I-TASSER results

I-TASSER results for job id Rv3404c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (234 residues)
MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLS
FHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPI
IAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQ
LRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA
Prediction	CEEEEEHCCCCCCCCHHHHHHHHHCCCEHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCCHHHHHCCCEEEEHCCCCCCCCCCHHHHHHHHHCCCEEEEEEEHCCCCCCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHCCCEEEEEEEEHCCCCCCCC
Conf.Score	979999669855688799999998997566776678899989999999999658999999758877999999758958986667898888558999999898656789997688876656788887589999989999999999999999999999989998776898888645689978858999998557767755434788999958999849999999988568898889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA
Prediction	420200044554321102420473705114043242771634502420450255000000020231025300621302000101004222210002002333400000020164120120113351505672315301520262015001400530473715444157641220341446404120645141440221000015312000001337633020232156665478
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEEEHCCCCCCCCHHHHHHHHHCCCEHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCCHHHHHCCCEEEEHCCCCCCCCCCHHHHHHHHHCCCEEEEEEEHCCCCCCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHCCCEEEEEEEEHCCCCCCCC
MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4pzuA

1.00

4.53

MUSTER

VTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4pzuA

1.00

6.96

dPPAS

VTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4pzuA

1.00

6.20

wdPPAS

VTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4pzuA

1.00

5.03

wMUSTER

VTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4pzuA

1.00

5.51

wPPAS

VTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4pzuA

1.00

7.54

dPPAS2

VTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4pzuA

1.00

5.33

PPAS

VTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4pzuA

1.00

6.65

Env-PPAS

VTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA

4yfvA

0.37

0.36

0.98

3.40

MUSTER

MILVISDNYQKNLYLSNEEWSKELFIDYSYSSINIELGMTEIDIKNKLNEL-NDYHLIISAHCKQIFPAHIVNNKLCINIHPGLNPYNRGWFPQVFSILNKKPIGATIHKMDSEVDHGEIYCQEEVSILSHETSIDIYNKVIELEKKLIKNNLLKIINNELQPKLPSQEGNYNSIQDFNKLCKLNLEDNGSLREHIDLLRALTHGDFKNAYFYDENNTKVFVKIELSLSQE---

4yfvA

0.37

0.36

0.99

5.20

dPPAS

KKILVISDNYQLVSYSNEEWSKELFIDYSYSSINRELGMTEIDIKNKNLNELNDYHLIISAHCKQIFPAHIVNNKLCINIHPGLNPYNRGWFPQVFSILNKKPIGATIHKMDSEVDHGEIYCQEEVSILSHETSIDIYNKVIELEKKLIKNNLLKIINNELQPKLPSQEGNYNSIQDFNKLCKLNLEDNGSLREHIDLLRALTHGDFKNAYFYDENNTKVFVKIELSLSQE---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=2.00

Estimated TM-score = 0.99±0.04

Estimated RMSD = 1.8±1.5Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4pzuA	0.978	0.93	0.996	1.000
2	4nv1C	0.924	1.54	0.378	0.983
3	4yfvA	0.921	1.65	0.368	0.983
4	1z7eD	0.833	2.23	0.184	0.940
5	4xczA	0.816	2.71	0.188	0.944
6	2cfiA	0.814	2.73	0.180	0.949
7	2fmtA	0.812	2.62	0.189	0.944
8	4lxqA	0.807	2.64	0.170	0.932
9	3rfoA	0.806	2.53	0.191	0.932
10	3tqqA	0.798	2.59	0.183	0.927

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.35	25	4lxyA	1YA	Rep, Mult	60,63,64,65,66,67,79,91,109,111,112,114,115,116,174,175
2	0.21	17	1rbzA	KT5	Rep, Mult	9,10,11,33,60,62,64,65,66,67,72,79,81,82,90,91,111,112,113,115,116,142,145
3	0.13	18	1menC	GAR	Rep, Mult	9,10,11,12,62,64,80,82,142,145
4	0.10	11	4lxxA	FNF	Rep, Mult	8,62,63,79,81,90,91,92,93,94,95,116,138,175,182,204,207,209
5	0.04	3	2ywrA	CO	Rep, Mult	79,81,116
6	0.02	2	2blnA	U5P	Rep, Mult	14,64,95,176,177,178,179,202,207,208
7	0.02	2	3r8xA	MOE	Rep, Mult	131,133,199,200,223,224
8	0.01	1	1s3iA	BME	Rep, Mult	31,34,63,65
9	0.01	1	3nrbA	NA	Rep, Mult	131,132,133,136
10	0.01	1	1grcA	PO4	Rep, Mult	9,10,11,12,61
11	0.01	1	1s3iA	BME	Rep, Mult	126,127,139
12	0.01	1	4nv1H	TYD	Rep, Mult	92,94,138,204,207,209
13	0.01	1	1s3iA	BME	Rep, Mult	121,162,164

