I-TASSER results

I-TASSER results for job id Rv3402c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (412 residues)
MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSFPGPAELAEDFVQIAQ
ANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHVSFGAGTRDRYLLMPSF
TFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRDRIAGILLANVFGVGNPQI
SVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFSFHATKPFAVGEGGALVSR
DPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLRQLVGLDRRLASRRKVLECY
RTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSLRRHAIEARDYYNPPQHRHPY
FVTNAELVESTDLAVTADICSRIVSLPVHDHMAPDDVARVVAAVQEAEVRGE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSFPGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHVSFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRDRIAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFSFHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLRQLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSLRRHAIEARDYYNPPQHRHPYFVTNAELVESTDLAVTADICSRIVSLPVHDHMAPDDVARVVAAVQEAEVRGE
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHHHHCCCCCCEEEHCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCCCCHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHCCEEEEHCCCCCCCEHCCCEHCCCCCCEEEHCCCCCCCCCCCCCEEEHCCCHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHCCCCHHHHHHHHHHHCCCCCHCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCHCCCCCCCCHHHHHHHHHHHHHHHHHCC
Conf.Score	9877788877888876667788766567889888875557778898579999999999998986688879999999999998998668986779999999999998999998899968997689899999989989999668987889999999999986899869997578888878889999999998994999778656876649878586543477668998788877756898698999999999999788888478874556678799999999878889999999999999999997689987899889986689999998588799999999998997655588887558888886777788889689999987543469999999999999999999999789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSFPGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHVSFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRDRIAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFSFHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLRQLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSLRRHAIEARDYYNPPQHRHPYFVTNAELVESTDLAVTADICSRIVSLPVHDHMAPDDVARVVAAVQEAEVRGE
Prediction	7544436544253544244334443252645554143030031315345401500340060010032354044105300621504200000000000000001002412542130000320000000000204030000100350110016203500661273000000000010001105301500662601000200000103134012000100000010113000002401000021650051032014102455030210031034110000001012620451052044005203620671704113236322000000002337405401520474635012001000010200252363156320010140052000230225034610530050034006538
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHHHHCCCCCCEEEHCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCCCCHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHCCEEEEHCCCCCCCEHCCCEHCCCCCCEEEHCCCCCCCCCCCCCEEEHCCCHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHCCCCHHHHHHHHHHHCCCCCHCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCHCCCCCCCCHHHHHHHHHHHHHHHHHCC
MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSFPGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHVSFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRDRIAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFSFHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLRQLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSLRRHAIEARDYYNPPQHRHPYFVTNAELVESTDLAVTADICSRIVSLPVHDHMAPDDVARVVAAVQEAEVRGE

4qgrA

0.24

0.22

0.90

3.79

MUSTER

-------------------------------HHHMQFIDLGAQRARIENRLNAAISKVVAEGRYI-LGPEVAEFEKKLGEYLGVE-HVIACANGTDALQMPLMTR--IGPGHAVFV-PSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQLEAAIAATRLEPKAIIPVDLFGLA-ASYNRITAIAEREGLFIIEDAAQSIGGKR-DNVMCGAFGHVGATSFYPAKPLGCGDGGAMFTNDAELADTLRSVLFHGKGEQYDNVRIGINSRLDTIQAAVLLEKLAILEDEMEARDRIARRYNEALKDV-VKVPELPAGNRSAWAQYSIES-ENRDGLKAQLQAEGIPSVIYYVKPLHLQTAYKHYS--VAPGGLPVSESLPSRILSLPMHPYLSEADQDKIIGVIRGFHGK-K

4qgrA

0.24

0.22

0.90

5.94

dPPAS

-------------------------------HHHMQFIDLGAQRARIENRLNAAISKVVAEGRYI-LGPEVAEFEKKLGEYLGVE-HVIACANGTDALQMPLMTRG-IGPGHAVFV-PSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQLEAAIAATRLEPKAIIPVDLFGLA-ASYNRITAIAEREGLFIIEDAAQSIGGKR-DNVMCGAFGHVGATSFYPAKPLGCGDGGAMFTNDAELADTLRSVLFHGKGEQYDNVRIGINSRLDTIQAAVLLEKLAILEDEMEARDRIARRYNEALKDV-VKVPELPAGNRSAWAQYSIES-ENRDGLKAQLQAEGIPSVIYYVKPLHLQTAYKHYS--VAPGGLPVSESLPSRILSLPMHPYLSEADQDKIIGVIRGFHGKK-

