I-TASSER results

I-TASSER results for job id Rv3376

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (217 residues)
MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGWLNGLTIDDAFVETQPI
SEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEEARRRGLKVGVLTNNSLLV
SARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEG
ARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGWLNGLTIDDAFVETQPISEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEEARRRGLKVGVLTNNSLLVSARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEGARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP
Prediction	CCCCEEEHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEHCCCCHHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCCHHHHHHHHHHHCCCHHHEEEEHCCHHHHHHHHHHCCEEEEHCCCCCCCCHHHHCHHHHHHHHHHCCC
Conf.Score	9864899879998756768999999999989995678899876678754899999876455556776788878889999999999865899999799999999998995999869998899999999979745587887545478889998999999999899977767775887889999998995999689998876777569999999987589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGWLNGLTIDDAFVETQPISEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEEARRRGLKVGVLTNNSLLVSARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEGARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP
Prediction	8526244734140200111120042016437151540253125314433134013433414511540453253135324211223235605124324521540364404213021233431042006314046034000002216334412324231374473515523434614341420443434041134654424311530550251067358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEHCCCCHHHHHHHHHHHHCCCCCCCEEEEHHHCCCCCCCHHHHHHHHHHHCCCHHHEEEEHCCHHHHHHHHHHCCEEEEHCCCCCCCCHHHHCHHHHHHHHHHCCC
MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGWLNGLTIDDAFVETQPISEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEEARRRGLKVGVLTNNSLLVSARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEGARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP

4uarA

0.19

0.98

2.71

MUSTER

M-IEAILFDVDGTLAETLHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTS-LPNVEALCRACFAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRADRLLDSFAELGGLAGLL--

4g9bA

0.18

0.99

2.91

dPPAS

MKLQGVIFDLDGVITDTLHFQAWQQIAAEIGISIDAQFNESLKGISRDESLRRILQHGGKEGDFNSQERAQLAYRKNLLYVHSLRELTVNAVLPGIRSLLADLRAQQISVGLASVSL---NAPTILAALELREFFTFCADASQLKNSKPDPEIFLAACAGLGVPPQACIGIEDAQAGIDAINASGMRSVGIGAGLTGAQLLLPSWPRLSAFWQNVAE

3e58A

0.17

0.16

0.93

3.44

wdPPAS

--VEAIIFD-DGVLFDTYYYDRRASFLGQKGISIDHLP---PSFFIGGNTKQVWENILRDEYDKWDVSTLQEEYNTYKQNNPL---PYKELIFPDVLKVLNEVKSQGLEIGLASSSV-KADIFRALEENRLQGFFDIVLSGEEFKESKPNPEIYLTALKQLNVQASRALIIEDSEKGIAAGVAADVEVWAIRDNEFGAKGLLDSLTDVLDLI-----

4uarA

0.19

0.18

0.98

3.05

wMUSTER

--IEAILFDVDGTLAETLHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTS-LPNVEALCRACFAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRADRLLDSFAELGGLAGLL--

4uarA

0.19

0.98

3.24

wPPAS

M-IEAILFDVDGTLAETLHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTS-LPNVEALCRACFAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRADRLLDSFAELGGLAGLL--

3e58A

0.17

0.16

0.93

3.87

dPPAS2

--VEAIIFD-DGVLFDTYYYDRRASFLGQKGISIDHLP---PSFFIGGNTKQVWENILRDEYDKWDVSTLQEEYNTYKQNNP---LPYKELIFPDVLKVLNEVKSQGLEIGLASSSV-KADIFRALEENRLQGFFDIVLSGEEFKESKPNPEIYLTALKQLNVQASRALIIEDSEKGIAAGVAADVEVWAIRDNEFGAKGLLDSLTDVLDLI-----

4uarA

0.19

0.98

3.04

PPAS

M-IEAILFDVDGTLAETLHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTS-LPNVEALCRACFAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRHDRLLDSFAELGGLAGLL--

4uarA

0.19

0.98

3.81

Env-PPAS

M-IEAILFDVDGTLAETLHRRAFNETFAALGVDWFWDREEYRELLTTTGGKERIARFLRHQKGDPAPLPIADIHRAKTERFVALMAEGEIALRPGIADLIAEAKRAGIRLAVATTTS-LPNVEALCRACFAREIFDVIAAGDMVAEKKPSPDIYRLALRELDVPPERAVALEDSLNGLRAAKGAGLRCIVSPGFYTRADRLLDSFAELGGLAGLL--

