I-TASSER results

I-TASSER results for job id Rv3395c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (204 residues)
MTAAFASDQRLENGAEQLESLRRQMALLSEKVSGGPSRSGDLVPAGPVSLPPGTVGVLSG
ARSLLLSMVASVTAAGGNAAIVGQPDIGLLAAVEMGADLSRLAVIPDPGTDPVEVAAVLI
DGMDLVVLGLGGRRVTRARARAVVARARQKGCTLLVTDGDWQGVSTRLAARVCGYEITPA
LRGVPTPGLGRISGVRLQINGRGR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MTAAFASDQRLENGAEQLESLRRQMALLSEKVSGGPSRSGDLVPAGPVSLPPGTVGVLSGARSLLLSMVASVTAAGGNAAIVGQPDIGLLAAVEMGADLSRLAVIPDPGTDPVEVAAVLIDGMDLVVLGLGGRRVTRARARAVVARARQKGCTLLVTDGDWQGVSTRLAARVCGYEITPALRGVPTPGLGRISGVRLQINGRGR
Prediction	CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHHHHCCCCCCEEHCCCCCCCHHHHHHHHHCCCEEEEHCCCCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCCEEEEEEEEEEEEEHCCCCCCCCCCCEEEEEEEEEEEEEHCC
Conf.Score	998755678899999999999998544556667788657887567888878987999968758999999999856998999788678989999989975548985899985999999997558599985888789988999999999977989999589898757999999768875788888888765688899999999859
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MTAAFASDQRLENGAEQLESLRRQMALLSEKVSGGPSRSGDLVPAGPVSLPPGTVGVLSGARSLLLSMVASVTAAGGNAAIVGQPDIGLLAAVEMGADLSRLAVIPDPGTDPVEVAAVLIDGMDLVVLGLGGRRVTRARARAVVARARQKGCTLLVTDGDWQGVSTRLAARVCGYEITPALRGVPTPGLGRISGVRLQINGRGR
Prediction	744435546525633541450364144265534524532241133344204332113044221000100020165321000011440112103612130420000143363113001000410100002335341444423403230364400000043516314130414334042133444344402020241403031558
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHHHHCCCCCCEEHCCCCCCCHHHHHHHHHCCCEEEEHCCCCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCCEEEEEEEEEEEEEHCCCCCCCCCCCEEEEEEEEEEEEEHCC
MTAAFASDQRLENGAEQLESLRRQMALLSEKVSGGPSRSGDLVPAGPVSLPPGTVGVLSGARSLLLSMVASVTAAGGNAAIVGQPDIGLLAAVEMGADLSRLAVIPDPGTDPVEVAAVLIDGMDLVVLGLGGRRVTRARARAVVARARQKGCTLLVTDGDWQGVSTRLAARVCGYEITPALRGVPTPGLGRISGVRLQINGRGR

1ubgA1

0.25

0.99

2.03

MUSTER

MAQAPDREKALELAMAQIDKNFGKGSVMRQPISVIPTGSISLDVLGIGGLPRGRVIEIYGKTTVALHAVANAQAAGGIAAFIDEHALDPEYAKKLGVDTDSLLVSPDTGEQALEIADMLVRALDIIVIDSVAALVPRAEARLMSQALRKMTGALNNSGTTAIFIN--LREKIGVMFGSPETTTGGK-ALKFYASVRLDVRRIET

1ubgA1

0.23

0.99

1.87

dPPAS

AQQAPDREKALELAMAQIDKNFGKGSVMRLGEEVRQPSISLDVALGIGGLPRGRVIEIYGKTTVALHAVANAQAAGGIAAFIDAEHLDPEYAKKLGVDTDSLLVSPDTGEQALEIADMLVRALDIIVIDSVAALVPRAEARLMSQALRKMTGALNNSGTTAIFINLREKIGVMF---GSPETTTGGKALKFYASVRLDVRRIET

1ubgA1

0.24

0.99

3.18

wdPPAS

MAQAPDREKALELAMAQIDKNFGKGSVMRLGISVIPTGISLDVALGIGGLPRGRVIEIYGKTTVALHAVANAQAAGGIAAFIDAEHLDPEYAKKLGVDTDSLLVSPDTGEQALEIADMLV-ALDIIVIDSVAALVPRAEARLMSQALRKMTGALNNSGTTAIFINQ-LREKIGVMFG-SPETTTGGKALKFYASVRLDVRRIET

1ubgA1

0.24

0.99

2.62

wMUSTER

AQQAPDREKALELAMAQIDKNFGKGSVMRLGISVIPTGSISLDVLGIGGLPRGRVIEIYGKTTVALHAVANAQAAGGIAAFIDAEHLDPEYAKKLGVDTDSLLVSPDTGEQALEIADMLVRALDIIVIDSVAALVPRAEARLMSQALRKMTGALNNSGTTAIFINQ-LREKIGVMFGSP-ETTTGGKALKFYASVRLDVRRIET

