1.48

wPPAS

----------------------------------------------LVPRGSAVPLCKQALESGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIR-KDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAPYGEY-GSWYKACKGKLEAA

2vq2A

0.12

0.10

0.80

1.22

dPPAS2

-----------------------------ANQVSNIKTQLAMEYMRGQDYRQATASIEDALKSDPK---NELAWLVRAEIYQYLKVNDKAQESFRQALSIKPDSAEINNNYGWFLCGR---LNRPAESMAYFDKALAD-PTYPTPYIANLNKGICSAKQ----GQFGLAEAYLKRSLAAQP--------QFPPAFKELARTKMLAGQLGDADYYFKKYQSRVEVL-QADDLLLGWKIAKALGNAQAAYEYEAQLQANFPYSEELQTVLT------

2vq2A

0.12

0.10

0.79

0.91

PPAS

-----------------------------ANQVSNIKTQLAMEYMRGQDYRQATASIEDALKSDPK----ELAWLVRAEIYQYLKVNDKAQESFRQALSIKPDS----AEINNNYGWFLCGLNRPAESMAYFDKALAD-PTYPTPYIANLNKGICSAKQ----GQFGLAEAYLKRSLAAQ--------PQFPPAFKELARTKMLAGQLGDADYYFKKYQSRVEVLQ--DDLLLGWKIAKALGNAQAAYEYEAQLQANFPYSEELQTVLT------

4xi0A

0.14

0.09

0.64

1.24

Env-PPAS

-----------------AMGDK-----------AKLYRNISQRCLRRGSPEEALRYLKEWARHEKN---DPEPLYQMGIALANLGDYQRAVTVFDKVLKLRPNH----FMASYRKGAVLLKIKQYKLALPVLEAVVAAAPAD-------ARAYYLLGLAYDGDEQLEKGIEAMQKAVDLD-------PEE-IKYHQHLGFMNVRKDDHKTAAEHFTKVMELERSQDS------------------------------------------------

2vq2A

0.12

0.10

0.79

1.05

MUSTER

-----------------------------ANQVSNIKTQLAMEYMRGQDYRQATASIEDALKSDPKN---ELAWLVRAEIYQYLKVNDKAQESFRQALSIKPDS----AEINNNYGWFLCGLNRPAESMAYFDKALADPTYPT-----PYIANLNKGICSAKQGQFGLAEAYLKRSLAAQ--------PQFPPAFKELARTKMLAGQLGDADYYFKKYQSRVEVLQ-ADDLLLGWKIAKALGNAQAAYEYEAQLQANFEELQTVLT---------

5cwqA

0.14

0.12

0.84

0.76

dPPAS

------------------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGN------------SEEAERASEKAQRVLEEARKVSEEAREQGDDEV--LALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEH

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.87

Estimated TM-score = 0.49±0.15

Estimated RMSD = 10.3±4.6Å

Download Model 2

C-score=-3.00

Download Model 3

C-score=-2.18

Download Model 4

C-score=-3.45

Download Model 5

C-score=-4.54

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4a1sA	0.754	3.62	0.149	0.931
2	3sf4A	0.746	3.42	0.110	0.920
3	3q15A	0.745	4.17	0.143	0.956
4	5dseA	0.727	3.31	0.122	0.873
5	3ulqA	0.718	4.11	0.062	0.927
6	4bujB	0.717	3.55	0.081	0.905
7	4i1aA	0.715	3.28	0.072	0.844
8	1w3bA	0.703	3.16	0.141	0.833
9	4ui9J	0.695	3.44	0.095	0.847
10	5l4kQ	0.693	4.11	0.086	0.924