3e58A

0.17

0.16

0.93

2.67

MUSTER

--VEAIIFD-DGVLFDTYYYDRRASFLGQKGISIDHLP---PSFFIGGNTKQVWENILRDEYDKWDVSTLQEEYNTYKQNN---PLPYKELIFPDVLKVLNEVKSQGLEIGLASSSV-KADIFRALEENRLQGFFDIVLSGEEFKESKPNPEIYLTALKQLNVQASRALIIEDSEKGIAAGVAADVEVWAIRDNEFAAKGLLDSLTDVLDLI-----

3e58A

0.17

0.16

0.93

2.85

dPPAS

--VEAIIFD-DGVLFDTYYYDRRASFLGQKGISIDHLP---PSFFIGGNTKQVWENILRDEYDKWDVSTLQEEYNTYKQNNPLPYKEL---IFPDVLKVLNEVKSQGLEIGLASSSV-KADIFRALEENRLQGFFDIVLSGEEFKESKPNPEIYLTALKQLNVQASRALIIEDSEKGIAAGVAADVEVWAIRDNEFGAKGLLDSLTDVLDLI-----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 2 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.65

Estimated TM-score = 0.80±0.09

Estimated RMSD = 4.2±2.8Å

Download Model 2

C-score=-0.49

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4uarA	0.903	1.78	0.192	0.982
2	4ex6A	0.855	2.25	0.163	0.954
3	4gibA	0.847	2.63	0.175	0.972
4	2hszA	0.830	2.29	0.160	0.949
5	1te2A	0.825	2.24	0.238	0.931
6	3iruA	0.816	2.55	0.150	0.949
7	2nyvA	0.810	2.56	0.167	0.940
8	2wheA	0.794	2.80	0.193	0.949
9	3e58A	0.793	2.62	0.173	0.931
10	2hi0A	0.791	2.88	0.155	0.949

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.79	208	2g06A	MG	Rep, Mult	9,11,173
2	0.21	57	2wf5A	MGF	Rep, Mult	9,10,11,114,115,148
3	0.04	14	4uatA	XBP	Rep, Mult	9,10,11,19,48,49,50,53,74,77,114,115,116,117,121,148
4	0.01	4	1z4nA	GL1	Rep, Mult	19,23,50,77,116,117,118,121
5	0.00	1	3ddhA	MG	Rep, Mult	46,47,52,53,117
6	0.00	1	3quqA	MG	Rep, Mult	192,203
7	0.00	1	3qxgB	CA	Rep, Mult	179,183
8	0.00	2	2no5B	CNR	Rep, Mult	18,35,38,39
9	0.00	1	2no5A	CNR	Rep, Mult	37,174,175,176
10	0.00	1	2b8jA	PO4	Rep, Mult	9,115,153,176
11	0.00	2	3s6jB	CA	Rep, Mult	195,196,197
12	0.00	1	3qx7A	PO4	Rep, Mult	24,25,28,39
13	0.00	1	1swv0	III	Rep, Mult	150,151,152,155,158,159,162,164,165,183
14	0.00	1	1te2B	CA	Rep, Mult	130,133
15	0.00	1	3qypB	UNL	Rep, Mult	19,23,48,78
16	0.00	1	2no5B	CNR	Rep, Mult	174,175,176,192