1ubgA1

0.24

0.98

3.56

wPPAS

MAQAPDREKALELAMAQIDKNFGKGSVMRLGISVIPTGISLDVALGIGGLPRGRVIEIYGKTTVALHAVANAQAAGGIAAFIDAEHLDPEYAKKLGVDTDSLLVSPDTGEQALEIADMLV-ALDIIVIDSVAALVPRAEARLMSQALRKMTGALNNSGTTAIFIN--LREKIGVMFG-SPETTTGGKALKFYASVRLDVRRIET

1ubgA1

0.24

0.99

3.36

dPPAS2

MAQAPDREKALELAMAQIDKNFGKGSVMRQPISVIPTGISLDVALGIGGLPRGRVIEIYGKTTVALHAVANAQAAGGIAAFIDAEHLDPEYAKKLGVDTDSLLVSPDTGEQALEIADMLVRALDIIVIDSVAALVPRAEARLMSQALRKMTGALNNSGTTAIFINLREKIGVMF---GSPETTTGGKALKFYASVRLDVRRIET

1ubgA1

0.25

0.24

0.98

2.59

PPAS

MAQAPDREKALELAMAQIDKNFGKGSVMRQPISVIPTGISLDVALGIGGLPRGRVIEIYGKTTVALHAVANAQAAGGIAAFIDAEHLDPEYAKKLGVDTDSLLVSPDTGEQALEIADMLV-ALDIIVIDSVAALVPRAEARLMSQALRKMTGALNNSGTTAIFINLREKIGVM----GSPETTTGGKALKFYASVRLDVRRIET

1ubgA1

0.24

0.99

3.51

Env-PPAS

MAQAPDREKALELAMAQIDKNFGKGSVMRQPISVIPTGISLDVALGIGGLPRGRVIEIYGKTTVALHAVANAQAAGGIAAFIDAEHLDPEYAKKLGVDTDSLLVSPDTGEQALEIADMLVRALDIIVIDSVAALVPRAEARLMSQALRKMTGALNNSGTTAIFINLREKIGVMF---GSPETTTGGKALKFYASVRLDVRRIET

1xp8A1

0.23

0.20

0.89

1.98

MUSTER

---AKERSKAIETAMSQIEKAFGKGSIMKLDVQVVSTGSLSLDLLGVGGIPRGRITEIYGKTTLALAIVAQAQKAGGTCAFIDEHALDPVYARALGVNTDELLVSPDNGEQALEIMELLVRAIDVVVVDSVAALTP-LQARLMSQALRKLTAILSKTGTAAIFINQ------------------GGRALKFYASVRLDVRKIGQ

1xp8A1

0.21

0.19

0.90

1.81

dPPAS

---AKERSKAIETAMSQIEKAFGKGSIMKLGAESKLDSLSLDLALGVGGIPRGRITEIYGKTTLALAIVAQAQKAGGTCAFIDAEHLDPVYARALGVNTDELLVSPDNGEQALEIMELLVRAIDVVVVDSVAALTPGLQARLMSQALRKLTAILSKTGT------------AAIFIN-----QVGGRALKFYASVRLDVRKIGQ

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.43

Estimated TM-score = 0.77±0.10

Estimated RMSD = 4.5±3.0Å

Download Model 2

C-score=-4.17

Download Model 3

C-score=-4.55

Download Model 4

C-score=-5.00

Download Model 5

C-score=-0.77

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1ubgA1	0.911	2.05	0.213	0.990
2	3hr8A1	0.844	2.10	0.166	0.936
3	1xp8A1	0.840	1.56	0.196	0.897
4	3cmuA	0.792	3.04	0.180	0.926
5	1xu4A2	0.694	3.26	0.110	0.843
6	1e0kA	0.671	3.39	0.074	0.863
7	1szpA	0.668	2.90	0.097	0.799
8	2zucB	0.667	3.02	0.111	0.799
9	1q57A	0.660	3.26	0.072	0.828
10	3dvlA2	0.659	3.14	0.102	0.814

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.33	37	2zriA	ADP	Rep, Mult	61,62,63,88,91,201
2	0.12	13	3cmvD	MG	Rep, Mult	61,62,129
3	0.05	5	4j7cD	ATP	Rep, Mult	62,200
4	0.04	5	3cmwA	NUC	Rep, Mult	140,141,144,148,167,168,169,170,171,186,187
5	0.02	2	3cmtA	ALF	Rep, Mult	191
6	0.02	2	3cmxD	NUC	Rep, Mult	140,141,144,186,187
7	0.01	1	2g88A	DTP	Rep, Mult	40,43
8	0.01	1	2zrcA	PO4	Rep, Mult	108,110,111,114,115,116
9	0.01	1	2gblB	MG	Rep, Mult	61,85,166
10	0.01	1	1xmvA	MG	Rep, Mult	19,24,27,28
11	0.01	1	3s99A	IOD	Rep, Mult	72,124,125,160