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	5	4wneA	III	Rep, Mult	38,39,42,68,69,72,73,75,76,79,82,83,94,97,107,110,114,117,120,121,135,152,155,156,162,193,197,200,203,204,218,232,236
2	0.07	3	1r3nG	BIB	Rep, Mult	91,157,164
3	0.05	2	3mkvG	CO3	Rep, Mult	87,155,156,190,192
4	0.02	1	1o6oB	III	Rep, Mult	72,75,76,80,107,110
5	0.02	1	2bo6B	MN	Rep, Mult	110,118
6	0.02	1	3mtwA	ZN	Rep, Mult	147,190,210
7	0.02	1	2ez2A	PO4	Rep, Mult	47,48,49,187,189,193
8	0.02	1	1f59B	III	Rep, Mult	192,196,199,200,233,237
9	0.02	1	2cypA	O	Rep, Mult	86,87
10	0.02	1	2bptA	III	Rep, Mult	38,41,42,45,47,76,79
11	0.02	1	3h2wA	CO	Rep, Mult	235,240
12	0.02	1	1f59A	III	Rep, Mult	196,199,200,203,204,233,237,241
13	0.02	1	2gl7D	III	Rep, Mult	198,201,206,208,213,217

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.165	1w3bA	0.703	3.16	0.141	0.833	2.4.1.-	89
2	0.060	1ks8A	0.525	4.80	0.080	0.753	3.2.1.4	NA
3	0.060	1hcuB	0.575	4.61	0.053	0.807	3.2.1.113	NA
4	0.060	1i8qA	0.554	4.76	0.045	0.793	4.2.2.1	54,60
5	0.060	1nxcA	0.545	4.81	0.082	0.782	3.2.1.113	NA
6	0.060	2q1fA	0.540	5.00	0.053	0.793	4.2.2.21	NA
7	0.060	1hn0A	0.567	4.97	0.054	0.836	4.2.2.20	NA
8	0.060	2dqmA	0.527	5.27	0.091	0.793	3.4.11.2	NA
9	0.060	1ojnA	0.560	4.93	0.045	0.811	4.2.2.1	NA
10	0.060	1w3bB	0.658	3.92	0.140	0.833	2.4.1.-	100,134,138
11	0.060	1w6jA	0.579	4.56	0.069	0.800	5.4.99.7	125
12	0.060	1ho8A	0.519	5.33	0.061	0.800	3.6.3.14	120
13	0.060	1ia7A	0.523	4.84	0.083	0.764	3.2.1.4	NA
14	0.060	2c0lA	0.555	3.47	0.130	0.654	2.3.1.176	96
15	0.060	1f1sA	0.557	4.87	0.059	0.807	4.2.2.1	153
16	0.060	1z1wA	0.550	5.39	0.084	0.844	3.4.11.-	NA
17	0.060	2sqcA	0.578	4.96	0.056	0.836	5.4.99.17	NA
18	0.060	2pziA	0.579	4.16	0.072	0.782	2.7.11.1	195
19	0.060	1dceA	0.549	5.40	0.091	0.840	2.5.1.60	NA
20	0.060	2jg0A	0.525	5.35	0.051	0.811	3.2.1.28	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.39	0.647	2.94	0.16	0.76	4a1sA	GO:0000132 GO:0005938 GO:0007400 GO:0007405 GO:0008105 GO:0008356 GO:0019904 GO:0030695 GO:0040001 GO:0045167 GO:0045175 GO:0045177 GO:0045179 GO:0045185 GO:0050790 GO:0051294 GO:0055059
1	0.28	0.704	2.86	0.12	0.81	5a6cB	GO:0000132 GO:0000166 GO:0000922 GO:0001965 GO:0005092 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005938 GO:0007052 GO:0007155 GO:0007165 GO:0007186 GO:0007267 GO:0008022 GO:0017016 GO:0030054 GO:0030695 GO:0034332 GO:0042802 GO:0043547 GO:0045177 GO:0050790 GO:0051661 GO:0060487 GO:0090557 GO:0097431 GO:0098609 GO:0098641
2	0.25	0.658	3.92	0.14	0.83	1w3bB	GO:0000123 GO:0000791 GO:0001933 GO:0001934 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006041 GO:0006110 GO:0006486 GO:0006493 GO:0006915 GO:0007165 GO:0007584 GO:0008047 GO:0008134 GO:0008289 GO:0008375 GO:0010628 GO:0010801 GO:0016020 GO:0016262 GO:0016568 GO:0016740 GO:0016757 GO:0019904 GO:0030854 GO:0030900 GO:0031397 GO:0032868 GO:0032869 GO:0032922 GO:0033137 GO:0035020 GO:0042277 GO:0042588 GO:0043005 GO:0043025 GO:0043085 GO:0043981 GO:0043982 GO:0043984 GO:0043995 GO:0043996 GO:0045793 GO:0045862 GO:0045944 GO:0046626 GO:0046972 GO:0048015 GO:0048029 GO:0048312 GO:0048511 GO:0051571 GO:0060548 GO:0061087 GO:0070207 GO:0070208 GO:0070688 GO:0071222 GO:0071300 GO:0071333 GO:0080182 GO:0090315 GO:0090526 GO:0097237 GO:0097363 GO:1900038 GO:1900182 GO:1903428
3	0.24	0.745	4.17	0.14	0.96	3q15A	GO:0004721 GO:0006470 GO:0016787