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.457	2i7dA	0.607	3.74	0.123	0.825	3.1.3.-	9,11
2	0.338	3bwvB	0.542	3.65	0.115	0.724	3.1.3.-	11
3	0.308	2jaoA	0.608	3.75	0.117	0.830	3.1.3.-	11
4	0.271	1qq5A	0.705	3.49	0.255	0.912	3.8.1.2	12,93,95,129,131,202
5	0.240	2no4B	0.680	3.89	0.225	0.871	3.8.1.2	9,115,148
6	0.224	1qh9A	0.683	3.73	0.246	0.889	3.8.1.2	12,100
7	0.221	1u7pC	0.579	2.55	0.178	0.673	3.1.3.48	93,193
8	0.217	3ewiB	0.555	2.64	0.119	0.659	2.7.7.43	12,179
9	0.211	1f5sA	0.677	3.46	0.133	0.866	3.1.3.3	9,11
10	0.208	2fpsB	0.536	3.24	0.178	0.664	3.1.3.15	12,115,137,173,175
11	0.208	2wm8A	0.574	2.58	0.164	0.673	3.1.3.48	9,93,173
12	0.174	1lvhA	0.819	2.74	0.209	0.972	5.4.2.6	NA
13	0.156	1l8oB	0.670	3.58	0.144	0.866	3.1.3.3	11,175
14	0.132	1k1eK	0.565	2.64	0.159	0.668	3.1.3.45	11,14,173
15	0.103	1q92A	0.607	3.78	0.133	0.834	3.1.3.5	9,11
16	0.087	1cqzB	0.618	4.53	0.186	0.857	3.3.2.10,3.3.2.3	114,148
17	0.075	2qltA	0.766	3.16	0.176	0.940	3.1.3.-	114,148
18	0.075	2gmwB	0.597	2.71	0.178	0.701	3.1.3.-	114,130,148
19	0.067	2r8zP	0.548	2.94	0.124	0.668	3.1.3.45	11,14,173,201
20	0.060	2feaA	0.635	3.87	0.141	0.853	3.1.3.-	12,50,173,179
21	0.060	2vkqA	0.663	4.28	0.088	0.926	3.1.3.5	11,173,181
22	0.060	1aq6A	0.702	3.52	0.255	0.912	3.8.1.2	9,115,148
23	0.060	1mhsA	0.606	4.71	0.103	0.899	3.6.3.6	9
24	0.060	3b8cB	0.654	4.31	0.106	0.935	3.6.3.6	184
25	0.060	1zd3A	0.613	4.42	0.217	0.843	3.3.2.10	94,104,132,136
26	0.060	1l8lA	0.670	3.89	0.131	0.876	3.1.3.3	NA
27	0.060	1te2A	0.825	2.24	0.238	0.931	3.1.3.18	NA
28	0.060	3nasA	0.633	3.67	0.212	0.848	5.4.2.6	9,11,173
29	0.060	2w11A	0.639	3.82	0.192	0.820	3.8.1.2	9,115,148
30	0.060	2nyvA	0.810	2.56	0.167	0.940	3.1.3.18	11,47,190
31	0.060	1judA	0.694	3.47	0.249	0.894	3.8.1.2	9,116,148
32	0.060	1eulA	0.528	4.12	0.071	0.719	3.6.3.8	9
33	0.060	3b8cA	0.655	4.37	0.106	0.940	3.6.3.6	9
34	0.060	2jc9A	0.690	3.99	0.142	0.945	3.1.3.5	151,154,186
35	0.060	1x42A	0.704	3.72	0.208	0.903	3.8.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.57	0.855	2.22	0.23	0.96	1te2A	GO:0000287 GO:0003850 GO:0004346 GO:0005829 GO:0008152 GO:0016311 GO:0016787 GO:0016791 GO:0046872 GO:0050308
1	0.55	0.829	2.60	0.22	0.97	1o03A	GO:0000287 GO:0005737 GO:0005975 GO:0008152 GO:0008801 GO:0016787 GO:0016853 GO:0046872
2	0.54	0.806	2.76	0.19	0.95	3s6jE	GO:0008152 GO:0016787 GO:0046872
3	0.54	0.754	3.21	0.14	0.95	2hcfA	GO:0016787 GO:0046872
4	0.49	0.741	3.08	0.20	0.94	2fdrA	GO:0008152 GO:0016787 GO:0046872
5	0.42	0.809	2.85	0.17	0.97	2hi0A	GO:0008152 GO:0016787
6	0.41	0.786	2.86	0.19	0.94	4g9bA	GO:0000287 GO:0005737 GO:0005975 GO:0006974 GO:0008152 GO:0008801 GO:0009294 GO:0016787 GO:0016853 GO:0046677 GO:0046872
7	0.41	0.798	2.52	0.15	0.92	3d6jA	GO:0008152 GO:0016787
8	0.41	0.906	1.88	0.18	0.99	4uauA	GO:0008152 GO:0016787