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	1g64B	0.538	3.28	0.086	0.667	2.5.1.17	NA
2	0.060	3gqbA	0.642	3.03	0.108	0.794	3.6.3.14	NA
3	0.060	1w36C	0.365	6.37	0.075	0.711	3.1.11.5	99
4	0.060	2r9vA	0.631	3.28	0.065	0.794	3.6.3.14	145
5	0.060	1xfkA	0.523	4.99	0.044	0.819	3.5.3.8	NA
6	0.060	2zrpA	0.853	1.55	0.227	0.907	3.4.99.37	168
7	0.060	3crvA	0.517	3.93	0.059	0.711	3.6.4.12	NA
8	0.060	2qe7D	0.646	3.02	0.076	0.794	3.6.1.34	NA
9	0.060	3l9oA	0.550	4.36	0.050	0.794	3.6.4.13	61
10	0.060	2dpyB	0.624	3.31	0.075	0.799	3.6.3.14	NA
11	0.060	1w4rA	0.509	2.81	0.111	0.608	2.7.1.21	197
12	0.060	2ocaA	0.559	4.02	0.069	0.784	3.6.4.12	63
13	0.060	1pq3D	0.513	4.68	0.100	0.784	3.5.3.1	NA
14	0.060	1cbuB	0.513	3.51	0.072	0.642	2.7.1.156,2.7.7.62	60,63,197
15	0.060	2aebA	0.514	4.63	0.077	0.784	3.5.3.1	86
16	0.060	1w36D	0.546	4.50	0.070	0.774	3.1.11.5	119,163
17	0.060	1fx0A	0.644	3.07	0.065	0.799	3.6.3.14	NA
18	0.060	3kx2B	0.536	4.10	0.086	0.750	3.6.4.13	NA
19	0.060	3fksF	0.621	3.62	0.081	0.804	3.6.3.14	NA
20	0.060	3b2qA	0.597	3.80	0.059	0.789	3.6.3.14	191