4	0.24	0.712	4.25	0.05	0.92	4i9eA	GO:0004721 GO:0006470 GO:0016787
5	0.22	0.749	3.59	0.08	0.93	4i1aB	GO:0004721 GO:0006470 GO:0016787
6	0.21	0.700	3.70	0.08	0.89	4gyoB	GO:0004721 GO:0006470 GO:0016787
7	0.20	0.703	3.16	0.14	0.83	1w3bA	GO:0000123 GO:0000791 GO:0001933 GO:0001934 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006041 GO:0006110 GO:0006486 GO:0006493 GO:0006915 GO:0007165 GO:0007584 GO:0008047 GO:0008134 GO:0008289 GO:0008375 GO:0010628 GO:0010801 GO:0016020 GO:0016262 GO:0016568 GO:0016740 GO:0016757 GO:0019904 GO:0030854 GO:0030900 GO:0031397 GO:0032868 GO:0032869 GO:0032922 GO:0033137 GO:0035020 GO:0042277 GO:0042588 GO:0043005 GO:0043025 GO:0043085 GO:0043981 GO:0043982 GO:0043984 GO:0043995 GO:0043996 GO:0045793 GO:0045862 GO:0045944 GO:0046626 GO:0046972 GO:0048015 GO:0048029 GO:0048312 GO:0048511 GO:0051571 GO:0060548 GO:0061087 GO:0070207 GO:0070208 GO:0070688 GO:0071222 GO:0071300 GO:0071333 GO:0080182 GO:0090315 GO:0090526 GO:0097237 GO:0097363 GO:1900038 GO:1900182 GO:1903428
8	0.19	0.687	3.28	0.13	0.81	4jhrA	GO:0000132 GO:0000166 GO:0000922 GO:0001965 GO:0005092 GO:0005737 GO:0005856 GO:0005938 GO:0007052 GO:0030695 GO:0042802 GO:0045177 GO:0050790 GO:0051661 GO:0060487 GO:0097431
9	0.19	0.582	5.09	0.12	0.81	4xifA	GO:0000123 GO:0000791 GO:0001933 GO:0001934 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006041 GO:0006110 GO:0006486 GO:0006493 GO:0006915 GO:0007165 GO:0007584 GO:0008047 GO:0008134 GO:0008289 GO:0008375 GO:0010628 GO:0010801 GO:0016020 GO:0016262 GO:0016568 GO:0016740 GO:0016757 GO:0019904 GO:0030854 GO:0030900 GO:0031397 GO:0032868 GO:0032869 GO:0032922 GO:0033137 GO:0035020 GO:0042277 GO:0042588 GO:0043005 GO:0043025 GO:0043085 GO:0043981 GO:0043982 GO:0043984 GO:0043995 GO:0043996 GO:0045793 GO:0045862 GO:0045944 GO:0046626 GO:0046972 GO:0048015 GO:0048029 GO:0048312 GO:0048511 GO:0051571 GO:0060548 GO:0061087 GO:0070207 GO:0070208 GO:0070688 GO:0071222 GO:0071300 GO:0071333 GO:0080182 GO:0090315 GO:0090526 GO:0097237 GO:0097363 GO:1900038 GO:1900182 GO:1903428
10	0.18	0.539	2.77	0.13	0.64	2pl2A
11	0.16	0.651	3.34	0.14	0.79	2fi7A	GO:0009297 GO:0043683 GO:0046903
12	0.14	0.641	3.77	0.10	0.82	4abnB	GO:0003677 GO:0003682 GO:0005634 GO:0005654 GO:0005737 GO:0006281 GO:0006974 GO:0045944
13	0.14	0.695	3.44	0.10	0.85	5a31J	GO:0005634 GO:0005654 GO:0005680 GO:0005737 GO:0005813 GO:0005815 GO:0005819 GO:0005829 GO:0005856 GO:0005876 GO:0007049 GO:0007067 GO:0007088 GO:0008283 GO:0016567 GO:0031145 GO:0042787 GO:0043161 GO:0051301 GO:0051436 GO:0051437 GO:0051439 GO:0070979
14	0.14	0.415	2.21	0.19	0.45	2vyiA	GO:0005737 GO:0005829 GO:0016020 GO:0016032 GO:1903071 GO:1904288
15	0.13	0.649	4.11	0.10	0.85	5a31F	GO:0005634 GO:0005654 GO:0005680 GO:0005737 GO:0005813 GO:0005819 GO:0005829 GO:0005876 GO:0007091 GO:0008283 GO:0016567 GO:0019903 GO:0031145 GO:0042787 GO:0043161 GO:0051436 GO:0051437 GO:0051439 GO:0070979
16	0.13	0.543	3.13	0.12	0.65	2q7fA
17	0.11	0.417	2.25	0.10	0.46	3sz7A	GO:0004721 GO:0006470 GO:0016787
18	0.09	0.556	3.10	0.14	0.67	3gw4B
19	0.07	0.635	3.31	0.14	0.76	5a01A	GO:0006486 GO:0006493 GO:0008375 GO:0016740 GO:0016757 GO:0035220 GO:0045475
20	0.07	0.459	1.69	0.21	0.49	2fo7A
21	0.06	0.423	1.91	0.12	0.45	3uq3A	GO:0003729 GO:0005737 GO:0006457 GO:0008104 GO:0030544 GO:0042030 GO:0043086 GO:0051879