4qgrA

0.24

0.22

0.90

5.62

wdPPAS

-------------------------------HHHMQFIDLGAQRARIENRLNAAISKVVAEGRYI-LGPEVAEFEKKLGEYLGVE-HVIACANGTDALQMPLMTR--IGPGHAVFV-PSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQLEAAIAATRLEPKAIIPVDLFGLA-ASYNRITAIAEREGLFIIEDAAQSIGGKR-DNVMCGAFGHVGATSFYPAKPLGCGDGGAMFTNDAELADTLRSVLFHGKGEQYDNVRIGINSRLDTIQAAVLLEKLAILEDEMEARDRIARRYNEALKDV-VKVPELPAGNRSAWAQYSIES-ENRDGLKAQLQAEGIPSVIYYVKPLHLQTAYKHYS--VAPGGLPVSESLPSRILSLPMHPYLSEADQDKIIGVIRGFHGKK-

4qgrA

0.24

0.22

0.89

4.08

wMUSTER

--------------------------------HHMQFIDLGAQRARIENRLNAAISKVVAEGRYI-LGPEVAEFEKKLGEYLGVE-HVIACANGTDALQMPLMTR--IGPGHAVFV-PSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQLEAAIAATRLEPKAIIPVDLFGLA-ASYNRITAIAEREGLFIIEDAAQSIGGKR-DNVMCGAFGHVGATSFYPAKPLGCGDGGAMFTNDAELADTLRSVLFHGKGEQYDNVRIGINSRLDTIQAAVLLEKLAILEDEMEARDRIARRYNEALKDV-VKVPELPAGNRSAWAQYSIES-ENRDGLKAQLQAEGIPSVIYYVKPLHLQTAYKHYS--VAPGGLPVSESLPSRILSLPMHPYLSEADQDKIIGVIRGFHGK-K

4qgrA

0.24

0.22

0.90

4.21

wPPAS

-------------------------------HHHMQFIDLGAQRARIENRLNAAISKVVAEGRYI-LGPEVAEFEKKLGEYLGVE-HVIACANGTDALQMPLMTR--IGPGHAVFV-PSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQLEAAIAATRLEPKAIIPVDLFGLA-ASYNRITAIAEREGLFIIEDAAQSIGGKR-DNVMCGAFGHVGATSFYPAKPLGCGDGGAMFTNDAELADTLRSVLFHGKGEQYDNVRIGINSRLDTIQAAVLLEKLAILEDEMEARDRIARRYNEALKDV-VKVPELPAGNRSAWAQYSIES-ENRDGLKAQLQAEGIPSVIYYVKPLHLQTAYKHYS--VAPGGLPVSESLPSRILSLPMHPYLSEADQDKIIGVIRGFHGK-K

4qgrA

0.24

0.22

0.90

5.65

dPPAS2

-------------------------------HHHMQFIDLGAQRARIENRLNAAISKVVAEGRYI-LGPEVAEFEKKLGEYLGVE-HVIACANGTDALQMPLMTRG-IGPGHAVFV-PSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQLEAAIAATRLEPKAIIPVDLFGLA-ASYNRITAIAEREGLFIIEDAAQSIGGKR-DNVMCGAFGHVGATSFYPAKPLGCGDGGAMFTNDAELADTLRSVLFHGKGEQYDNVRIGINSRLDTIQAAVLLEKLAILEDEMEARDRIARRYNEALKDV-VKVPELPAGNRSAWAQYSIES-ENRDGLKAQLQAEGIPSVIYYVKPLHLQTAYKHYS--VAPGGLPVSESLPSRILSLPMHPYLSEADQDKIIGVIRGFHGKK-

4qgrA

0.24

0.22

0.90

4.20

PPAS

-------------------------------HHHMQFIDLGAQRARIENRLNAAISKVVAEGRYI-LGPEVAEFEKKLGEYLGVE-HVIACANGTDALQMPLMTR--IGPGHAVFV-PSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQLEAAIAATRLEPKAIIPVDLFGLA-ASYNRITAIAEREGLFIIEDAAQSIGGKR-DNVMCGAFGHVGATSFYPAKPLGCGDGGAMFTNDAELADTLRSVLFHGKGEQYDNVRIGINSRLDTIQAAVLLEKLAILEDEMEARDRIARRYNEALKDV-VKVPELPAGNRSAWAQYSIES-ENRDGLKAQLQAEGIPSVIYYVKPLHLQTAYKHYS--VAPGGLPVSESLPSRILSLPMHPYLSEADQDKIIGVIRGFHGKK-