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.882	1.87	0.22	0.95	1mo4A	GO:0000150 GO:0000166 GO:0000287 GO:0000400 GO:0000725 GO:0000730 GO:0003677 GO:0003690 GO:0003697 GO:0004518 GO:0004519 GO:0004520 GO:0005524 GO:0005737 GO:0005829 GO:0006259 GO:0006281 GO:0006310 GO:0006312 GO:0006314 GO:0006974 GO:0008094 GO:0009432 GO:0009650 GO:0010212 GO:0016539 GO:0016787 GO:0016887 GO:0030145 GO:0042148 GO:0046677 GO:0090305
1	0.19	0.844	2.10	0.17	0.94	3hr8A	GO:0000150 GO:0000166 GO:0000400 GO:0000730 GO:0003677 GO:0003684 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0005737 GO:0005829 GO:0006259 GO:0006281 GO:0006310 GO:0006312 GO:0006974 GO:0008094 GO:0009432 GO:0010212 GO:0042148
2	0.19	0.853	2.00	0.22	0.92	2g88A	GO:0000166 GO:0003677 GO:0003697 GO:0005524 GO:0006259 GO:0006281 GO:0006310 GO:0006974 GO:0008094 GO:0009432
3	0.19	0.840	1.56	0.20	0.90	1xp8A	GO:0000150 GO:0000166 GO:0000400 GO:0000730 GO:0003677 GO:0003684 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0005737 GO:0005829 GO:0006259 GO:0006281 GO:0006302 GO:0006310 GO:0006312 GO:0006974 GO:0008094 GO:0009432 GO:0010212 GO:0042148
4	0.19	0.846	2.43	0.17	0.94	3cmvA	GO:0000150 GO:0000166 GO:0000400 GO:0000730 GO:0003677 GO:0003684 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0005737 GO:0005829 GO:0006259 GO:0006281 GO:0006310 GO:0006312 GO:0006974 GO:0008094 GO:0009432 GO:0010212 GO:0042148 GO:0048870
5	0.18	0.820	1.89	0.18	0.89	3cmvG	GO:0000150 GO:0000166 GO:0000400 GO:0000730 GO:0003677 GO:0003684 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0005737 GO:0005829 GO:0006259 GO:0006281 GO:0006310 GO:0006312 GO:0006974 GO:0008094 GO:0009432 GO:0010212 GO:0042148 GO:0048870
6	0.17	0.810	1.80	0.17	0.87	1xmvA	GO:0000150 GO:0000166 GO:0000400 GO:0000730 GO:0003677 GO:0003684 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0005737 GO:0005829 GO:0006259 GO:0006281 GO:0006310 GO:0006312 GO:0006974 GO:0008094 GO:0009432 GO:0010212 GO:0042148 GO:0048870
7	0.13	0.668	2.90	0.10	0.80	1szpA	GO:0000150 GO:0000166 GO:0000228 GO:0000400 GO:0000709 GO:0000722 GO:0000724 GO:0000730 GO:0000794 GO:0003677 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0006259 GO:0006281 GO:0006310 GO:0006974 GO:0007131 GO:0008094 GO:0010212 GO:0030491 GO:0042148 GO:0042802 GO:0045002 GO:0070192 GO:1990426
8	0.10	0.688	3.02	0.09	0.82	3ew9A	GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0006259 GO:0006281 GO:0006310 GO:0006974 GO:0008094
9	0.10	0.693	3.19	0.10	0.84	1xu4A	GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0006259 GO:0006281 GO:0006310 GO:0006974 GO:0008094
10	0.10	0.667	3.02	0.11	0.80	2zucB	GO:0000150 GO:0000166 GO:0000400 GO:0000730 GO:0003677 GO:0003684 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0006259 GO:0006281 GO:0006310 GO:0006312 GO:0006974 GO:0008094 GO:0010212 GO:0042148
11	0.09	0.644	3.07	0.07	0.80	1fx0A	GO:0000166 GO:0005524 GO:0006754 GO:0006810 GO:0006811 GO:0009507 GO:0009535 GO:0009536 GO:0009579 GO:0015986 GO:0015991 GO:0015992 GO:0016020 GO:0016787 GO:0016820 GO:0033178 GO:0045261 GO:0046034 GO:0046933 GO:0046961
12	0.09	0.657	2.80	0.14	0.79	2cvfA	GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0006281 GO:0006310 GO:0006974 GO:0008094 GO:0016887
13	0.09	0.678	2.82	0.07	0.80	4hyyA	GO:0000150 GO:0000166 GO:0000400 GO:0000730 GO:0000781 GO:0000794 GO:0001541 GO:0001556 GO:0003677 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0006259 GO:0006281 GO:0006312 GO:0007049 GO:0007126 GO:0007129 GO:0007131 GO:0007141 GO:0007276 GO:0007283 GO:0007286 GO:0007292 GO:0008094 GO:0010212 GO:0042148 GO:0051321 GO:0070192
14	0.08	0.653	2.42	0.14	0.75	3io5B	GO:0000166 GO:0003677 GO:0003697 GO:0005524 GO:0006259 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0008094
15	0.07	0.650	2.88	0.10	0.77	3fyhA	GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0006259 GO:0006281 GO:0006310 GO:0006974 GO:0008094
16	0.07	0.626	2.53	0.09	0.73	1n0wA	GO:0000150 GO:0000166 GO:0000228 GO:0000400 GO:0000722 GO:0000724 GO:0000730 GO:0000731 GO:0000732 GO:0000784 GO:0000785 GO:0000790 GO:0000793 GO:0000794 GO:0000800 GO:0001932 GO:0003677 GO:0003682 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005739 GO:0005759 GO:0005815 GO:0005856 GO:0006259 GO:0006268 GO:0006281 GO:0006310 GO:0006312 GO:0006974 GO:0007126 GO:0007127 GO:0007131 GO:0008022 GO:0008094 GO:0009636 GO:0010165 GO:0010569 GO:0010833 GO:0014070 GO:0016605 GO:0031297 GO:0032200 GO:0035861 GO:0042148 GO:0042493 GO:0042802 GO:0043142 GO:0048471 GO:0051106 GO:0051260 GO:0070182 GO:0070192 GO:0071312 GO:0071479 GO:0071480 GO:0072711 GO:0072719 GO:0072757 GO:1902521 GO:1990414 GO:1990426
17	0.07	0.624	3.02	0.09	0.76	4wiaA	GO:0000166 GO:0005524 GO:0097589
18	0.07	0.616	2.84	0.11	0.74	2w0mA	GO:0000150 GO:0000400 GO:0000730 GO:0003690 GO:0003697 GO:0004520 GO:0005524 GO:0006312 GO:0008094 GO:0010212 GO:0042148 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0008094	GO:0003697	GO:0003690	GO:0000150	GO:0000400	GO:0004520	GO:0003684	GO:0046914
GO-Score	0.67	0.67	0.67	0.59	0.59	0.59	0.59	0.47	0.44
Biological Processes	GO:0009432	GO:0000730	GO:0042148	GO:0010212	GO:0006312	GO:0042221	GO:0030908	GO:0009411	GO:0051674	GO:0006928	GO:0040011
GO-Score	0.67	0.59	0.59	0.59	0.59	0.44	0.44	0.44	0.38	0.38	0.38
Cellular Component	GO:0005829
GO-Score	0.59

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.