9	0.39	0.712	3.13	0.21	0.89	4rn3A	GO:0008152 GO:0016787 GO:0046872
10	0.39	0.813	2.53	0.18	0.94	2nyvA	GO:0005975 GO:0008152 GO:0008967 GO:0016311 GO:0016787 GO:0046295 GO:0046872
11	0.38	0.599	2.69	0.22	0.70	3l8hA	GO:0000287 GO:0005737 GO:0005975 GO:0008270 GO:0009244 GO:0016311 GO:0016787 GO:0016791 GO:0034200 GO:0046872 GO:0097171
12	0.37	0.729	3.67	0.28	0.91	4ygqA	GO:0008152 GO:0016787 GO:0046872
13	0.37	0.673	3.77	0.17	0.86	2w4mA	GO:0005829 GO:0005975 GO:0006045 GO:0008152 GO:0016311 GO:0016787 GO:0046380 GO:0050124
14	0.37	0.792	3.05	0.17	0.96	3qu5B	GO:0008152 GO:0016787 GO:0046872
15	0.36	0.855	2.25	0.16	0.95	4ex6A	GO:0008152 GO:0016787 GO:0046872
16	0.36	0.797	2.67	0.15	0.94	3dv9A	GO:0008152 GO:0016787 GO:0046872
17	0.35	0.643	3.90	0.20	0.82	3cnhA	GO:0008152 GO:0016787
18	0.35	0.729	3.36	0.26	0.92	3kbbA	GO:0005975 GO:0008152 GO:0016787 GO:0046872
19	0.35	0.759	3.04	0.21	0.94	3l5kA	GO:0005829 GO:0008152 GO:0009117 GO:0016311 GO:0016787 GO:0043097 GO:0046872 GO:0070062 GO:1990738
20	0.35	0.847	2.63	0.17	0.97	4gibA	GO:0000287 GO:0005975 GO:0008152 GO:0008801 GO:0016787 GO:0016853
21	0.34	0.738	3.59	0.19	0.95	4uavA	GO:0008152 GO:0009507 GO:0009536 GO:0009570 GO:0009941 GO:0016787 GO:0046872
22	0.33	0.647	3.55	0.20	0.86	3nasA	GO:0000287 GO:0005737 GO:0005975 GO:0008152 GO:0008801 GO:0016787 GO:0016853 GO:0046872
23	0.31	0.685	2.91	0.14	0.81	3kzxA	GO:0008152 GO:0016787
24	0.31	0.715	3.58	0.19	0.94	4eekA	GO:0008152 GO:0016787 GO:0046872
25	0.30	0.803	2.59	0.17	0.94	3e58A	GO:0008152 GO:0016787
26	0.30	0.694	3.47	0.25	0.89	1judA	GO:0008152 GO:0016787 GO:0018784 GO:0019120
27	0.29	0.791	2.40	0.19	0.92	2hdoA	GO:0004427 GO:0008152 GO:0008967 GO:0016311 GO:0016787
28	0.28	0.642	4.20	0.23	0.86	2b0cA	GO:0000287 GO:0008152 GO:0008877 GO:0016311 GO:0016787 GO:0030145 GO:0046872
29	0.28	0.658	3.82	0.17	0.85	4jb3A	GO:0008152 GO:0009231 GO:0016311 GO:0016787 GO:0043726 GO:0046872
30	0.26	0.729	3.73	0.21	0.93	4ffdA	GO:0008152 GO:0016787
31	0.25	0.595	4.16	0.15	0.84	2msnA	GO:0008152 GO:0016787
32	0.24	0.578	2.99	0.22	0.70	2o2xA	GO:0005737 GO:0005975 GO:0016311 GO:0016787 GO:0016791 GO:0046872 GO:0097171
33	0.24	0.639	3.82	0.19	0.82	2w11A	GO:0008152 GO:0016787 GO:0018784 GO:0019120
34	0.23	0.780	2.51	0.16	0.92	2ah5A	GO:0016787
35	0.19	0.651	3.85	0.16	0.83	3umcA	GO:0008152 GO:0016787 GO:0019120
36	0.13	0.702	3.52	0.26	0.91	1aq6A	GO:0008152 GO:0016787 GO:0018784 GO:0019120
37	0.12	0.680	3.89	0.23	0.87	2no4B	GO:0008152 GO:0016787 GO:0018784 GO:0019120

Consensus prediction of GO terms

Molecular Function	GO:0000287	GO:0004346	GO:0003850	GO:0008801
GO-Score	0.81	0.57	0.57	0.55
Biological Processes	GO:0016311	GO:0005975
GO-Score	0.57	0.55
Cellular Component	GO:0005829
GO-Score	0.57

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.