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.502	2fmtA	0.812	2.62	0.189	0.944	2.1.2.9	79,81,107,116
2	0.498	3kcqC	0.616	2.54	0.171	0.709	2.1.2.2	79,81,107,116
3	0.482	3da8A	0.607	2.62	0.176	0.709	2.1.2.2	79,81,107,116
4	0.423	1meoA	0.598	2.60	0.135	0.692	2.1.2.2	79,81
5	0.331	2cfiA	0.814	2.73	0.180	0.949	1.5.1.6	81,116
6	0.173	1z7eD	0.833	2.23	0.184	0.940	2.1.2.-,1.1.1.-	79,81,107,116
7	0.159	2blnA	0.842	2.20	0.183	0.944	2.1.1.2	79,81,107,116
8	0.113	1c2tA	0.631	2.35	0.224	0.714	2.1.2.2	79,81,116
9	0.095	1cddA	0.534	2.54	0.232	0.620	2.1.2.2	79,81,116
10	0.060	2p5uA	0.476	4.87	0.107	0.688	5.1.3.2	NA
11	0.060	1l7qA	0.486	5.43	0.072	0.761	3.1.1.1	NA
12	0.060	3cmmC	0.523	4.68	0.089	0.744	6.3.2.19	104,110
13	0.060	3enkA	0.477	4.89	0.103	0.697	5.1.3.2	NA
14	0.060	3hfsB	0.476	4.77	0.063	0.684	1.3.1.77	NA
15	0.060	2gruA	0.476	5.12	0.057	0.731	4.2.3.-	NA
16	0.060	1q0lA	0.478	4.92	0.065	0.709	1.1.1.267	NA
17	0.060	2c82B	0.476	4.76	0.063	0.671	1.1.1.267	175
18	0.060	2gasA	0.482	5.01	0.074	0.705	1.3.1.45	7,13
19	0.060	3itkC	0.475	5.40	0.046	0.748	1.1.1.22	NA
20	0.060	3lp8A	0.480	4.76	0.071	0.714	6.3.4.13	NA
21	0.060	3eifA	0.493	5.32	0.032	0.778	3.4.21.110	18
22	0.060	1i24A	0.488	4.61	0.064	0.692	3.13.1.1	NA
23	0.060	2c20A	0.485	4.28	0.056	0.658	5.1.3.2	NA
24	0.060	3lxuX	0.485	5.28	0.092	0.765	3.4.14.10	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.70	0.978	0.93	1.00	1.00	4pzuA	GO:0004479 GO:0006413 GO:0009058 GO:0009405 GO:0016742 GO:0071951
1	0.57	0.921	1.65	0.37	0.98	4yfvA	GO:0009058 GO:0016742
2	0.53	0.919	1.53	0.38	0.98	4nv1E	GO:0009058 GO:0016740 GO:0016742
3	0.45	0.623	2.37	0.14	0.71	2ywrA	GO:0004644 GO:0006164 GO:0006189 GO:0009058 GO:0016740 GO:0016742
4	0.37	0.810	2.66	0.18	0.94	3r8xA	GO:0003824 GO:0004479 GO:0006412 GO:0006413 GO:0009058 GO:0016740 GO:0016742 GO:0071951
5	0.35	0.810	2.67	0.20	0.94	3q0iA	GO:0003824 GO:0004479 GO:0006412 GO:0006413 GO:0006431 GO:0009058 GO:0016740 GO:0016742 GO:0071951
6	0.35	0.816	2.71	0.19	0.94	4xczA	GO:0003824 GO:0009058 GO:0016742
7	0.35	0.826	2.44	0.19	0.94	4iqfC	GO:0003824 GO:0004479 GO:0006412 GO:0006413 GO:0009058 GO:0016740 GO:0016742 GO:0071951
8	0.35	0.806	2.64	0.17	0.93	4lxqB	GO:0009058 GO:0016742
9	0.34	0.815	2.57	0.18	0.94	3tqqA	GO:0003824 GO:0004479 GO:0006412 GO:0006413 GO:0009058 GO:0016740 GO:0016742 GO:0071951
10	0.33	0.820	2.56	0.21	0.94	4qpcA	GO:0001755 GO:0003824 GO:0005737 GO:0006730 GO:0007369 GO:0007507 GO:0008152 GO:0009058 GO:0009258 GO:0016155 GO:0016491 GO:0016620 GO:0016742 GO:0016787 GO:0048703 GO:0048885 GO:0055114