4qgrA

0.24

0.22

0.90

5.66

Env-PPAS

-------------------------------HHHMQFIDLGAQRARIENRLNAAISKVVAEGRYI-LGPEVAEFEKKLGEYLGVE-HVIACANGTDALQMPLMTRG-IGPGHAVFV-PSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQLEAAIAATRLEPKAIIPVDLFGLA-ASYNRITAIAEREGLFIIEDAAQSIGGKR-DNVMCGAFGHVGATSFYPAKPLGCGDGGAMFTNDAELADTLRSVLFHGKGEQYDNVRIGINSRLDTIQAAVLLEKLAILEDEMEARDRIARRYNEALKDV-VKVPELPAGNRSAWAQYSIES-ENRDGLKAQLQAEGIPSVIYYVKPLHLQTAYKHYS--VAPGGLPVSESLPSRILSLPMHPYLSEADQDKIIGVIRGFHGKK-

2ogaA

0.24

0.22

0.89

3.72

MUSTER

-------------------------------TPRVPFLDLKAAYEELRAETDAAIARVLDSGRYL-LGPELEGFEAEFAAYCETD-HAVGVNSGMDALQLALRGL--IGPGDEVIV-PSHTYIASWLAVSATGATPVPVEPHEDHPTLDPLLVEKAI---TPRTRALLPVHLYGHP-ADMDALRELADRHGLHIVEDAAQAHGARY-RGRRIGAGSSVAAFSFYPGKNLGCGDGGAVVTGDPELAERLRMLRNYGSRQKYSHETKGTNSRLDEMQAAVLRIRLAHLDSWNGRRSALAAEYLSGLAGLGIGLPVTAPDTDPVWHLFTVRT-ERRDELRSHLDARGIDTLTHYPVPVHLSPAYAGEA--PPEGSLPRAESFARQVLSLPIGPHLERPQALRVIDAVREWAERVD

3frkA

0.24

0.21

0.88

5.84

dPPAS

--------------------------------MKISFASFKPMHDEIEYEIKFKFEEIYKRNWFI-LGDEDKKFEQEFADYCNVN-YCIGCGNGLDALHLILKGYD-IGFGDEVIV-PSNTFIATALAVSYTGAKPIFVEPDIRTYNIDPSLIESAI---TEKTKAIIAVHLYGQP-ADMDEIKRIAKKYNLKLIEDAAQAHGSLY-KGMKVGSLGDAAGFSFYPAKNLGSGDGGAVVTNDKDLAEKIKALSNYGSEKKYHHIYKGFNSRLDELQAGFLRVKLKYLDKWNEERRKIAQKYIAGINNPNVIIPVEADYAKHVWYTFVIRS-EKRDELQKYLNNNGIGTLIHYPIPIHLQQAYKDLG--FKTGNFPIAEKIANEILSIPIWYGMKNEEIEYVIDKINAWK----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.52

Estimated TM-score = 0.78±0.09

Estimated RMSD = 5.8±3.6Å

Download Model 2

C-score=-0.94

Download Model 3

C-score=-1.02

Download Model 4

C-score=-0.24

Download Model 5

C-score=0.60

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4qgrA	0.877	1.15	0.238	0.896
2	2ogaA	0.858	1.71	0.238	0.896
3	3frkA	0.848	1.69	0.234	0.883
4	3bcxA	0.842	2.45	0.192	0.905
5	3nu7A	0.838	1.42	0.224	0.867
6	1b9iA	0.832	2.07	0.219	0.888
7	4k2bA	0.830	2.17	0.182	0.888
8	2fniA	0.827	2.02	0.228	0.883
9	3dr4C	0.827	1.81	0.261	0.874
10	4lc3A	0.826	2.06	0.259	0.881