Consensus prediction of GO terms

Molecular Function	GO:1901265	GO:0036094	GO:0098632	GO:0045296	GO:0031267	GO:0030695	GO:0019904	GO:0030246	GO:0008375	GO:1901981	GO:0033218	GO:0010485	GO:0004721
GO-Score	0.57	0.57	0.57	0.57	0.57	0.56	0.54	0.49	0.49	0.49	0.49	0.49	0.42
Biological Processes	GO:0060428	GO:0022610	GO:0061028	GO:0043087	GO:0051657	GO:0045216	GO:0051642	GO:0051345	GO:0060479	GO:0000132	GO:0071219	GO:0032526	GO:1903426	GO:0006096	GO:0006486	GO:1903829	GO:1903578	GO:0090313	GO:0012501	GO:1900180	GO:0061085	GO:0010799	GO:0051291	GO:0051569	GO:1901071	GO:0033135	GO:0042327	GO:0051196	GO:0043470	GO:0071396	GO:0045893	GO:0090317	GO:0018023	GO:0006111	GO:1900076	GO:0007623	GO:0043467	GO:0031062	GO:0001933	GO:0002763	GO:0071229	GO:0030162	GO:0016601	GO:0007420	GO:0030852	GO:0008286	GO:1900037	GO:0031667	GO:0048017	GO:0048311	GO:0032496	GO:0009749	GO:0001678	GO:0008361	GO:0046578	GO:0051260	GO:0043967	GO:0031396	GO:0070206	GO:1903321	GO:0010941	GO:2000379	GO:0006357	GO:0009636	GO:0071331	GO:0048585	GO:0051129	GO:0006470	GO:0055059	GO:0045167	GO:0045175	GO:0045185	GO:0007400
GO-Score	0.57	0.57	0.57	0.57	0.57	0.57	0.57	0.57	0.57	0.56	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.42	0.39	0.39	0.39	0.39	0.39
Cellular Component	GO:0072686	GO:0005912	GO:0005911	GO:0031248	GO:0035097	GO:0000785	GO:0030141	GO:0036477	GO:0042995	GO:0044297	GO:0005886	GO:0005829	GO:0045179
GO-Score	0.57	0.57	0.57	0.49	0.49	0.49	0.49	0.49	0.49	0.49	0.46	0.46	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.