11	0.33	0.616	2.54	0.17	0.71	3kcqC	GO:0004644 GO:0006164 GO:0006189 GO:0009058 GO:0016740 GO:0016742
12	0.31	0.609	2.30	0.21	0.68	3p9xA	GO:0004644 GO:0006164 GO:0006189 GO:0009058 GO:0016740 GO:0016742
13	0.31	0.812	2.62	0.19	0.94	2fmtA	GO:0003824 GO:0004479 GO:0005829 GO:0006412 GO:0006413 GO:0009058 GO:0016740 GO:0016742 GO:0019988 GO:0071951
14	0.29	0.611	2.57	0.14	0.71	4ew1A	GO:0000166 GO:0003360 GO:0003824 GO:0004637 GO:0004641 GO:0004644 GO:0005524 GO:0005737 GO:0005829 GO:0006164 GO:0006189 GO:0006544 GO:0008152 GO:0009058 GO:0009113 GO:0009156 GO:0009168 GO:0010033 GO:0010035 GO:0016740 GO:0016742 GO:0016874 GO:0021549 GO:0021987 GO:0046654 GO:0046872 GO:0070062
15	0.29	0.631	2.35	0.22	0.71	1c2tA	GO:0004644 GO:0005829 GO:0006164 GO:0006189 GO:0006974 GO:0009058 GO:0016740 GO:0016742
16	0.28	0.586	2.34	0.15	0.67	4ds3A	GO:0004644 GO:0006164 GO:0006189 GO:0009058 GO:0016740 GO:0016742
17	0.28	0.591	2.28	0.18	0.67	5cjjB	GO:0004644 GO:0006164 GO:0006189 GO:0009058 GO:0016740 GO:0016742
18	0.27	0.628	2.29	0.19	0.71	3aufA	GO:0004644 GO:0006164 GO:0006189 GO:0009058 GO:0016740 GO:0016742
19	0.27	0.723	3.05	0.14	0.89	1zghA	GO:0003824 GO:0009058 GO:0016740 GO:0016742
20	0.27	0.617	2.45	0.19	0.71	3o1lA	GO:0006164 GO:0006189 GO:0006730 GO:0008152 GO:0008864 GO:0009058 GO:0016597 GO:0016742 GO:0016787
21	0.25	0.607	2.62	0.18	0.71	3da8A	GO:0000287 GO:0004644 GO:0006164 GO:0006189 GO:0009058 GO:0016740 GO:0016742 GO:0046653 GO:0046872
22	0.24	0.604	2.13	0.19	0.68	3av3A	GO:0004644 GO:0006164 GO:0006189 GO:0009058 GO:0016740 GO:0016742
23	0.22	0.583	3.07	0.19	0.71	3louA	GO:0006164 GO:0006189 GO:0006730 GO:0008864 GO:0009058 GO:0016742 GO:0016787
24	0.19	0.598	2.71	0.19	0.70	3nrbD	GO:0006164 GO:0006189 GO:0006730 GO:0008152 GO:0008864 GO:0009058 GO:0016597 GO:0016742 GO:0016787
25	0.18	0.833	2.23	0.18	0.94	1z7eD	GO:0003824 GO:0006629 GO:0008152 GO:0009058 GO:0009103 GO:0009245 GO:0016491 GO:0016616 GO:0016740 GO:0016742 GO:0033320 GO:0046493 GO:0046677 GO:0048040 GO:0050662 GO:0055114 GO:0070403 GO:0099618 GO:0099619
26	0.12	0.717	3.23	0.20	0.84	5es8B	GO:0003824 GO:0008152 GO:0009058 GO:0016742 GO:0016874 GO:0017000 GO:0031177

Consensus prediction of GO terms

Molecular Function	GO:0004479	GO:0004644
GO-Score	0.81	0.45
Biological Processes	GO:0006413	GO:0071951	GO:0009405	GO:0006189
GO-Score	0.81	0.81	0.70	0.45
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.