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.59	88	1b9iA	PXG	Rep, Mult	93,94,95,98,121,122,124,170,197,199,200,222,224,227,385
2	0.36	51	3frkA	TQP	Rep, Mult	37,40,93,94,95,122,124,170,197,199,200,222,224,225,226,227,323,348,350,351
3	0.08	14	2po3A	T4K	Rep, Mult	62,63,64,65,66,268
4	0.06	12	3dr7A	GPD	Rep, Mult	37,40,122,224,225,226,227,323,346,348,351
5	0.06	12	3nubA	UD0	Rep, Mult	254,268,270
6	0.05	10	3frkA	TQP	Rep, Mult	62,63,64,65,254,259,268
7	0.03	6	1i48L	PLP	Rep, Mult	93,94,95,122,197,222,224,227
8	0.01	2	2ogaA	PGU	Rep, Mult	254,259,260,268,270
9	0.00	1	2gmsA	MG	Rep, Mult	392,395
10	0.00	1	1mdxA	AKG	Rep, Mult	224,233
11	0.00	1	3dr7C	GPD	Rep, Mult	62,63,64,65
12	0.00	1	2fn60	III	Rep, Mult	39,52,55,59,60,62,64,65,66,92,93,95,103,122,127,128,130,131,224,232,233,254,256,261,262,263,264,265,267,268,269,270,272,274,275,337,347,348,358,359,360
13	0.00	1	4ytjE	TYD	Rep, Mult	40,225,226
14	0.00	1	3ju7B	CA	Rep, Mult	53,284

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.373	1lc7A	0.665	3.74	0.105	0.803	4.1.1.81	122,197,227;159
2	0.311	1p3wA	0.688	3.90	0.101	0.835	2.8.1.7,4.4.1.-	197,227
3	0.269	2e7iA	0.647	3.87	0.118	0.782	2.5.1.73	222,227
4	0.262	1u08A	0.681	4.04	0.088	0.840	2.6.1.-	95
5	0.228	2f8jC	0.633	3.67	0.107	0.762	2.6.1.9	199,230
6	0.124	3cq5B	0.674	3.72	0.116	0.816	2.6.1.9	227
7	0.119	1v72A	0.664	3.14	0.107	0.772	4.1.2.26	NA
8	0.116	1v2eA	0.673	4.14	0.121	0.835	2.6.1.15	122,197
9	0.115	1fg3A	0.666	3.59	0.122	0.794	2.6.1.9	227
10	0.112	1p3wB	0.688	3.88	0.099	0.835	2.8.1.7	224
11	0.110	2wk8B	0.668	3.69	0.125	0.784	2.3.-.-	120,197,227
12	0.108	2wk7A	0.687	3.89	0.122	0.818	2.3.-.-	120,197
13	0.105	1uu1C	0.640	3.62	0.113	0.762	2.6.1.9	197,227
14	0.101	3eucB	0.653	3.80	0.137	0.784	2.6.1.9	93,122
15	0.094	1pffA	0.622	3.18	0.105	0.709	4.4.1.11	227
16	0.060	1b9hA	0.832	2.07	0.221	0.888	4.2.1.-	122,197,227
17	0.060	2vmzA	0.690	3.94	0.101	0.830	2.1.2.1	199
18	0.060	1iayA	0.689	4.24	0.106	0.862	4.4.1.14	NA
19	0.060	1i29A	0.694	3.93	0.079	0.852	4.4.1.16	276
20	0.060	1ejiA	0.689	3.92	0.091	0.830	2.1.2.1	135
21	0.060	1mdxA	0.814	2.06	0.235	0.869	2.6.1.87	197,225,227
22	0.060	2zc0A	0.683	4.36	0.112	0.867	2.6.1.44	197
23	0.060	1ax4A	0.687	3.96	0.105	0.845	4.1.99.1	122,197
24	0.060	3a2bA	0.698	3.62	0.113	0.823	2.3.1.50	197,227
25	0.060	2c7tA	0.820	2.25	0.229	0.881	2.6.1.-	NA
26	0.060	3b46B	0.687	4.17	0.077	0.852	2.6.1.7	NA
27	0.060	1dj9A	0.694	3.78	0.116	0.823	2.3.1.47	197,227,229
28	0.060	1szkC	0.694	3.98	0.092	0.837	2.6.1.19,2.6.1.22	94,205,210
29	0.060	2r5cA	0.684	4.29	0.096	0.864	2.6.1.64	122,197
30	0.060	2jisB	0.688	3.97	0.092	0.835	4.1.1.29	197,227
31	0.060	1rv3B	0.689	3.91	0.093	0.830	2.1.2.1	211
32	0.060	1sf2A	0.695	3.92	0.109	0.835	2.6.1.19,2.6.1.22	197,227
33	0.060	2dkjA	0.687	3.94	0.119	0.828	2.1.2.1	197,227
34	0.060	2cfbA	0.655	3.77	0.128	0.777	5.4.3.8	94,100,102,124,201

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.49	0.832	2.07	0.22	0.89	1b9hA	GO:0003824 GO:0016740 GO:0016829 GO:0017000
1	0.47	0.844	1.34	0.23	0.87	3nu7B	GO:0000271 GO:0003824 GO:0008483 GO:0009103 GO:0009243 GO:0016740 GO:0030170 GO:0071555
2	0.44	0.877	1.15	0.24	0.90	4qgrA	GO:0003824 GO:0008483 GO:0016740
3	0.43	0.827	2.02	0.23	0.88	2fniA	GO:0003824 GO:0008483 GO:0016740
4	0.43	0.828	1.85	0.24	0.88	4zahA	GO:0003824 GO:0009246 GO:0016740 GO:0019180 GO:0030170
5	0.42	0.858	1.71	0.24	0.90	2ogaA	GO:0003824 GO:0008483 GO:0016740 GO:0017000 GO:0030170 GO:0033068
6	0.41	0.820	2.25	0.23	0.88	2c7tA	GO:0003824 GO:0008483 GO:0016740 GO:0017000
7	0.40	0.826	2.06	0.26	0.88	4lc3A	GO:0003824
8	0.40	0.848	1.69	0.23	0.88	3frkA	GO:0003824
9	0.39	0.814	2.06	0.23	0.87	1mdxA	GO:0003824 GO:0006629 GO:0008483 GO:0009103 GO:0009245 GO:0016740 GO:0046493 GO:0046677 GO:0099621
10	0.39	0.794	2.59	0.22	0.87	5k8bA	GO:0000271 GO:0003824 GO:0008483 GO:0009103 GO:0016740
11	0.38	0.795	2.38	0.30	0.87	3ju7A	GO:0003824
12	0.37	0.816	2.40	0.24	0.89	2po3A	GO:0003824
13	0.37	0.846	1.77	0.18	0.89	3uwcA	GO:0003824 GO:0008483 GO:0016740
14	0.37	0.842	2.45	0.19	0.91	3bcxA	GO:0003824 GO:0008483 GO:0016740
15	0.37	0.823	1.94	0.17	0.87	2gmsA	GO:0003824 GO:0008483 GO:0016740
16	0.37	0.827	1.81	0.26	0.87	3dr4C	GO:0003824 GO:0008483 GO:0009103 GO:0009243 GO:0016740
17	0.35	0.820	2.22	0.22	0.88	4xauB	GO:0003824 GO:0008483 GO:0016740
18	0.34	0.811	1.86	0.22	0.86	4zasA	GO:0003824
19	0.34	0.836	2.04	0.19	0.89	4k2mA	GO:0003824 GO:0008483 GO:0016740 GO:0017000 GO:0030170
20	0.29	0.666	3.25	0.13	0.76	3cogD	GO:0000098 GO:0003824 GO:0003962 GO:0004123 GO:0005516 GO:0005634 GO:0005737 GO:0005829 GO:0006534 GO:0008652 GO:0016829 GO:0016846 GO:0018272 GO:0019343 GO:0019344 GO:0019346 GO:0030170 GO:0030968 GO:0043066 GO:0043123 GO:0044524 GO:0044540 GO:0047982 GO:0051092 GO:0051289 GO:0070062 GO:0070814 GO:0071266 GO:0080146 GO:1904831 GO:2001234
21	0.28	0.826	1.83	0.21	0.87	4ztcA	GO:0003824 GO:0006486 GO:0008483 GO:0016740 GO:0047302
22	0.24	0.646	3.71	0.13	0.76	1pg8A	GO:0003824 GO:0016829 GO:0018826 GO:0030170 GO:0047982
23	0.23	0.673	4.14	0.12	0.83	1v2eA	GO:0003824 GO:0008483 GO:0009058 GO:0016740 GO:0030170
24	0.13	0.678	4.16	0.12	0.85	2o0rA	GO:0003824 GO:0005618 GO:0005737 GO:0008483 GO:0008652 GO:0009016 GO:0009058 GO:0009085 GO:0009089 GO:0016740 GO:0030170
25	0.11	0.670	3.24	0.15	0.78	2fm1D	GO:0003824 GO:0004793 GO:0005829 GO:0006520 GO:0006545 GO:0006567 GO:0008732 GO:0016829 GO:0046872
26	0.11	0.681	4.04	0.09	0.84	1u08A	GO:0003824 GO:0005737 GO:0008483 GO:0009058 GO:0010326 GO:0016740 GO:0030170
27	0.11	0.681	4.21	0.10	0.85	1j32A	GO:0003824 GO:0004069 GO:0008483 GO:0009058 GO:0016740 GO:0030170 GO:0080130
28	0.11	0.668	4.12	0.11	0.83	2o1bA	GO:0003824 GO:0008483 GO:0009058 GO:0016740 GO:0030170
29	0.10	0.667	4.24	0.10	0.84	4my5A	GO:0003824 GO:0008483 GO:0009058 GO:0016740 GO:0030170
30	0.10	0.670	4.26	0.09	0.84	1gd9A	GO:0003824 GO:0008483 GO:0009058 GO:0016740 GO:0030170
31	0.10	0.647	4.43	0.10	0.83	2z61A	GO:0003824 GO:0005737 GO:0008483 GO:0009058 GO:0016740 GO:0030170
32	0.10	0.683	4.36	0.11	0.87	2zc0A	GO:0003824 GO:0008453 GO:0008483 GO:0009058 GO:0016740 GO:0030170
33	0.10	0.679	4.36	0.10	0.87	3e2yA	GO:0003824 GO:0005739 GO:0006103 GO:0006520 GO:0008483 GO:0009058 GO:0016212 GO:0016740 GO:0016829 GO:0030170 GO:0042803 GO:0044822 GO:0047315 GO:0047804 GO:0070189 GO:0097052
34	0.09	0.650	4.84	0.12	0.86	4cvqA	GO:0003824 GO:0004021 GO:0005737 GO:0006523 GO:0006974 GO:0008483 GO:0009058 GO:0016740 GO:0019272 GO:0030170 GO:0030632 GO:0046677
35	0.09	0.652	4.44	0.12	0.83	1b5oA	GO:0003824 GO:0004069 GO:0005737 GO:0008483 GO:0009058 GO:0016740 GO:0030170 GO:0080130
36	0.09	0.664	4.59	0.13	0.86	1xi9C	GO:0003824 GO:0008483 GO:0009058 GO:0016740 GO:0030170
37	0.09	0.697	3.73	0.11	0.83	3mc6A	GO:0003824 GO:0006629 GO:0006665 GO:0008117 GO:0009267 GO:0016829 GO:0016831 GO:0019722 GO:0019752 GO:0030170 GO:0032541 GO:0097038
38	0.09	0.687	4.17	0.08	0.85	3b46B	GO:0001558 GO:0003824 GO:0004061 GO:0005737 GO:0005739 GO:0008483 GO:0009058 GO:0016212 GO:0016740 GO:0030170 GO:0034276 GO:0047536 GO:0097053
39	0.09	0.670	4.56	0.09	0.87	3fvsA	GO:0003824 GO:0005654 GO:0005737 GO:0005829 GO:0006559 GO:0006569 GO:0006575 GO:0008483 GO:0008652 GO:0009058 GO:0016212 GO:0016740 GO:0016829 GO:0030170 GO:0042803 GO:0047312 GO:0047316 GO:0047804 GO:0047945 GO:0070189 GO:0097053
40	0.07	0.694	3.92	0.11	0.85	2c44C	GO:0003824 GO:0005737 GO:0005829 GO:0006520 GO:0006568 GO:0006569 GO:0009034 GO:0009072 GO:0016020 GO:0016829 GO:0016830 GO:0030170 GO:0030955 GO:0042802 GO:0060187 GO:0080146
41	0.07	0.626	3.95	0.10	0.78	4w1yB	GO:0003824 GO:0005737 GO:0005829 GO:0006520 GO:0006568 GO:0006569 GO:0009034 GO:0009072 GO:0016020 GO:0016829 GO:0016830 GO:0030170 GO:0030955 GO:0042802 GO:0060187 GO:0080146

Consensus prediction of GO terms

Molecular Function	GO:0030170	GO:0016829	GO:0019180
GO-Score	0.69	0.49	0.43
Biological Processes	GO:0017000	GO:0009243	GO:0071555	GO:0009246
GO-Score	0.49	0.47	0.47	0.43
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.